Understanding the interactions of oxidizing agents with macromolecules and microbial cell components
Introduction
The research project concerns the understanding of oxidising agents with
macromolecules and microbial cell components. Oxidising agents such
as hydrogen peroxide and peracetic acid are important chemicals used
for high-level disinfection/ sterilization of medical equipment and
surfaces. Hydrogen peroxide can be used for fumigation and as such as
many advantages when compared to other agents such as formaldehyde,
for example, they are degradable and do not produce any toxic
residues.
Aims of Project
Although, oxidising agents are very potent microbicidal
agents, there are many unanswered questions as to their mechanisms of
action against microbial cells, including bacteria, spores and
viruses, especially considering that some of their effects do not
necessarily involved oxidation of certain cell components.
Understanding better the interactions between oxidising agents and
macromolecules and cell components, provide the platform for
potentiation and improved usage of these important biocides. This
study was initiated 2 years ago and important preliminary results
have been obtained. The objectives will concentrate on the
interactions of oxidising components with bacterial cell components
and bacterial structure.
Funder
Welsh School of Pharmacy, Cardiff University and an Industrial partner
For further information
Prof Stephen Denyer
