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Dr Arwyn Tomos Jones  -  BSc (Hons) MSc PhD Dip-Journalism


Peer Reviewed publications

Vercauteren, D., Deschout, H.,  Remaut, K., Engbersen, J.F.J. Jones, A.T., Demeester, J., De Smedt, S.C., and Braeckmans, K. (2011) Dynamic Colocalization Microscopy to Characterize Intracellular Trafficking of Nanomedicines ACS Nano - In Press DOI: 10.1021/nn2020858

Fricke, T., Mart, R.J., Watkins, C., Wiltshire, M., Errington, R.J., Smith, P.J., Jones, A.T., Allemann, R.K. (2011)Chemical Synthesis of Cell-Permeable Apoptotic Peptides from in Vivo Produced Proteins  Bioconj Chem- in press   DOI: 10.1021/bc200338u

Watkins, C.L., Sayers, E.J., Allender, C., Barrow, D., Fegan, C., Brennan, P., Jones, A.T. (2011) Co-operative membrane disruption between cell penetrating peptide and cargo - implications for the therapeutic use of the Bcl-2 converter peptide D-NuBCP-9-r8. Molecular Therapy; doi:10.1038/mt.2011.175

Vercauteren, D., Piest, M., van der Aa, L.J., Al Soraj, M., Jones, A.T., Engbersen, J.F.J., De Smedt, S.C and Braeckmans, K. (2011) Flotillin dependent endocytosis and a phagocytosis-like mechanism for cellular internalization of disulfide-based poly(amido amine)/DNA polyplexes. Biomaterials; 32 (11):3072-84.  doi: 10.1016/j.biomaterials.2010.12.045

Kaur, I., Schramm, G., Everts, B., Scholzen, T., Kindle, K., Beetz, C., Montiel-Duarte, C., Blindow, S., Jones, A.T., Haas, H., Stolnik, S., Heery, D.M., Falcone, F.H. (2011) Interleukin-4 Inducing Principle from Schistosoma mansoni Eggs (IPSE/alpha−1) contains a functional C-terminal nuclear localization signal necessary for nuclear translocation in mammalian cells but not for its uptake. Infection and Immunity; (4):1779-88. doi:10.1128/IAI.01048-10

Bruyère, H., Westwell, A.D and Jones, A.T.  (2010) Tuning the pH sensitivities of orthoester based compounds for drug delivery applications by simple chemical modification. Bioorganic & Medicinal Chemistry Letters-  20(7): 561-569

Vercauteren, D., Vandenbroucke, R.E., Jones, A.T., Rejman, J., Demeester, J., De Smedt, S.C., Sanders, N.N., Braeckmans, K. (2010) The use of inhibitors to study endocytic pathways of gene carriers: Optimisation and pitfalls. Molecular Therapy; 18(3)  561-569  (doi:10.1038/mt.2009.281)

Watkins C, Schmaljohann, D., Futaki, S., and Jones, A.T. (2009) Low concentration thresholds of plasma membranes for rapid energy-independent translocation of a cell penetrating peptide. Biochem J. 420 (2) 179-189

Watkins, C., Brennan, P., Fegan, C., Nakase, I., Futaki, S., and Jones, A.T. (2009) Cellular uptake, distribution and cytotoxicity of the hydrophobic cell penetrating peptide sequence PFVYLI linked to the proapoptotic domain peptide PAD. J. Control Release (2009) 140(3):237-44.

Jin, J. and Jones, A.T. (2009) The pH sensitive probe 5-(and-6)-carboxyl seminaphthorhodafluor-acetomethylester (SNARF-1) is a substrate for the multidrug resistance-related protein MRP1. Int. J. Cancer 15;124(1):233-23.

Jin, J., Pastrello, D., Penning, N.A., and Jones, A.T. (2008) Clustering of endocytic organelles is a feature of leukaemia cells lacking centrosomally organised microtubule arrays Int J Biochem Cell Biol 40(10):2240-52.

Kosuge M., Takeuchi, T., Nakase, I.,  Jones, A.T.,  and Futaki, S. (2008) Cellular Internalization and Distribution of Arginine-Rich Peptides as a Function of Extracellular Peptide Concentration, Serum, and Plasma–Membrane Associated Proteoglycans  Bioconj. Chem; 19(3):656-64 

Jones A.T. (2008) Gateways and tools for drug delivery: Analysis of endocytic pathways and the intracellular dynamics of cell penetrating peptides. Int. J. Pharmaceutics; 354(1-2):34-8.

