Dr Mark Toleman

2023

• Abdullah, S. et al. 2023. Whole genome-based genetic insights of blaNDM producing clinical E. coli isolates in hospitals settings of Pakistan. Microbiology Spectrum 11(5), article number: e00584-23. (10.1128/spectrum.00584-23)

2022

• Martins, W. M. et al. 2022. Diversity of lytic bacteriophages against XDR Klebsiella pneumoniae sequence type 16 recovered from sewage samples in different parts of the world. Science of the Total Environment 839, article number: 156074. (10.1016/j.scitotenv.2022.156074)
• Zhang, L. et al. 2022. Co‐evolutionary adaptations of Acinetobacter baumannii and a clinical carbapenemase‐encoding plasmid during carbapenem exposure. Evolutionary Applications (10.1111/eva.13441)
• Martins, W. M. B. S. et al. 2022. Effective phage cocktail to combat the rising incidence of extensively drug-resistant Klebsiella pneumoniae sequence type 16. Emerging Microbes and Infections 11(1), pp. 1015 -1023. (10.1080/22221751.2022.2051752)

2021

• Loh, B. et al. 2021. Complete genome sequence of the virulent Klebsiella pneumoniae Phage Geezett infecting multidrug-resistant clinical strains. Microbiology Resource Announcements 10(48), article number: e00685-21. (10.1128/MRA.00685-21)
• Martins, W. M. B. S. et al. 2021. BKC-2, a new BKC variant detected in MCR-9.1-producing Enterobacter hormaechei subsp. xiangfangensis. Antimicrobial Agents and Chemotherapy 65(3), article number: e01193-20. (10.1128/AAC.01193-20)

2020

• Usman Qamar, M. et al. 2020. The present danger of New Delhi metallo-β-lactamase: a threat to public health. Future Microbiology 15(18), pp. 1759-1778. (10.2217/fmb-2020-0069)
• Martins, W. M. B. S. et al. 2020. Clinical and molecular description of a high-copy IncQ1 KPC-2 plasmid harbored by the international ST15 Klebsiella pneumoniae clone. mSphere 5, article number: e00756-20. (10.1128/mSphere.00756-20)
• Martins, W. M. B. S., Toleman, M. A. and Gales, A. C. 2020. Clinical utilization of bacteriophages: a new perspective to combat the antimicrobial resistance in Brazil. Brazilian Journal of Infectious Diseases 24(3), pp. 239-246. (10.1016/j.bjid.2020.04.010)
• Paul, D., Babenko, D. and Toleman, M. A. 2020. Human carriage of cefotaxime-resistant Escherichia coli in North-East India: an analysis of STs and associated resistance mechanisms. Journal of Antimicrobial Chemotherapy 75(1), pp. 72-76., article number: dkz416. (10.1093/jac/dkz416)

2019

• Day, M. J. et al. 2019. Extended-spectrum β-lactamase-producing Escherichia coli in human-derived and foodchain-derived samples from England, Wales, and Scotland: an epidemiological surveillance and typing study. Lancet Infectious Diseases 19(12), pp. 1325-1335. (10.1016/S1473-3099(19)30273-7)
• Farzana, R. et al. 2019. Emergence of mcr-1 mediated colistin resistant Escherichia coli from a hospitalized patient in Bangladesh. Journal of Infection in Developing Countries 13(8), pp. 773-776. (10.3855/jidc.11541)
• Qamar, M. U., Walsh, T. R., Toleman, M. A., Tyrrell, J. M., Saleem, S., Aboklaish, A. and Jahan, S. 2019. Dissemination of genetically diverse NDM-1, -5, -7 producing-Gram-negative pathogens isolated from pediatric patients in Pakistan. Future Microbiology 14(8) (10.2217/fmb-2019-0012)
• Livermore, D. M. et al. 2019. OXA-1 β-lactamase and non-susceptibility to penicillin/β-lactamase inhibitor combinations among ESBL-producing Escherichia coli. Journal of Antimicrobial Chemotherapy 74(2), pp. 326-333. (10.1093/jac/dky453)

