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Dr Alex White  -  BSc PhD CChem MRSC


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Journal articles  

 

Lau, W.M.; White, A.W.; Gallagher, S.J.; Donaldson, M.; McNaughton, G.; Heard, C.M. Scope and limitations of the co-drug approach to topical drug delivery. Curr. Pharm. Des. (2008), 14, 794-802. 

Alex W. White, Andrew D. Westwell and Ghali Brahemi. Protein–protein interactions as targets for small-molecule therapeutics in cancer. Expert Rev. Mol. Med. (2008), 10, e8. 

White, A.W.; Lottin, J.R.P.; Barrow, D.; Nicholson, R.I.; Anti-proliferative extracts from a Welsh Sponge. J. Pharm. Pharmacol. (2005), 57 (9 Suppl.), 141. 

White, A.W.; Curtin, N.J.; Eastman, B.W.; Golding, B.T.; Hostomsky, Z.; Kyle, S.; Li, J.; Maegley, K.A.; Skalitzky, D.J.; Webber, S.E.; Yu, X-H.; Griffin, R.J. Potentiation of cytotoxic drug activity in human tumour cell lines by amine substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors; Bioorg.Med.Chem.Lett. (2004), 14, 2433-2437. 

White, A.W.; Almassey, R.; Calvert, A.H.; Curtin, N.J.; Griffin, R.J.; Hostomsky, Z.; Maegley, K.; Newell, D.R.; Srinivasan, S; Golding, B.T. Resistance Modifying Agents. 9. Synthesis and biological properties of benzimidazole inhibitors of the DNA repair enzyme Poly (ADP-ribose) polymerase (PARP); J.Med.Chem. (2000), 43, 4084-4097. 

Delaney, C.A.; Wang, L.Z.; Kyle, S.; White, A.W.; Calvert, A.H.; Curtin, N.J.; Durkacz, B.W.; Hostomsky, Z.; Newell, D.R. Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines; Clin.Cancer Res. (2000), 6, 2860-2867. 

Meijer, L.; Thunnissen, A-M.W.H.; White, A.W.; Garnier, M.; Nikolic, M.; Tsai, L-H.; Walter, J.; Cleverley, K.E.; Salinas, P.C.; Wu, Y-Z.; Biernat, J.; Mandelkow, E-M.; Kim, S-H.; Pettit, G.R. Inhibition of cyclin-dependent kinases, GSK-3 and CK1 by hymenialdisine, a marine sponge constituent; Chemistry & Biology (2000), 7, 51-63. 

Bowman, K.J.; White, A.W.; Golding, B.T.; Griffin, R.J.; Curtin, N.J. Potentiation of anti-cancer agent cytotoxicity by the potent poly (ADP-ribose) polymerase inhibitors NU1025 and NU1064; Br.J.Cancer (1998), 78, 1269-1277. 

Griffin, R.J.; Srinivasan, S.; White, A.W.; Bowman, K.J.; Calvert, A.H.; Curtin, N.J.; Newell, D.R.; Golding, B.T. Novel benzimidazole and quinazolinone inhibitors of the DNA repair enzyme poly (ADP-ribose) polymerase; Pharm.Sci. (1996), 2, 43-47. 
 
 

Books and book chapters 

 

Nicola J. Curtin, Bernard T. Golding, Roger J. Griffin, David R. Newell, Michael J. Roberts, Sheila Srinivasan and Alex W. White; New PARP Inhibitors for Chemo- and Radio-therapy of Cancer. In: Poly ADP-ribosylation Reactions: From DNA Damage and Stress Signalling to Cell Death; Eds. Gilbert De Murcia and Sydney Shall; Oxford University Press, 2000, 177-206, ISBN 0-19-850633-3.