Welsh School of Pharmacy

Peer reviewed articles since January 2001 - date

Morris CJ, Smith MW, Griffiths PC, McKeown NB, Gumbleton M. (2011)  Enhanced pulmonary absorption of a macromolecule through coupling to a sequence-specific phage display-derived peptide.  J Control Release. 151:83-94.

Gumbleton, M. Al-Jayyoussi. G., Francombe, D., Morris, C.J. and Mathew Smith. M.W. (2011) Spatial expression and functionality of  drug transporters in intact lung:  areas for further investigation in pulmonary drug transporter research .  Advanced Drug Delivery Reviews  63: 110-118

Forbes, B., Asgharian, B., Dailey, L.A., Ferguson, D., Gerde, P., Gumbleton, M., Gustavsson, L., Hardy, C., Hassall, D., Jones, R., Lock, R., Maas, J., McGovern, T., Pitcairn, G.R., Somers, G., Wolff, R.K. (2011)  Challenges in inhaled product development and opportunities for open innovation.   Advanced Drug Delivery Reviews  63: 69-87

Patton, J., Brain, J.D., Davies, L.A., Fiegel, J., Gumbleton, M., Kim, K.J., Sakagami, M., Vanbever, R., Ehrhardt, C. The particle has landed – discerning the fate of inhaled particles. J. Aerosol. Med.  and Pulmonary Drug Delivery (2010)  23: S71-S87

Griffiths, P., Occhipinti, P., Morris, C., Heenan, R., King, S. Gumbleton, M., (2010) PGSE-NMR and SANS studies of the interaction of model polymer therapeutics with mucin. Biomacromolecules 11: 120-125

Omidi, Y., Barar, J., Asadi, M., Gumbleton, M. (2010) Barrier functionality and transport machineries of human ECV304 cells.  Medical Science Monitor  16: BR52-60

Thomas, N.B.P., Hutcheson, I.R., Campbell, L., Gee, J., Taylor, K.M., Nicholson, R.I., Gumbleton, M. (2010)  Growth of hormone-dependent MCF-7 breast cancer cells  is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. Breast Cancer Res Treat   119: 575-591

Endter, S. Francombe, D., Ehrhardt, C., Gumbleton, M. (2009) RT-PCR analysis of ABC-, SLC-and SLCO-drug transporters in human lung epithelial cell models. J. Pharmac. Pharmacol. .61, 583-591

Campbell, L., Nuttal, R., Griffiths, D.F.R., Gumbleton, M. (2009) Activated Extracellular-signal Regulated Kinase (pERK) is an independent prognostic factor in clinically confined renal cell carcinoma   Cancer  115, 3457-3467

Francombe, D., Taylor, G., Taylor, S., Somers, G., Edwards, C., Gumbleton, M.  (2008)  Functional role of P-gp efflux in limiting pulmonary drug absorption within an intact lung: application of an isolated perfused rat lung model.   Proc. Resp. Drug Deliv 2008.  Volume II, pp  461-464   ISBN 1-930114-95-8   

Campbell, L., Jasani, B., Edwards, K., Gumbleton, M., Griffiths, D.F.R. (2008) Combined expression of caveolin-1 and activated AKT/ mTOR pathway predicts reduced disease free survival in clinically confined clear cell renal carcinoma. Br. J. Cancer  98, 931-940.

Omidi, Y., Barar, J., Ahmadian, S., Heidari, H.R., Gumbleton, M. (2008) Characterisation and astrocytic modulation of system L transporters in brain microvasculature endothelial cells.  Cell Biochemistry Function.  26, 381-391.

Barar, J., Campbell, L., Hollins, A.J., Thomas, N.P.J., Smith, M.J., Morris, C.J., Gumbleton, M. (2007) Glucocorticoid induction of caveolin-1 and caveolae formation in differentiating pulmonary alveolar epithelial cell cultures: a cell selective event Biochem. Biophys. Res. Comm. 359: 360-366

Smith, M.W., Smith, J.W., Harris, C., Brancale, A., Allender, C.J., Gumbleton, M. (2007) Phage display identification of functional binding peptides against 4-acetamidophenol (Paracetamol): an exemplified approach to target low molecular weight organic molecules. Biochem. Biophys. Res. Comm. 358: 285-291

Smith, M., Omidi, Y., Gumbleton, M. (2007) Primary porcine brain microvascular endothelial cells: biochemical and functional characterisation as a model for drug transport and targeting. Journal of Drug Targeting 15(4):253-68

