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Ryan Moseley BSc (Hons), PGDip, PhD, PGCert, FHEA

Professor Ryan Moseley

BSc (Hons), PGDip, PhD, PGCert, FHEA

Professor in Tissue Repair

School of Dentistry

Email
MoseleyR@cardiff.ac.uk
Telephone
+44 29225 10649
Campuses
University Dental Hospital, Room 413, 4th Floor, Heath Park, Cardiff, CF14 4XY
Comment
Media commentator
Users
Available for postgraduate supervision

Overview

Research Group

Disease Mechanisms Group

As Leader of the Disease Mechanisms Group, my research specialises in the mechanisms underlying cellular wound healing responses in oral (bone, oral mucosa, dental pulp, gingiva) and dermal (normal skin, chronic skin wounds, fibrotic skin) tissues during health and disease.  By understanding these mechanisms, my Research Group develops novel cellular, biomaterial, pharmaceutical and other strategies to promote normal tissue repair and improved wound management in these patients.  Such research activities include the translational development of a novel class of natural and semi-synthetic compounds, termed epoxy-tiglianes, for the treatment of non-healing chronic skin wounds and dermal scarring/fibrosis, with industrial and academic collaborators based in Australia.

I have successfully managed numerous projects in these research areas, supported by non-commercial and commercial funding sources worldwide (>£3.6M to date).  These include the MRC, BBSRC, NHMRC (Australia), Wellcome Trust, Dunhill Medical Trust, Life Sciences Research Network Wales (Sêr Cymru), NISCHR, Knowledge Economy Skills Scholarships (KESS2) East Wales, Malaysian Government, Iraqi Government; and Kingdom of Saudi Arabia Government, in addition to industrial partners including Convatec Wound Care Ltd., Johnson and Johnson Wound Management Ltd. (now Systagenix Wound Management Ltd.), Peplin Inc. (now owned by LEO Pharma A/S), QBiotics Group, Phillips Research, Cultech Ltd. and Copner Biotech.

My research has culminated in numerous published peer-reviewed papers, filed patents with industrial and academic partners in the dermal wound healing sector; and many local, national and international conference prizes for staff and students under my supervision.

Publication

2023

2022

2021

2020

2019

2018

2017

2016

2014

2013

2011

2010

2009

2008

2004

2003

2002

2000

1998

1997

1996

1995

Articles

Book sections

Research

Recent Research Grant Awards

  • QBiotics Group (2019-21). Elucidation of the downstream signalling mechanisms by which epoxy-tiglianes promote preferential dermal wound healing responses.  £165,925. Principle Investigator.
  • Kingdom of Saudi Arabia Government, PhD Studentship (2019-21). Ophthalmic applications of pomegranate extracts.  £105,970. Co-Investigator.
  • Kingdom of Saudi Arabia Government, PhD Studentship (2019-22). Evaluation of the antibacterial, anti-inflammatory and wound healing properties of frankincense (Boswellia frereana).  £107,850. Co-Investigator.
  • Phillips Research (2020-23). Investigating the effects of blue light on cells of the periodontium.  £112,211. Co-Investigator.
  • Dunhill Medical Trust (2021-24). Development of epoxy-tiglianes as novel small molecule therapeutics for impaired re-epithelialisation associated with non-healing, chronic skin wounds in the aged.  £337,405. Principle Investigator.
  • QBiotics Group (2021-23). Elucidation of the mechanisms by which epoxy-tiglianes promote preferential wound healing responses in dermal fibroblasts.  £272,205. Principle Investigator.
  • Knowledge Economy Skills Scholarships (KESS2) East Wales and Cultech Ltd. (2022-23). The impact of probiotic bacteria on intestinal barrier function.  £22,202. Principle Investigator.
  • QBiotics Group (2023-24).  Epoxy-tigliane analogue promotion of preferential wound healing and aesthetic responses in dermal fibroblasts.  £78,932.  Principle Investigator.
  • MRC Harmonised Impact Acceleration Account (HIAA) Award (2023-24).  Small extracellular vesicle scale-up utilising custom designed 3D scaffolds.  £47,000.  Co-Investigator.
  • BBSRC International Partnership Funding, Strengthen Existing Partnership Award (2024).  Unravelling the roles of protein kinase C (PKC) isoforms and downstream kinase signalling activities in the formation and functions of scar forming, skin myofibroblasts.  £28,172.  Principle Investigator.

