Welsh School of Pharmacy

Broadley, K.J., Davies, R.H., Escargueil, C., Lee, A.T.L., Penson, P., Thomas, E.J. (2011). Synthesis of antagonists of muscarinic (M₃) receptors. Collect. Czech. Chem. Commun. 76, 781-801. (doi:10.1135/cccc2011017)

Lauder, S.N., Taylor, P.R., Clark, S.R., Evans, R.L., Hindley, J.P., Smart, K., Leach, H., Kidd, E.J., Broadley, K.J., Jones, S.A., Wise, M.P., Godkin, A.J., O’Donnell, V., Gallimore, A.M. (2011). Paracetamol reduces influenza-induced immunopathology in a model of infection without compromising virus clearance or the generation of protective immunity. Thorax doi:10.1136/thx.2010.150318.

Broadley, K.J, Sykes, S.C, Davies, R.H. (2010). Towards a thermodynamic definition of efficacy in partial agonism: The thermodynamics of efficacy and ligand proton transfer in a G protein-coupled receptor of the rhodopsin class.Biochem Pharmacol. 80(10):1537-45.

Broadley, K.J., Blair A.E., Kidd, E.J., Bugert J.J., Ford, W.R. (2010). Bradykinin-induced lung inflammation and bronchoconstriction: role in PIV-3-induced inflammation and airways hyperreactivity J. Pharmacol. Exp. Ther. 335, 681-692.

Fehler, M., Broadley, K.J., Ford, W.R., Kidd, E.J. (2010). Identification of trace amine-associated receptors (TAAR) in the aorta and their role in vasoconstriction by β-phenylethylamine. Naunyn-Schmiedeberg’s Arch. Pharmacol. 382, 385-398.

Turner, D.L., Ferrari, N., Ford, W.R., Kidd, E.J., Paquet, L., Renzi, P., Broadley, K.J. (2010). TPI 1020, a novel anti-inflammatory, nitric oxide donating compound, potentiates the bronchodilator effects of salbutamol. Eur. J Pharmacol. 641, 213-219.

Al-Motarreb, A., Al-Habori, M., Broadley, K.J. (2010). Khat chewing, cardiovascular diseases and other internal medical problems: The current situation and directions for future research. J. Ethnopharmacol. 132, 540-548.

Smith, N., Broadley, K.J. (2010). Adenosine receptor subtypes in airways responses to inhaled ovalbumin. Pulm. Pharmacol. Ther. 23, 355-364.

Fernandez-Rodriguez,S., Broadley, K. J., Ford, W. R., Kidd, E. J. (2010). Increased muscarinic receptor activity of airway smooth muscle isolated from a model of allergic asthma. Pulm. Pharmacol. Ther. 23, 300-307.

Broadley, K.J. (2010). The vascular effects of trace amines and amphetamines. Pharmacol Ther. 125, 363-375.

Broadley, K. J., Anwar, M.A., Herbert, A.A., Fehler, M., Jones, E.M., Davies, W.E., Kidd, E.J. & Ford W.R. (2009) Effects of dietary amines on the gut and its vasculature. Br. J. Nutrition 101, 1645-1652.

Bradshaw, B., Evans, P., Fletcher, J., Lee, A.T., Mwashimba, P.G., Oehlrich, D., Thomas, E.J., Davies, R.H., Allen, B.C., Broadley, K.J., Hamrouni, A., & Escargueil, C. (2008) Synthesis of 5-hydroxy-2,3,4,5-tetrahydro-[1H]-2-benzazepin-4-ones: selective antagonists of muscarinic (M3) receptors. Org. Biomol. Chem. 6, 2138-2157.

Allen, B.P.C., Nederkoorn, P.H.J., Timmerman, H., Timms, D, Broadley, K.J. & Davies, R.H. (2008) Monocation-driven proton transfer relays within G protein-coupled receptors of the rhodopsin class and the GTP synthase mechanism. J. Mol Structure: THEOCHEM 859, 51-68.