Peeters, L., Sanders, N.N., Jones, A.T., Demeester, De Smedt, S.C. (2007)  Post-pegylated lipoplexes are promising vehicles for gene delivery in RPE cells. J Cont. Release Aug 28; 121(3):208-17.

McGuigan, M.,  Pathirana,  R.N. , Migliore, M., Adak, R.,  Luoni, G., Jones, A.T., Díez-Torrubia, A.,  Camarasa, M-J., Velázquez, S., Henson G, Verbeken, E.,  Sienaert, R.,  Naesens, L.,  Snoeck. R.,  Andrei, G and  Balzarini, J. (2007) PreClinical Development of Bicyclic Nucleoside Analogues as Potent and Selective Inhibitors of Varicella Zoster Virus.  J Antimicrob Chemoth 60 (6) :1316-30.

Maiti, K.K., Woo, S.L., Takeuchi, T., Watkins, C., Fretz, M., Kim, D-C., Futaki, S., Jones, A.T, Kim, K-T and Chung, S.K (2007) Novel Guanidine-containing Molecular Transporters: Sorbitol-based Transporters Show High Intracellular Selectivity toward Mitochondria. Angew Chem Int Ed Engl. Aug 3; 46 (31): 5880-5884.

Futaki, S. Nakase I, Tadokoro A, Takeuchi T, Jones AT. (2007) Arginine-rich peptides and their internalization mechanisms. : Biochem Soc Trans. 2007 Aug; 35 (Pt 4):784-7.

Jones, A.T.  (2007) Macropinocytosis : Searching for an endocytic identity and a role in the uptake of cell penetrating peptides. J. Cell Molec Med 113 (3) 1-15. Review.

Fretz, M.M., Penning, N.A., Al-Taei, S., Futaki, S., Takeuchi, T., Nakase, I., Storm, G. and Jones, A.T. (2007) Temperature, concentration and cholesterol dependent translocation of L- and D-octaarginine across the plasma and nuclear membrane of CD34+ leukaemia cells. Biochem. J. Apr 15;403 (2):335-42.

Greco, F., Vicent, M.J., Gee, S., Jones, A.T., Gee J., Nicholson, R.I. and Duncan, R. (2007) The Mechanism of Enhanced Cytotoxicity of HPMA Copolymer-DOX-AGM in Breast Cancer Cells. J Cont. Release 117, 28-39.

Manunta, M., Izzo, L., Duncan, R and Jones, A.T.  (2007) Establishment of subcellular fractionation techniques to monitor the intracellular fate of polymer therapeutics II. Identification of endosomal and lysosomal compartments in HepG2 cells combining single-step subcellular fractionation with fluorescent imaging. J Drug Targeting 15 (1) 37-50.

Seib, F. P., Jones, A. T., and Duncan, R. (2006). Comparison of the endocytic properties of linear and branched PEIs, and cationic PAMAM dendrimers in B16f10 melanoma cells.  J. Control Release  117, 291-300.

 Fretz, M., Jin, J., Conibere, R., Penning, N.A., Al-Taei, Storm, G., S., Futaki, S., Takeuchi, T., Nakase I. and Jones, A.T. (2006) Effects of Na+/H+ exchanger inhibitors on subcellular localisation of endocytic organelles and intracellular dynamics of protein transduction domains HIV-TAT peptide and octaarginine- J Cont. Release;116(2):247-54.

Jones A.T.  Rab21 Molecule page Nature-Association for Cell Signalling 2006

                  http://www.signaling-gateway.org/molecule/query?afcsid=A001971

Al-Taei S, Penning NA, Simpson JC, Futaki S, Takeuchi T, Nakase I and Jones A.T. (2006) Intracellular Traffic and Fate of Protein Transduction Domains HIV-1 TAT Peptide and Octaarginine. Implications for Their Utilization as Drug Delivery Vectors. Bioconjugate Chemistry, 17; 90-100.

 Seib, F.P., Jones, A.T. and Duncan R. (2006) Establishment of subcellular fractionation techniques that can be used to monitor the intracellular fate of polymer therapeutics I. Differential centrifugation fractionation from B16F10 cells and use to study the intracellular fate of HPMA copolymer-doxorubicin-J. Drug Targeting 14 (6) 375-390.

