Dr Matthias Eberl

Dr Matthias Eberl

Reader, Division of Infection and Immunity. Engagement Lead, Systems Immunity Research Institute.

School of Medicine

Email:
eberlm@cardiff.ac.uk
Telephone:
+44 (0)29 2068 7011
Location:
3F08, Henry Wellcome Building for Biomedical Research, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN

I have always been interested in the molecular and cellular basis of host-pathogen relationships and the underlying modulation of complex immune responses.

During my PhD I established a screening method to identify CD4+ T cell antigens from cDNA libraries of the parasite Schistosoma mansoni. I then extended these studies during a two-year postdoc, and investigated the cellular and humoral immune response to schistosomes upon infection and vaccination.

My research since 2000 has concentrated on defining the role of human γδ T cells in bridging innate and adaptive immune responses.

γδ T cells are the prototype of 'unconventional' lymphocytes in that they are not restricted by classical MHC and display characteristics of 'conventional' T cells, NK cells and myeloid cells. Normally only constituting a minor population in human blood, they occupy a unique niche in microbial recognition and contribute to tumour surveillance.

More recently we have started to characterise early immune responses in acutely infected patients and define pathogen-specific signatures of cellular and soluble biomarkers ('immune fingerprints').

My research is placed at the interface of basic, translational and clinical research and benefits greatly from interdisciplinary collaborations with immunologists, microbiologists, biochemists, epidemiologists and clinicians.

Besides implications for diagnosis and treatment of microbial infections this work has direct consequences for vaccine design and cancer immunotherapy.

Career profile

  • since 08/2015
    Reader, Division of Infection & Immunity, School of Medicine, Cardiff University
  • 2011-2015
    Senior Lecturer, Cardiff Institute of Infection & Immunity, School of Medicine, Cardiff University
  • 2007-2011
    RCUK Fellow in Translational Research, School of Medicine, Cardiff University
  • 2005-2006
    Postdoc, Institute of Cell Biology, University of Bern (Switzerland)
    Lab: Prof Bernhard Moser
  • 2000-2005
    Postdoc, Institute of Biochemistry, School of Medicine, University of Giessen (Germany)
    Lab: Dr Hassan Jomaa
  • 1998-2000
    Postdoc, Department of Biology, University of York (UK)
    Lab: Prof Alan Wilson
  • 1995-1998
    PhD Student, Institute of Biochemistry, School of Medicine, University of Giessen (Germany)
    Lab: Prof Ewald Beck

Honours and awards

  • 2015: Promotion to Reader, Cardiff University
  • 2011: Promotion to Senior Lecturer, Cardiff University
  • 2009: Best Free Communications Prize at 9th European Peritoneal Dialysis Meeting, Strasbourg, France
  • 2007: RCUK Fellowship in Translational Research in Experimental Medicine
  • 2007: Wellcome Trust 'VIP' Award
  • 1995: PhD Studentship, "Graduiertenkolleg Molekulare Biologie und Pharmakologie", German Research Foundation (DFG)

Professional memberships

  • German Society for Immunology (DGfI)

Speaking engagements

Invited speaker and/or session chair

  • Dublin 2017: European Peritoneal Dialysis Meeting (EuroPD)
  • Liverpool 2016: British Society for Immunology / Dutch Society for Immunology
  • London 2016: International γδ T Cell Conference
  • Chicago 2015: FASEB Conference on Autoimmunity
  • Newcastle 2014: BSI Immunology North East Annual Symposium
  • Chicago 2014: International γδ T Cell Conference
  • Maastricht 2013: European Peritoneal Dialysis Meeting (EuroPD)
  • Glasgow 2012: European Congress of Immunology
  • Amsterdam 2012: EuTRiPD Academy
  • Freiburg 2012: International γδ T Cell Conference
  • Palermo 2012: International PhD Program in Immunopharmacology
  • Birmingham 2011: European Peritoneal Dialysis Meeting (EuroPD)
  • Cervo Ligure 2011: 5th Cervo Preclinical Working Conference
  • Galway 2011: Irish Society for Immunology
  • Vancouver 2010: Society for Leukocyte Biology / International Endotoxin and Innate Immunity Society
  • Kiel 2010: International γδ T Cell Conference
  • London 2008: Miltenyi T Cell Day
  • Marseille 2008: International γδ T Cell Conference
  • Cardiff 2008: Wales Cancer Conference