2018

• Qamar, M. U. et al. 2018. In vitro and in vivo activity of Manuka honey against NDM-1-producing Klebsiella pneumoniae ST11. Future Microbiology 13(1), pp. 13. (10.2217/fmb-2017-0119)
• Qamar, M. U., Walsh, T. R., Toleman, M. A., Saleem, S. and Jahan, S. 2018. First identification of clinical isolate of a Novel “NDM-4” producing Escherichia coli ST405 from urine sample in Pakistan. Brazilian Journal of Microbiology 49(4), pp. 949-950. (10.1016/j.bjm.2018.02.009)
• Zahra, R., Javeed, S., Malala, B., Babenko, D. and Toleman, M. A. 2018. Analysis of Escherichia coliSTs and resistance mechanisms in sewage from Islamabad, Pakistan indicates a difference in E. coli carriage types between South Asia and Europe. Journal of Antimicrobial Chemotherapy 73(7), pp. 1781-1785. (10.1093/jac/dky109)
• Liakopoulos, A. et al. 2018. High prevalence of intra-familial co-colonization by extended-spectrum cephalosporin resistant enterobacteriaceae in preschool children and their parents in Dutch households. Frontiers in Microbiology 9, article number: 293. (10.3389/fmicb.2018.00293)
• Toleman, M. A. 2018. Direct in gel genomic detection of antibiotic resistance genes in S1 pulsed field electrophoresis gels. In: Gillespie, S. ed. Antibiotic Resistance Protocols. Methods in Molecular Biology., Vol. 1736. Methods in Molecular Biology New York, NY: Humana Press, pp. 129-136., (10.1007/978-1-4939-7638-6_12)

2017

• Tanner, W. D., Atkinson, R. M., Goel, R. K., Toleman, M. A., Benson, L. S., Porucznik, C. A. and VanDerslice, J. A. 2017. Horizontal transfer of the blaNDM-1 gene to Pseudomonas aeruginosa and Acinetobacter baumannii in biofilms. FEMS Microbiology Letters 364(8), pp. 102-120. (10.1093/femsle/fnx048)
• Toleman, M. 2017. The future of peritoneal dialysis in a moving landscape of bacterial resistance. Peritoneal Dialysis International 37(2), pp. 134-140. (10.3747/pdi.2016.00038)

2016

• Sattar, H., Toleman, M. A. H., Nahid, F. and Zahra, R. 2016. Co-existence of blaNDM-1 and blaKPC-2 in clinical isolates of Klebsiella pneumoniae from Pakistan. Journal of Chemotherapy 28(4), pp. 346-349. (10.1179/1973947814Y.0000000223)
• Tyrrell, J. M., Wootton, M., Toleman, M. A., Howe, R. A., Woodward, M. and Walsh, T. R. 2016. Genetic & virulence profiling of ESBL-positive E. coli from nosocomial & veterinary sources. Veterinary Microbiology 186, pp. 37-43. (10.1016/j.vetmic.2016.02.007)

2015

• Toleman, M. A., Bugert, J. J. and Nizam, S. A. 2015. Extensively drug-resistant New Delhi metallo-β-lactamase–encoding bacteria in the environment, Dhaka, Bangladesh, 2012. Emerging Infectious Disease 21(6), pp. 1027-1030. (10.3201/eid2106.141578)
• Jones, L. S. et al. 2015. Characterization of plasmids in extensively drug-resistant acinetobacter strains isolated in India and Pakistan. Antimicrobial Agents and Chemotherapy 59(2), pp. 923-929. (10.1128/AAC.03242-14)