Penson, P.E., Ford, W.R., Kidd, E.J. & Broadley, K.J. (2008)Activation of β-adrenoceptors mimics preconditioning of isolated atria and ventricles against ischaemic contractile dysfunction. Naunyn-Schmiedeberg’s Arch Pharmacol 378, 587-597.

Herbert, A.A., Kidd, E.J. & Broadley, K.J. (2008) Dietary trace amine-dependent vasoconstriction in porcine coronary artery. Br. J. Pharmacol. 155, 525-534.

Smith, N. & Broadley, K.J. (2008) Adenosine receptor subtypes in the airways responses to 5’-adenosine monophosphate inhalation. Clin. Exp. Allergy 38, 1536-1547.

Fernandez-Rodriguez, S, Ford, W.R., Broadley, K.J. & Kidd, E.J. (2008) Establishing the phenotype in novel acute and chronic murine models of allergic asthma. Int Immunopharmacol. 8, 756-763.

Penson, P.E., Ford, W.R. & Broadley, K.J. (2007) Vasopressors for cardiopulmonary resuscitation: Does pharmacological evidence support clinical practice? Pharmacol. Ther. 115, 37-55.

Baker, K.E., Herbert, A.A. & Broadley, K.J. (2007) Vasoconstriction of porcine left anterior descending coronary artery by ecstasy and cathinone is not an indirect sympathomimetic effect. Vasc. Pharmacol. 47, 10-17

Smith, N. & Broadley, K.J. (2007) Optimisation of the sensitisation conditions for an ovalbumin challenge model of asthma. Int. Immunopharmacol., 7, 183-190.

Broadley, K.J. (2006) b-Adrenoceptor responses of the airways: For better or worse? Eur. J. Pharmacol. 533, 15-27.

Yates, L., Clark, J.H. Martin, T.J., James, S., Broadley, K.J. & Kidd, E.J. (2006) Radioligand binding and functional responses of human recombinant adenosine A₃ receptors. Auton. Autacoid Pharmacol.,26, 1-10.

Broadley, K.J. & Penson, P.E. (2006) Effects of hypoxia on the vasodilator activity of nifedipine and evidence of secondary pharmacological properties. Eur. J. Pharmacol., 536, 279-286.

Chidgey, S.M. & Broadley, K.J. (2005) Respiratory syncytial virus infections: characteristics and treatment. J. Pharm. Pharmacol., 57, 1371-1381.

Al-Motarreb, A., Briancon, S., Al-Jaber, N., Al-Adhi, B., Al-Jailani, F., Salek, M.S. & Broadley, K.J. (2005) Khat chewing is a risk factor for acute myocardial infarction: a case-control study. Br. J. Clin. Pharmacol., 59, 574-581.

Broadley, K.J. & Penson, P.E. (2004) The roles of a- and b-adrenoceptor stimulation in myocardial ischaemia. Auton. Autacoid Pharmacol., 24, 87-93.

Nevin, B.J. & Broadley, K.J. (2004) Comparative effects of inhaled budesonide and the NO-donating budesonide derivative, NCX 1020, against leukocyte influx and airway hyperreactivity following lipopolysaccharide challenge. Pulm. Pharmacol. Ther. 17, 219-232.

Al-Motarreb, A.L. & Broadley, K.J.  (2003) Coronary and aortic vasoconstriction by cathinone, the active constituent of khat. Auton Autacoid Pharmacol., 23, 319-326.

Gardner, N.M., Yates, L. & Broadley, K.J. (2004) Effects of endogenous adenosine and adenosine receptor agonists on hypoxia-induced stunning. J. Cardiovasc. Pharmacol. 43, 358-368.

Toward, T.J. & Broadley, K.J. (2004) Early and late bronchoconstrictions, airway hyper-reactivity, leucocyte influx and lung histamine and nitric oxide after inhaled antigen: effects of dexamethasone and rolipram. Clin. Exp. Allergy 33, 91-102.

Toward, T.J., Smith, N. & Broadley, K.J. (2004) Effect of phosphodiesterase-5 inhibitor, sildenafil (Viagra), in airways disease. Am. J. Respir. Crit. Care Med. 169, 227-234.

