Dr Emyr Lloyd-Evans

Dr Emyr Lloyd-Evans

Senior Lecturer

School of Biosciences

Email:
lloyd-evanse@cardiff.ac.uk
Telephone:
+44 (0)29 2087 4304
Location:
Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX
Welsh speaking

Research overview

Lysosomes are a subset of organelles that are crucial for cellular function, as epitomised by the 50 human diseases that are caused by mutations in the genes encoding lysosomal and associated proteins. My laboratory is interested in the function of novel uncharacterised lysosomal transmembrane proteins, their roles in normal cellular function and the events that unfold when these proteins become dysfunctional in lysosomal diseases. We are particularly interested in applying our research on lysosomal proteins to other human diseases, particularly infectious and neurodegenerative diseases. Lysosomal research is an emerging area owing to the development of new tools capable of measuring lysosomal function at the acidic pH found within these compartments. My lab utilises these tools to investigate the function of this enigmatic class of organelles.

Division

Biomedicine

My first degree was an undergraduate masters in Biochemistry (M.Biochem) at the University of Bath. During this degree I spent 11 months (2 successive placements) in the lab of Prof. Tony Futerman at the Weizmann Institute of Science, Rehovot, Israel. It was here that I gained an interest in lysosomal storage diseases, researching the role of altered endoplasmic reticulum Ca2+ homeostasis in Gaucher disease. Following my degree in 2002 I moved to Oxford to do my DPhil with Prof. Fran Platt at the Glycobiology Institute. Here I researched the role of the simple sphingolipid sphingosine in the pathogenesis of Niemann-Pick type C1. Upon completion of my DPhil In 2005, I moved with Fran to the Department of Pharmacology (Oxford) where, in collaboration with Prof. Antony Galione, we developed techniques to study lysosomal Ca2+ homeostasis in the lysosomal diseases. In 2010 I was appointed as an RCUK Fellow at the School of Biosciences, Cardiff University, to continue my research into lysosomal function.

Our current interests

  • Mechanisms regulating lysosomal calcium ion (Ca2+) and zinc ion (Zn2+) homeostasis in health and disease
  • Use of superparamagnetic ferrofluid to purify lysosomes
  • Function of the NPC1 protein as a lysosomal RND multi-substrate permease and it's role in tuberculosis
  • Sterol precursor inhibition of the NPC1 protein as a therapeutic target for the sterol biosynthetic disease Smith-Lemli-Opitz Syndrome
  • Role of lysosomal dysfunction in the pathogenesis of Parkinson's disease
  • Mechanisms of pathogenesis and therapy development for soluble lysosomal protein diseases (MPS type II, NPC2, Tay-Sachs)

Lloyd-Evans Lab website

Group members