Berna M, Dalzoppo, D, Pasut G, Manunta M, Izzo L, Jones AT, Duncan R and Veronese FM. (2006) Novel Monodisperse PEG-Dendrons as New Tools for Targeted Drug Delivery: Synthesis, Characterization and Cellular Uptake. Biomacromolecules 7 (1):146-53.

Simpson JC, Jones AT. (2005) Lipids, Rafts and Traffic: Chapter 10 - Early endocytic Rabs: functional prediction to functional characterization. Biochem Soc Symp. 72 : 99-108.

Watson P, Jones AT, Stephens DJ (2005) Intracellular trafficking pathways and drug delivery: fluorescence imaging of living and fixed cells. Adv Drug Deliv Rev. 57(1):43-61.

Simpson JC, Griffiths G, Wessling-Resnick M, Fransen JA, Bennett H, Jones AT. (2004) A role for the small GTPase Rab21 in the early endocytic pathway. J Cell Sci 117(Pt 26):6297-311.

 Nakase I, Niwa M, Takeuchi T, Sonomura K, Kawabata N, Koike Y, Takehashi M, Tanaka S, Ueda K, Simpson JC, Jones AT*, Sugiura Y, Futaki S*. (2004) Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement. Molecular Therapy 10 (6):1011-22. * Joint Corresponding authors.

Jones, A.T., Gumbleton, M. and Duncan, R. (2003) Understanding endocytic pathways and intracellular trafficking:a prerequisite for effective design of advanced drug delivery systems. Advanced Drug Delivery Reviews 1254, 1353-1357.

Jones, A.T. (2001) Intracellular Drug Delivery. Workshop Report from the 28th International Symposium on Controlled Release of Bioactive Materials. Traffic 2, 917-920.

Jones, A.T., Spiro, D., Melancon, P., Kirchhausen, T. and Wessling-Resnick, M. (1999) Studies on the mechanism of endosome fusion by activated ARF. J. Cell Sci. 112, 3477-3485.

Clague, M.J., Jones, A.T., Mills, I.G., Walker, D.M. and Urbe, S. (1999) Regulation of early endosome dynamics by phosphatidylinositol 3-phosphate binding proteins. Biochem Soc. Trans. 27, 662-667.

Mills, I.G., Jones, A.T. and Clague, M.J. (1999) Regulation of endosome fusion. Molecular Membrane Biology 16, 73-79.

Jones, A.T. and Wessling-Resnick, M. (1998) Evidence that phospholipids are required for endosomal vesicle fusion:inhibition of in vitro fusion activity by aminoglycoside antibiotics. J. Biol. Chem. 273, 25301-25309.

Jones, A.T., Mills, I.G., Scheidig, A.J., Alexandrov, K and Clague, M.C. (1998) Inhibition of endosome fusion by wortmannin persists in the presence of activated rab5. Mol. Biol. Cell 9, 323-332.

Mills, I, Jones, A.T. and Clague, M.J. (1998) Involvement of the endosomal autoantigen EEA1 in homotypic fusion of early endosomes. Curr Biol. 8, 881-4.

Jones, A.T., and Clague, M.C. (1997) Regulation of early endosome fusion by phospholipase D activity. Biochem. Biophys. Res. Comm. 236, 285-288.

Gaffet, P., Jones, A.T. Clague, M.C. (1997) Inhibition of cation-independent mannose 6-phosphate receptor incorporation into TGN derived clathrin coated vesicles by wortmannin. J. Biol. Chem. 272, 24170-24175.

Jones, A.T. and Clague, M.C., (1995) Phosphatidylinositol 3-kinase activity is required for early endosome fusion. Research Communication Biochem. J. 311, 31-34.

Clague, M.C., Thorpe, C., and Jones, A.T. (1995) Phosphatidylinositol 3-kinase regulation of fluid phase endocytosis, (1995) FEBS Letters 367, 272-274.

Green, B.N., Jones, A.T., and Roberts N.B. (1996) Electrospray mass spectrometric evidence for the occurrence of two major variants of pig pepsin A. Biochem. J. 313, 241-244.

Balan, K.K., Jones, A.T., Roberts, N.B., Pearson, J.P., Critchley, M., Jenkins, S.A. (1996) The effects of Helicobacter pylori colonisation on gastric function and the incidence of portal hypertensive gastropathy in patients with cirrhosis of the liver. American J. of Gastroenterology 91, 1400-1406.