Toward, T.J., Lewis-Lakelin, M.B., Burgaud, J-L & Broadley, K.J. (2001).  Comparison of the inhibition by salbutamol-NO and salbutamol of the bronchoconstriction by histamine. Inflammation Research, 50 (Suppl. 3) S181.

Martin, T.J. & Broadley, K.J. (2001).  Identification of bronchoconstrictor mediators released by adenosine in airways.  Proc. Br. Pharmaceutical Conference, Glasgow.  P. 191.

Martin, T.J. & Broadley, K.J. (2002).  Exposure of a contractile response to adenosine in isolated trachea by passive sensitization.  Br. J. Pharmacol. 135, 74P.

Toward, T.J., Maillard, J-Y., Boult, J.E. & Broadley,K.J. (2002).  Airway function, hyperreactivity, cell influx and nitric oxide, in parainfluenza-3 infection:  effect of dexamethasone and rolipram.  Br. J. Pharmacol.  135, 73P.

Clark, J.H., Broadley, K.J., Hutcheson, I.R., Nicholson, R.I. & Kidd, E.J. (2002).  Adenosine receptor agonists mediate the phosphorylation of mitogen activated protein kinase (MAPK) in MCF-7 human breast cancer cells. Br. J. Pharmacol. 135, 46P.

Yates, L. & Broadley, K.J. (2002).  Protection by an adenosine A₃ agonist from myocardial stunning induced by simulated ischaemia.  Br. J. Pharmacol. 135, 139P.

Toward, T.J., Lewis-Lakelin, M.B. Burgaud, J-L. & Broadley, K.J. (2001).  Comparison of the inhibition by salbutamol-NO and salbutamol of the bronchoconstriction by histamine.  Proc. Br. Pharmaceutical Conference, Glasgow.  (ISBN 0 85369 512 1)  P.192.

Toward, T.J. & Broadley, K.J. (2001).  Lung nitric oxide, histamine and leukocyte influx after antigen inhalation: relation to EAR, LAR and AHR. Br. J. Pharmacol (Pharmacology Vancouver (2001) 133, C70.

Toward, T.J. & Broadley, K.J. (2002).  Adenylyl and guanylyl cyclase and PDE activities towards cAMP and cGMP in isolated lungs during LPS-induced airway reactivity changes.  Br. J. Pharmacol. 135, 272P.

Nevin, B.J. & Broadley, K.J. (2002).  Effects of inhaled corticosteroid on ovalbumen-challenge.  Br. J. Pharmacol. 135, 273P.

Clark, J.H., Martin, T.J., Yates, L., Kidd, E.J., Nicholson, R.I. & Broadley, K.J. (2002).  Characterization of transfected human adenosine A₃ receptors.  Br. J. Pharmacol. 136, 38P.

Nevin, B.J., Smith, N., Toward, T.J. & Broadley, K.J. (2002).  Activities of nitro derivatives of steroids against histamine-induced bronchoconstriction.  J. Pharm. Pharmacol.(Suppl). S98.

Baker, K. E. & Broadley, K.J. (2003). Vascular actions of ecstasy: roles of adrenergic neurones, endothelin, thromboxane, 5-HT, angiotensin and a₁-adrenoceptors, Br. J. Pharmacol. 138, 166P.

Yates, L. & Broadley, K.J. (2003). The effect of adenosine A₃ receptor activation on the recovery from simulated ischaemia. Br J Pharmacol 138, 141P.

Clark, J.H., Broadley, K.J., Hutcheson, I.R., Nicholson, R.I. & Kidd, E.J. (2003). Expression of adenosine receptors in MCF-7 human breast cancer cells. Br. J. Pharmacol. 138, 130P.

Nevin, B.J. & Broadley, K.J. (2003). Effects of L-arginine on neutrophil influx and airway hyperreactivity 1h after lipopolysaccharide challenge. Br. J. Pharmacol. 138, 133P.

Parija, S.C. & Broadley, K.J. (2003). 8sPT resistant component of A₁ mediated negative inotropic response in presence of 4-AP is pertussis toxin sensitive. Br. J. Pharmacol. 138, 142P.