Filed Patents

  • Convatec Wound Care Ltd., UK.  EP1245239A1 and US2003040690A1, relating to the antioxidant properties of wound dressing-based, biomaterials.
  • Johnson and Johnson Wound Management Ltd., UK (Systagenix Wound Management Ltd., UK).  EP1889069A1, EP1889069B1, GB2426335A, US8491852B2, US2009299161A1 and WO2006123091A1, relating to the use of total antioxidant capacity as a prognostic/diagnostic biomarker of chronic wound infection and healing.
  • Johnson and Johnson Wound Management Ltd., UK (Systagenix Wound Management Ltd., UK).  GB2447865A, US2010166694, US2012010099A1, US8012698B2 and WO2008119974A1, relating to the quantification of various cytokines and growth factors as prognostic/diagnostic biomarkers of diabetic foot ulcer wound infection and healing.
  • Peplin Inc., Australia (LEO Pharma A/S, Denmark).  AU20050906601, AU2006317523A1, AU20100213362A1, AU20100213362B2, BRPI0618926A2, CA2629899A1, CA2752389A1, CA2752389C, CN101360506A, CN102316866A, DK2395993T3, EP1965818A1, EP1965818A4, EP2395993A1, EP2395993A4, EP2395993B1, ES2633755T3, IL214133A, JP2009517345A, JP2012517450A, JP5638008B2, KR20080077625A, NZ568168A, NZ594184A, PL2395993T3, PT2395993T, RU2011137530A, RU2491050C2, US10143638B2, US2009215884A1, US2012041064A1, US2016317486A1, WO2007059584A1; and WO2010091472A1, relating to the application of ingenol mebutate and related compounds in the promotion of dermal wound healing and reduced scarring.
  • QBiotics Group, Australia.  AU2014253608A1, AU2014253608B2, BR112015026388A2,  BR112015026388A8, CA2909653A1, CA2909653C, CN105308052A, CN105308052B, CY1121515T1, DK2986615T3, EA032501B1, EA032501B9, EA201591996A1, EP2986615A1, EP2986615A4, EP2986615B1, ES2715105T3, HK1214256A1, HRP20190435T1, HUE043272T2, IL242137A, JP2016522801A, JP6415538B2, KR102147796B1, KR20160023651A, LT2986615T, MX2015014607A, MX365255B, NZ713954A, PH12015502405A1,  PH12015502405B1, PL2986615T3, PT2986615T, RS58532B1, SG11201508588XA, SI2986615T1, TR201903565T4, UA118670C2, US10183921B2, US10183922B2, US10822317B2, US2016068499A1, US2017144981A1, US2019161462A1, WO2014169356A1; and ZA201508186B, relating to the application of epoxy-tigliane compounds, such as EBC-46, in the promotion of dermal wound healing and reduced scarring.
  • University of the Sunshine Coast, Australia.  WO2023004473A1, relating to the application of tomentosenol A derived from the cerumen of Australian native stingless bee (Tetragonula carbonaria), in the promotion of dermal wound healing and reduced scarring.

Current External Collaborators

  • Professor Glen Boyle. QIMR Berghofer Medical Research Institute, Australia.
  • Professor Matthias Born, Dr Monique Stoffels.  Phillips Research, The Netherlands.
  • Dr Paul Reddell, Dr Jason Cullen, Dr Simone Gaeta.  QBiotics Group, Australia.
  • Dr Fraser Russell.  University of the Sunshine Coast, Australia.
  • Dr Adam Midgley, Nankai University, China.
  • Dr Ahmed Al-Qarakhli, University of Anbar, Iraq.
  • Dr Tom Prescott.  Royal Botanical Gardens Kew, UK.
  • Dr Daryn Michael, Dr Susan Plummer.  Cultech Ltd., UK.
  • Mr Jordan Copner.  Copner Biotech Ltd., UK.

Current Cardiff University Collaborators

  • School of Dentistry:  Professor Rachel Waddington, Professor Phil Stephens, Professor Daniel Aeschlimann, Dr Vera Knäuper, Dr Sharon Dewitt.
  • School of Pharmacy and Pharmaceutical Sciences:  Dr Ahmed Ali, Dr Christopher Thomas.

Current Postgraduate Students

Lead Supervisor

  • Ahmed Asiri (PhD student, Thesis writing).  Ophthalmic applications of pomegranate extracts (in collaboration with the School of Pharmacy and Pharmaceutical Sciences, Cardiff University).
  • Abdulaziz Alqarni (PhD student, Thesis writing).  Evaluation of the antibacterial, anti-inflammatory and wound healing properties of frankincense (Boswellia frereana) (in collaboration with the School of Pharmacy and Pharmaceutical Sciences, Cardiff University).

Current Postdoctoral Research Staff

Principle Investigator

  • Dr Jordanna Dally.  Development of epoxy-tiglianes as novel small molecule therapeutics for impaired re-epithelialisation associated with non-healing, chronic skin wounds in the aged.
  • Dr Emma Woods.  Unravelling the roles of protein kinase C (PKC) isoforms and downstream kinase signalling activities in the formation and functions of scar forming, skin myofibroblasts.

