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Prof Anthony Campbell  -  MA PhD


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Key publications

Books

  1. Ashley,CC Campbell,AK (eds).(1979). The detection and measurement of free Ca2+ in cells. pp 461 Elsevier/North Holland,Amsterdam.
  2. Campbell,AK (1983). Intracellular Calcium: its universal role as regulator. pp 556. John Wiley and Sons:Chichester. ISBN 0 471 10488 4
  3. Campbell,AK. (1988). Chemiluminescence: principles and applications in biology and medicine, pp608. Horwood/VCH, Chichester and Weinheim. ISBN 30527-263420X and 0-89573-501-6.
  4. Herring,PJ, Campbell,AK, Whitfield, M and Maddock, L (eds) (1990). Light and Life in the Sea. pp  357. Cambridge  University  Press, Cambridge.
  5. Campbell,AK (1994). Rubicon: the fifth dimension of biology. pp 304. Duckworth, London. ISBN 0 7156 2499 7.
  6. Campbell, AK, Kricka, LJ and Stanley, PE ed. (1994). Bioluminescence and Chemiluminescence: fundamental and applied aspects. pp 680. Wiley, Chichester.
  7. Campbell, AK and Matthews, SB (2001). Lactose intolerance and the MATHS:syndrome: what are they and how can I cope? Pp 32. Welston Press, Pembrokeshire. ISSN 1474-6794, ISBN 0-9540866-0-0).
  8. Campbell, AK and Matthews, SB (2005). Tony’s lactose free recipe book – the science of lactose intolerance and how to live without lactose. The Welston Press, Pembrokeshire. ISBN 0-9540866-1-9.

 