Collins, E., Birchall, J., Williams, J.L., Gumbleton, M. (2007) Dependencies between Nuclear localisation and pDNA condensation in non-viral gene delivery. Journal of Gene Medicine 9(4):265-74

Endter S., Becker, U., Huwer, H., Lehr, C-M., Gumbleton, M., Ehrhardt, C. (2007) Human alveolar epithelial cell monolayers express functional P-glycoprotein (MDR1). Cell Tissue Research 328(1):77-84

Sakagami, M., Gumbleton, M. (2006) Endogenous and Exogenous IgG transfer in the airways. Proc. Resp. Drug Deliv. X. Volume 1, pp 57-64 ISBN 1-930114-95-8

Smith, M., Gumbleton, M. (2006) Endocytosis at the blood-brain barrier: From basic understanding to drug delivery strategies. Journal of Drug Targeting 14, 191-214

Sakagami, M., Omidi, Y., Barar, J. Campbell, L., Kandalaft, L., Morris, C.J., Gumbleton, M. (2006) Expression and transport functionality of FcRn within rat alveolar epithelium: a study in primary cell culture and in the isolated perfused lung. Pharm. Res. 23: 270-279

Gumbleton, M., Stephens D.J. (2005) “Coming out of the dark: The evolving role of fluorescence imaging in drug delivery research” Adv.Drug Deliv. Rev. 57, 5-15.

Abulrob, A.N., Suller, M.T.E., Gumbleton, M., Simons, C., Russell, A.D. (2004) Identification and biological evaluation of grapefruit oil components as potential novel efflux pump modulators in methicillin-resistant Staphylococcus aureus bacterial strains. Phytochem. 65, 3021-3027 

Sakagami, M., Omidi, Y., Campbell, L., Kandalaft, L.E., Barar, J., Gumbleton, M. (2004) Molecular evidence for the expression of MHC Class I - like IgG receptor FcRn within intact rat lung alveolar epithelium and in primary alveolar cell cultures. Proc. Resp. Drug Deliv. IX. Volume II, 885-888. ISBN 1-930114-52-4

Von Ruhland C.J., Campbell, L., Gumbleton, M., Jasani, B. and Newman, G.R. (2004) The immunolocalisation of caveolin – 1 in rat and human mesothelium. J. Histochem. Cytochem. 52, 1415-1425

Taylor G., Gumbleton, M. (2004) Aerosols for macromolecule delivery: Design challenges and solutions. Am. J. Drug. Deliv. 2, 143-155

Siccardi, D., Gumbleton, M., Omidi, Y., McGuigan, C. (2004) Stereospecific chemical and enzymatic stability of phosphoramidate triester prodrugs of d4T in-vitro E. J. Pharm. Sci. 22, 25-31.

Siccardi, D., Kandalaft, L, Gumbleton, M., McGuigan, C. (2003) Stereoselective and concentration-dependent polarised epithelial permeability of a series of Phosphoramidate Triester Prodrugs of d4T: An in-vitro study in Caco-2 and MDCK Cell Monolayers. J. Pharm. Exp. Ther. 307, 1112-1119

Campbell, L. Gumbleton, M., Griffiths, D.F.R. (2003) Caveolin-1 overexpression predicts poor disease-free survival of patients with clinically confined renal cell carcinoma. Br. J. Cancer 89, 1909-1913

Jones, A.T., Gumbleton, M., Duncan R. (2003) “Understanding endocytic pathways and intracellular trafficking: A prerequisite for effective design of advanced drug delivery systems” Adv.Drug Deliv. Rev. 55, 1353-1357

Omidi, Y., Campbell, L. Barar, J., Connell, D., Akhtar S., Gumbleton, M. (2003) Evaluation of the immortalized mouse brain capillary endothelial cell linje, b.End3, as an in-vitro blood brain barrier model for drug uptake and transport studies. Brain Res. 990, 95-112

Campbell, L. Abulrob, A.N.G., Kandalaft, L.E., Plummer, S. Hollins, A.J., Gibbs, A., Gumbleton, M. (2003) Constitutive expression of P-glycoprotein in normal lung alveolar epithelium and functionality in primary alveolar epithelial cultures. J. Pharm. Exp. Ther. 304:441-52.

