Professor Richard Wise

Professor, Head of Magnetic Resonance Imaging

School of Psychology

: wiserg@cardiff.ac.uk
: +44(0)29 2087 0358
: Cardiff University Brain Research Imaging Centre, Maindy Road, Cardiff, CF24 4HQ

Research summary

My research aims to develop ways of non-invasively imaging human brain function using magnetic resonance imaging and electrophysiological techniques. Functional magnetic resonance imaging (fMRI) has taught us much about human brain function over the last 15 years, allowing us to map where in the brain information processing is taking place. We are now developing these imaging techniques to provide more quantitative measurements of brain function based on alterations in blood flow and the brain's oxygen usage. The development of these techniques is helping us to study the action of drugs in the human brain and to probe disease processes in the brain more deeply.

Teaching summary

I teach at the postgraduate level on the theory and practice of functional MRI. Courses are held at CUBRIC throughout the year and cover the basics of FMRI physiology, acquisition methods, data analysis, experimental design and interpretation as well as advanced FMRI techniques such as simultaneous EEG-FMRI and arterial spin labelling perfusion measurements. Details of CUBRIC’s Neuroimaging Training can be found here.

Other roles

I am the Head of Magnetic Resonance Imaging and Lead for Finance at CUBRIC (Cardiff University Brain Research Imaging Centre).

Undergraduate education

1991-1994: BA Hons (First Class). Natural Sciences (Part II: Physics and Theoretical Physics), Fitzwilliam College, Cambridge University

Postgraduate education

1994-1998: PhD, Fitzwilliam College and Herchel Smith Laboratory for Medicinal Chemistry, Department of Clinical Medicine, Cambridge University. “Magnetic Resonance Imaging Studies of Cardiovascular Function and its Changes in Hypertension”

Employment

2006-2010: MRC Career Development Fellow, Cardiff University

2005-Sept 2006: MRC Career Development Fellow, FMRIB Centre, University of Oxford

2006-Sept 2006: University Research Lecturer, Department of Clinical Neurology, University of Oxford

2005: Wellcome Trust “Value in People” Fellow, Department of Human Anatomy and Genetics, University of Oxford

2002-2005: Wellcome Trust Advanced Training Research Fellow, Department of Human Anatomy and Genetics and FMRIB Centre, University of Oxford

2000-2002: Post-doctoral research scientist, FMRIB Centre, Department of Clinical Neurology, University of Oxford

1999: System Engineer, The Smith Group, Guildford, UK

1994-1998: Wellcome Trust 4 year PhD Research Training studentship in Mathematical Biology, Cambridge University

Honours and awards

Awards/external committees

Samantha Dickson Brain Tumour Trust (SDBTT) Grant Review and Monitoring Committee member
Associate Editor of the journal “Human Brain Mapping”

2013

Poon, C. Y. et al. 2013. Assessment of pulmonary artery pulse wave velocity in children: An MRI pilot study. Magnetic Resonance Imaging 31(10), pp. 1690-1694. (10.1016/j.mri.2013.08.006)
Caseras, X., Lawrence, N. S., Murphy, K., Wise, R. G. and Phillips, M. L. 2013. Ventral striatum activity in response to reward: differences between bipolar I and II disorders. American Journal of Psychiatry 170(5), pp. 533-541. (10.1176/appi.ajp.2012.12020169)
Hart, E., Harris, A. D., Wise, R. G., Warnert, E. A., Stewart, L., Connor, K. and Paton, J. F. R. 2013. Cerebral artery resistance is directly related to sympathetic nerve activity in men [Abstract]. The FASEB Journal 27(S), article number: 697.1.
Saxena, N., Muthukumaraswamy, S. D., Diukova, A., Singh, K. D., Hall, J. E. and Wise, R. G. 2013. Enhanced stimulus-induced gamma activity in humans during propofol-induced sedation. PLoS ONE 8(3), article number: e57685. (10.1371/journal.pone.0057685)
Harris, A. D. et al. 2013. Temporal dynamics of lactate concentration in the human brain during acute inspiratory hypoxia. Journal of Magnetic Resonance Imaging 37(3), pp. 739-745. (10.1002/jmri.23815)
Tailor, N., Warnert, E. A., Stone, A., Harris, A. D., Murphy, K., Hall, J. E. and Wise, R. G. 2013. Non-invasive measurement of brainstem blood flow [Abstract]. Anaesthesia 68(3), pp. 322. (10.1111/anae.12097)
Gili, T., Saxena, N., Diukova, A., Murphy, K., Hall, J. E. and Wise, R. G. 2013. The thalamus and brainstem act as key hubs in alterations of human brain network connectivity induced by mild propofol sedation. The Journal of Neuroscience 33(9), pp. 4024-4031. (10.1523/JNEUROSCI.3480-12.2013)
Hayen, A., Herigstad, M., Kelly, M., Okell, T. W., Murphy, K., Wise, R. G. and Pattinson, K. T. S. 2013. The effects of altered intrathoracic pressure on resting cerebral blood flow and its response to visual stimulation. NeuroImage 66, pp. 479-488. (10.1016/j.neuroimage.2012.10.049)
Wise, R. G., Harris, A. D., Stone, A. and Murphy, K. 2013. Measurement of OEF and absolute CMRO2: MRI-based methods using interleaved and combined hypercapnia and hyperoxia. NeuroImage 83, pp. 135-147. (10.1016/j.neuroimage.2013.06.008)
Harris, A. D., Murphy, K., Diaz, C., Saxena, N., Hall, J. E., Liu, T. T. and Wise, R. G. 2013. Cerebral blood flow response to acute hypoxic hypoxia. NMR in Biomedicine 26(12), pp. 1844-1852. (10.1002/nbm.3026)