2014

• Aboklaish, A., Dordet-Frisoni, E., Citti, C., Toleman, M. A., Glass, J. I. and Spiller, O. B. 2014. Random insertion and gene disruption via transposon mutagenesis of Ureaplasma parvum using a mini-transposon plasmid. International Journal of Medical Microbiology 304(8), pp. 1218-1225. (10.1016/j.ijmm.2014.09.003)
• Jones, L. S., Toleman, M. A., Weeks, J. L., Howe, R. A., Walsh, T. R. and Kumarasamy, K. K. 2014. Plasmid carriage of blaNDM-1 in clinical Acinetobacter baumannii isolates from India. Antimicrobial Agents and Chemotherapy 58(7), pp. 4211-4213. (10.1128/AAC.02500-14)
• Toleman, M. 2014. The challenge to patient safety by emerging Gram negative pathogens. Journal of Infection and Public Health 7(1), pp. 1-5. (10.1016/j.jiph.2013.12.001)

2013

• Edelstein, M. V. et al. 2013. Spread of extensively resistant VIM-2-positive ST235 Pseudomonas aeruginosa in Belarus, Kazakhstan, and Russia: a longitudinal epidemiological and clinical study. The Lancet Infectious Diseases 13(10), pp. 867-876. (10.1016/S1473-3099(13)70168-3)
• Wendel, A. F. et al. 2013. Genetic characterization and emergence of the Metallo-β-Lactamase GIM-1 in Pseudomonas spp. and Enterobacteriaceae during a long-term outbreak. Antimicrobial Agents and Chemotherapy 57(10), pp. 5162-5165. (10.1128/AAC.00118-13)

2012

• El Salabi, A., Borra, P. S., Toleman, M. A. H., Samuelsen, O. and Walsh, T. R. 2012. Genetic and biochemical characterization of a novel metallo-β-lactamase, TMB-1, from an achromobacter xylosoxidans strain isolated in Tripoli, Libya. Antimicrobial Agents and Chemotherapy 56(5), pp. 2241-2245. (10.1128/AAC.05640-11)
• Giske, C. G. et al. 2012. Diverse sequence types of klebsiella pneumoniae contribute to the dissemination of blaNDM-1 in India, Sweden, and the United Kingdom. Antimicrobial Agents and Chemotherapy 56(5), pp. 2735-2738. (10.1128/AAC.06142-11)
• Toleman, M. A. H., Spencer, J., Jones, L. S. and Walsh, T. R. 2012. blaNDM-1 is a chimera likely constructed in acinetobacter baumannii. Antimicrobial Agents and Chemotherapy 56(5), pp. 2773-2776. (10.1128/AAC.06297-11)
• Walsh, T. R., Livermore, D. M., Weeks, J. L. and Toleman, M. A. H. 2012. Dissemination of NDM-1 - authors' reply [Letter]. The Lancet Infectious Diseases 12(2), pp. 101-102. (10.1016/S1473-3099(11)70372-3)

