Dr Emma Kidd

Dr Emma Kidd

Dean of Postgraduate Research Studies, College of Biomedical and Life Sciences

Email:
kiddej@cardiff.ac.uk
Telephone:
+44 (0)29 2087 5803
Fax:
+44 (0)29 2087 4149

Qualifications

  • BSc in Pharmacology, University of Bath, 1987
  • PhD in Neuropharmacology, University of Nottingham, 1990

Relevant websites

Professional memberships

University committees

University Graduate College Board

Career profile

I graduated with a degree in Pharmacology from the University of Bath in 1987 and then went to the Department of Physiology and Pharmacology at Nottingham University to do a Ph.D. on the "Functional Adaptation of 5-HT Receptors" under the supervision of Prof. Charles Marsden. Having graduated from Nottingham in 1990, I went to Paris to work for two years as a postdoctoral research associate in Dr Michel Hamon's INSERM-funded laboratory. In 1992 I returned to the U.K. to work as a Postdoctoral Research Associate and subsequently as a Senior Postdoctoral Research Associate for Prof. Pat Humphrey in the Glaxo Institute for Applied Pharmacology in the Department of Pharmacology at Cambridge University. In 1999, I joined the School of Pharmacy and Pharmaceutical Sciences at Cardiff University as a lecturer and was promoted to senior lecturer in 2009, and promoted again to Reader in 2013.

Scientific and professional service

External examiner in Pharmacology, University of East Anglia, MPharm degree.

  • PH1122  The role of the pharmacist in professional practice
  • PH1124  Human body systems
  • PH1125  Chemical and biological properties of drug molecules
  • PH2110  Clinical & professional pharmacy
  • PH2112  Principles of drug design
  • PH2113  Diseases and drugs I
  • PH3110  Optimisation of pharmaceutical care
  • PH3113  Diseases and drugs II
  • PH4116  Pharmacy research or scholarship project
  • PH4117  Pharmaceutical sciences, pharmacy practice and the population
  • PH4118  Pharmaceutical sciences, pharmacy practice and the patient

Research interests

I am interested in understanding how Alzheimer's disease develops and how it could be treated. Research in my laboratory is concentrated on cellular and molecular pharmacology to understand more about the mechanisms underlying several disease processes, with the ultimate aim of improving or developing new therapies for these conditions. We use a variety of human cell lines, animal models and human tissue and many biochemical and molecular biological techniques to investigate cell function.

  • Ageing in the brain
  • Alzheimer's disease
  • Development of models of respiratory disease

Director of Postgraduate Research Studies for the School of Pharmacy and Pharmaceutical Sciences

Novel therapeutic antibodies for Alzheimer's disease

Alzheimer's disease is a progressive neurodegenerative condition with very limited treatment and no cure. The incidence of this disease is rising worldwide as the population ages, as are the associated socioeconomic costs. There is therefore much interest in developing novel therapies. We proposed      a 'blue skies' approach to devise an antibody-based therapy which would potentially halt the disease process and possibly also be used as a preventative treatment in high risk individuals. This approach differs to many others under investigation by other groups and companies worldwide and could be used      in combination with other therapies to treat this debilitating and distressing disease.

Investigating how changes in endocytosis could give rise to Alzheimer's disease

It is highly likely that many factors contribute to the development of Alzheimer's disease. We are interested in changes in endocytosis, the process whereby cells take up material from the extracellular space. These changes have been identified in patients' brains and also as susceptibility genes which      give a small, increased risk of developing Alzheimer's disease. We have manipulated a variety of proteins intimately involved in the two main types of endocytosis, clathrin-dependent and caveolin-dependent. Altering the levels of these proteins has contrasting effects on the levels of a number of proteins      implicated in the pathogenesis of Alzheimer's disease.

Understanding the contribution of ageing to Alzheimer's disease

The main risk factor for Alzheimer's disease is increasing age but we still do not understand how ageing leads to the disease. Since endocytosis is known to be affected in Alzheimer's disease, we are examining how the expression of endocytic proteins is affected by ageing in mouse and human brains.      We are investigating this using human brain samples from young, middle-aged and older people and comparing these results to those from people with Alzheimer's disease. We are also using a series of mouse brains from different ages and comparing normal mice and transgenic mice which are a model for Alzheimer's      disease.

Development of asthma models

I am involved in the development of animal models of respiratory disease which more closely the mimic human disease. Such models will allow us to learn more about the pathophysiology of these conditions and may lead to novel or improved therapeutic drugs.

Collaborators

Postdoctoral research associates

  • Dr Mouhamed Alsaqati (funded by BRACE)

School of Pharmacy and Pharmaceutical Sciences

  • Prof Ken Broadley, Pharmacology & Physiology
  • Dr Will Ford, Pharmacology & Physiology
  • Dr Julia Gee, Pharmacology & Physiology
  • Prof Arwyn Jones, Pharmaceutical Biology
  • Dr Emma Lane, Pharmacology & Physiology
  • Dr Rhian Thomas, Pharmcology & Physiology

Cardiff University

  • Dr Dominic Dwyer, Psychology.
  • Prof Mark Good, Psychology
  • Prof Lesley Jones, Institute of Medical Genetics
  • Prof Paul Kemp, Biosciences
  • Dr Colin Powell, Child health
  • Prof Daniela Riccardi, Biosciences
  • Prof. Julie Williams, Psychological Medicine
  • Dr Nigel Willams, Psychological Medicine

Key expertise

  • Western blotting
  • Immunocytochemistry and immunohistochemistry with bright field and fluorescent microscopy including laser scanning confocal microscopy
  • ELISA
  • Cell culture techniques
  • RT-PCR
  • In situ hybridisation
  • In vivo measurements of lung function
  • sIRNA

Current research students

  • Charles Evans
  • Adam Brelsford

Previous research students

  • Dr Zakky Cholisoh
  • Dr Ceri Davies
  • Dr Alex Lowe
  • Dr Martha Hvoslef-Eide
  • Dr Gaudencio Natividad
  • Dr Jill Clark
  • Dr Sofia Fernandez-Rodriguez
  • Dr Martina Fehler
  • Dr Peter Penson
  • Dr Rhys Evans
  • Dr Dawn Turner
  • Dr Alex Henson
  • Dr Mohammed Al-Qallaf

Projects

  • Novel therapies and Alzheimer's disease
  • Endocytosis and Alzheimer's disease
  • Ageing and Alzheimer's disease
  • Development of models of respiratory disease.
  • Studies on the exacerbation of pulmonary inflammation by viral infection