2012

Harvey, A., Taylor, A. M. and Wise, R. G. 2012. Imaging pain in arthritis: Advances in structural and functional neuroimaging. Current Pain and Headache Reports 16(6), pp. 492-501. (10.1007/s11916-012-0297-4)
Tailor, N., Warnert, E. A., Stone, A., Harris, A. D., Murphy, K., Hall, J. E. and Wise, R. G. 2012. Non-invasive measurement of brainstem blood flow in normocapnia and hypercapnia using arterial spin labelling MRI [Abstract]. Anaesthesia 67(S2), pp. 18. (10.1111/anae.12032)
Diukova, A., Ware, J. J., Smith, J. E., Evans, C. J., Murphy, K., Rogers, P. J. and Wise, R. G. 2012. Separating neural and vascular effects of caffeine using simultaneous EEG-FMRI: Differential effects of caffeine on cognitive and sensorimotor brain responses. NeuroImage 62(1), pp. 239-249. (10.1016/j.neuroimage.2012.04.041)
Tomassini, V., Johansen-Berg, H., Jbabdi, S., Wise, R. G., Pozzilli, C., Palace, J. and Matthews, P. M. 2012. Relating brain damage to brain plasticity in patients with multiple sclerosis. Neurorehabilitation and Neural Repair 26(6), pp. 581-593. (10.1177/1545968311433208)
Carhart-Harris, R. L. et al. 2012. Implications for psychedelic-assisted psychotherapy: functional magnetic resonance imaging study with psilocybin. The British Journal of Psychiatry 200(3), pp. 238-244. (10.1192/bjp.bp.111.103309)
Muthukumaraswamy, S. D., Evans, C. J., Edden, R. A. E., Wise, R. G. and Singh, K. D. 2012. Individual variability in the shape and amplitude of the BOLD-HRF correlates with endogenous GABAergic inhibition. Human Brain Mapping 33(2), pp. 455-465. (10.1002/hbm.21223)
Carhart-Harris, R. L. et al. 2012. Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin. Proceedings of the National Academy of Sciences of the United States of America 109(6), pp. 2138-2143. (10.1073/pnas.1119598109)
Smith, J. E., Lawrence, A. D., Diukova, A., Wise, R. G. and Rogers, P. J. 2012. Storm in a coffee cup: caffeine modifies brain activation to social signals of threat. Social Cognitive and Affective Neuroscience 7(7), pp. 831-840. (10.1093/scan/nsr058)
Harvey, A., Taylor, A. M. and Wise, R. G. 2012. Erratum to: Imaging pain in arthritis: Advances in structural and functional neuroimaging. Current Pain and Headache Reports 16(6), pp. 554. (10.1007/s11916-012-0302-y)