Fuchs, S. Hollins. A.J., Laue, M., Schaefer, U.F., Roemer, K., Gumbleton, M., Lehr, C.M. (2003) Differentiation of human alveolar epithelial cells in primary culture. Morphological characterization and synthesis of caveolin-1 and Sp-C. Cell Tiss. Res. 311, 31-45

Gumbleton, M., Hollins, A.J., Campbell, L., Taylor, G. (2003) Targeting caveolae for vesicular drug delivery. J. Control. Rel. 87, 139-151. [B]

Hollins, A.J., Campbell, L., Gumbleton, M., Evans, D.J.R. (2002) Caveolin expression during chondrogenesis in the avian limb. Dev. Dynamics 225, 205-211.

Campbell, L., Laidler, P. , Watson, R.E.B., Kirby, B., Griffiths, C.E.M., Gumbleton, M. (2002) Downregulation and altered spatial pattern of caveolin-1 in chronic plaque psoriasis. Br. J. Dermatol. 147, 701-709

Jones, B.G., Dickinson, P.A., Gumbleton, M., Kellaway, I.W. (2002) Lung surfactant phospholipids inhibit the uptake of respirable microspheres by the alveolar macrophage NR8383. J. Pharm. Pharmacol. 54, 1065-1072.

Taylor G, Gumbleton, M., (2002) Predicting the effects of mucociliary clearanace on systemic bioavailability from the lung. Proc. Resp. Drug Deliv. VIII. Volume II, 803-806. ISBN 1-930114-52-4

Gumbleton, M., Taylor, G (2002) The role of caveolae in pulmonary macromolecule absorption: Mechanistic and kinetic considerations. Proc. Resp. Drug Deliv. VIII. Volume I, 85-95. ISBN 1-930114-51-6 

Jones, B.G., Dickinson, P.A., Gumbleton, M., Kellaway, I.W. (2002) The inhibition of phagocytosis of respirable microspheres by alveolar and peritoneal macrophages. Int. J. Pharm. 236, 65-79

Ramsay, E.C., Gumbleton, M. (2002) Polylysine and polyornithine gene transfer complexes: A study of complex stability and cellular uptake as a basis for their differential in-vitro transfection efficiency J. Drug Targeting 10, 1-9

Gumbleton, M., Audus, K. (2001) Progress and limitations in the use of in-vitro cell cultures to serve as a permeability screen for the blood brain barrier J. Pharm. Sci. 90, 1681-1698.

Birchall, J.C., Waterworth, C., Luscombe, C., Parkins, D., Gumbleton, M. (2001) Statistical modelling of formulation variables in non-viral gene delivery vectors. J. Drug Targeting 9, 169-184.

Campbell, L, Gumbleton., M. Ritchie, K., (2001) Caveolae and Caveolins in human disease Advanced Drug Delivery Reviews 49, 325-335

Gumbleton, M. (2001) Caveolae as potential trafficking compartments within alveolar epithelium. Advanced Drug Delivery Reviews. 49, 281-300.

Edited Books, Edited Journal Series and Authored Textbook Chapters since January 2001

As Executive Editor for Advanced Drug Delivery Reviews (Impact Factor 7.2 – 2005) I have commissioned, developed and served in an executive editorial position on the following publications:

“Advances in Fluorescence Imaging: Opportunities for Pharmaceutical Science” (2005) Advanced Drug Delivery Reviews Volume 57, Issue 1.

“Adhesion Proteins in Cellular Tight Junctions: Critical Components in the Modulation of Paracellular Permeability” (2005) Advanced Drug Delivery Reviews Volume 57, Issue 6.

“Mechanisms of Antimicrobial Resistance: Opportunities for New Targeted Therapies” (2005) Advanced Drug Delivery Reviews Volume 57, Issue 10.

“Molecularly Imprinted Polymers: Technology and Applications” (2005) Advanced Drug Delivery Reviews Volume 57, Issue 12.

“Embryonic stem cell science and at the therapeutic interface” (2005) Advanced Drug Delivery Reviews Volume 57, Issue 13.

“Engineered Antibody therapeutics” (2006) Advanced Drug Delivery Reviews Volume 58, Issues 5-6.

“Human Cancer vaccines” (2006) Advanced Drug Delivery Reviews Volume 58, Issue 8

“Challenges and innovations in effective pulmonary systemic and macromolecular drug delivery” (2006) Advanced Drug Delivery Reviews Volume 58, Issues 9-10 – Also served as co-Theme editor for this issue (see below)

“2006 supplementary non-thematic collection” Advanced Drug Delivery Reviews Volume 58, Issue 15 - Also served as Theme editor for this issue (see below)

“siRNA: from lab to clinic” (2007) Advanced Drug Delivery Reviews Volume 59, Issue 2-3

