Dr Kathryn Taylor - PhD
Recent Peer reviewed articles
K. M. Taylor, S. Hiscox, R. I. Nicholson, C. Hogstrand, P. Kille, (2012) Protein kinase CK2 triggers cytosolic zinc signaling pathways by phosphorylation of zinc channel ZIP7. Sci. Signal. 5, ra11 .
Thornton JK, Taylor KM, Ford D, Valentine RA (2011) Differential subcellular localization of the splice variants of the zinc transporter znt5 is dictated by the different c-terminal regions. PLoS One. 6(8):e23878.
Taylor KM, Gee JMW, Kille P (2011) Zinc and Cancer, a chapter in Zinc in human health ed Rink L IOS press , p283-304.
Weaver BP, Zhang Y, Hiscox S, Guo GL, Apte U, Taylor KM, Sheline CT, Wang L and Andrews GK, (2010) Zip4 (Slc39a4) Expression is Activated in Hepatocellular Carcinomas and Functions to Repress Apoptosis, Enhance Cell Cycle and Increase Migration, PLoS One. 2010 Oct 4;5(10). pii: e13158.
Nicholson RI, Hutcheson IR, Hiscox S, Taylor KM, Gee JMW (2009) Experimental endocrine resistance: concepts and strategies, in therapeutic resistance to anti-hormonal drugs in breast cancer, new molecular aspects and their potential as targets, Ed. Hiscox S, Gee J, Nicholson RI, Springer, DOI 10.1007/978-1-4020-8526-0.
Thomas NB, Hutcheson IR, Campbell L, Gee J, Taylor KM, Nicholson RI, Gumbleton M. (2010) Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. Breast Cancer Res Treat. 2010 Feb;119(3):575-91. Epub 2009 Mar 15.
Hogstrand C, Kille P, Nicholson RI, Taylor KM, (2009) Zinc transporters and Cancer: A potential role for ZIP7 as a hub for tyrosine kinase activation, Trends Mol Med, 15(3):101-11.
Ma X, Ma Q, Liu J, Tian Y, Wang B, Taylor KM, Wu P, Wang D, Xu G, Meng L, Wang S, Ma D, Zhou J. (2009) Identification of LIV1, a putative zinc transporter gene responsible for HDACi-induced apoptosis, using a functional gene screen approach. Mol Cancer Ther. 8, 3108-16.
Taylor KM, (2008) A distinct role in breast cancer for two LIV-1 family zinc transporters, Biochem Soc Trans, 36 (Pt6), 1247-51.
Taylor, K.M, Vichova, P., Jordan, N., Hiscox, S., Hendley, R. and Nicholson, R. (2008) ZIP7-mediated intracellular zinc transport contributes to aberrant growth factor signaling in anti-hormone resistant breast cancer cells. Endocrinology. 149(10):4912-20.
Hiscox, S., Jordan, N.J., Smith, C., James, M., Morgan, L., Taylor, K.M., Green, T.P., Nicholson, R.I. (2008) Dual targeting of Src and ER prevents acquired antihormone resistance in breast cancer cells. Breast Cancer Res Treat. In press. doi:10.1007/s10549-008-0058-6.
Taylor, K.M., Morgan, H.E., Smart K, Zahari NM, Pumford S, Ellis IO, Robertson JFR, Nicholson RI, (2007) The emerging role of the LIV-1subfamily of zinc transporters in breast cancer, Molecular Medicine, 13 l (7-8): 396-406.
Zhao L, Chen W, Taylor KM, Cai B, Li X. (2007) LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway. Biochem Biophys Res Commun. 363(1):82-88.
RI Nicholson, IR Hutcheson, HE Jones, SE Hiscox, M Giles, K M Taylor and JMW Gee (2007) Growth factor signalling in endocrine and anti-growth factor resistant breast cancer, Rev Endocr Metab Disord. 8(3):241-53. Review.
Taylor KM and Nicholson RI. (2006) Fear of intimacy: a close LIV-1 acquaintancy? Development 133, 3053
Hiscox S, Jiang WG, Obermeier K, Taylor K, Morgan L, Burmi R, Barrow D, Nicholson RI. (2006) Tamoxifen resistance in MCF7 cells promotes EMT-like behaviour and involves modulation of beta-catenin phosphorylation. Int J Cancer. 118(2):290-301.
Taylor KM, Vichova P, Hiscox S, and Nicholson RI. (2005) Zinc-dependant stimulation of Src, EGFR and IGFR signalling pathways in tamoxifen-resistant breast cancer and the role of zinc transporters. Breast Cancer Research and Treatment 94, S162.
Taylor KM, Hiscox S,Nicholson RI.(2004) Zinc transporter LIV-1;A link between cellular development and cancer progression.Trends Endocrin and Metab,15(10);461-463.
Taylor, K.M., Morgan, H.E., Johnson, A. & Nicholson, R.I., (2004) Structure-Function Analysis of HKE4, a member of the new LIV-1 subfamily of zinc transporters. Biochem J. 377(1), 131-139.