Research papers

  1. Campbell,AK. (1974). Biochem. J. 143:411-418. Extraction, partial purification and properties of obelin, the calcium- activated luminescent protein from the hydroid Obelia geniculata.
  2. Campbell,AK and Siddle,K (1976). Biochem J. 158:211-221. The effect of intracellular calcium ions on adrenaline-stimulated adenosine 3':5'-cyclic monophosphate concentrations in pigeon erythrocytes, studied by using the ionophore A23187.
  3. Simpson, JSA, Campbell, AK, Ryall, MET and Woodhead, JS. (1979). Nature 279:646-647. A stable chemiluminescent-labelled antibody for immunological assays.
  4. Campbell,AK Daw,RA and Luzio,JP. (1979). FEBS Lett. 107:55-60. Rapid increase in intracellular free Ca2+ induced by antibody plus complement.
  5. Hallett, MB and Campbell, AK (1982). Nature 295: 155-158. Measurement of changes in cytoplasmic free Ca in fused cell hybrids.
  6. Weeks, I Beheshti, I McCapra, F Campbell, AK and Woodhead, JS. (1983) Clin. Chem. 29:1474-1479. Acridinium esters as high specific activity chemiluminescent labels.
  7. Campbell,AK and Hallett,MB.(1983) J.Physiol. 338. 537-562. Measurement of intracellular calcium ions and  oxygen  radicals  in polymorphonuclear leucocyte-erythrocyte ghost hybrids.
  8. Campbell,AK and Patel,A (1983). Biochem J. 216:185-194. A homogeneous immunoassay for cyclic nucleotides based on chemiluminescence energy transfer.
  9. Matthews,SB and Campbell,AK. (1984) Lancet ii: 759-757. Neutrophil activation after myocardial infarction.
  10. Campbell, AK and Morgan, BP (1985). Nature 317:164-166. Monoclonal antibodies demonstrate protection of polymorphonuclear leucocytes against complement attack.
  11. Roberts,PA Knight,J and Campbell,AK (1987). Anal. Biochem. 160:139-148. Pholasin - a bioluminescent indicator for detecting activation of single neutrophils.
  12. Campbell,AK and Herring,PJ (1987). Comp. Biochem. Physiol. 86B:411-417. A novel red fluorescent protein from the  deep sea luminous fish Malacosteus niger.
  13. Scolding, NJ Morgan, BP Houston, WAJ, Linington, C Campbell, AK and Compston,DAS (1989). Nature 339:690-692. Oligodendrocytes activate complement but resist lysis by vesicular removal of membrane attack complexes.
  14. Campbell, AK and Herring, PJ (1990). Marine Biology 104:219-225. Imidazolopyrazine bioluminescence in copepods and other marine animals.
  15. Knight, MR, Campbell, AK, Smith, SM and Trewavas, AJ (1991). Nature 352:524-526. Transgenic tobacco aequorin reports touch, cold-shock and elicitor effects on cytoplasmic calcium.
  16.  Knight,MR, Campbell,AK, Smith,SM and Trewevas,AJ (1991) FEBS Lett 282,405-408. Recombinant aequorin as a probe for cytosolic free Ca2+ in Escherichia coli.
  17. Sala-Newby,G and Campbell,AK (1991) Biochem.J. 279:727-732. Engineering a bioluminescent indicator for cyclic AMP dependent protein kinase .
  18.  Davies,EV, Campbell,AK, Williams,BD and Hallett,MB (1991). Br.J.Rheum.30:443-448. Single cell imaging reveals abnormal intracellular calcium stores within rheumatoid synovial neutrophils.
  19. Sala-Newby, G and Campbell, AK (1992). FEBS Lett. 307:241-244. Engineering firefly luciferase as an indicator of cyclic AMP-dependent protein kinase in living cells.
  20. Kendall, JM, Dormer, RL and Campbell, AK (1992). Biochem.Biophys.Res.Commun. 189: 1008-1016. Targeting aequorin to the endoplasmic reticulum of living cells.
  21. Watkins, NJ and Campbell, AK (1993) Biochemical Journal 292: 181-185. Requirement of the C-terminal proline residue for stability of the Ca2+ - activated photoprotein aequorin.
  22. Kendall, JM, Dormer,RL, Badminton, MD and Campbell, AK (1994). Anal. Biochem. 221:173-181. Changes in free calcium inside the endoplasmic reticulum of live cells using targeted aequorin.
  23. Badminton, M, Kendall, JM, Sala-Newby, G and Campbell AK (1995). Nucleoplasmin-targeted aequorin shows evidence for a nuclear Ca2+ barrier. Exptl.Cell Res. 216:236-243.
  24. Thomson, CM, Herring, PJ and Campbell AK (1995) J Mar Biol Assoc. 75:165-171. Evidence for de novo synthesis of coelenterazine in the bioluminescent midwater shrimp Systellaspis debilis.
  25. Watkins, NJ, Knight MR, Trewavas, AJ and Campbell AK (1995). Biochemical Journal 306:865-869. Free calcium transients in chemotactic and non-chemotatcic strains of Escherichia coli determined by using recombinant aequorin.
  26. Thomson, CM, Herring, PJ and Campbell AK (1995). Marine Biology 124:197-207. Coelenterazine distribution and luciferase characteristics in oceanic decapods.