Co-Investigator

  • Dr Frank Antwi.  Small extracellular vesicle scale-up utilising custom designed 3D scaffolds.

Teaching

Current Undergraduate Teaching

BDS Dental Undergraduates

  • Leader of the Year 1 BDS and Year 2 BDS Oral Ecosystems and Foundation Basic Sciences Modules (since 2023).
  • Lecture to Year 1 BDS students as part of the ‘Oral Ecosystems’ Module, on (i) dentine-pulp complex, and (ii) prenatal jaw development.
  • Lecture and provide revision tutorials to Year 2 BDS students as part of the ‘Oral Ecosystems’ Module, including (i) dentine matrix proteins, (ii) alveolar bone, (iii) pulpal reactions to restorative materials, and (iv) plaque pH and salivary flow.
  • Provide practical sessions to Year 1 BDS on (i) dentine-pulp complex.
  • Provide practical sessions to Year 2 BDS on (i) salivary glands and (ii) salivary flow.
  • Organize all Year 2 BDS revision tutorial sessions.
  • Organize all Year 2 BDS Teaching-Based Learning (TBL) Exercises.
  • Setting/marking of in-course assessments and examination papers for Year 2 BDS.
  • Supervision of Year 4-5 BDS research projects.

BSc Dental Therapy and Hygiene Undergraduates

  • Lecture to Year 1 BSc students as part of the ‘Biomedical Sciences’ Module, including (i) tissues and organs; and (ii) dental-pulp complex and dentine sensitivity.

 

Current Postgraduate Teaching

MSc in Tissue Engineering

  • Provide lectures on (i) impaired dermal wound healing, (ii) modelling of cell-extracellular matrix interactions in vitro; and (iii) large-scale tissue/organ engineering in vitro, for the ‘Tissue Engineering: Concept-Clinical Practice’ Module.
  • Provide lectures on (i) skin in health, for the ‘Cellular and Molecular Biology’ Module.
  • Setting/marking of in-course assessments and examination papers.
  • Supervision of laboratory-based, MSc research projects.

MSc in Implantology

  • Provide lectures and revision tutorials on (i) the principles of osseointegration; (ii) cytokines and growth factors in bone repair; and (iii) extracellualr matrix turnover and bone repair; for the ‘Implantology’ and ‘Cellular and Molecular Biology’ Modules.
  • Setting/marking of in-course assessments and examination papers.

MSc in Clinical Dentistry

  • Provide lectures on (i) cytokines and growth factors in bone repair; and (ii) extracellular matrix turnover and bone repair; as part of the Year 1 ‘Bone Biology’ Symposium.

MSc in Orthodontics

  • Provide lectures on (i) cytokines and growth factors in bone repair, as part of the Year 1 ‘Bone Biology’ Symposium.

MSc in Oral Biology

  • Provide lectures on (i) histology of healthy tissues, for the 'Cell Biology of Oral Tissues' Module.
  • Provide lectures on (i) cytokines and growth factors in bone repair; and (ii) fibroblast heterogeneity and wound healing, for the 'Tissue Repair, Regeneration and Scientific Methods’ Module.
  • Setting/marking of in-course assessments and examination papers.
  • Supervision of laboratory-based, MSc research projects.

Biography

I graduated with a 2.1 BSc (Honours) degree in Biochemistry from Swansea University in 1991, before commencing an MRC-funded, PhD at the School of Dentistry, University of Wales College of Medicine (UWCM) in 1992.  I completed my PhD in 1996, before embarking on Postdoctoral Researcher positions at UWCM/Cardiff University, funded by the British Heart Foundation (1996-98), Wellcome Trust (1998-00) and Johnson & Johnson Wound Management Ltd. (2002-08); in addition to being appointed as a Locum Lecturer in Oral Biochemistry within the School of Dentistry (2000-02).  In 2008, I was appointed Lecturer in Tissue Repair within the School of Dentistry, being promoted to Senior Lecturer in 2012, Reader in 2017, and Professor in 2022.

Qualifications

  • 2010: Postgraduate Certificate in University Teaching and Learning (PCUTL).  Cardiff University, UK.
  • 1996: PhD (Oral Biochemistry), Thesis entitled ‘Structural Changes in Periodontal Proteoglycans by Reactive Oxygen Species’.  School of Dentistry, University of Wales College of Medicine, UK.
  • 1993: Diploma in Biomedical Methods, University of Wales College of Medicine, UK.
  • 1991: BSc (Honours) Degree in Biochemistry,  Swansea University, UK.