2011

Taylor, A. M. et al. 2011. Imaging neural responses to affective and pain-related stimuli in chronic non-malignant pain patients vs healthy controls [Abstract]. British Journal of Anaesthesia 107(5), pp. 830-831. (10.1093/bja/aer234)
Murphy, K., Harris, A. D., Diukova, A., Evans, C. J., Lythgoe, D. J., Zelaya, F. and Wise, R. G. 2011. Pulsed arterial spin labeling perfusion imaging at 3 T: estimating the number of subjects required in common designs of clinical trials. Magnetic Resonance Imaging 29(10), pp. 1382-1389. (10.1016/j.mri.2011.02.030)
Murphy, K., Harris, A. D. and Wise, R. G. 2011. Robustly measuring vascular reactivity differences with breath-hold: Normalising stimulus-evoked and resting state BOLD fMRI data. NeuroImage 54(1), pp. 369-379. (10.1016/j.neuroimage.2010.07.059)
Hu, L., Liang, M., Mouraux, A., Wise, R. G., Hu, Y. and Iannetti, G. D. 2011. Taking into account latency, amplitude, and morphology: improved estimation of single-trial ERPs by wavelet filtering and multiple linear regression. Journal of Neurophysiology 106(6), pp. 3216-3229. (10.1152/jn.00220.2011)
Mouraux, A., Diukova, A., Lee, M. C., Wise, R. G. and Iannetti, G. D. 2011. A multisensory investigation of the functional significance of the 'pain matrix'. NeuroImage 54(3), pp. 2237-2249. (10.1016/j.neuroimage.2010.09.084)
Cochand, N. J., Wild, M., Brugniaux, J. V., Davies, P. J., Evans, K. A., Wise, R. G. and Bailey, D. M. 2011. Sea-Level Assessment of Dynamic Cerebral Autoregulation Predicts Susceptibility to Acute Mountain Sickness at High Altitude. Stroke 42(12), pp. 3628-3630. (10.1161/STROKEAHA.111.621714)

2010

Mayhew, S. D., Dirckx, S. G., Niazy, R. K., Iannetti, G. D. and Wise, R. G. 2010. EEG signatures of auditory activity correlate with simultaneously recorded fMRI responses in humans. NeuroImage 49(1), pp. 849-864. (10.1016/j.neuroimage.2009.06.080)
Edden, R. A. E. et al. 2010. Edited MRS is sensitive to changes in lactate concentration during inspiratory hypoxia. Journal of Magnetic Resonance Imaging 32(2), pp. 320-325. (10.1002/jmri.22233)
Mayhew, S. D., Macintosh, B. J., Dirckx, S. G., Iannetti, G. D. and Wise, R. G. 2010. Coupling of simultaneously acquired electrophysiological and haemodynamic responses during visual stimulation. Magnetic Resonance Imaging 28(8), pp. 1066-1077. (10.1016/j.mri.2010.03.027)
Wise, R. G., Pattinson, K. T., Bulte, D. P., Rogers, R., Tracey, I., Matthews, P. M. and Jezzard, P. 2010. Measurement of relative cerebral blood volume using BOLD contrast and mild hypoxic hypoxia. Magnetic Resonance Imaging 28(8), pp. 1129-1134. (10.1016/j.mri.2010.06.002)
Mhuircheartaigh, R. N., Rosenorn-Lanng, D., Wise, R. G., Jbabdi, S., Rogers, R. and Tracey, I. 2010. Cortical and subcortical connectivity changes during decreasing levels of consciousness in humans: a functional magnetic resonance imaging study using propofol. The Journal of Neuroscience 30(27), pp. 9095-9102. (10.1523/JNEUROSCI.5516-09.2010)
Wise, R. G. and Preston, C. 2010. What is the value of human FMRI in CNS drug development?. Drug Discovery Today 15(21-22), pp. 973-980. (10.1016/j.drudis.2010.08.016)

2009

Pattinson, K. T. S., Governo, R. . J., MacIntosh, B. . J., Russell, E. . C., Corfield, D. . R., Tracey, I. and Wise, R. G. 2009. Opioids depress cortical centers responsible for the volitional control of respiration. The Journal of Neuroscience 29(25), pp. 8177-8186. (10.1523/JNEUROSCI.1375-09.2009)
Piechnik, S. K., Evans, C. J., Bary, L. H., Wise, R. G. and Jezzard, P. 2009. Functional changes in CSF volume estimated using measurement of water T2 relaxation. Magnetic Resonance in Medicine 61(3), pp. 579-586. (10.1002/mrm.21897)
Pattinson, K. T. S. et al. 2009. Determination of the human brainstem respiratory control network and its cortical connections in vivo using functional and structural imaging. NeuroImage 44(2), pp. 295-305. (10.1016/j.neuroimage.2008.09.007)
Mundy, M. E., Honey, R. C., Downing, P. E., Wise, R. G., Graham, K. S. and Dwyer, D. M. 2009. Material-independent and material-specific activation in functional MRI after perceptual learning. NeuroReport 20(16), pp. 1397-1401. (10.1097/WNR.0b013e32832f81f4)

