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Dr Jean-Yves Maillard  -  BSc PhD


 

 Member of the School's    Drug Delivery & Microbiology Research Discipline  

 

Research interests include: 

  • Efficacy of biocidal agents against micro-organisms
  • Mechanisms of action of biocidal agents
  • Mechanisms of microbial resistance and cross-resistance to antimicrobials
  • Development of efficacy testing protocols
  • New delivery systems for biocidal agents 
Efficacy of Sporicidal Wipes [3.6 Mb]
Presentation by Dr Jean-Yves Maillard to the Infection Prevention Society, Cardiff 2011

 

Current Research Projects

 Biocide impregnated surface materials for use in clinical areas – under what conditions do they work? 

 

Development of novel sporicidal formulations 

 

Assessing the in vivo efficacy of sporicidal wipes 

 

 Bacterial resistance to biocides: an assessment of resistance mechanisms and method development. 

 

 Preventing dental pain, abscess and tooth loss in older adults: Development of antimicrobial restorative materials to manage dental disease in older adults 

 

 Understanding the interactions of oxidizing agents with macromolecules and microbial cell components 

 

 Identification and validation of method(s) to describe antimicrobial resistance development 

 

 Characterisation of pulpal responses to bacterial challenge and novel antimicrobials for management of bacterial contamination of infected pulps and root canals. 

 

Detection of Lipopolysaccharide pyrogens by molecularly-imprinted polymers*  
 
Collaborators
Prof SP Denyer, Welsh School of Pharmacy, Cardiff University
Dr M Gumbleton, Welsh School of Pharmacy, Cardiff University
Dr C Allender, Welsh School of Pharmacy, Cardiff University
Dr C Simons, Welsh School of Pharmacy, Cardiff University
Prof GW Hanlon, School of Pharmacy and Molecular Sciences, University of Brighton g.w.hanlon@brighton.ac.uk
Dr A. Sloan, School of dentistry, Cardiff University
Dr R Waddington, School of dentistry, Cardiff University
Dr D Thomas, School of dentistry, Cardiff University
Dr K Hill, School of dentistry, Cardiff University
Dr E Mahenthiralingam, School of Biosciences, Cardiff University 
Postdoctoral Fellows

Dr Mark Legget (2011-2013) : Development of novel sporicidal formulations.

Gareth Williams (2006-2008) Surveillance of susceptibility profile to disinfectants in ITU isolates of Staphylococcus aureus including MRSA

Sukyul Jung (2006-2008) Ex-vivo modelling of antimicrobial control measures in pulpal disease 
 
 

Key Expertise 
  • Biocide efficacy against micro-organisms including bacteria, viruses, bacterial endospores, protozoa
  • Biocide efficacy standard test protocols
  • Biocide interactions with microbial cells
  • Development of microbial resistance to biocides and to chemotherapeutic antibiotics
  • Design of efficacy test protocols including antimicrobial wipe efficacy test (link to wipe ppt)

 

Research Funding   (current) 

Efficacy of antimicrobial agents: 

 

2012-2013 Dunhill Medical Trust (£50,523): Preventing dental pain, abscess and tooth loss in older adults: Development of antimicrobial restorative materials to manage dental disease in older adults

2012-2014 KTP (Cardiff University/GAMA Healthcare) (£138,000): Assessing the in vivo efficacy of sporicidal wipes – R&D development

2010-2013  NIHR (£241,5277): Biocide impregnated surface materials for use in clinical areas – under what conditions do they work?

2011-2013  KTP (Cardiff University/Steris) (£142,027): Development of novel sporicidal formulations

2009-      GAMA Healthcare. Testing of the sporicidal activity of commercially available wipes against Clostridium difficile

 

Molecular mechanisms of action of, and resistance to, antimicrobial agents:

2008-2011  Steris Corporation, UK/WSOP (£34,000): Understanding the interactions of oxidizing agents with macromolecules and microbial cell components

 

Effects of biocides on the transfer of antibiotic-resistant genes & linkage between antibiotic & biocide resistance in bacteria:

 

2011-2014 Unilever (£112,332): Bacterial resistance to biocides: an assessment of resistance mechanisms and method development.              

2012       L’Oréal, Paris. Preliminary testing of the propensity of preservative molecules to induce/select/trigger bacterial resistance                    

2010-2013  Unilever (£105,765): Identification and validation of method(s) to describe antimicrobial resistance development