  27. Trewavas, AJ, Knight, MR and Campbell,AK (1995). Proc. Natl. Acad. Sci. US 92:4142-4128. The effects of mechanical signalling on plant cell cytosolic calcium.
  28. Sala-Newby, GB, Thomson, CM and Campbell, AK (1996). Biochem. J. 313: 761-767. Sequence and biochemical similarities between luciferases of the glow-worm Lampyris noctiluca and the firefly Photinus pyralis.
  29. Waud, J, Sala-Newby, GB and Campbell, AK (1996). Biochim. Biophys. Acta 1292:89-98. Engineering the C-terminus of firefly luciferase as an indicator of covalent modification of proteins.
  30. Badminton, M, Kendall, JM, Sala-Newby, G and Campbell AK (1995). Differences in stability of recombinant apoaequorin within subcellular compartments. Biochem. Biophys. Res. Commun. 217:950-957.
  31. Badminton, MN, Campbell, AK and Rembold, CR (1996). Differential regulation of nuclear and cytosolic Ca2+ in HeLa cells. J. Biol. Chem. 271:31210-31214.
  32. Campbell, AK, Trewavas, AJ and Knight, MR (1996). Calcium imaging shows differential sensitivity to cooling and communication in luminous transgenic plants. Cell Calcium 19: 211-218.
  33. Thomson, CM, Herring, PJ and Campbell, AK (1997). The widespread occurrence and tissue distribution of the imidazolopyrazine luciferins. J.Biolum.Chemilum. 12:87-91.
  34. Sala Newby, GB, Taylor, KT, Badminton, MN, Rembold, CR and Campbell, AK (1998). Imaging bioluminescent indicators shows Ca2+ and ATP permeability thresholds in live cells attacked by complement. Immunology. 93:4:601-609
  35. Jones HE, Holland IB, Baker HL, Campbell AK (1999). Slow changes in cytosolic free Ca2+ in Escherichia Coli highlight two putative influx mechanisms in response to changes in extracellular calcium. Cell Calcium 25:3:265-274.
  36. Dunstan, S, Sala-Newby, GB, Bermudez-Fajardo, A, Taylor, K.M. and Campbell, A.K. (2000). Cloning and expression of the bioluminescent photoprotein pholasin from the bivalve mollusc Pholas dactylus. J.Biol.Chem.275, 9403-9409.
  37. Matthews, SB and Campbell, AK (2000). When sugar is not so sweet. Lancet 355:1330.
  38. Baubet,V, Le Mouellic, H, Campbell, AK, Lucas-Meunier, E, Fossier, P and Brulet, P (2000). Chimeric GFP-aequorin as bioluminescent Ca2+ reporters at the single cell level. Proc.Natl.Acad.Sci.97:7260-7265.
  39. Waud, J, Bermudez-Fajardo, A, Sudadhaharan, T, Jefferies, J, Jones, A,Campbell, AK (2001). Measurement of proteases using chemiluminescence resonance energy transfer chimaeras between green fluorescent protein and aequorin. Biochem.J. 357: 687-697.
  40. Jones, HE, Holland, IB and Campbell, AK (2002). Direct measurement of free Ca2+ shows different regulation of Ca2+ between the periplasm and the cytosol of Escherichia coli. Cell Calcium. 32(4):183-192
  41. Campbell, AK, Matthews, SB and Wann, KT (2004). Lactose causes heart arrhythmia in the water flea Daphnia pulex. Comp. Biochem. Physiol. B 139;225-234.
  42. Matthews SB, Waud J, Roberts A and Campbell AK (2005). Systemic lactose intolerance: a new perspective on an old problem. Post Grad. Med. J. 81:167-183.
  43. Campbell, AK and Matthews, SB (2005). Darwin’s illness revealed. Post. Grad. Med. J. 81,248-251.
  44. Campbell, AK, Naseem, R, Wann, KT, Holland, IB and Matthews, SB (2007). Fermentation product butane 2,3 diol induces Ca2+ transients in E. coli through activation of lanthanum-sensitive Ca2+ channels. Cell Calcium 41, 97-106.
  45. Naseem, R, Rosser Davies, S, Jones, H, Wann, KT, Holland, IB and Campbell, AK (2007). Cytosolic Ca2+ regulates protein expression in E. coli through release from inclusion bodies. Biochem. Biophys. Res. Commun. 468,107-113.
  46. Campbell, AK, Naseem, R, Wann, KT, Holland, IB, and Matthews, SB. (2007). Methylglyoxal and other carbohydrate metabolites induce lanthanum-sensitive Ca2+ transients and inhibit growth in E. coli. Arch. Biochem. Biophys. 437, 107-113.
  47. Waud JP, Matthews SB, Campbell AK. (2008). Measurement of breath hydrogen and methane, together with lactase genotype, defines the current best practice for investigation of lactose sensitivity. Ann. Clin. Biochem. 45:50-58.
  48. Naseem, R, Holland, I.B, Jacq, A, Wann, KT and Campbell, AK (2008). pH and monovalent cations regulate cytosolic free Ca2+ in E. coli. Biochim. Biophys. Acta Biomembranes 1778,1415-1422.
  49. Naseem, R, Wann, KT, Holland, I.B and Campbell, AK (2009). ATP regulates calcium efflux and growth in E. coli. J.Mol.Biol. 391,42-56.
  50. Campbell, AK, Matthews, SB, Vassell, N, Cox, C Naseem, R, Chaichi, MJ, Holland IB and Wann, KT (2010). Bacterial metabolic ‘toxins’. A new mechanism for lactose and food intolerance, and irritable