Honours and awards

  • 2022: Septodont poster prize.  Pan European (PER)/International Association for Dental Research (IADR) Meeting, Marseille, France (PhD student, Edward Gait-Carr).
  • 2021: Oral presentation prize, Cardiff University School of Dentistry Research Day.  Cardiff, UK (PhD student, Edward Gait-Carr).
  • 2020: Poster prize, Cardiff University Postgraduate Research Day.  Cardiff, UK (PhD student, Vildan Celiksoy).
  • 2019: Poster prize, Cardiff University School of Dentistry Research Day.  Cardiff, UK (Postdoctoral Research Associate, Dr Jordanna Dally).
  • 2018: Poster prize, Cardiff University Postgraduate Research Day.  Cardiff, UK (PhD student, Nadia Alaidaroos).
  • 2017: Poster prize, European Tissue Repair Society (ETRS) Meeting.  Brussels, Belgium (PhD student, Glyn Morris).
  • 2017: Oral presentation prize, Cardiff Institute of Tissue Engineering & Repair (CITER) Meeting.  Cardiff, UK (PhD student, Glyn Morris).
  • 2015: Oral presentation prize, Sêr Cymru (Life Sciences Research Network Wales) Meeting.  Cardiff, UK (PhD student, Jordanna Dally).
  • 2015: Poster prize, Cardiff University Postgraduate Research Day.  Cardiff, UK (PhD student, Jordanna Dally).
  • 2014: Poster prize, European Tissue Repair Society (ETRS) Meeting.  Edinburgh, UK (PhD student, Rachael Moses).
  • 2013: Poster prize, Cardiff University Postgraduate Research Day.  Cardiff, UK (PhD student, Rachael Moses).
  • 2012: British Society for Oral and Dental Research (BSODR) Unilever poster prize, Pan European (PER)/International Association for Dental Research (IADR) Meeting.  Helsinki, Finland (PhD student, Amr Alraies).
  • 2012: Poster prize, Cardiff University Stem Cell Research Day.  Cardiff, UK (PhD student, Amr Alraies).
  • 2010: Jackson Prize for Burns and Plastic Surgery Research, Society for Academic and Research Surgery Conference.  London, UK (PhD student, Joseph Hardwicke).
  • 2008: Poster prize, Cardiff University Metabolism, Regeneration and Repair Group Meeting.  Cardiff, UK (PhD student, Joseph Hardwicke).
  • 2007: Oral presentation prize, Cardiff Institute of Tissue Engineering & Repair (CITER) Meeting.  Abergavenny, UK (PhD student, Joseph Hardwicke).
  • 2007: Oral presentation prize, Cardiff University Metabolism, Regeneration and Repair Group Meeting.  Cardiff, UK (PhD student, Joseph Hardwicke).
  • 2007: Poster prize, International Symposium on Polymer Therapeutics Meeting.  Berlin, Germany (PhD student, Joseph Hardwicke).
  • 2006: Oral presentation prize, Cardiff University Postgraduate Research Day.  Cardiff, UK (PhD student, Joseph Hardwicke).
  • 2006: Poster prize, Cardiff Institute of Tissue Engineering & Repair (CITER) Meeting.  Cardiff, UK (PhD student, Joseph Hardwicke).
  • 2003: Oral presentation prize, European Tissue Repair Society (ETRS) Meeting.  Cardiff, UK (MD student, Joanna Hilton).
  • 1998-00: Honorary Research Fellow.  School of Dentistry, University of Birmingham.  Birmingham, UK.

Professional memberships

  • Member of the Association of Science Educators in Dentistry (ASEiD).
  • Member of the British Society for Oral and Dental Research (BSODR).
  • Member of the European Tissue Repair Society (ETRS).
  • Fellow of the Higher Education Academy (HEA).
  • Member of the International Association for Dental Research (IADR).
  • Member of STEM Learning.

Academic positions

  • 2017-22: Reader in Tissue Repair.  Regenerative Biology Group, School of Dentistry, Cardiff University, UK.
  • 2012-17: Senior Lecturer in Tissue Repair. Stem Cells, Wound Repair and Regeneration, School of Dentistry, Cardiff University, UK.
  • 2008-12: Lecturer in Tissue Repair. Wound Biology Group, Tissue Engineering and Reparative Dentistry, School of Dentistry, Cardiff University, UK.
  • 2002-08: Senior Postdoctoral Research Officer. Wound Biology Group, Tissue Engineering and Reparative Dentistry, School of Dentistry, Cardiff University, UK.
  • 2000-02: Locum Lecturer in Oral Biochemistry. Matrix Biology and Tissue Repair Research Unit, Department of Dental Health and Biological Sciences, School of Dentistry, University of Wales College of Medicine, UK.
  • 1998-00: Postdoctoral Research Fellow, funded by The Wellcome Trust. Department of Basic Dental Science, School of Dentistry, University of Wales College of Medicine, UK.
  • 1996-98: Postdoctoral Research Fellow, funded by The British Heart Foundation. Department of Cardiology and the Institute of Nephrology, University of Wales College of Medicine, UK.