2008

Brooks, J. C. W., Beckmann, C. F., Miller, K. L., Wise, R. G., Porro, C. A., Tracey, I. and Jenkinson, M. 2008. Physiological noise modelling for spinal functional magnetic resonance imaging studies. NeuroImage 39(2), pp. 680-692. (10.1016/j.neuroimage.2007.09.018)
Harvey, A., Pattinson, K. T. S., Brooks, J. C. W., Mayhew, S. D., Jenkinson, M. and Wise, R. G. 2008. Brainstem Functional Magnetic Resonance Imaging: Disentangling Signal From Physiological Noise. Journal of Magnetic Resonance Imaging 28(6), pp. 1337-1344. (10.1002/jmri.21623)
MacIntosh, B. J. et al. 2008. Measuring the effects of remifentanil on cerebral blood flow and arterial arrival time using 3D GRASE MRI with pulsed arterial spin labelling. Journal of Cerebral Blood Flow and Metabolism 28(8), pp. 1514-1522. (10.1038/jcbfm.2008.46)
Mitsis, G. D., Iannetti, G. D., Smart, T. S., Tracey, I. and Wise, R. G. 2008. Regions of interest analysis in pharmacological fMRI: How do the definition criteria influence the inferred result?. NeuroImage 40(1), pp. 121-132. (10.1016/j.neuroimage.2007.11.026)
Pattinson, K. T. S. et al. 2008. Imaging the human brainstem respiratory network. BJA: British Journal of Anaesthesia 100(4), pp. 582P-583P.
Miskowiak, K., Inkster, B., Selvaraj, S., Wise, R. G., Goodwin, G. M. and Harmer, C. J. 2008. Erythropoietin improves mood and modulates the cognitive and neural processing of emotion 3 days post administration. Neuropsychopharmacology 33(3), pp. 611-618. (10.1038/sj.npp.1301439)
Pattinson, K. T. S., Rogers, R., Mayhew, S. D., MacIntosh, B. J., Lee, M. and Wise, R. G. 2008. Remifentanil-Induced Cerebral Blood Flow Effects in Normal Humans: Dose and ApoE Genotype [Letter]. Anesthesia & Analgesia 106(1), pp. 347. (10.1213/01.ane.0000297279.12358.29)

2007

Chiarelli, P. A., Bulte, D. P., Wise, R. G., Gallichan, D. and Jezzard, P. 2007. A calibration method for quantitative BOLD fMRI based on hyperoxia. Neuroimage 37(3), pp. 808-820. (10.1016/j.neuroimage.2007.05.033)
Wise, R. G., Lujan, B. J., Schweinhardt, P., Peskett, G. D., Rogers, R. and Tracey, I. 2007. The anxiolytic effects of midazolam during anticipation to pain revealed using fMRI. Magnetic Resonance Imaging 25(6), pp. 801-810. (10.1016/j.mri.2007.03.016)
Iannetti, G. D. and Wise, R. G. 2007. BOLD functional MRI in disease and pharmacological studies: room for improvement?. Magnetic Resonance Imaging 25(6), pp. 978-988. (10.1016/j.mri.2007.03.018)
Chiarelli, P. A., Bulte, D. P., Gallichan, D., Piechnik, S. K., Wise, R. G. and Jezzard, P. 2007. Flow-metabolism coupling in human visual, motor, and supplementary motor areas assessed by magnetic resonance imaging. Magnetic Resonance in Medicine 57(3), pp. 538-547. (10.1002/mrm.21171)
Leknes, S. G., Bantick, S., Willis, C. M., Wilkinson, J. D., Wise, R. G. and Tracey, I. 2007. Itch and motivation to scratch: an investigation of the central and peripheral correlates of allergen- and histamine-induced itch in humans. Journal of Neurophysiology 97(1), pp. 415-422. (10.1152/jn.00070.2006)
Miller, K. L. et al. 2007. Evidence for a vascular contribution to diffusion FMRI at high b value. Proceedings of the National Academy of Sciences of the United States of America 104(52), pp. 20967-20972. (10.1073/pnas.0707257105)
Bulte, D., Chiarelli, P., Wise, R. G. and Jezzard, P. 2007. Measurement of cerebral blood volume in humans using hyperoxic MRI contrast. Journal of Magnetic Resonance Imaging 26(4), pp. 894-899. (10.1002/jmri.21096)
Wise, R. G. et al. 2007. Dynamic forcing of end-tidal carbon dioxide and oxygen applied to functional magnetic resonance imaging. Journal of Cerebral Blood Flow and Metabolism 27(8), pp. 1521-1532. (10.1038/sj.jcbfm.9600465)
Pattinson, K. T. S., Rogers, R., Mayhew, S. D., Tracey, I. and Wise, R. G. 2007. Pharmacological FMRI: measuring opioid effects on the BOLD response to hypercapnia. Journal of Cerebral Blood Flow and Metabolism 27(2), pp. 414-423. (10.1038/sj.jcbfm.9600347)
Bulte, D. P., Chiarelli, P. A., Wise, R. G. and Jezzard, P. 2007. Cerebral perfusion response to hyperoxia. Journal of Cerebral Blood Flow and Metabolism 27(1), pp. 69-75. (10.1038/sj.jcbfm.9600319)
Dunckley, P., Aziz, Q., Wise, R. G., Brooks, J., Tracey, I. and Chang, L. 2007. Attentional modulation of visceral and somatic pain. Neurogastroenterology & Motility 19(7), pp. 569-577. (10.1111/j.1365-2982.2007.00908.x)