Seminars

  • Université Libre de Bruxelles (2017)
  • University of Würzburg (2016)
  • University of Cambridge (2013)
  • Barts and The London (2012)
  • CIDR, King's College London (2012)
  • University College Cork (2011)
  • CMCBI, King's College London (2011)
  • Dstl Porton Down, Salisbury (2009)
  • University of Würzburg (2008)
  • BSI South Wales Immunology Group, Cardiff (2007)
  • Institut Pasteur Parise (2005)
  • University of Bern (2005)
  • University of Freiburg (2005)
  • University of Giessen (2005)
  • Universitat Pompeu Fabra, Barcelona (2005)
  • University of Tübingen (2004)
  • University College Cork (2003)
  • Bakh Institute of Biochemistry, Moscow (2003)
  • Université Montpellier II (2002)

Conference attendance

  • Krakow 2015: European Peritoneal Dialysis Meeting (EuroPD)
  • Madrid 2014: International Society for Peritoneal Dialysis
  • Sheffield 2014: PD Research Day
  • Liverpool 2013: British Society for Immunology
  • Liverpool 2010: British Society for Immunology
  • Strasbourg 2009: European Peritoneal Dialysis Meeting (EuroPD)
  • Berlin 2009: European Congress of Immunology
  • Glasgow 2008: British Society for Immunology
  • Heidelberg 2007: German Society for Immunology
  • La Jolla 2006: International γδ T Cell Conference
  • Kiel 2005: German Society for Immunology / Scandinavian Society for Immunology
  • Uppsala 2004: XV International Symposium on Problems of Listeriosis
  • Maastricht 2004: German Society for Immunology / Dutch Society for Immunology
  • Harrogate 2003: British Society for Immunology
  • Berlin 2003: German Society for Immunology
  • Harrogate 2002: British Society for Immunology / British Society for Allergy and Clinical Immunology
  • Marburg 2002: German Society for Immunology
  • Harrogate 1999: British Society for Immunology / British Society for Allergy and Clinical Immunology
  • Woods Hole 1999: 3rd Immunoparasitology Meeting
  • Cambridge 1999: WHO/UNDP/World Bank Schistosoma Genome Network Meeting
  • Aussois 1998: Conferences Jacques Monod "Parasite Interactions with the Immune System: Protection or Pathology?"
  • Dresden 1998: German Society for Parasitology
  • Harrogate 1998: British Society for Immunology
  • Edinburgh 1997: "Parasitic Helminths - from Genomes to Vaccines"
  • Würzburg 1997: German Society for Immunology
  • Manchester 1997: British Society for Parasitology
  • Munich 1996: German Society for Parasitology

Committees and reviewing

  • since 08/2015: Engagement Lead, Systems Immunity Research Institute
  • since 04/2014: Chair of PhD Appraisal Panel, Infection & Immunity
  • since 05/2011: Founder and Administrator, γδ T Cell Forum
  • since 11/2009: Web Editor, Infection & Immunity

Reviewer experience

Funding bodies

  • AERES - Evaluation Agency for Research and Higher Education, France
  • Barts and The London Charity
  • BBSRC - Biotechnology and Biological Sciences Research Council
  • Cancer Research UK
  • Crohn’s in Childhood Research Association (CICRA)
  • Crohn's and Colitis UK
  • European Research Council (ERC)
  • Fondation pour la Recherche Médicale, France
  • German-Israeli Foundation for Scientific Research and Development
  • Institut National du Cancer (INCa), France
  • Kay Kendall Leukaemia Fund
  • Kidney Research UK
  • King’s Health Partners R&D Challenge Fund
  • MRC - Medical Research Council
  • Ministry of Science, Technology and Space, Israel
  • Multiple Sclerosis Society, UK
  • Research Grants Council, Hong Kong
  • Wellcome Trust
  • Wilhelm Sander Foundation, Germany

PhD examiner

  • Cardiff University
  • King's College London
  • National University of Ireland, Maynooth
  • University of Lisbon, Portugal
  • University of Palermo, Italy
  • Medical University of Vienna, Austria
  • University of Bordeaux, France

