Professor David Lloyd

Honorary Professor

School of Biosciences

Research overview

Studies in Professor David Lloyd's Laboratory include:-

  • Biological timekeeping especially in the range seconds to hours in living organisms.
  • Monitoring intracellular events by non-invasive methods such as mass spectrometry, fluorescence techniques & nmr.
  • Using these approaches to solve medical, environmental and industrial problems.
  • Microwave interactions with biological systems: separated electric and magnetic field effects, and putative non-thermal components.

Cardiff Research into Infection and Parasites in Ecological Systems (CRIPES)

  • 2015-present Collaboration with US National Institute of Health on Aging, Baltimore.
  • 2008-present Honorary Professor, Cardiff University, and H. C. Andersen Professor of Biochemistry and Molecular Biology, University of Southern Denmark, Odense.
  • 2001-present Johns Hopkins Medical University, Molecular Cardiology.
  • 1978-2008 Professor of Microbiology, Cardiff University
  • 2001-2009  (six 1 week visits)  Johns Hopkins University, Mol. Cardiobiol.
  • 1999  (6 months) University of New South Wales, Biochemistry
  • 1998-2009 (4 visits) AIST, Tsukuba City and Keio University
  • 1998 (3 months) Tata Institute of Fundamental Research, Mumbai, Mol. Biol
  • 1997 (3 months) University of New South Wales, Biochemistry
  • 1990 (4 months) Odense University (U.S. Denmark), Biochemistry
  • 1986 (2 months) Harvard University, Biolabs
  • 1985 (2 months) ATOMKI  Debrecen
  • 1984 (1 month) INRA Bordeaux
  • 1982-1987 Head of the Microbiology Department, UC Cardiff, U of Wales
  • 1978  Personal Chair
  • 1976 -1978 Reader
  • 1978 Senior Lecturer
  • 1977 Guest Scientist (2 months) Rockefeller  University, New York
  • 1972  DSc (Sheff)
  • 1969-1976 Lecturer UCC
  • 1968-1979 (4 visits Wellcome, Leverhulme & RS)  University of Pennsylvania
  • 1967  U Pennsylvania, Biophysics, Philadelphia
  • 1967-1969 Research Assistant MRC Group (Microbial Structure & Function)
  • 1964-1967 ICI Research Fellowship (UC South Wales & Monmouthshire)
  • 1964  PhD (Wales) (UC South Wales & Monmouthshire)
  • 1961  BSc (Biochemistry, 1st Class Hons) Sheffield University

Current research

  1. Biology of the flagellate fish parasite, Spironucleus vortens (with Professor Jo Cable).
  2. Newly-synthesised fluorophores and phosphors as biological optical imaging agents (with Dr. Simon J. A. Pope, Dr. Ian A. Fallis and Dr. Angelo J. Amoroso, Chemistry), Dr. Catrin F. Williams (Engineering and Biosi), and Dr. Anthony J. Hayes (Biosi Confocal).
  3. Biological effects of microwaves with Catrin F. Williams (Engineering and Biosi) and Professor Adrian Porch (Engineering).
  4. Coupling of oscillatory behaviour in yeasts by intracellular water dynamics with Dr. Lars Folke Olsen and Professor Luis A. Bagatolli (University of Southern Denmark).

Grants

Work supported by EU Funding, NERC, BBSRC, Wellcome, The Royal Society, Ser Cymru.

Collaborations

  • University of Pennsylvania, 1967; 1969; 1971; 1975; 1978; 1979;
  • Rockefeller University 1978: Odense University 1977; 1978; 1980; 1981; 1983; 1986; 1990; 1994; 1996;
  • University of Southern Denmark at Odense, 1978 to present
  • Soviet Academy of Science 1979: Moscow State University 1979;
  • INRA, Bordeaux 1984;
  • ATOMKI, Debrecen 1984;
  • Harvard 1986;
  • TATA Institute for Fundamental Research, Bombay 1989; 1991; 1993; 1995; 1997; 1998 to present;
  • University of Kebansang, Kuala Lumpur 1989;
  • University of New South Wales, Sydney 1997;
  • National Institute for Biosciences/Human Technology, Tsukuba Science City 1997; 1998;
  • INTECH, Buenos Aires 1998; Sabbatical at University of New South Wales 1999;
  • Johns Hopkins Medical School, Molecular Cardiobiology, Baltimore 2002 to present.
  • Keio University: Institute for Advanced Biosciences at Tsuruoka, 2005 to present

Industrial collaboration with more than 50 companies and institutes.

Associates

Professor Marc Roussel (on sabbatical leave from Lethbridge, Alberta) used membrane inlet mass spectrometry to reveal the strange attractor that underlies the respiratory dynamics of yeast in continuous culture. This required simultaneous monitoring of dissolved H2S, CO2 and O2; 40,000 points at 15s intervals were acquired in a 3 month continuous culture experiment. This is the first unequivocal demonstration of chaotic control in a biological system at whole cell level.

Dr Katey Lemar established mechanisms for the anti-candidal properties of selected garlic components, diallyldisulphide and allyl alcohol produce apoptotic cell death in this organism without being too toxic to humans. This affords a new way of tackling antibiotic resistance; there are no reported incidents of microorganisms becoming resistant to the garlic compounds.

Dr. Catrin F. Williams with Neem Biotechnology (Dr. David Williams, Dr. Gareth Evans, Dr. Robert Saunders and Dr, MIchael Graz), Professor Jo Cable and Dr Michael P. Coogan studied the biochemistry and infectivity of the protozoan, Spironucleus vortens towards angelfish, especially sensitivity of the parasite to garlic comstituents.

With Professor Adrian Porch (Engineerinng), Catrin currently studies effects and their mechanisms of 2.45 GHz microwaves on the bioluminescence of the marine bacterium, Vibrio fischeri and on cultured normal and cancerous human cell lines.

Recent former associates

Dr Stefanie Scheerer and Dr Francisco Gomez have established a stable continuous culture of Photobacterium fisheri. This can be used as an on-line monitor for toxic compounds (e.g. biocides) in environmental samples including water supplies. Miniaturization will lead to the development of personal protection systems. Effects of microwaves were studied.

Dr. Simon Cottrell showed that freeze dried garlic powder is toxic to MRSA, and that synergistic affects in combination with oxycillin may provide a new chemotherapeutic strategy.

Dr Victoria Gray has shown that the morphology of Salmonella typhimurium and poona species is continually dependent on the tyrosine content of the growth medium. Various sources of the peptone used in the complex diagnostic media may be quite unsuitable on account of their tyrosine deficiency. Aflagellate organisms, unrecognisable as the pathogen, result if the medium is unsuitable.

Dr Kristina Harris investigated the effects of difluoro methylornithine on the growth, structure and function of Trichomonas vaginalis. Defective hydrogenosemes are one consequence of this ornithine decarboxylase inhibitor.

Dr Jonathan Wood investigated the application of garlic as an antibacterial specifically against MRSA. Resolution of effects required separation of the main toxic constituents; synergy with penicillin derivatives was researched.

Dr Coralie Millet investigated protozoal fish parasites Hexamita and Spironucleus spp.  Market for viticulture of aquarium fish is $7b/an. Pathogenicity and invasiveness; biodiversity was studied and compared with that of free living species.

External profiles

Research links