Smith, N. & Broadley, K.J. (2003) Early and late asthmatic responses to 5’-AMP and ovalbumin inhalation. Proc. Br. Pharmacol.Soc.,pA₂online V1, issue 3, 039P.

Fernandez-Rodriguez, S., Broadley, K.J. & Kidd, E.J. (2004) Pharmacology of tracheal smooth muscle in males and females. Proceedings of the British Pharmacological Society.

Yates, L., Ford, W.R. & Broadley, K.J. (2004) Effect of an adenosine A₃ receptor agonist on myocardial infarct size. Proc. Br. Pharmacol. Soc. pA₂onlineVol1, issue 4 095P

Fernandez-Rodrigues, S., Broadley, K.J. & Kidd, E.J. (2004) Pharmacology of airway smooth muscle and cell influx in asthma. Eur. Respir. J., 24, Suppl. 48, 4222, p690s.

Smith, N. & Broadley, K.J. (2004)The airway response to eotaxin inhalation. Proc. Br. Pharmacol. Soc. pA₂online, Vol 2 Issue 2, 128P.

Smith, N. & Broadley, K.J. (2004) Optimization of sensitization protocols for asthmatic responses to ovalbumin. Proc. Br. Pharmacol. Soc. pA₂online, Vol 2 Issue 2, 131P.

Baker, K.E. & Broadley, K.J. (2004) Vasoconstriction by ecstasy and cathinone on pig left anterior descending coronary artery: lack of involvement of a₁-receptors. Proc. Br. Pharmacol. Soc. pA₂online, Vol 2 Issue 2, 054P.

Broadley, K.J. (2004) The rationale of NO-releasing drugs. In: Proc of the Ivth VIFB Conference ‘Rational Modifications of Original Drugs’ Prague 24-25^th November 2004.

Smith, N. & Broadley, K.J. (2004) Role of adenosine A_2a receptors in inflammatory responses to 5’-AMP. Am. J. Respir. Crit. Care Med. 169, A77.

Chidgey, S.M. & Broadley, K.J. (2006) Time course correlations of lung function, inflammation and viral titre after airways infection with parainfluenza-3. Proc. Br. Pharmacol. Soc. pA₂online, 4, 124P.

John, E., Jackson, A & Broadley, K.J. (2006) Mucus production and tolerance to inhaled ovalbumin. Proc. Br. Pharmacol. Soc. pA₂online, 4, 119P.

Penson, P.E, Ford, W.R., Kidd, E.J. & Broadley, K.J. (2006) Preconditioning by the b-adrenoceptor agonist, isoprenaline, in the atrium but not ventricle. Proc. Br. Pharmacol. Soc. pA₂online, 4, Issue 2 115P.

John, E., Jackson, A. & Broadley, K.J. (2006) Reductions in stored mucin and airway responses to secretogogues in chronic asthma. Proc. Br. Pharmacol. Soc. pA₂online, 4, Issue 2, 131P.

Fehler, M., Broadley, K. & Kidd, E. (2006) Contraction of aorta to beta-phenylethylamine not mediated by adrenoceptors. Proc. Br. Pharmacol. Soc. pA₂online, 4, Issue 2, 182P

Herbert, A.A. & Broadley, K.J. (2006) Action of trace amine p-tyramine on adrenergic receptors in isolated porcine coronary artery. Proc. Br. Pharmacol. Soc. pA₂online, 4, Issue 2, 104P.

Anwar, M.A., Ford, W.R. & Broadley, K.J. (2006) Mediators regulating tryptamine-induced tone of mesenteric arterial bed. Proc. Br. Pharmacol. Soc. pA₂online, 4, Issue 2, 113P.

Penson, P.E., Ford, W.R. & Broadley, K.J. (2007) Vasopressors for cardiopulmonary resuscitation: Does pharmacological evidence support clinical practice? Pharmacol. Ther. 115, 37-55

John, E., Jackson, A., Sugar, R., Growcott, E. & Broadley, K.J. (2007) Development of chronic asthma demonstrating a mucus hypersecretory phenotype. Amer. J. Respir. Crit. Care Med. 175, A464