International journals

  • American Journal of Physiology – Renal Physiology
  • Blood
  • Bone
  • BMC Immunology
  • Breast Cancer Research
  • Cancer Immunology Immunotherapy
  • Cancer Research
  • Carcinogenesis
  • Cell Biochemistry & Function
  • Cellular Immunology
  • Chronobiology International
  • Clinical Cancer Research
  • Clinical and Developmental Immunology
  • Clinical and Experimental Immunology
  • Clinical and Experimental Medicine
  • Current Cancer Drug Targets
  • Current Immunology Reviews
  • Cytokine
  • EMBO Reports
  • European Journal of Immunology
  • Experimental Parasitology
  • FASEB Journal
  • FEBS Journal
  • Frontiers in Immunology
  • Haematologica
  • Human Immunology
  • Immunology
  • Immunology and Cell Biology
  • Immunology Letters
  • Infection and Immunity
  • International Immunology
  • International Journal of Artificial Organs
  • International Journal of Immunogenetics
  • International Urology and Nephrology
  • Journal of the American Chemical Society
  • Journal of the American Society of Nephrology
  • Journal of Biological Chemistry
  • Journal of Biological Regulators and Homeostatic Agents
  • Journal of Clinical Investigation
  • Journal of Immunology
  • Journal of Infectious Diseases
  • Journal of Leukocyte Biology
  • Journal of Medicinal Chemistry
  • Journal of Molecular Medicine
  • Journal of Translational Medicine
  • Kidney International
  • Microbes and Infection
  • Molecular Immunology
  • Mucosal Immunology
  • Nephrology, Dialysis, Transplantation
  • OncoImmunology
  • Oncology Reviews
  • Parasite Immunology
  • Peritoneal Dialysis International
  • PLoS ONE
  • PLoS Pathogens
  • Science Translational Medicine
  • Scientific Reports
  • Trends in Immunology
  • Trends in Parasitology

Teaching

In order to overcome the awe-inspiring complexity of the immune system and press it into digestible portions, immunology teaching is often in the danger to over-simplify scenarios and/or follow temporary fashions.  The main challenges are to keep up abreast with the latest literature and incorporate recent advances into the lessons; to transport one’s own enthusiasm for science to the students; to demonstrate that even the most complex mechanisms can be of enormous clinical relevance in health and disease; and to confront students with standard methods in diagnostic and research labs, but also to make them aware of the possibilities of modern technology.  My goal is to educate open-minded and critical students that are provided with all the scientific but also interpersonal tools required for being capable of questioning contemporary points of view and solving new problems.

Undergraduate teaching

I have been participating in the Year 2 SSC module “Interactive Immunology” for eight consecutive years, which comprises lectures, student lab paracticals and an assessment of student presentations. From 2017 on I will be lecturing in a new module on Biomarkers and Diagnostics developments.

I have trained undergraduate summer students as well as internship and Erasmus students.

Since 2010 I have acted as Personal Tutor for Medicine students, since 2013 as Academic Mentor.

Postgraduate teaching

I have supervised or co-supervised more than ten PhD students, all of whom completed, or are on course to complete, their PhD within four years.

I serve as Chair of approx. 20 appraisal panels for PhD and MD students per year, and have been appointed as internal examiner or viva chair of PhD theses at Cardiff University and as external examiner of PhD theses in the UK, Ireland, Italy and Portugal.

Public engagement and involvement

As Engagement Lead and member of the Steering Group of the Systems Immunity Research Institute, I aim to reach out to all stake-holders and engage with patients, health care providers, schools, policy makers, media, funding bodies and industry, and have set up a Lay Faculty of members of the public who help us reach our goals.

Current projects

- Please see details at Moser/Eberl Lab -

External profiles

Present and past group members

  • Raya Ahmed, Research Associate
  • Simone Cuff, Research Associate
  • Loic Raffray, Research Associate
  • Ann Kift-Morgan, Research Assistant
  • Amy Brook, PhD student
  • Ariadni Kouzeli, PhD student (co-supervisor)
  • Teja Rus, PhD student (co-supervisor)
  • Maximilian Keisker, Erasmus student
  • Raj Bansal, PhD student 2007-2012
  • Hung-Chang Chen, PhD student 2011-2016
  • Chantal Colmont, Research Assistant 2013-2014
  • Martin Davey, PhD student/Research Associate 2008-2013
  • Ida Jackson (Friberg), Research Associate 2013-2015
  • Chan-Yu Lin, PhD student 2009-2012
  • Anna Rita Liuzzi, PhD student/Research Associate 2013-2016
  • Christophe Macri, internship student 2009
  • Salvador Martí Pérez, Research Associate 2009-2010
  • Matt Morgan, PhD student 2011-2014 (co-supervisor)
  • Luke Piggott, PhD student 2009-2012 (co-supervisor)
  • Michele Scotto di Mase, internship student 2015
  • Yasmin Shanneik, Erasmus student 2014-2015
  • Chris Tyler, PhD student 2012-2016
  • Joanne Welton, Research Associate 2011-2013
  • Jingjing Zhang, Research Associate 2015-2016


