Dr Boris Shorning
Senior Research Laboratory Technician
School of Biosciences
- ShorningB@cardiff.ac.uk
- +44 29206 88508
- Hadyn Ellis Building, Room European Cancer Stem Cell Research Institute, Cardiff School of BiosciencesHadyn Ellis Building, Maindy Road, Cardiff CF24 4HQ, Maindy Road, Cardiff, CF24 4HQ
Publication
2023
- Shorning, B., Trent, N., Griffiths, D. F., Worzfeld, T., Offermanns, S., Smalley, M. J. and Williamson, M. 2023. Plexin-B1 mutation drives metastasis in prostate cancer mouse models. Cancer Research Communications 3(3), pp. 444-458. (10.1158/2767-9764.CRC-22-0480)
2022
- Morgan, H. J. et al. 2022. CD200 ectodomain shedding into the tumor microenvironment leads to NK cell dysfunction and apoptosis. Journal of Clinical Investigation 132(21), article number: e150750. (10.1172/JCI150750)
2020
- Shorning, B. Y., Dass, M. S., Smalley, M. J. and Pearson, H. B. 2020. The PI3K-AKT-mTOR pathway and prostate cancer: at the crossroads of AR, MAPK, and WNT signaling. International Journal of Molecular Sciences 21(12), article number: 4507. (10.3390/ijms21124507)
2017
- Jefferies, M. T. et al. 2017. PTEN loss and activation of K-RAS and β-catenin cooperate to accelerate prostate tumourigenesis. Journal of Pathology 243(4), pp. 442-456. (10.1002/path.4977)
2016
- Shorning, B. and Clarke, A. R. 2016. Energy sensing and cancer: LKB1 function and lessons learnt from Peutz-Jeghers syndrome. Seminars in Cell and Developmental Biology 52, pp. 21-29. (10.1016/j.semcdb.2016.02.015)
2014
- Holik, A. Z., Young, M., Krzystyniak, J., Williams, G. T., Metzger, D., Shorning, B. Y. and Clarke, A. R. 2014. Brg1 loss attenuates aberrant Wnt-signalling and prevents Wnt-dependent tumourigenesis in the murine small intestine. PLoS Genetics 10(7), article number: e1004453. (10.1371/journal.pgen.1004453)
2013
- Holik, A. et al. 2013. Brg1 is required for stem cell maintenance in the murine intestinal epithelium in a tissue-specific manner. Stem Cells 31(11), pp. 2457-2466. (10.1002/stem.1498)
2012
- Khritankova, I. V., Kukharskiy, M. S., Lytkina, O. A., Bachurin, S. O. and Shorning, B. 2012. Dimebon activates autophagosome components in human neuroblastoma SH-SY5Y cells. Doklady Biochemistry and Biophysics 446(1), pp. 251-253. (10.1134/S1607672912050079)
- Williams, R., Shorning, B., Datta, S., Kynaston, H. and Clarke, A. R. 2012. Development and characterisation of a bladder cancer model [Poster]. BJU International 109(S7), pp. 25-25. (10.1111/j.1464-410X.2012.11177.x)
- Shorning, B. et al. 2012. Intestinal renin-angiotensin system is stimulated after deletion of Lkb1. Gut 61(2), pp. 202-213. (10.1136/gutjnl-2011-300046)
2011
- Shorning, B. and Clarke, A. R. 2011. LKB1 loss of function studied in vivo.. FEBS Letters 585(7), pp. 958-966. (10.1016/j.febslet.2011.01.019)
- Shorning, B., Griffiths, D. F. R. and Clarke, A. R. 2011. Lkb1 and Pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladder. PLoS ONE 6(1), article number: e16209. (10.1371/journal.pone.0016209)
2009
- Ruzov, A., Shorning, B., Mortusewicz, O., Dunican, D. S., Leonhardt, H. and Meehan, R. R. 2009. MBD4 and MLH1 are required for apoptotic induction in xDNMT1-depleted embryos. Development 136(13), pp. 2277-2286. (10.1242/dev.032227)