Speaking engagements

  • 2023:  School of Dentistry, Cardiff University, UK.  Inaugural Professorial Lecture, An academic journey within the Glamorgan trapezoid.
  • 2021:  School of Dentistry, University of Leeds, UK.  Overview of dental pulp stem cell and small molcule therapeutics development for regenerative medicine-based applications.
  • 2021:  School of Dentistry, Cardiff University, UK.  Annual Research Day, Development of novel epoxy-tigliane small molecule therapeutics for impaired wound re-epithelialisation and scarring in skin.
  • 2018:  Cardiff Institute for Tissue Engineering and Repair (CITER)/Life Sciences Research Network Wales (LSRNW) Workshop on Natural Compound Development for Enhanced Tssue Repair and Regeneration, Cardiff, UK.  Repurposing ingenol mebutate as a novel pharmaceutical therapy for normal and pathological dermal fibrosis.
  • 2018:  5th International Conference on Advances in Skin, Wound Care and Tissue Science and the 14th International Conference on Clinical Dermatology, Rome, Italy.  Development of epoxy-tigliane pharmaceuticals as novel therapeutics for dermal scarring.
  • 2018:  International Conference on Wound Care, Tissue Repair and Regenerative Medicine, London, UK.  Repurposing ingenol mebutate as a novel pharmaceutical therapy for normal and pathological dermal fibrosis.
  • 2018:  International Translational and Regenerative Medicine Conference, Rome, Italy.  Development of epoxy-tigliane pharmaceuticals as novel therapeutics for imapired wound re-eppithelialisation in skin.
  • 2017:  2nd International Conference on Advances in Skin, Wound Care and Tissue Science, Frankfurt, Germany.  Repurposing ingenol mebutate as a novel pharmaceutical therapy for normal and pathological dermal fibrosis.
  • 2014:  LEO Pharma A/S, Denmark.  (i) Ingenol mebutate, wound healing and dermal cosmesis.  (ii) The effects of ingenol mebutate on the tumour microenvironment.
  • 2011:  LEO Pharma A/S, Denmark.  Overview of dermal wound healing, cosmesis and 3-ingenyl angelate (PEP005).
  • 2005:  Wound Healing Research Unit, Cardiff University, UK.  Prognostic/diagnostic biomarkers of chronic wound infection.
  • 2002:  Johnson & Johnson Wound Management Ltd., UK.  Extracellular matrix metabolites as prognostic/diagnostic biomarkers of chronic wound infection.
  • 2000:  School of Dentistry, University of Birmingham, UK.  The influence of fluoride on the dentine-pulp complex in vitro.
  • 1997:  Bristol Heart Institute, Bristol Royal Infirmary, UK.  The role of matrix metalloproteinases in the extracellular matrix turnover associated with atherosclerosis.
  • 1995:  Oral Health Division, SmithKiline Beecham Ltd., UK.  Reactive oxygen species and their potential role in periodontal disease.

Committees and reviewing

Editorial Boards

  • Biomolecules.
  • Current Research in Regenerative Medicine.
  • Dermato.
  • Journal of Oral Biology.
  • Review Editor, Regenerative Dentistry Editorial Board, Frontiers in Dental Medicine.
  • Review Editor, Craniofacial Biology and Dental Research Editorial Board, Frontiers in Physiology.

Lead Guest Editorships for Journal Special Issues

Grant and Manuscript Reviewer

  • Grant reviewer for funders, including BBSRC, EPSRC, MRC, National Institute for Health Research (NIHR), Marie Skłodowska-Curie COFUND Fellowship Programme, AO Foundation, Austrian Research Promotion Agency (FFG), Dunhill Medical Trust, Qatar National Research Fund, Kidney Research UK, and the International Rett Syndrome Foundation.
  • Manuscript reviewer for >100 different journals, including Biomaterials, Journal of Investigative Dermatology, Journal of Dental Research, Stem Cell Research and Therapy, ACS Applied Materials & Interfaces, Scientific Reports, Free Radicals in Biology and Medicine, Biochemical Pharmacology, Journal of Controlled Release, Acta Biomaterialia, Biomolecules, Antioxidants, and Pharmaceutics.