2006

Wise, R. G. and Tracey, I. 2006. The role of fMRI in drug discovery. Journal of Magnetic Resonance Imaging 23(6), pp. 862-876. (10.1002/jmri.20584)
Matthews, P. M. and Wise, R. G. 2006. Noninvasive brain imaging for experimental medicine in drug discovery. Expert Opinion on Drug Discovery 1(2), pp. 111-121. (10.1517/17460441.1.2.111)
Mayhew, S. D., Iannetti, G. D., Woolrich, M. W. and Wise, R. G. 2006. Automated single-trial measurement of amplitude and latency of laser-evoked potentials (LEPs) using multiple linear regression. Clinical Neurophysiology 117(6), pp. 1331-1344. (10.1016/j.clinph.2006.02.017)

2005

Wise, R. G., Al-Shafei, A. I. M., Carpenter, T. A., Hall, L. D. and Huang, C. L. 2005. Simultaneous measurement of blood and myocardial velocity in the rat heart by phase contrast MRI using sparseq-space sampling. Journal of Magnetic Resonance Imaging 22(5), pp. 614-627. (10.1002/jmri.20423)
Iannetti, G. et al. 2005. Simultaneous recording of laser-evoked brain potentials and continuous, high-field functional magnetic resonance imaging in humans. Neuroimage 28(3), pp. 708-719. (10.1016/j.neuroimage.2005.06.060)
Tjandra, T., Brooks, J. C. W., Figueiredo, P., Wise, R. G., Matthews, P. M. and Tracey, I. 2005. Quantitative assessment of the reproducibility of functional activation measured with BOLD and MR perfusion imaging: implications for clinical trial design. Neuroimage 27(2), pp. 393-401. (10.1016/j.neuroimage.2005.04.021)
Zambreanu, L., Wise, R. G., Brooks, J. C. W., Iannetti, G. and Tracey, I. 2005. A role for the brainstem in central sensitisation in humans. Evidence from functional magnetic resonance imaging. Pain 114(3), pp. 397-407. (10.1016/j.pain.2005.01.005)
Dunckley, P., Wise, R. G., Aziz, Q., Painter, D., Brooks, J., Tracey, I. and Chang, L. 2005. Cortical processing of visceral and somatic stimulation: differentiating pain intensity from unpleasantness. Neuroscience 133(2), pp. 533-542. (10.1016/j.neuroscience.2005.02.041)
Iannetti, G. D. et al. 2005. Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humans. Proceedings of the National Academy of Sciences 102(50), pp. 18195-18200. (10.1073/pnas.0506624102)
Pattinson, K. T. S., Bowes, M., Wise, R. G., Parkes, M. J. and Morrell, M. J. 2005. Evaluation of a non-invasive method of assessing opioid induced respiratory depression. Anaesthesia 60(5), pp. 426-432. (10.1111/j.1365-2044.2005.04153.x)