2011

• Toleman, M. A. H. and Walsh, T. R. 2011. Combinatorial events of insertion sequences and ICE in Gram-negative bacteria. FEMS Microbiology Reviews 35(5), pp. 912-935. (10.1111/j.1574-6976.2011.00294.x)
• Davey, M. S., Tyrrell, J. M., Howe, R. A., Walsh, T. R., Moser, B., Toleman, M. A. H. and Eberl, M. 2011. A promising target for treatment of multidrug-resistant bacterial infections [Letter]. Antimicrobial Agents and Chemotherapy 55(7), pp. 3635-3636. (10.1128/AAC.00382-11)
• Davey, M. S. et al. 2011. Human neutrophil clearance of bacterial pathogens triggers anti-microbial γδ T cell responses in early infection. Plos Pathogens 7(5), article number: e1002040. (10.1371/journal.ppat.1002040)
• Walsh, T. R., Weeks, J. L., Livermore, D. M. and Toleman, M. A. H. 2011. Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study. The Lancet Infectious Diseases 11(5), pp. 355-362. (10.1016/S1473-3099(11)70059-7)
• Livermore, D. M., Walsh, T. R., Toleman, M. A. H. and Woodford, N. 2011. Balkan NDM-1: Escape or transplant? [Correspondence]. The Lancet Infectious Diseases 11(3), pp. 164. (10.1016/S1473-3099(11)70048-2)
• Walsh, T. R. and Toleman, M. A. H. 2011. The new medical challenge: why NDM-1? Why Indian?. Expert Review of Anti-infective Therapy 9(2), pp. 137-141. (10.1586/eri.10.159)
• Samuelsen, ?. et al. 2011. Molecular characterization of VIM-producing Klebsiella pneumoniae from Scandinavia reveals genetic relatedness with international clonal complexes encoding transferable multidrug resistance. Clinical Microbiology and Infection 17(12), pp. 1811-1816. (10.1111/j.1469-0691.2011.03532.x)
• Mata, C., Miró, E., Toleman, M. A. H., Rivera, M. A., Walsh, T. R. and Navarro, F. 2011. Association of blaDHA-1 and qnrB genes carried by broad-host-range plasmids among isolates of Enterobacteriaceae at a Spanish hospital. Clinical Microbiology and Infection 17(10), pp. 1514-1517. (10.1111/j.1469-0691.2011.03539.x)
• Nordmann, P., Poirel, L., Toleman, M. A. H. and Walsh, T. R. 2011. Does broad-spectrum β-lactam resistance due to NDM-1 herald the end of the antibiotic era for treatment of infections caused by Gram-negative bacteria?. Journal of Antimicrobial Chemotherapy 66(4), pp. 689-692. (10.1093/jac/dkq520)
• Mata, C., Navarro, F., Miro, E., Walsh, T. R., Mirelis, B. and Toleman, M. A. H. 2011. Prevalence of SXT/R391-like integrative and conjugative elements carrying blaCMY-2 in Proteus mirabilis. Journal of Antimicrobial Chemotherapy 66(10), pp. 2266-2270. (10.1093/jac/dkr286)
• Walsh, T. R. and Toleman, M. A. H. 2011. The emergence of pan-resistant Gram-negative pathogens merits a rapid global political response. Journal of Antimicrobial Chemotherapy 67(1), pp. 1-3. (10.1093/jac/dkr378)
• Mata, C. et al. 2011. Plasmid typing and genetic context of AmpC β-lactamases in Enterobacteriaceae lacking inducible chromosomal ampC genes: findings from a Spanish hospital 1999-2007. Journal of Antimicrobial Chemotherapy 67(1), pp. 115-122. (10.1093/jac/dkr412)

2010

• Davey, M. S. et al. 2010. Innate crosstalk of gamma delta T cells, neutrophils and monocytes in response to HMB-PP producing bacteria [Abstract]. Immunology 131, pp. 63-63. (10.1111/j.1365-2567.2010.03390.x)
• Hammerum, A. M., Toleman, M. A. H., Hansen, F., Kristensen, B., Lester, C. H., Walsh, T. R. and Fuursted, K. 2010. Global spread of New Delhi metallo-β-lactamase 1. The Lancet Infectious Diseases 10(12), pp. 829-830. (10.1016/S1473-3099(10)70276-0)
• Kumarasamy, K. K. et al. 2010. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. The Lancet Infectious Diseases 10(9), pp. 597-602. (10.1016/S1473-3099(10)70143-2)
• Walsh, T. R., Toleman, M. A. H., Sarma, J. B., Irfan, S., Woodford, N. and Livermore, D. M. 2010. New Delhi metallo-beta-lactamase 1 [Authors' reply]. The Lancet Infectious Diseases 10(11), pp. 752-754. (10.1016/S1473-3099(10)70245-0)
• Ferreira, S., Toleman, M. A. H., Ramalheira, E., Da Silva, G. J., Walsh, T. R. and Mendo, S. 2010. First description of klebsiella pneumoniae clinical isolates carrying both qnrA and qnrB genes in Portugal. International Journal of Antimicrobial Agents 35(6), pp. 584-586. (10.1016/j.ijantimicag.2010.01.019)
• Toleman, M. A. H., Walsh, T. R. and Call, D. R. 2010. ISCR elements are key players in IncA/C plasmid evolution [Letter]. Antimicrobial Agents and Chemotherapy 54(8), pp. 3534. (10.1128/AAC.00383-10)
• Nordmann, P., Poirel, L., Carrer, A., Toleman, M. A. H. and Walsh, T. R. 2010. How to detect NDM-1 producers. Journal of Clinical Microbiology 49(2), pp. 718-721. (10.1128/JCM.01773-10)