Conference Prize Reviewer

  • 2023: Young Investigators' Oral Presentation Reviewer.  European Tissue Repair Society (ETRS) Conference (Coimbra, Portugal).
  • 2023: Senior Colgate Prize Reviewer.  British Society for Oral and Dental Research (BSODR) Meeting (London, UK).
  • 2022: Young Investigators’ Oral Presentation Reviewer.  European Tissue Repair Society (ETRS) Conference (Lyon, France).
  • 2022: Senior Colgate Prize Reviewer.  Pan European (PER)/International Association for Dental Research (IADR) Meeting (Marseille, France).
  • 2021: Senior Colgate Prize Reviewer.  British Society for Oral and Dental Research (BSODR) Meeting (Birmingham, UK).
  • 2020: Senior Colgate Prize Reviewer.  British Society for Oral and Dental Research (BSODR) Meeting (Virtual).
  • 2019: Senior Colgate Prize Reviewer.  British Society for Oral and Dental Research (BSODR) Meeting (Leeds, UK).
  • 2018: Mineralised Tissue (MINTIG) Prize Reviewer.  Pan European (PER)/International Association for Dental Research (IADR) Meeting (London, UK).
  • 2018: Senior Colgate Prize Reviewer.  Pan European (PER)/International Association for Dental Research (IADR) Meeting (London, UK).
  • 2016: Senior Colgate Prize Reviewer.  Pan European (PER) Dental Research Meeting (Jerusalem, Israel).
  • 2015: Mineralised Tissue (MINTIG) Prize Reviewer.  British Society for Oral and Dental Research (BSODR) Meeting (Cardiff, UK).
  • 2014: Young Investigators’ Oral Presentation Reviewer.  European Tissue Repair Society (ETRS) Conference (Edinburgh, UK).
  • 2013: Mineralised Tissue (MINTIG) Prize Reviewer.  British Society for Oral and Dental Research (BSODR) Meeting (Bath, UK).
  • 2012:  Mineralised Tissue (MINTIG) Prize Reviewer.  Pan European (PER)/International Association for Dental Research (IADR) Meeting (Helsinki, Finland).
  • 2011: Senior Colgate Prize Reviewer.  British Society for Oral and Dental Research (BSODR) Meeting (Sheffield, UK).
  • 2010: Mineralised Tissue (MINTIG) Prize Reviewer.  Pan European (PER)/International Association for Dental Research (IADR) Meeting (Barcelona, Spain).
  • 2009: Mineralised Tissue (MINTIG) Prize Reviewer.  British Society for Dental Research (BSDR) Meeting (Glasgow, UK).
  • 2008: Senior Colgate Prize Reviewer.  Pan European (PER) Dental Research Meeting (London, UK).
  • 2007: Mineralised Tissue (MINTIG) Prize Reviewer.  British Society for Dental Research (BSDR) Meeting (Durham, UK).

External Thesis Examiner

  • 2024: MRes Examiner.  Swansea University, UK.
  • 2023: PhD Examiner.  University of Leeds, UK.
  • 2021: PhD Examiner.  King's College London, UK.
  • 2019: PhD Examiner.  King's College London, UK.
  • 2018: PhD Examiner.  Queen Mary University of London, UK.
  • 2018: MRes Examiner.  Swansea University, UK.
  • 2015: PhD Examiner.  Swansea University, UK.
  • 2012: PhD Examiner.  University of Birmingham, UK.
  • 2009: MRes Examiner.  Swansea University, UK.

Internal Thesis Examiner

  • 2023: PhD Examiner.   School of Dentistry.
  • 2023: PhD Examiner.   School of Pharmacy and Pharmaceutical Sciences.
  • 2021: PhD Examiner.   School of Dentistry.
  • 2020: PhD Examiner.   School of Dentistry.
  • 2017: PhD Examiner.   School of Medicine.
  • 2016: PhD Examiner.   School of Dentistry.
  • 2016: PhD Examiner.   School of Medicine.
  • 2014: PhD Examiner.   School of Dentistry.
  • 2014: PhD Examiner.   School of Medicine.
  • 2012: PhD Examiner.   School of Medicine.
  • 2012: MD Examiner.     School of Medicine.
  • 2012: MScD Examiner. School of Dentistry.

Invited Workshop/Conference Organising Committees

  • 2023-present.  Leader of the Organising Committee for the European Tissue Repair Society (ETRS) Annual Conference.  Cardiff, UK (09/2025).
  • 2023-present.  Joint European Tissue Repair Society (ETRS)/Wound Healing Socety (WHS) Conference, 'Research, Repair, Regenerate'.  Amersfoort, The Netherlands (09/2024).
  • 2023: Lead Organiser of the Joint Regenerative Dentistry and Mineralised Tissue Research Group Symposium on 'Novel Strategies for the Enhancement of Bone Regeneration in Healthy and Compromised Patients'.  British Society for Oral and Dental Research (BSODR) Annual Meeting.  London, UK (09/2023).
  • 2017-18:  Leader of the Organising Committee for the Cardiff Institute for Tissue Engineering and Repair (CITER), Life Science Research Network Wales (LSRNW) and MediWales Workshop on 'Natural Compound Research for Tissue Repair and Regeneration in Wales’.  Cardiff, UK (11/2018).
  • 2017-18:  5th International Conference on Advances in Skin, Wound Care and Tissue Science and the 14th International Conference on Clinical Dermatology.  Rome, Italy (10/2018).
  • 2017-18:  International Conference on Wound Care, Tissue Repair and Regenerative Medicine:  Fostering Advances in Wound Healing and Tissue Regeneration Techniques.  London, UK (06/2018).
  • 2016-17:  Cardiff Institute for Tissue Engineering and Repair (CITER) Workshop on ‘Ageing’.  Cardiff, UK (03/2017).