2004

Youell, P. D., Wise, R. G., Bentley, D. E., Dickinson, M. R., King, T. a., Tracey, I. and Jones, A. K. P. 2004. Lateralisation of nociceptive processing in the human brain: a functional magnetic resonance imaging study. Neuroimage 23(3), pp. 1068-1077. (10.1016/j.neuroimage.2004.07.004)
Wise, R. G., Ide, K., Poulin, M. J. and Tracey, I. 2004. Resting fluctuations in arterial carbon dioxide induce significant low frequency variations in BOLD signal. NeuroImage 21(4), pp. 1652-1664. (10.1016/j.neuroimage.2003.11.025)
Wise, R. G., Williams, P. and Tracey, I. 2004. Using fMRI to quanitfy the time dependence on remifentanil analgesia in the human brain. Neuropsychopharmacology 29(3), pp. 626-635. (10.1038/sj.npp.1300364)
Rogers, R., Wise, R. G., Painter, D., Longe, S. E. and Tracey, I. 2004. An investigation to dissociate the analgesic and anesthetic properties of ketamine using functional magnetic resonance imaging. Anesthesiology 100(2), pp. 292-301.

2003

Adcock, J. E., Wise, R. G., Oxbury, J. M., Oxbury, S. M. and Matthews, P. M. 2003. Quantitative fMRI assessment of the differences in lateralization of language-related brain activation in patients with temporal lobe epilepsy. Neuroimage 18(2), pp. 423-438. (10.1016/S1053-8119(02)00013-7)

2002

Wise, R. G. et al. 2002. Combining fMRI with a pharmacokinetic model to determine which brain areas activated by painful stimulation are specifically modulated by remifentanil. Neuroimage 16(4), pp. 999-1014. (10.1006/nimg.2002.1146)
Bantick, S. J., Wise, R. G., Ploghaus, A., Clare, S., Smith, S. M. and Tracey, I. 2002. Imaging how attention modulates pain in humans using functional MRI. Brain 125(2), pp. 310-319. (10.1093/brain/awf022)
Al-Shafei, A. I. M., Wise, R. G., Gresham, G. A., Bronns, G., Carpenter, T. A., Hall, L. D. and Huang, C. L. 2002. Non-invasive magnetic resonance imaging assessment of myocardial changes and the effects of angiotensin-converting enzyme inhibition in diabetic rats. The Journal of Physiology 538(2), pp. 541-553. (10.1113/jphysiol.2001.012856)
Al-Shafei, A. I. M., Wise, R. G., Gresham, G. A., Carpenter, T. A., Hall, L. D. and Huang, C. L. 2002. Magnetic resonance imaging analysis of cardiac cycle events in diabetic rats: the effect of angiotensin-converting enzyme inhibition. The Journal of Physiology 538(2), pp. 555-572. (10.1113/jphysiol.2001.012857)

2001

Ploghaus, A. et al. 2001. Exacerbation of pain by anxiety is associated with activity in a hippocampal network. Journal of Neuroscience 21(24), pp. 9896-9903.
Tracey, I. and Wise, R. G. 2001. Pharmacological fMRI: A New Tool for Drug Development in Humans. Journal of Pharmacy Practice 14(5), pp. 368-375. (10.1106/QACM-FBX4-90UK-FRW6)
Al-Shafei, A. I. M., Wise, R. G., Grace, A. A., Carpenter, T. A., Hall, L. D. and Huang, C. L. 2001. MRI analysis of right ventricular function in normal and spontaneously hypertensive rats. Magnetic Resonance Imaging 19(10), pp. 1297-1304. (10.1016/S0730-725X(01)00466-0)
Longe, S. E., Wise, R. G., Bantick, S., Lloyd, D., Johansen-Berg, H., McGlone, F. and Tracey, I. 2001. Counter-stimulatory effects on pain perception and processing are significantly altered by attention: an fMRI study. Neuroreport 12(9), pp. 2021-2025.

1999

Wise, R. G., Huang, C. L., Al-Shafei, A. I. M., Carpenter, T. A. and Hall, L. D. 1999. Geometrical models of left ventricular contraction from MRI of the normal and spontaneously hypertensive rat heart. Physics in Medicine and Biology 44(10), pp. 2657-2676. (10.1088/0031-9155/44/10/319)

1998

Wise, R. G., Huang, C. L., Gresham, G. A., Al-Shafei, A. I. M., Carpenter, T. A. and Hall, L. D. 1998. Magnetic resonance imaging analysis of left ventricular function in normal and spontaneously hypertensive rats. The Journal of Physiology 513(3), pp. 873-887. (10.1111/j.1469-7793.1998.873ba.x)

1996

Wise, R. G., Newling, B., Gates, A. R. C., Xing, D., Carpenter, T. A. and Hall, L. D. 1996. Measurement of pulsatile flow using MRI and a Bayesian technique of probability analysis. Magnetic Resonance Imaging 14(2), pp. 173-185. (10.1016/0730-725X(95)02059-3)

Research topics and related papers

My research focuses on the development and application of quantitative FMRI techniques as well as multimodal imaging such as the combination of EEG and FMRI. We aim to apply these advanced techniques to the study of brain function in health and disease and to study drug effects in the brain including analgesics (Wise et al 2002, 2004), sedatives and caffeine (Diukova et al 2012).