 

Selected reviews

  1. Campbell,AK Dormer,RL and Hallett,MB (1985). Cell Calcium  6:69-82.Coelenterate photoproteins as indicators of cytoplasmic free Ca2+.
  2. Campbell,AK (1986). Cell Calcium. 7:287-296. Lewis Victor Heilbrunn: Pioneer of calcium as an intracellular regulator.
  3. Campbell,AK (1989). Essays in Biochemistry. 24:41-81. Living Light:biochemistry, function and biomedical applications.
  4. Campbell AK (2003).  What Darwin missed. Astrophysics and Space Science 285:1-5
  5. Campbell AK (2003).  Rainbow Makers. Chemistry in Britain June 2003:30-33
  6. Campbell AK (2003).  Dr Darwin’s Botanical Garden.  Nature First 32:11
  7. Campbell AK (2003).  Imaging genetically engineered Rainbow proteins. The Pezcoller Foundation Journal.  20:20-22.
  8. Campbell AK (2003).  Save those molecules! Molecular biodiversity and life.  Journal of Applied Ecology. 40:193-203
  9. Campbell, AK, Jenkins-Waud, J and Matthews, SB (2005). The Molecular Basis of Lactose intolerance. Science Progress 88, 157-202.
  10. Campbell, AK (2007). Making Pembrokeshire a beacon for science. In The Preceli Papers, pp. 97-108. Ed John Osmond. ISBN 0-905077-72-5.
  11. Campbell, A. K., Waud, J. P. & Matthews, S. B. (2009). The molecular basis of lactose intolerance. Sci Prog, 92, 241-87.

 

Patents

  1. Campbell,AK Simpson,JSA Woodhead,JS. (1979) Detection or quantifying substances using labelling techniques. UK Patent GB 20008247A.
  2. Campbell,AK, Weeks,I and Woodhead,JS (1982). Mass photon immunoassay. UK Patent GB822593 .
  3. Campbell,AK, Simpson,JSA and Woodhead,JS(1984). US patent 4,478,817. Detecting or quantifying substances using labelling techniques, priority date Dec.11, 1981: GB 8137522.
  4. Campbell,AK (1989). British Patent Application 8916806.6. Modified proteins. International patent application PCT/GB90/01131. Modified Bioluminescent Proteins and Their Use: Rainbow proteins. Priority date July 22, 1989.
  5. Campbell,AK, Woodhead,JS and Weeks,I (1990). US patent 4,946,958. Chemiluminescent acridinium labelling compounds, priority date Dec.11, 1981: GB 8137522.
  6. Campbell, AK (1997). US patent 5,683,888. Modified Bioluminescent proteins and their use. Patent issued 4 November 1997
  7. Campbell AK, Dunstan S, Sala-Newby G (1998/2005). British Patent Application 9824357.9. Oxygen Metabolites and Bioluminescent Proteins. Patent published November 1998. Issues US 2005
  8. Campbell, AK (2001). German patent 690 33 855.4-08. European patent 90910819.3. Modified Bioluminescent proteins and their use. Patent – Rainbow proteins. Patent granted 14 November, 2001.
  9. Campbell, AK (2001). French patent EP(FR) 0 484 369. European patent 90910819.3. Modified Bioluminescent proteins and their use. Patent – Rainbow proteins. Patent granted 14 November, 2001.
  10. Campbell, AK (2001). UK patent EP(FR) 0 484 369. European patent 90910819.3. Modified Bioluminescent proteins and their use. Patent – Rainbow proteins. Patent granted 14 November, 2001.
  11. Campbell, AK (2002). US patent 6,440,665 B1. Modified Bioluminescent proteins and their use. Patent issued 27 Aug, 2002.
  12. Campbell, AK (2002). US patent 6,492,500 B1. Modified Bioluminescent proteins and their use. Patent issued 10 Dec. 2002.
  13. Campbell AK, Dunstan S, Sala-Newby G (1998/2005). British Patent Application 9824357.9. Oxygen Metabolites and Bioluminescent Proteins. Patent published November 1998. Issues US 2005