Other External Committees and Responsibilities

  • 2023-present: External Examiner for the BSc Programme in Bio-Dental Science and Technology.  School of Clinical Dentistry, University of Sheffield, UK.
  • 2023: External Advisor for the MRes Programme in Regenerative Medicine.  Faculty of Medicine and Dentistry, Queen Mary University of London, UK.
  • 2021-present: Elected Board Member.  European Tissue Repair Society (ETRS).
  • 2021-23: Chair of the Regenerative Dentistry Research Group.  British Society for Oral and Dental Research (BSODR), UK.

University Committees and Responsibilities

  • 2023-present:  Member of the Outreach and Student Mobility Working Group.  School of Dentistry, Cardiff University, UK.
  • 2023-present.  Member of the Professoriate Forum.  School of Dentistry, Cardiff University, UK.
  • 2023-present.  Leader of the Year 1 BDS and Year 2 BDS Oral Ecosystems and Foundation Basic Sciences Modules, and Teaching-Based Learning (TBL) Session Lead for the Year 2 Oral Ecosystems Module.  School of Dentistry, Cardiff University, UK.
  • 2022-present:  Leader of the Disease Mechanisms Group, School of Dentistry, Cardiff University, UK.
  • 2021-present:  Lead Tutor for Postgraduate Taught (Non-Clinical) Student and Postgraduate Research Student Programmes. School of Dentistry, Cardiff University, UK.
  • 2021-present:  Member of the School Board.  School of Dentistry, Cardiff University, UK.
  • 2021-present: Member of the Cardiff University Biobank Review Committee.  Cardiff University, UK.
  • 2019-21: Member of the Cardiff Institute for Tissue Engineering and Repair (CITER) Executive Board.  Cardiff University, UK.
  • 2018-19: Deputy Chair of the Cardiff Institute for Tissue Engineering and Repair (CITER) Research Committee.  Cardiff University, UK.
  • 2016-present: Member of the Admissions and Monitoring Committee for Postgraduate Research Programmes.  School of Dentistry, Cardiff University, UK.
  • 2016-19: Member of the Cardiff Institute for Tissue Engineering and Repair (CITER) Research Committee.  Cardiff University, UK.
  • 2015-present: International Student Mobility Coordinator.  School of Dentistry, Cardiff University, UK.
  • 2015-present:  Member of the Student International Mobility Group and College Student International Committee.  College of Life and Biomedical Sciences, Cardiff University, UK.
  • 2015-17: Member of the Web Editorial Board.  School of Dentistry, Cardiff UniversIty, UK.
  • 2014-17: Member of the Research Ethics Committee.  School of Dentistry, Cardiff University, UK.
  • 2014-15: Member of the Programme Advisory Panel for the MRes Programme in 'Medical Research and Innovation'.  School of Medicine, Cardiff University, UK.
  • 2010-present: Member of the Staff-Student Panel for Undergraduate Programmes.  School of Dentistry, Cardiff University, UK.
  • 2009-18: Member of the Admissions and Monitoring Committee for Taught Programmes.  School of Dentistry, Cardiff University, UK.
  • 2008-18: Director for the Cardiff Institute for Tissue Engineering and Repair (CITER) MSc Programme in Tissue Engineering.  Cardiff University, UK.
  • 2008-16: Member of the Cardiff Institute for Tissue Engineering and Repair (CITER) Learning, Teaching and Engagement Committee.  Cardiff University, UK.
  • 2008-13: Member of the Postgraduate Board of Studies Committee.  School of Dentistry, Cardiff University, UK.
  • 2008-11: Member of the Staff-Student Panel Committee for Taught Programmes.  School of Dentistry, Cardiff University, UK.
  • 2008-09: Member of the Postgraduate Suite Task Group Committee.  School of Dentistry, Cardiff University, UK.
  • 2007-08: Deputy Radiation Protection Supervisor.  School of Dentistry, Cardiff University, UK.
  • 2004-18: Member of the Cardiff Institute for Tissue Engineering and Repair (CITER) MSc Programme in Tissue Engineering Board of Studies Committee.  Cardiff University, UK.
  • 2001-04: Member of the Year 4 BDS Dental Undergraduate Elective Committee.  School of Dentistry, Cardiff University, UK.
  • 1993-95: Secretary of the Postgraduate Society.  University of Wales College of Medicine, Cardiff, UK.