Specifically we are investigating the coupling between neural and vascular activity and between metabolic and vascular activity in the brain. We are investigating the physiology underlying the BOLD response and the factors that affect this image contrast. An aim of our work is to improve our interpretation of FMRI data as a marker of neural activity in demanding applications such as disease and drug studies where underlying cerebral physiology may be altered (see Iannetti and Wise 2007).

We are applying techniques to measure drug-induced changes in cerebral perfusion (using arterial spin labelling) (see Murphy et al 2011 and Carhart-Harris et al 2012) to localise drug effects. We are developing techniques to maximise the information extracted from simultaneous EEG and FMRI which has the advantage of providing electrophysiological as well as haemodynamic information. We are also developing methods for the measurement of cerebro-vascular reactivity and cerebral oxygen metabolism with the use of respiratory challenges in the MRI scanner to modulate blood flow and oxygenation (Murphy et al 2011, Chiarelli et al 2007).

We are applying our research to study pharmacological sedation in collaboration with Anaesthetists. We are also investigating changes in the brain with chronic pain and with neurological conditions such as epilepsy and multiple sclerosis. We are also applying our techniques to understand the brain’s control of basic body functions such as breathing (Pattinson et al 2009) and cardiovascular control and cerebral autoregulation.

Funding

Current
EPSRC, Improving EEG reading of brain states for clinical applications using a data-driven joint model of FMRI and EEG. Richard Wise, Yulia Hicks and Cyril Charron. 2011-2012. £132,000.

Arthritis Research UK (Centre Grant). Cardiff University Biomechanics and Bioengineering Centre. 2009-2014. Vic Duance, Debbie Mason, Cathy Holt, Sam Evans, Daniel Aeschlimann, Stephen Denyer, Bronwen Evans, Simon Jones, Daniela Riccardi, Robert van Deursen, Anwen Williams, Richard Wise. £2,500,000.

Wellcome Trust. 4 year PhD programme in Integrative Neuroscience. 2008-2014. Vincenzo Crunelli (PI) John Aggleton (PI), Mark Good, Kim Graham, Robert Honey, Derek Jones, Simon Killcross, Andrew Lawrence, John Pearce, Krish Singh, Ed Wilding, Richard Wise, Nick Craddock, Lesley Jones, George Kirov, Michael O’Donovan, Michael Owen, Anita Thapar, Marianne van den Bree, Lawrence Wilkinson, Julie Williams, Nigel Williams, Vladimir Buchman, Alun Davies, Stephen Dunnett, Kevin Fox, AJ Harwood, Stuart Hughes, Anne Rosser, Frank Sengpiel. £4m.

Marie Curie (FP7) European Fellowship, Routes to Arousal: a simultaneous EEG-FMRI investigation of pharmacological sedation in humans. 2010-2012. Awarded to Dr Tommaso Gili (host, Richard Wise). €181,000.

Current Fellowships sponsored/supervised

Natural Sciences and Engineering Research Council of Canada, Banting Fellowship awarded to Dr Ashley Harris

Wellcome Trust Career Development Fellowship. Quantifying vascular influences on neurovascular coupling with fMRI, awarded to Dr Kevin Murphy

Selected past funding
Pfizer Ltd, Pharmacological modulation of free-running EEG. Richard Wise. 2010-2011. £61,000.

Waterloo Foundation. Advanced Neuroimaging in BECCTS. 2010-2012. Derek Jones, Krish Singh, Richard Wise, Dave McGonigle, Suresh Muthukumaraswamy. £110,000.

Welsh Assembly Government: Academic expertise for business (A4B), collaborative industrial research project. The integrated brain imaging and stimulation project (IBIS). 2010-2012. Chris Chambers, Krish Singh, Richard Wise, Derek Jones, David Jiles. £194,000.

Alzheimer’s Research Trust. Cerebral small vessel disease, blunted perfusion responses and adaptation to early Alzheimer’s disease. 2010-2012. Mike O’Sullivan, Richard Wise, Derek Jones, Tony Bayer. £26,950.