Jones, A.T., Green, B.N., Wood, S.P. and Roberts, N.B (1994). Molecular mass determination by Electrospray Mass Spectrometry of human pepsins, gastricsins and porcine pepsin A variants. In :"Advances in Experimental Medicine and Biology; Aspartic Proteinases" Takahashi, K. (ed.) Plenum Press, London, pp 83-89.

Tarasova, N., Denslow, N.D., Parten, B.F., Tran, N., Nhuyen, H.P., Jones, A.T., Roberts, N.B., Dunn, B. (1995). A comparative study on amino acid sequences of three major isoforms of human pepsin A. In :Advances in Experimental Medicine and Biology; Aspartic Proteinases. Takahashi, K.(ed.). Plenum Press, London, pp 77-81.

Jones, A.T., Keen, J. and Roberts, N.B. (1993). Human pepsin 3b peptide map sequence analysis, genotype and hydrophobic nature. Journal of Chromatography 646, 207-212.

Jones A.T., Balan, K.K. Jenkins, S.A., Sutton, R., Critchley, M. and Roberts N.B. (1993). The assay of gastricsin and individual pepsins in human gastric juice. Journal of Clinical Pathology 46, 254-258.

Jones, A.T. and Roberts, N.B. (1992). Peptide maps of five human pepsin isoenzymes and other aspartic proteinases. Journal of Chromatography 599,179-184.

 

Scientific Abstracts Since 2001

Watkins C., Fretz, M.M, Hickey, J, Futaki, S and Jones, A.T.  (2007) Characterisation of the uptake of octaarginine in different cell types in the absence or presence of the cholesterol sequestering agent methyl-ß-cyclodextrin. Biochemical Society Focused Meeting: Cell Penetrating Peptides, Telford UK. P003

Marjan Fretz, M.M, Watkins, C.L., Penning, N.A , Futaki, A and Jones, A.T. (2007) Temperature and concentration dependent translocation of cell penetrating peptides across the plasma and nuclear membrane of cells. 2nd Workshop on bioactive peptides, Lisbon. Selected for oral presentation

M.M.Fretz. N. A. Penning, S. Al-Taei, G.Storm, S.Futaki and A.T.Jones (2007) Effect of temperature, concentration and cellular cholesterol on the intracellular distribution of the cell-penetrating peptide octaarginine. 3rd Pharmaceutical Sciences World Congress 2007 (PSWC 2007) (22-25 April 2007) and the pre-satellite meeting of PSWC for PhD students and postdoctoral fellows (21-22 April 2007).

M.M. Fretz, N.A. Penning, S. Al-Taei, G. Storm, S.Futaki and A.T. Jones. (2006) Effects of temperature on intracellular distribution of cell-penetrating peptides Biochemical Society Focused Meeting Cellular Delivery of Therapeutic Macromolecules, Cardiff University. No 04 Selected for oral presentation

Jing, J. and Jones A.T. (2006) Reorganisation of the endocytic pathways of multidrug resistant cells. Biochemical Society Focused Meeting Cellular Delivery of Therapeutic Macromolecules, Cardiff University No 08.

M. Manunta, L. Izzo, R. Duncan and A.T. Jones (2006) A validated method for subcellular fractionation of epithelial and endothelial cells: effect of endocytosis of dextran and PEG-dendrons on intracellular traffic 33nd Annual Meeting and Exposition of the Controlled Release Society, Vienna. Poster No. 188 Selected for oral presentation.

Lucile Dieudonné, Verena Pohl, Arwyn T. Jones and Dirk Schmaljohann. (2006) Controlled Synthesis Strategies for the Preparation of Tailor-Made Polymer Therapeutics. 33nd Annual Meeting and Exposition of the Controlled Release Society, Vienna. Poster No. 907.

Jing Jin and Arwyn T. Jones (2006) Progression of multidrug resistance in leukaemia cells is accompanied by distinct changes in subcellular distribution of early and late endocytic organelles. BioScience2006 Glasgow. Poster No 0335

Jing Jin and Arwyn T. Jones (2006) Endocytic Pathways and drug sequestration in multidrug resistant leukaemia cells. Wales Cancer Institute Inaugural Conference: Collaborating in Cancer Research, Cardiff. Poster No. 27

Saly al Taei, Neal Penning, Jeremy Simpson, Shiroh Futaki, Toshihide Takeuchi, Ikuhiko Nakase and Arwyn T. Jones (2005) Delineating the endocytic traffic and destination of HIV-TAT peptide and Octaarginine  via double labelling confocal microscopy and live cell imaging. Satellite Meeting of the Joint 15th IUPAB and 5th EBSA International Biophysics Congress: Mechanisms of carrier-Mediated Intracellular Delivery of Therapeutics, Montpelier, France. Selected for Oral presentation given by A T. Jones.