Grant support

2017-2018
EU Horizon 2020, Marie Skłodowska-Curie Individual Fellowship (to Dr. Loic Raffray)
"Innate-like T-cells in sepsis (ILTIS): Implications for early diagnosis and rescue of immune suppression"
Main supervisor (co-supervisor Dr. Matt Morgan)
€ 97,727 (12 months)

2017

Life Sciences Bridging Fund Wales, Pathfinder Grant
"Development of rapid in vitro diagnostic tests for early detection and characterisation of infection"
Co-applicant (Lead applicant: Prof. Ian Weeks; co-applicants: Prof. Nicholas Topley, Dr. Fraser Logue)
£ 74,554 (12 months)

2016-2019
MRC research grant
"Innate pathogen sensing by local unconventional T cells during microbial infections"
Principal Applicant (co-applicants: Prof. Donald Fraser, Prof. David Price, Dr. Kristin Ladell, Prof. Phil Taylor, Prof. Jamie Rossjohn)
£ 660,663 (36 months)

2016-2019
Health and Care Research Wales, Clinical Research Time Award (to Dr. Matt Morgan)
Academic Supervisor
£ 66,535 (36 months)

2016
Wellcome Trust ISSF Seedcorn Award
"γδ T-cell-mediated polarisation of CD4+ T-cell responses: implications for Crohn's disease"
Principal Applicant (co-applicants: Prof. Bernhard Moser, Dr. Andrew Stagg, Dr. James Lindsay)
£ 34,000 (6 months)

2016
Cardiff Incoming Visiting Fellowship (to Prof. Thomas Herrmann)
Principal Applicant
£ 5,500 (3 months)

2015-2018
MRC PhD Studentship (to Amy Brook)
"Pathogen-specific microRNA signatures during acute peritoneal infection"
Principal Applicant (co-applicants: Prof. Donald Fraser, Dr. Timothy Bowen)
£ 60,000 (36 months)

2015-2018
MRC PhD Studentship (to Ariadni Kouzeli)
"Use of human gamma/delta T-APCs in anti-tumour immunity"
Co-applicant (Principal applicant: Prof. Bernhard Moser; co-applicant: Prof. Andrew Godkin)
£ 60,000 (36 months)

2015-2018
Tenovus PhD Studentship (to Teja Rust)
"Human gamma/delta T-APCs: Processing of tumour antigens and induction of anti-tumour immunity"
Co-applicant (Principal applicant: Prof. Bernhard Moser; co-applicant: Prof. Awen Gallimore)
£ 89,780 (36 months)

2015-2018
NISCHR, Wales Cancer Research Centre project grant
"Preclinical models for novel immunotherapies"
Principal Applicant (co-applicants: Prof. Awen Gallimore, Prof. Bernhard Moser, Prof. Andrew Godkin, Dr. Ann Ager)
£ 110,000 (36 months)

2015-2016
Kidney Research UK, Project Grant
"Rapid detection of infection and improving survival in dialysis patients: the role of unconventional T-cell driven inflammatory responses"
Principal Applicant (co-applicants: Prof. Nicholas Topley, Prof. Bernhard Moser, Dr. Kieron Donovan, Prof. Donald Fraser)
£ 199,218 (24 months)

2014-2015
MRC-Confidence in Concept Scheme (Biomedical Catalyst)
"Point-of-care diagnosis of acute sepsis"
Principal Applicant (co-applicants: Prof. Nicholas Topley, Prof. Paul Davis, Dr. Peter Morgan, Dr. Tamas Szakmany, Dr. Matt Morgan)
£ 44,935 (12 months)

2014
Severnside Alliance for Translational Research (SARTRE), Health Technology Challenge Project Award
"Point-of-care diagnosis of bloodstream infections"
Principal Applicant (co-applicants: Prof. Nicholas Topley, Prof. Judith Hall, Prof. Paul Davis)
£ 24,912 (6 months)

2014
British Society for Immunology
BSI Travel Awards to Chris Tyler, Hung-Chang Chen, Matt Morgan and Matthias Eberl
gamma/delta T Cell Conference in Chicago, USA, 16-18 May 2014
£ 4,000

2013-2016
EU FP7 Marie Curie Initial Training Network, ITN 287813
"European Training and Research in Peritoneal Dialysis (EuTRiPD)"
PhD Supervisor (in collaboration with academic centres in Amsterdam, Berlin, Cardiff, Heidelberg, Madrid, Poznan, Strasbourg, Vienna; industrial partners: Zytoprotect, Baxter, Abbott; and Dutch Kidney Foundation, Kidney Research UK, EuroPD)
€ 3,140,988 in total; € 517,568 of which to Cardiff University (48 months)