- Shorning, B. et al. 2009. Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine. PLoS ONE 4(1), article number: e4264. (10.1371/journal.pone.0004264)
Erthyglau
- Shorning, B., Trent, N., Griffiths, D. F., Worzfeld, T., Offermanns, S., Smalley, M. J. and Williamson, M. 2023. Plexin-B1 mutation drives metastasis in prostate cancer mouse models. Cancer Research Communications 3(3), pp. 444-458. (10.1158/2767-9764.CRC-22-0480)
- Morgan, H. J. et al. 2022. CD200 ectodomain shedding into the tumor microenvironment leads to NK cell dysfunction and apoptosis. Journal of Clinical Investigation 132(21), article number: e150750. (10.1172/JCI150750)
- Shorning, B. Y., Dass, M. S., Smalley, M. J. and Pearson, H. B. 2020. The PI3K-AKT-mTOR pathway and prostate cancer: at the crossroads of AR, MAPK, and WNT signaling. International Journal of Molecular Sciences 21(12), article number: 4507. (10.3390/ijms21124507)
- Jefferies, M. T. et al. 2017. PTEN loss and activation of K-RAS and β-catenin cooperate to accelerate prostate tumourigenesis. Journal of Pathology 243(4), pp. 442-456. (10.1002/path.4977)
- Shorning, B. and Clarke, A. R. 2016. Energy sensing and cancer: LKB1 function and lessons learnt from Peutz-Jeghers syndrome. Seminars in Cell and Developmental Biology 52, pp. 21-29. (10.1016/j.semcdb.2016.02.015)
- Holik, A. Z., Young, M., Krzystyniak, J., Williams, G. T., Metzger, D., Shorning, B. Y. and Clarke, A. R. 2014. Brg1 loss attenuates aberrant Wnt-signalling and prevents Wnt-dependent tumourigenesis in the murine small intestine. PLoS Genetics 10(7), article number: e1004453. (10.1371/journal.pgen.1004453)
- Holik, A. et al. 2013. Brg1 is required for stem cell maintenance in the murine intestinal epithelium in a tissue-specific manner. Stem Cells 31(11), pp. 2457-2466. (10.1002/stem.1498)
- Khritankova, I. V., Kukharskiy, M. S., Lytkina, O. A., Bachurin, S. O. and Shorning, B. 2012. Dimebon activates autophagosome components in human neuroblastoma SH-SY5Y cells. Doklady Biochemistry and Biophysics 446(1), pp. 251-253. (10.1134/S1607672912050079)
- Williams, R., Shorning, B., Datta, S., Kynaston, H. and Clarke, A. R. 2012. Development and characterisation of a bladder cancer model [Poster]. BJU International 109(S7), pp. 25-25. (10.1111/j.1464-410X.2012.11177.x)
- Shorning, B. et al. 2012. Intestinal renin-angiotensin system is stimulated after deletion of Lkb1. Gut 61(2), pp. 202-213. (10.1136/gutjnl-2011-300046)
- Shorning, B. and Clarke, A. R. 2011. LKB1 loss of function studied in vivo.. FEBS Letters 585(7), pp. 958-966. (10.1016/j.febslet.2011.01.019)
- Shorning, B., Griffiths, D. F. R. and Clarke, A. R. 2011. Lkb1 and Pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladder. PLoS ONE 6(1), article number: e16209. (10.1371/journal.pone.0016209)
- Ruzov, A., Shorning, B., Mortusewicz, O., Dunican, D. S., Leonhardt, H. and Meehan, R. R. 2009. MBD4 and MLH1 are required for apoptotic induction in xDNMT1-depleted embryos. Development 136(13), pp. 2277-2286. (10.1242/dev.032227)
- Shorning, B. et al. 2009. Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine. PLoS ONE 4(1), article number: e4264. (10.1371/journal.pone.0004264)