Prof Derek K Jones - BSc (Physics) Nottingham MSc (Med Physics) Leeds PhD (Diffusion MRI) Leicester Dip. IPSM
As a physicist, my research focuses on maximizing the amount of information that can be extracted about white matter non-invasively using magnetic resonance imaging techniques. If the grey matter acts as the ‘service stations’ – then the white matter acts as the ‘motorways’ and hence forms an integral and fundamental part of brain networks. My research has been primarily focussed on development of methods for diffusion tensor magnetic resonance imaging (DT-MRI) and its application to both healthy and diseased states, but we are extending the range of white matter imaging methods to include relaxometry and magnetization transfer imaging, with the aim of providing a more complete multi-spectral characterization of white matter.
Selected Publications
Jones DK, Catani M, Pierpaoli C, Reeves SJC, Shergill SS, O’Sullivan MO, Malley JD, McGuire P, Horsfield MA, Simmons A, Williams SCR, Howard RJ. 2005. Age effects on diffusion tensor magnetic resonance imaging tractography measures of frontal cortex connections in schizophrenia. Human Brain Mapping 2006 27(3):230-8.
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Jones DK, Symms MR, Cercignani M, Howard RJ. 2005. The Effect of Filter Size on the Outcome of VBM Analyses of DT-MRI Data NeuroImage 26:546-554.
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Jones DK, Alexander DC, Griffin LD, Catani M, Horsfield MA, Howard RJ, Williams SCR. 2002. Spatial normalisation and averaging of diffusion tensor MRI data sets. NeuroImage 17: 592-617.
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Catani M, Howard RJ, Pajevic S, Jones DK. 2002. Virtual in vivo interactive dissection of white matter fasciculi in the human brain. NeuroImage 17:77-94.
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Research Projects
Grants in the last five years
Awarding Body: Cure Autism Now Foundation
Title: "Brain anatomy and connectivity: an endophenotype in Autism Spectrum Disorders”
Type: Pilot Research Study
Principal Investigator: Murphy DGM; Co-Investigators: Jones DK, Bullmore ET, Happe FGE, Rijsdijk FV, Bolton PF, Catani M, Baron-Cohen S, Curran S, Williams SCR. Start: Feb 10th 2006; Duration: 24 months
Amount $120,00 US
Awarding Body: Medical Research Council
Title: “Brain anatomy in autism; a multi-centre study”
Type: Strategic Grant
Principal Investigator: Prof DGM Murphy; Co-Investigators: Prof S Baron-Cohen, Prof PF Bolton, Prof M Brammer, Prof E Bullmore, Dr S Curran, Dr FG Happé, Prof P Jezzard, Dr DK Jones, Prof SCR Williams.
Start Date: June 1st 2005; Duration: 48 months,
Amount: £641,000.
Awarding Body: Wellcome Trust
Principal Investigator: Dr Derek K Jones
Grant Number: 067437/Z/02/A
Title of Project: “Toward Robust Statistical Comparisons of White Matter Tracts in the Human Brain”
Type: Advanced Training Fellowship.
Duration: 36 months. Amount: £290,000.
Role: Applicant
Awarding Body: Medical Research Council.
Principal Investigator: Prof R Campbell.
Co-Investigators: Prof B Woll, Prof MJ Brammer, Prof AS David, Dr M McSweeney, Dr DK Jones.
Grant Number: GR068607MA
Title of Project: “Imaging the Deaf Brain: Functional and Structural Studies Using MRI”
Type: Project Grant.
Duration: 36 months, Amount: £422,000.
Role: Co-applicant
Research Students
Dr Marco Catani, Ph.D. Student – ‘Neuronal connectivity in autism spectrum disorder’ (I am co-supervisor, at the Institute of Psychiatry, Kings College London).