2009

• Yong, D., Toleman, M. A. H., Giske, C. G., Cho, H. S., Sundman, K., Lee, K. and Walsh, T. R. 2009. Characterization of a new metallo-β-lactamase gene, blaNDM-1, and a novel erythromycin esterase gene carried on a unique genetic structure in klebsiella pneumoniae sequence Type 14 from India. Antimicrobial Agents and Chemotherapy 53(12), pp. 5046-5054. (10.1128/AAC.00774-09)
• El Salabi, A., Toleman, M. A. H., Weeks, J. L., Bruderer, T., Frei, R. and Walsh, T. R. 2009. First report of the metallo-β-lactamase SPM-1 in Europe. Antimicrobial Agents and Chemotherapy 54(1), pp. 582. (10.1128/AAC.00719-09)
• Patzer, J. A., Walsh, T. R., Weeks, J. L., Dzierzanowska, D. and Toleman, M. A. H. 2009. Emergence and persistence of integron structures harbouring VIM genes in the Children's Memorial Health Institute, Warsaw, Poland, 1998-2006. Journal of Antimicrobial Chemotherapy 63(2), pp. 269-273. (10.1093/jac/dkn512)
• Poirel, L., Mugnier, P. D., Toleman, M. A. H., Walsh, T. R., Rapoport, M. J., Petroni, A. and Nordmann, P. 2009. ISCR2, another vehicle for blaVEB gene acquisition. Antimicrobial Agents and Chemotherapy 53(11), pp. 4940-4943. (10.1128/AAC.00414-09)
• Samuelsen, O. et al. 2009. Molecular epidemiology of metallo-β-lactamase-producing pseudomonas aeruginosa isolates from Norway and Sweden shows import of international clones and local clonal expansion. Antimicrobial Agents and Chemotherapy 54(1), pp. 346-352. (10.1128/AAC.00824-09)

2008

• Toleman, M. A. H. and Walsh, T. R. 2008. Evolution of the ISCR3 group of ISCR elements. Antimicrobial Agents and Chemotherapy 52(10), pp. 3789-3791. (10.1128/AAC.00479-08)
• Li, H., Walsh, T. R. and Toleman, M. A. H. 2008. Molecular analysis of the sequences surrounding blaOXA-45 reveals acquisition of this gene by pseudomonas aeruginosa via a novel ISCR element, ISCR5. Antimicrobial Agents and Chemotherapy 53(3), pp. 1248-1251. (10.1128/AAC.00480-08)
• Samuelsen, O., Buaro, L., Toleman, M. A. H., Giske, C. G., Hermansen, N. O., Walsh, T. R. and Sundsfjord, A. 2008. The first metallo-β-lactamase identified in Norway is associated with a TniC-like transposon in a pseudomonas aeruginosa isolate of sequence type 233 imported from Ghana. Antimicrobial Agents and Chemotherapy 53(1), pp. 331-332. (10.1128/AAC.00785-08)
• Li, H., Toleman, M. A. H., Bennett, P. M., Jones, R. N. and Walsh, T. R. 2008. Complete sequence of p07-406, a 24,179-base-pair plasmid harboring the blaVIM-7 metallo-β-lactamase gene in a pseudomonas aeruginosa isolate from the United States. Antimicrobial Agents and Chemotherapy 52(9), pp. 3099-3105. (10.1128/AAC.01093-07)

2007

• Toleman, M. . A. H., Bennett, P. M., Bennett, D. M. C., Jones, R. N. and Walsh, T. R. 2007. Global emergence of trimethoprim/sulfamethoxazole resistance in Stenotrophomonas maltophilia mediated by acquisition of sul genes. Emerging infectious diseases 13, pp. 559-65.