“Intersection of Nanoscience and modern surface analysis technology” (2007) Advanced Drug Delivery Reviews Volume 59, Issue 14 - Also served as Theme editor for this issue (see below)

“2007 Editors’ Choice” Advanced Drug Delivery Reviews Volume 59, Issue 15 - Also served as Theme editor for this issue (see below)

Gumbleton, M., (2007) Theme Editor “2007 Editors’ Choice” Advanced Drug Delivery Reviews. Volume 59, Issue 15

Gumbleton, M., (2007) Theme Editor “Intersection of Nanoscience and modern surface analysis technology” Advanced Drug Delivery Reviews. Volume 59, Issue 14

Gumbleton, M., (2006) Theme Editor “2006 supplementary non-thematic collection” Advanced Drug Delivery Reviews. Volume 58, Issue 15

Editors: Akhtar S., Gait, M., Gumbleton, M. Jones A.T (2007) of the Proceedings of the Biochem Soc Focused Meeting (Aug 29-31 2006) “Cellular delivery of Therapeutic macromolecules” Biochem Soc Transactions 35, pp 41-76

Gumbleton, M., Morris, C.J., Francombe, D., Sakagami, M. (2007) “Drug transport processes of the air-blood barrier” In the textbook “Pulmonary Drug Delivery: Basics, Applications and Opportunities for small molecules and biopharmaceuticals” Ed. K. Bechtold-Peters and H. Luessen Editio Cantor Verlag (ECV) An APV publication reflections in pharmaceutrical sciences vol 2. pp 332-353 ISBN 978-3-87193-322-6

Gumbleton, M., Taylor G. (2006) co-Theme Editor “Challenges and innovations in effective pulmonary systemic and macromolecular drug delivery” Advanced Drug Delivery Reviews. Volume 58, Issues 9-10

Gumbleton, M., Omidi, Y. (2005) “Biological Membranes & Barriers” In the textbook “Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids” 1st Edition Ed. Ram Mahato (2005) CRC Press pp 232-273 ISBN 0-8493-2334-7

Gumbleton, M. (2005) “Processes in drug handling by the body” In the textbook “Introduction to the Principles of Drug Design and Action” 4th Edition Ed H.J. Smith (2005) Taylor & Francis ISBN 0-415-28877-0 pp 1-32.

Gumbleton, M., Furr, J.R. (2004) “Basic aspects in the structure and functioning of the immune system” In the textbook “7th Edition Hugo & Russell’s Pharmaceutical Microbiology” Ed S. Denyer, N.A. Hodges, S. Gorman (2004) Blackwells Publishing, UK pp 117-137 ISBN 0-632-06467-6

Campbell, L., Gumbleton, M. (2002) “Basic aspects of cell growth and cell cycle in culture” in the textbook ‘‘Cell Culture Models of Biological barriers: and in-vitro test systems for drug absorption and delivery’ Ed C.M. Lehr (2002) pp 3-20 Taylor and Francis ISBN 0-415-27724-8

Fuchs, S., Gumbleton, M. Schafer, U., Lehr, C.M. (2002) “ Models of the alveolar epithelium” in the book ‘Cell Culture Models of Biological barriers: and in-vitro test systems for drug absorption and delivery’ Ed C.M. Lehr (2002) pp 189-211 Taylor and Francis. ISBN 0-415-27724-8

Gumbleton, M., (2001) Theme Editor “Caveolae mediated membrane transport” Advanced Drug Delivery Reviews. Volume 49, Issue 3

Editorials/ Commentarys/Letters ‘To the Editor’ / other Public Output. Since January 2001

Gumbleton, M. (2007) Editorial “2007 Editors’ Choice” Advanced Drug Delivery Reviews. Volume 59, Issue 15 p1481

Gumbleton, M. (2007) Preface “Intersection of Nanoscience and modern surface analysis technology” Advanced Drug Delivery Reviews. Volume 59, Issue 14 p1383

Gumbleton, M. (2006) Editorial “A supplementary review format” Advanced Drug Delivery Reviews. Volume 58, Issue 15 p1579-1580

Gumbleton, M., Taylor, G. (2006) Preface “Challenges and innovations in effective pulmonary systemic and macromolecular drug delivery. Adv.Drug Deliv. Rev. 58, 993-995.

Jones, R., Gumbleton, M., John, D. “Just what the pharmacist ordered: Delivering an effective prescribing role” Academic Pharmacy Group Newsletter volume 15 March 2004 pages 1-3.

Gumbleton, M. (2001) Preface to “Caveolae mediated membrane transport” Advanced Drug Delivery Reviews. 49, 217-221.