2013-2016
NIHR Invention for Innovation (i4i) Early Stage Product Development Award
"Rapid, non-invasive tests for acute bacterial infections based on pathogen specific immune fingerprints"
Principal Applicant (co-applicants: Prof. Nicholas Topley, Prof. Ian Weeks, Prof. Chris Butler, Dr. Eryl Cox, Prof. Paul Davis)
£ 421,961 (30 months)

2013-2014
NISCHR/Wellcome Trust ISSF Seedcorn/Feasibility Grant
"Defining pathogen-specific responses in acute infection: development of point-of-care tests for bacterial identification"
Principal Applicant (co-applicants: Prof. Nicholas Topley, Dr. Kieron Donovan, Dr. Julian Marchesi, Dr. James Chess)
£ 49,972 (12 months)

2013
NISCHR Academic Health Science Collaboration Equipment Call
Co-applicant (lead applicant: Dr. Kieron Donovan)
£ 5,000

2013
Cancer Research UK, Cardiff CR-UK Centre Development Fund
"Overcoming the resistance of breast cancer stem cells to novel immunotherapies"
Principal Applicant (co-applicants: Dr. Richard Clarkson, Hung-Chang Chen)
£ 4,950 (12 months)

2012-2015
MRC PhD Studentship (to Chris Tyler)
"Control of alpha/beta T cell responses by human gamma/delta T-APCs"
Principal Applicant (co-applicant: Prof. Bernhard Moser)
£ 60,000 (36 months)

2012
British Society for Immunology
BSI Travel Awards to Martin Davey, Joanne Welton and Chan-Yu Lin
gamma/delta T Cell Conference in Freiburg, Germany, 31 May-2 June 2012
£ 2,100

2011-2015
Tenovus PhD Studentship (to Hung-Chang Chen)
"Human gamma/delta T cells for immunotherapy of breast cancer"
Principal Applicant (co-applicant: Dr. Richard Clarkson)
£ 89,993 (45 months)

2010-2013
Welsh Assembly Government, Health Research Award
"Improving patient outcomes from peritoneal dialysis related infections"
Principal co-applicant (Lead applicant: Dr. Gareth Roberts; co-applicants: Prof. Nicholas Topley, Prof. Aled Phillips)
£ 207,325 (45 months)

2010
Wellcome Trust, Biomedical Vacation Scholarship (to Sarah Rollason)
"gamma/delta T cells for cancer immunotherapy"
Principal applicant
£ 1,080 (6 weeks)

2010
Cancer Research UK, Cardiff CR-UK Centre Development Fund
Principal Applicant (co-applicants: Prof. Malcolm Mason, Prof. Peter Barrett-Lee)
£ 4,940 (9 months)

2010
British Society for Immunology
BSI Travel Awards to Raj Bansal, Martin Davey
gamma/delta T Cell Conference in Kiel , Germany, 19-21 May 2010
£ 1,000

2009-2013
Baxter Healthcare, Renal Discoveries Extramural Grant
"T cells, monocytes and neutrophils: detrimental crosstalk in peritoneal dialysis-related infection"
Principal Applicant (co-applicant: Prof. John D. Williams)
US$ 374,947 (48 months)

2009-2012
Cancer Research UK, Project Grant
"The functional plasticity of gamma/delta T cells and their exploitation in cancer therapy"
Principal Applicant (co-applicants: Prof. Malcolm Mason, Prof. Peter Barrett-Lee)
£ 170,067 (42 months)

2009-2010
Breast Cancer Campaign, Small Pilot Grant
"The role of TRAIL in human gamma/delta T cell-mediated cytotoxicity toward breast cancer cells"
Principal Applicant (co-applicant: Dr. Richard Clarkson)
£ 19,944 (12 months)

2008-2010
Welsh Assembly Government, MRC Health Research Partnership Award
"The role of T cells in peritoneal dialysis-related inflammation and infection"
Principal Applicant (co-applicant: Prof. Nicholas Topley)
£ 209,660 (27 months)

2007-2010
MRC Studentship (to Raj Bansal)
"B cell help provided by human gamma/delta T cells"
Principal Applicant (co-applicant: Prof. Bernhard Moser)
£ 55,050 (36 months)

2007-2011
Research Councils UK
RCUK Fellowship in Translational Research in Experimental Medicine
£ 125,000 (60 months)

2007
Wellcome Trust, 'Value in People' Award
"Cells in bridging innate and adaptive immune responses"
Principal Applicant (co-applicant: Prof. Paul Morgan)
£ 34,786 (12 months)

External profiles