Dr Andrew Shore
Transcriptional control of Uncoupling Protein 1 by gene silencing. The impact of learning technology on medical and bioscience education.
Deputy Admissions Tutor (Biological Schemes)
Having completed my undergraduate degree at the Wye Campus of Imperial College London I took up a research assistant post in the Comparative Medicine Section of Imperial which led onto a PhD in the same laboratory. With the continual evolution of research and university departments I left Imperial with a PhD and DIC from the National Heart and Lung Institute within the Faculty of Medicine.
This was followed by two years as a lecturing in Dorset on Bournemouth University degrees focussing on comparative anatomy, physiology, nutrition, genetics and epidemiology. While lecturing I completed my PGCertEP, became a Fellow of the Higher Education Academy and gained experience in the delivery of vocational qualifications and promoting widening access to Higher Education. With increasing lecturing commitments my research interests focussed on Bioscience Education, widening access to Higher Education and Bioinformatics.
I took up my current post at the School of Biosciences in 2009. Allied to my role as an admissions tutor I have also recently contributed to the Science and Learning Expert Group, developed science units for of level 3, 4 and 5 vocational qualifications (including HNDs) and advised City and Guilds on the progression of vocational learners to Higher Education.
Silencing of Uncoupling Protein 1 Expression
Uncoupling Protein 1 (UCP1) uncouples the respiratory chain from ATP Synthase by providing an alternative route for protons to cross the inner mitochondrial membrane. When this route is activated large quantities of heat are produced at the expense of ATP. UCP1 is specific to brown adipose tissue. In humans brown adipose tissue is only found in neonates for whom it is vital to maintain their body temperature. Thermogenically active brown adipose tissue consumes more energy than any other tissue, if transcription and activation of this protein could be easily manipulated in adults it may provide an important treatment to combat obesity and the metabolic syndrome. New evidence suggests that DNA methylation and chromatin remodelling may play a key role in regulating UCP1 expression. Although murine models are widely used to study UCP1 expression, epigenetic control of the gene may be significantly different in humans making findings difficult to transfer to humans. Recent research has focussed on identifying and validating more appropriate models for epigenetic regulation of UCP1 transcription in humans.
Allied collaborative research projects have included regulation of gene silencing by RIP140 and the role of gene silencing in tumour formation in mouse models for adenoviral gene therapy.
Current pedagogic research interests span medical and bioscience education and focus on managing the student experience, particularly in the transition from level 3 to level 4 upon entering higher education. This research often involves the role that learning technology can play to engage students and develop their study skills as well as their subject specific knowledge. Current projects involve:
- The use of technology to engage learners in large and small group contexts
- Using learning technology for formative assessment
- Transition of learners from level 3 to level 4 – study skills development
- The impact of elective feedback
- The performance and experience of vocational learners in Higher Education
Recent research presentations
Engaging students through questioning. QUILT Technology Enhanced Education Conference 2010, Cardiff.
Innovative uses of an audience response system for formative assessment & student directed lectures. STEM Network SW, July 2009.
Using VLE directed physiology practicals & data loggers to improve student learning. STEM Summer School SW, July 2009.
Front loading of practicals via a VLE icreases student engagement and maximises practical teaching time. STEM Network SW, March 2009.
Embedding an audience response system for formative assessment: the effect on VLE engagement. Education Enhancement Conference 2009, Bournemouth.
Tissue specific expression of Uncoupling Protein 1 is determined by DNA methylation. European Congress on Obesity 2007, Budapest.
Development fund for technology enhanced education – Cardiff University (2010)
VETNET LLN (2010)
Collaborative research fund - Bournemouth University (2009)