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Wednesday, 24th October 2012

Starts: 24 October 2012

Dr Ingunn Holen

Dr Ingunn Holen BSc, MSc, PhD

Sheffield University

Reader in Bone Oncology, Head of Laboratory Research Academic Unit of Clinical Oncology


“The tumour microenvironment in breast cancer bone metastasis - role in development and response to therapy”

Dr Holen completed her PhD at the University of Oslo and the Norwegian Radium Hospital in 1995, before joining the University of Sheffield, UK, as a research associate in the Department of Human Metabolism and Clinical Biochemistry. In 2001 she was appointed Lecturer in Bone Oncology in the Academic Unit of Clinical Oncology, with responsibility for establishing and developing a laboratory research program for the studies of therapeutic approaches in advanced breast cancer and bone metastasis. Dr Holen was promoted to Senior Lecturer in 2005 and appointed as Reader in Bone Oncology in 2009. She is deputy chair of the Scientific Advisory Board of the Breast Cancer Campaign, a member of the British Association for Cancer Research Executive and serves on a number of editorial boards of international scientific journals.

Research in the Holen team is focussed on therapeutic approaches to advanced breast and prostate cancer, in particular how combining drugs can reduce tumour growth in bone. Working in collaboration with colleagues both within the University and abroad, her team has studied the effects of combining chemotherapy agents (targeting the tumour cells) with bisphosphonates (targeting the bone microenvironment). Dr Holen has established range of in vitro and complex in vivo models for studies of tumour growth in bone that have been utilised in numerous studies published in prestigious international journals. Other research areas include the anti-angiogenic effects of combination therapy, and determining the cellular and molecular mechanisms involved in cancer-induced bone disease in breast cancer. The research lead by Dr Holen is funded by a number of local and national charities, including a Cancer Research UK and Breast Cancer Campaign, as well as by the pharmaceutical industry.


Host: Dr Julia Gee

4pm (refreshments from 3:50pm)

New Lecture Theatre, 2.60c Redwood Building

Other information

Cost: Free

Open To: Postgraduate Students
Staff and Students
Undergraduate Students