Dr Vera Knauper

Director of Postgraduate Research Studies/Programme Director Oral Biology

School of Dentistry

Email:
knauperv@cardiff.ac.uk
Telephone:
+44 29207 42595
Location:
University Dental Hospital, Heath Park, Cardiff, CF14 4XY
Available for postgraduate supervision

Research Theme

Oral and biomedical sciences

Research Group

Matrix Biology and Tissue Repair

Research Interests

Major research interests in my group focus on the understanding of metalloproteinase function in inflammation and cancer. The groups main focus is to understand the role of metalloproteinases in cellular signalling at the molecular level and design novel therapeutic regimens to control inflammation and cancer.

Current PhD projects

  • Novel cancer drug regulates disintegrin and metalloproteinase (ADAM) activity in Head and Neck cancer.
    • Frank Antwi
  • Engineering homing properties of cancer-specific T lymphocytes in adoptive cell therapy.
    • Owen Moon
  • The regulation of protective immunity to viruses by effector T cell trafficking.
    • Abdullah Alanazi
  • Mapping changes to vascular health in late-onset Alzheimers disease.
    • Helen Owens
  • Dissecting the relationship between phosphinositide3-kinase δ activity and L-selectin expression by leucocytes.
    • Sophie Rees

Additional Information

  • Matrix metalloproteinase research group leader

Career Profile

1985 Diploma in Chemistry University of Bielefeld Germany

1989 Dr. Rer. Nat. (PhD in Biochemistry) University of Bielefeld Germany

1993-1995 Wellcome Trust Travelling Fellow Strangeways Research Laboratory Cambridge UK

1995-2000 Post-Doctoral Research Associate with Prof. Gillian Murphy Strangeways Research Laboratory & University of East Anglia Norwich

2001-2006 Lecturer at the University of York (Biology Department)

From 2006 Senior Lecturer at Cardiff University (School of Dentistry)

Memberships / External Activities

BSMB member

ASMB member

2018

2017

2016

2015

2014

2013

2010

2009

2007

2003

2002

2001

Dr Knauper teaches on the second year BDS course. In the Oral ecosystems module she is discussing the regulation of the mechanism of saliva flow. Aspects of how medication taken for other conditions interferes with saliva flow and function and subsequent tooth decay are taught. She also teaches the mechanisms of integument formation, leading to adhesion of oral microorganisms to the enamel surfaces and subsequent biofilm formation.

Dr Knauper is the course director for the MSC in Oral Biology. She teaches aspects of matrix degradation and oral cancer development, as well as, scientific methodology.

Current Research Projects:

  • Novel cancer drug regulates disintegrin and metalloproteinase (ADAM) activity in Head and Neck cancer. Reseach Excellence Studentship. Cardiff University, Lead supervisor, 2018-2021, £ 129,973.
    • Frank Antwi
  • Engineering homing properties of cancer-specific T lymphocytes in adoptive cell therapy. Cardiff University, Co-supervisor, 2017-2020, £73,000
    • Owen Moon
  • The regulation of protective immunity to viruses by effector T cell trafficking. Saudi Arabian Government, Co-supervisor, 2017-2020, £153,000
    • Abdullah Alanazi
  • The regulation of protective immunity to viruses by L-selectin. BBSRC project grant No. 514650, Co-PI Jan 2019 – Dec 2021, £ 548,955

I am interested in supervising research students in the following areas:

  • Tissue repair and regeneration
  • Oral cancer
  • Regulation of signalling by proteolysis
  • Stem cell markers
  • protein engineering

Past projects

Awarded PhD projects:

Melanie Hurtz (2014-2017, PhD awarded 2017) 'ADAM15/PTK6/cMET interplay: promotors of prostate cancer progression'

Andrew Newman (2013-2017, PhD awarded 2017) 'The regulation of L-selectin activity by proteolysis'

Jens Mattern (2012-2016, PhD awarded 2016) 'Characterisation of ADAM15 mediated changes to cellular behaviour in breast cancer cells'

Tim Wanger (2011-14, PhD awarded 2014) 'TROP2, a stem cell marker with oncogenic potential in prostate cancer: Differential cleavage and regulation by PKC isoforms'

Lea Bauer(2010-14, PhD awarded 2014) 'Characterisation of G protein-coupled receptor 56-signalling and its potential role in tumour progression'

Magdalena Adamczyk (2009-13, PhD awarded 2013) 'Biomarkers for arthritis: Regulation of transglutaminase activity by non-conventional export' (2nd prize for poster at BSODR meeting, Bath, 2013; Prize for best presentation 5th UK Purine Club Symposium, Cambridge, 2013; awarded Arthritis Research UK Foundation fellowship, 2014-17)

Katarzyna Gawel-Beben (2009-13, PhD awarded 2013) 'Characterization of TMEFF2: its role in tumour progression and development of targeting strategies for anti-cancer therapy'

Nazim Ali (PhD awarded 2007) 'The role of the novel ADAM17 substrate TMEFF2 in regulating cell proliferation'

Jan Stracke (PhD awarded 2001)

Margaret L. Patterson (PhD awarded 2001) 'The collagenolytic mechanism of the collagenases'