Dr Xiao-Qing Wei
Senior Lecturer in Immunology, School of Dentistry
Dr. Xiao-Qing Wei is a Senior Lecturer in Immunology. His research focuses on the study of cytokine function in infection and immunity. He is one of the pioneer researchers in the identification of IL-35 and its application as an immune suppressing molecule in rheumatoid arthritis. His work has significantly contributed to the understanding of the mechanism of autoimmune and inflammatory diseases.
Dr. Xiao-Qing Wei graduated in medicine from the Medical School of Peking University (Beijing Medical University) in Beijing, China, and worked in the Beijing Hepatitis Research Institute of Youan Hospital, where he carried out research on infectious diseases, particularly hepatitis. He joined an immunology group at the University of Glasgow to investigate the role of inducible nitric oxide (iNOS) in infection and immunity and gained a PhD at the University of Glasgow. His post-doctoral research has concentrated on investigating the role of some important cytokines such as IL-15, IL-18, IL-23 and IL-27 in T cell development. The primary aim of his research in infectious and autoimmune diseases is to develop a practical anti-cytokine therapy to treat the inflammatory disorder, such as rheumatoid arthritis (RA). As a Senior Research Fellow, his research was supported by Arthritis Research UK to study the function of IL-18 and its receptors in RA. During that time, Dr Wei applied his research to studying the mechanism of anti-inflammation. Dr Wei is a pioneer researcher in the discovery of IL-35 and demonstrated its immune suppressing role in the treatment of the joint inflammation in mouse collagen induced arthritis model, which closely mimics rheumatoid arthritis in humans. His IL-35 study contributed significantly to the understanding of inflammatory disease mechanisms and may also benefit in future therapies of human autoimmune and inflammatory disorders. He was first appointed as a Lecturer in School of Dentistry, Cardiff University and was recently promoted to Senior Lecturer. Dr Wei's current research now focuses on the study of the role of novel IL-34 and IL-35 cytokines in the regulation of host immunity, particular concerning tissue macrophages andCandida infection, tumour survival, skin vaccine and skin/spinal wound healing. He is also interested in studying the functions of cytokine associations with mineralised tissue destruction related to RA, osteoarthritis and periodontal diseases.
Honours and awards
MB BCh, Medical School of Peking University (Beijing Medical University)PhD, University of Glasgow
Apart from research undertaken at the School of Dentistry, Cardiff University, Dr. Wei also has responsibility for teaching on the oral ecosystem course for year 2 BDS students. He is involved in the examination and assessment of this course. Dr Wei also has an assessment role in Problem Based Learning (PBL). Recently, he has took a model lead role in the mentorship of year 2 students post presentation and assessment. Dr Wei also supervises projects of final year BDS students. ed on )
Cytokines play a pivotal role in controlling the outcome of infectious and inflammatory diseases by regulation of host innate and adaptive immunity. My research has focused on the understanding of the role of some important pro-inflammatory cytokines, such as IL-15, IL-18, IL-12, IL-23, IL-27 and the novel anti-inflammatory cytokines, IL-34 and IL-35, in disease processes in order to find practical ways to regulate host immune responses for treatment. Inflammatory cytokines promote host immunity against pathogen invasion and tumour formation. However, over reaction also results in autoimmune and inflammatory diseases, such as rheumatoid arthritis and periodontal diseases. Host cells produce anti-inflammatory cytokines to avoid this over-reaction. One of these important anti-inflammatory cytokines is IL-35. I am one of the pioneer researchers who discovered IL-35 and identified its anti-inflammatory role using a mouse rheumatoid arthritis model. My research is continuing to understand the role of IL-35 in other human diseases such as candidosis, tumour development and neuronal degeneration. Through understanding the biological mechanisms of IL-35 in human diseases, development of therapies to treat those human diseases may be achieved.
Tissue resident macrophages occupy 5-10% of the cell component of tissues and play important roles in the removal of dead cells and cytokine production during disease processes. Tissue macrophages are highly heterogeneous and exhibit plasticity. Inflammatory tissues with higher pro-inflammatory cytokines will induce macrophages to their M1 phenotype, while in an anti-inflammatory environment with higher levels of growth factors and anti-inflammatory cytokines, conversion to the M2 phenotype is favoured. My research aims to determine how the tissue environment modulates this macrophage phenotype transition and how these macrophages contribute to the outcome of human diseases, including candidosis, tumour development, neuron degeneration and tissue repair.Vaccines are effective tools in preparing the host immune system for protection against pathogen invasion. Cytokines also play a key role during vaccination. T cell development in a certain cytokine environment determines the types of immunity,i.e.cellular or humoral immunity. Many failures of vaccination result from the stimulation of the wrong type immune responses. Cell mediated immunity is absolutely critical for the success of some vaccination. Currently I am working on developing a vaccination process that combines cytokines with physical stimulation, nanoparticle and microneedle delivery system. The novel protocol and device for vaccination should be highly benefitial in promoting human health.
Development of a novel electric-field mediated PLGA micro-needle vaccine patch
Studying the role of novel cytokines, IL-34 and IL-35, in the regulation of host immune response against tumour and yeast infection. Studying the influential role of IL-12 family cytokines in dopaminegic neuronal cell death in Parkinson's disease
Studying the influential role of IL-12 family cytokines in dopaminegic neuronal cell death in Parkinson's disease