Supervisions

I am currently interested in supervising PhD students in the following areas:

  • Mechanisms underlying oral mucosal and dermal wound healing responses.
  • Drug development for enhanced wound healing outcomes in skin.
  • Dental pulp stem cell (DPSC) heterogeneity.
  • Oxidative stress and impaired diabetic bone healing.

Past projects

Completed PhD Students

  • 2023:  Edward Gait-Carr.  Investigating the effects of blue light on cells of the periodontium.  Co-Supervisor.
  • 2021:  Frank Antwi.  Novel role of PKC isoforms in the regulation of disintegrin and metalloproteinase (ADAM) activity - Impact on tyrosine kinase signalling in head and neck cancer.  Co-Supervisor.
  • 2020:  Vildan Celiksoy.  Pomegranate rind extract with Zn (II) combination as a new therapeutic agent for oral care products.  Co-Supervisor.
  • 2018:  Nadia Alaidaroos.  Role of oxidative stress responses in clonal variations in dental pulp progenitor cell ageing and regenerative potential.  Lead Supervisor.
  • 2017:  Jordanna Dally.  Pharmaceutical evaluation of novel tigliane compounds as modulators of dermal fibroblast-myofibroblast differentiation, scar tissue resolution and fibrosis; and elucidation of their underlying mechanisms of action.  Lead Supervisor.
  • 2017:  Glyn Morris.  Role of microRNA-7 in the age-related impairement of TGF-B1-driven differentiation in chronic wound fibroblasts.  Co-Supervisor.
  • 2017:  Ahmed Al-Qarakhli.  Altered bone cell biology associated with type 2 diabetes mellitus -  Consequences for periodontal disease.  Co-Supervisor.
  • 2015:  Rachael Moses.  Evaluation of the stimualtory effects of EBC-46 on dermal fibroblast and keratinocyte wound helaing responses in vitro.  Lead Supervisor.
  • 2014:  Karina Hamilton.  Evaluation of the wound-healing poperties of cerumen from the Ausralian native stingless bee (Tetragonula carbonaria) for the treatment of chronic wounds, and the effects of bee foraging behaviours on cerumen bioactivity.  Co-Supervisor.
  • 2014:  Norhayati Yusop.  Growth factor responsiveness of mesenchymal progenitor cells during bone repair associated with type 2 diabetes.  Co-Supervisor.
  • 2012:  Amr Alraies.  Exploiting dental pulp stem cells for dental tissue regeneration.  Co-Supervisor.
  • 2009:  Nicole Kane-Maguire.  An in vitro study on the potential effects of PEP005 on the wound healing responses of fibroblasts and keratinocytes.  Lead Supervisor.
  • 2009:  Joseph Hardwicke.  Polymer therapeutics to modify cellular responses in impaired human wound healing.  Co-Supervisor.
  • 2008:  Rachael McInnes.  Prognostic and diagnostic markers of chronic wound infection.  Lead Supervisor.

 

Completed MPhil, MD and MScD Students

  • 2023:  Pascale Aeschlimann (MPhil student).  The impact of probiotic bacteria on intestinal barrier function.  Lead Supervisor.
  • 2009:  Arshhad Kazi (MScD student).  Influence of the hydrogen peroxide pre-treatment of titanum surfaces on the induction of osteoblast differentiation in vitro.  Lead Supervisor.
  • 2007:  Parkash Lohana (MPhil student).  Oxidative stress mediation of cellular ageing in patient-matched, oral mucosal and skin fibroblasts.  Lead Supervisor.
  • 2006:  Mariam Nagassa (MScD student).  Influence of hydrogen peroxide pre-treatment on protein interaction and the topography of titanium implant surfaces.  Lead Supervisor.
  • 2006:  Abdulaziz Daw (MPhil student).  An investigation of the potential enhancement of osseointegration on titanium implant surfaces, via the pre-application of hydrogen peroxide.  Lead Supervisor.
  • 2005:  Albert Suryprawira (MScD student).  Immunohistochemical comparison of oxidative stress biomarker and antioxidant enzyme profiles between oral mucosal and dermal tissues.  Lead Supervisor.
  • 2003: Joanna Hilton (MD student).  A study of cellular and molecular ageing in the tissues of patients with chronic venous leg ulceration.  Co-Supervisor.

Research themes

Specialisms

  • Wound healing
  • Scarring
  • Regenerative medicine
  • Drug development
  • Mesenchymal stem cells

External profiles