Pfizer Ltd. Optimising pharmacological FMRI for drug development. 2008-2010.Richard Wise. £257,000.

MRC Career Development Award. Pharmacological neuroimaging: assessing FMRI as a biomarker of changes in neuronal activity using combined EEG and FMRI. 2005-2010. Richard Wise. £473,000.

Research group

Dr Cyril Charron (Postdoctoral scientist, School of  Psychology, Cardiff University)
Dr Tommaso Gili (Postdoctoral fellow, School of Psychology,  Cardiff University)
Dr Ashley Harris (Postdoctoral fellow, School of Psychology,  Cardiff University)
Ilona Lipp (PG, School of  Psychology, Cardiff University)
Kevin Poon (PG, School of  Psychology, Cardiff University)
Dr Neeraj Saxena (PG, School of  Psychology, Cardiff University)
Alan Stone (PG, School of  Psychology, Cardiff University)
Ann Taylor (PG, School of  Psychology, Cardiff University)
Esther Warnert (PG, School of  Psychology, Cardiff University)

Research collaborators

School of Psychology, Cardiff
Dr Chris Chambers
Prof Derek Jones
Dr David McGonigle
Dr Kevin Murphy
Prof Krish Singh

Cardiff University
Prof Judith Hall (Cardiff Institute of Infection and Immunity, School of Medicine, Cardiff University)

Dr Ann Harvey (Arthritis Research UK Biomechanics and Bioengineering Centre, Cardiff University)

Prof John Cockcroft (Institute of Molecular and Experimental Medicine, School of Medicine, Cardiff University)

Prof Sailesh Kotecha (Institute of Molecular and Experimental Medicine, School of Medicine, Cardiff University)

Dr Valentina Tomassini (Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine)

Dr Xavier Caseras (Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine)

Prof William Gray (Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine)

External
Prof Damian  Bailey (University of Glamorgan)
Prof Carlo  Caltagirone (Santa Lucia Foundation, Rome)
Dr  Federico Giove (University of Rome, La Sapienza)
Dr Giandomenico  Iannetti (University College London)
Dr Emma  Hart (Bristol University)
Dr Tom Liu  (UCSD FMRI Center)
Prof Bruno  Maraviglia (University of Rome, La Sapienza)
Prof David  Nutt (Imperial College)
Prof  Julian Paton (Bristol University)
Dr Kyle  Pattinson (Oxford University, Nuffield Department of anaesthetics)
Prof Peter  Rogers (Bristol University)
Dr Bill  Vennart (Pfizer Ltd.)
Dr Fernando  Zelaya (Institute of Psychiatry, King’s College London)

Postgraduate research interests

My research involves developing and applying quantitative FMRI techniques to study the physiology of the human brain. My group also aims to combine multiple techniques such as EEG or MEG and FMRI to examine neurovascular coupling. Vascular function is an important aspect of brain function and this underlies the generation of the BOLD FMRI signal. We are studying vascular function using FMRI techniques included arterial spin labelling perfusion measurement and we are also aiming to provide more quantitative measurements of brain function including the rate of oxygen consumption. In the course of our research we use respiratory challenges in the MRI scanner. We aim to apply our techniques in pharmacological studies to examine drug effects on the brain and in studies of pain, hypertension, epilepsy, multiple sclerosis and cerebrovascular disease.

Opportunities for research range from basic methods development (suited to the more technically oriented), through to application of these methods to study healthy and diseased brains.
If you are interested in applying for a PhD, or for further information regarding my postgraduate research, please contact me directly (contact details available on the 'Overview' page), or submit a formal application.

Current students

Ilona Lipp. Emotion regulation and associated physiological  changes and regulating genetic factors
Kevin Poon. Study of pulmonary hypertension
Dr Neeraj Saxena. MRI and MEG studies of propofol sedatio
Alan Stone. Development of quantitative FMRI methods  including measurement of oxygen metabolism
Ann Taylor. Chronic non-malignant pain studied with FMRI
Esther Warnert. Development of brainstem FMRI to study  cardiovascular control

Past projects

Previous students

Dr Laura  Zambreanu
Dr Steve Mayhew (School of Psychology, Birmingham  University)
Dr Kyle  Pattinson (Oxford University, Nuffield Department of anaesthetics)

Professor Richard Wise

Overview

Research summary

Teaching summary

Other roles

Biography

Undergraduate education

Postgraduate education

Employment

Honours and awards

Awards/external committees

Publications

2024

2023

2022

2021

2020

2019

2018

2017

2016

2015

2014