Walters KM and Taylor KM (2004) Activation of EGFR at different phosphorylation sites in tamoxifen resistant breast cancer, 2004 WSP UG Research Abstract Book, (ed. John DN) STS Publishing, Cardiff 81. ISBN 0 9489 17 28 8.
Taylor, K. M., Morgan, H. E., Johnson, A., Hadley, L. J., & Nicholson, R.I., (2003) Structure-Function Analysis of LIV-1, the breast cancer associated protein that belongs to a new subfamily of zinc transporters. Biochem. J. 375 (1), 51-59.
Taylor K.M. and Nicholson R.I. (2003) The LZT proteins; the new LIV-1 subfamily of zinc transporters. BBA biomembranes,1611, 16-30
Taylor, K.M., & Nicholson, R.I., (2003) The LIV-1 subfamily of ZIP transporters have a unique metalloprotease motif, HEXPHEXGD. Biochem. Soc. Trans 31 (2) 10.
Patent Application
International Patent Application No PCT/GB01/02597 and entitled ‘Zinc transporters’, filed 13th June 2001. This application claims priority from two other UK patents GB0014411.3 and GB0014493.1 and US patent No. 60/216,349.
Recent Abstracts and Conference Proceedings
Taylor, KM., Invited oral presentation at 60th Fugihara Seminar series, Osaka, Japan, October, 2010.
Taylor, KM., Invited oral presentation at inaugural meeting of ‘Zink UK’ in London, May, 2010.
Taylor, KM., Invited oral presentation at International society for Zinc Biology in Jerusalem, December 2009 entitled ‘Zinc transporters and Cancer; ZIP7 as a hub for intracellular zinc’.
Taylor, KM., Invited oral presentation at Rank Prize Fund Mini-symposium on Micronutrients in Animals and Plants in Grasmere, October 2008 entitled The LIV-1 family of zinc transporters and their role in cancer’.
Taylor, KM., Invited oral presentation at Biochemical Society meeting Metal metabolism: transport, development and neurodegeneration at Imperial College, May, 2008, entitled ‘The emerging role of zinc transporters in breast cancer’.
Taylor, KM, Jordan, N., Hiscox, S., and Nicholson, RI at Biochemical Society meeting Metal metabolism: transport, development and neurodegeneration at Imperial College, May, 2008 entitled ‘ZIP7 controls intracellular zinc distribution providing a breast cancer target’.
Taylor, KM, Jordan, N., Hiscox, S., Gee, JMW., and Nicholson, RI at the Breast Cancer Campaign annual conference at the Royal Society, London, May 2008 entitled ‘The zinc transporter HKE4 as a new target in anti-hormone resistant breast cancer’.
Taylor, KM., Invited oral presentation at International Society for Zinc Biology, Banff, February, 2008, entitled ‘a central role for HKE4/ZIP7 in zinc-dependant signalling in breast cancer’.
Taylor KM, Vichova P, Hiscox S and Nicholson RI Zinc-dependant stimulation of Src, EGFR and IGFR signalling pathways in Tamoxifen-resistant breast cancer and the role of zinc transporters. 2nd AstraZeneca/Tenovus cancer conference, Cardiff, 2006.
Taylor KM, Zahari NM, Vichova P. and Nicholson RI Involvement Of Zinc Transporter HKE4 In Tamoxifen-Resistant Breast Cancer. 2nd AstraZeneca/Tenovus cancer conference, Cardiff, 2006.
Taylor KM, invited oral presentation ‘The LIV-1 subfamily as new targets in anti-hormone resistance and metastasis of breast cancer’, at Zinc Signals, Siena, Italy, 2006.
Vichova P, Taylor KM, and Nicholson RI. (2005) Zinc-dependant activation of c-Src, EGFR and IGF-1R mitogenic pathways in tamoxifen-resistant breast cancer cells. 9th Nottingham International Breast Cancer Conference, Nottingham, UK.
Taylor KM, Vichova P, Hiscox S, and Nicholson RI. (2005) Zinc-dependant activation of EGFR and co-localisation with vinculin in focal adhesions in Tamoxifen resistant breast cancer cells. Beatson Cancer Conference, Glasgow.
Scheper M, Nikitakis NG, Siavash H, Gupta A, Taylor KM, Sauk JJ. (2005) LIV-1, a potential novel immunohistochemical marker for salivary gland tumors, IADR conference.
Taylor KM, Vichova P and Nicholson RI (2005) Activation of EGFR in Tamoxifen resistant breast cancer by a zinc-dependant Src kinase mechanism. 1st AstraZeneca/Tenovus cancer conference, Cardiff.
Taylor, K M. Invited oral presentation ‘Characterisation of the new LIV-1 subfamily of ZIP transporters and their role in breast cancer’. at Zinc Signals Aarhus, Denmark, 2004.
Taylor KM invited oral presentation ‘The LIV-1 Subfamily of Zinc Transporters’ at IRG on ionic signalling and health, Cardiff University, 2003.
Taylor KM invited oral presentation ‘The LIV-1 Subfamily of Zinc Transporters’ at Cardiff Biomedical Imaging Forum, Cardiff University, 2003.