M. Berna, D. Dalzoppo, G. Pasut, M. Manunta, L. Izzo, A. T. Jones, R. Duncan, and F. M. Veronese. (2005) Novel Monodisperse PEG-Dendrons as New Tools for Targeted Drug Delivery: Synthesis, Characterisation and Cellular Uptake. 32nd Annual Meeting and Exposition of the Controlled Release Society, Florida USA. Selected for Oral presentation given by M. Berna.

Shiroh Futaki, Ikuhiko Nakase, Miki Niwa, Toshihide Takeuchi,Yukio Sugiura, Jeremy C. Simpson and Arwyn T. Jones. (2004). Characterisation of the Cellular uptake of Arginine-rich peptides. First Asia-Pacific International Peptide Symposium. The 41st Japanese peptide symposium. P-3-015

S. Al-Taei and A.T. Jones (2004) Unravelling the Spatial Distribution of Daunorubicin with Human Leukaemic Cells Displaying Differential Drug Distribution and Sensitivity. Presented at British Pharmaceutical Conference 2004 Manchester Published   J. Pharm. Pharmacol. 56 (supplement) abstract 029 Selected for Oral Presentation-delivered by Saly al Taei

Morris, C.J., Sherwood, A., Kandalaft, L., Stephens, D.J., Jones, A.T., Gumbleton, M. (2004) Alveolar epithelium is able to internalize macromolecules via the caveolae membrane system. Presented at British Pharmaceutical Conference 2004 Manchester Published   J. Pharm. Pharmacol. 56 (supplement) abstract 056.

Jeremy C. Simpson, Gareth Griffiths, Marianne Wessling-Resnick, and Arwyn T. Jones. (2004) Multiple endocytic defects in cells expressing mutants of the small GTPase Rab21. Bioscience 2004, Glasgow. Selected for Oral Presentation-delivered by A.T. Jones.

Shiroh Futaki, Ikuhiko Nakase, Toshihide Takeuchi, Miki Niwa, Jeremy C. Simpson, Arwyn T. Jones and Yukio Sugiura. (2004). Arginine-rich peptides: the structures and manners of internalization. Third International/28th European Peptide Symposium, Prague.

Jeremy Simpson, Gareth Griffiths, Marianne Wessling-Resnick, and Arwyn T. Jones. (2004). Endocytic defects in cells expressing mutants of the small GTPase Rab 21. 6th Annaberg Conference: Protein secretion on the endocytic Pathway. Goldegg Austria.

Saly Al-Taei and Arwyn T. Jones (2004) Characterisation of the membrane trafficking of P-glycoprotein: establishing a model for the screening potential P-glycoprotein inhibitors. 6th international Symposium on Polymer Therapeutics.

F.P. Seib, A.T. Jones and R. Duncan. (2004) Endocytic capture and intracellular trafficking: effect of polymer architecture. 6th international Symposium on Polymer Therapeutics, Cardiff University. Poster No 717.

Seib, F.P., Xyloyiannis, M., Patrick, N., Jones, A.T., Duncan, R. (2004) Intracellular trafficking of polymeric medicines. SET for Britain (Science Engineering and Technology), House of Commons.

Jones, A.T. (2003) Endocytic Pathways: New avenues for drug delivery and targeting. Primary Congress of the Portuguese Pharmaceutical Society, Lisbon, Portugal. Abstract published in Revista Portuguesa de Farmácia ISSN 0484-811 X Vol LII (n.˚1) Suplemento

Seib F.P., Hann A., Arwyn T. Jones, Duncan R. (2003) Establishing a quantitative subcellular fractionation method in B16F10 cells: Use to monitor the intracellular trafficking of polymer therapeutics. Poster no 520. Proceed. International Symp. Control. Rel. Bioact. Mater. 30 p. 519. Awarded 1st Prize

Knutson, M., Newman, G., Wessling-Resnick, M., Griffiths, G., Jones, A.T. (2002) Localisation of Rab21 on the endocytic pathway and on wortmannin-induced swollen vacuoles. 55th Harden Conference. Dynamics of Membrane Traffic. Ambleside.