Prof Kim Graham - BSc (Hons Edin), PhD (Cantab)
Research Summary
My main research interest is in human long-term memory (our store of episodes from the past and our factual knowledge about the world). I am particularly interested the neural substrates of long-term memory, and how this key cognitive system interacts with language, perception and attention. My aim is to develop a theoretical view of memory that provides a sensible account of brain-behaviour relationships, and to consider the translational potential of this account for clinical conditions that result in memory impairment, including epilepsy and dementia.
To study long-term memory, I use cognitive neuropsychology (the study of how memory breaks down after brain damage, such as dementia, stroke, encephalitis), functional brain imaging (the use of functional magnetic resonance imaging to measure activity in the brain while performing memory tests, both in healthy participants and in patients with memory impairment) and magnetoencephalography (the measurement of magnetic fields generated by neural activity in the brain).
Selected Publications (2008 onwards)
Lee, A.C.H., Scahill, V.L., & Graham, K.S. (2008). Activating the medial temporal lobe during oddity judgement for faces and scenes. Cerebral Cortex, 18, 683-696.
Graham, K.S., Lee, A.C.H. & Barense, M.D. (2008). Impairments in visual discrimination in amnesia: implications for theories of the role of medial temporal lobe regions in human memory. European Journal of Cognitive Psychology, 20, 655-696.
Graham, K.S., Lee, A.C.H. & Barense, M.D. (2008). Memory and perceptual impairments in amnesia and dementia. In Handbook of Behavioural Neuroscience: Episodic Memory Research, (Eds., E. Dere, A. Easton, J. Huston & L. Nadel), p483-501.
Ahmed, S., Arnold, R., Thompson, S.A., Graham, K.S. & Hodges, J.R. (2008). Naming of objects, faces and buildings in mild cognitive impairment. Cortex, 44, 746-752.
Duarte, A, Henson, R.N.A. & Graham, K.S. (2008). The effects of aging on the neural correlates of subjective and objective recollection. Cerebral Cortex, 18, 2169-2180.
Duarte, A., Graham, K.S. & Henson, R.N.A. (2009). Age-related changes in neural activity associated with familiarity, recollection and false recognition. Neurobiology of Aging. Epub Nov 10.
Butler, C.R., Bhaduri, A., Acosta-Cabronero, J., Nestor, P.J., Kapur, N., Graham, K.S., Hodges, J.R. & Zeman, A.Z. (2009). Transient Epileptic Amnesia: regional brain atrophy and its relation to memory deficits. Brain, 132, 357-368.
Davies, R.R., Scahill, V.L., Graham, A., Williams, G.B., Graham, K.S. & Hodges, J.R. (2009). Development of an MRI rating scale for multiple brain regions: comparison with volumetrics and with voxel-based morphometry. Neuroradiology, 51, 491-503.
Dewar, B-K, Patterson, K., Wilson, B. & Graham, K.S. (2009). Re-acquisition of person knowledge in semantic memory disorders. Neuropsychological Rehabilitation, 19, 383-421.
Barense, M.D., Henson, R.N.A., Lee, A.C.H. & Graham, K.S. (2009). Medial temporal lobe activity during complex discriminations of faces, objects and scenes: effects of viewpoint. Hippocampus. Epub Jul.
Hornberger, M, Bell, B., Graham, K.S. & Rogers, T.T. (2009). Are judgements of semantic relatedness systematically impaired in Alzheimer’s disease? Neuropsychology, 47, 3084-3094.
Duarte, A., Henson, R.N.A., Knight, R.T., & Graham, K.S. (2009). The orbital frontal cortex is necessary for temporal context memory. Journal of Cognitive Neuroscience. Epub Jul 30.
Mundy, M.E., Honey, R.C., Downing, P.E., Wise, R.G., Graham, K.S. & Dwyer, D.M. (2009). Stimulus-invariant and stimulus-specific activations in fMRI after perceptual learning. NeuroReport, 20, 1387-1401.
Barense, M.D., Rogers, T.T., Bussey, T.J., Saksida, L. & Graham, K.S. (in press). Influence of conceptual knowledge on visual object discrimination: semantic dementia and MTL amnesia. Cerebral Cortex.
Graham, K.S., Barense, M.D. & Lee, A.C.H. (in press). Going beyond LTM in the MTL: a synthesis of neuropsychological and neuroimaging findings on the role of the medial temporal lobe in memory and perception. Neuropsychologia.