Professor Alastair J Sloan
BSc (Hons), PhD, FHEA
Vice-Dean of Research and International, Professor in Bone Biology & Tissue Engineering, School of Dentistry
Alastair Sloan is Professor of Bone Biology and Tissue Engineering in the School of Dentistry and in the Cardiff Institute for Tissue Engineering and Repair (CITER) at Cardiff University. He is currently the Director of Research and International in the School of Dentistry where he co-leads the MIneralised Tissue Research Group.
He obtained his BSc in Biomedical Sciences from the University of Wales in 1993 and his PhD from The University of Birmingham, UK in 1997, where he undertook his PhD in Oral Cell Biology in the Faculty of Medicine and Dentistry. Following postdoctoral research he was appointed to a Lectureship in Oral Biology at the School of Dentistry in 2000. In 2005, he moved to the School of Dentistry and was awarded his personal chair in 2012.
Professor Sloan's research is focussed on the repair and regeneration of mineralised tissues and the behaviour and therapeutic use of dental pulp stem cells. He is interested in the cellular and molecular responses of these cells to natural biomatrices and compromised biological environments to understand their functional behaviour during tissue injury and developing methods to mediate natural repair processes in bone trauma. Complimentary to this work, he is also interested in understanding the heterogeneity within dental pulp progenitor populations and their function in 3D environments. His research is also focussed on understanding bacterial invasion and attachment in dental and bone infections and development of novel delivery mechanisms for antimicrobial agents to control infection within these tissues. In support of these studies, he has significant interest in the development of 3D organotypic culture models to provide high throughput model systems with high reproducibiilty and address the 3Rs in this field of bioengineering.
Professor Sloan is the recipient of several awards and honours. In 1998 he was awarded the IADR, British Division's Mineralised Tissue Research Prize and several of his students have won national research prizes including the IADR British Division Mineralised Tissue Prize in 2008, 2013, 2014, the British Division Unilever Poster Prize in 2012 and the TCES Poster Prize in 2014. Professor Sloan was the President of the Pulp Biology and Regeneration Group of the IADR in 2010-2011. In 2011 he was awarded the IADR Distinguished Scientist Award, the Young Investigators Award, in recognition of his research to date. He holds a Visiting Chair at the Fourth Military Medical University in Xi'an, China since 2013, Dalian Medical University since 2015 and China Medical University since 2016.
From 2015-2017 Professor Sloan was Chair of the Cardiff Insitute for Tissue Engineering and Repair (CITER). He currently sits on the Management Committee of the British Society for Oral and Dental Research (BSODR), the Executive Committee of the Tissue and Cell Engineering Society (UK) and the Grant Assessment Panel of the NC3Rs. He acts a reviewer for all RCUK funding bodies and the EU. He has attracted research funding from the NC3Rs, Health and Care Research Wales, MRC, EPSRC, Dr Hadwen Trust and Dunhill Medical Research Trust along with those from the industrial sector (Philips, Renishaw plc). In addition to this he is currently Chair / Director of Cardiff Institute for Tissue Engineering and Repair (CITER). In August 2017 he will assume the role of Head of School of Dentistry.
Honours and awards
1998 - British Society for Oral and Dental Research (BSODR) MIneralised Tissue Prize
2011 - IADR Distinguished Scientist Award, Young Investigators Award
IADR, BSODR, TCES, TERMIS
Previous academic positions
Aug 2010 – July 2012: Reader in Bone Biology & Tissue Engineering, Cardiff University, School of Dentistry
Aug 2007 – July 2010: Senior Lecturer in Bone Biology & Tissue Engineering, Cardiff University, School of Dentistry
Aug 2005 – July 2007: Lecturer in Bone Biology and Tissue Engineering, Cardiff University, School of Dentistry
Jan 2000 – Aug 2005: Lecturer in Oral Biology, The University of Birmingham, School of Dentistry
Oct 1997 – Dec 1999: Postdoctoral Research Fellow, The University of Birmingham, School of Dentistry
- Executive Board - Cardiff Institute of Tissue Engineering and Repair Learning
BDS: Oral Ecosystems (dental anatomy and oral and craniofacial biology).
MSc Tissue Engineering (stem cell biology and bioengineering)
MSc Oral Biology
Philips - Development of an epithelial tissue culture model to assess direct Contact of H2O2 and light on cell responses. AJ Sloan (PI), RJ Waddington, WN Ayre. 2015-2016; £120,471
Research Network Wales Life Sciences Bridging Fund - Towards the Commercialization of Dual Action Mucoadhesive Patches to Treat Periodontal Diseases. C Heard, AJ Sloan. 2017-2018; £75,000
Philips – Effect of light activated peroxide agents on gingival tissue. RJ Waddington, AJ Sloan, WN Ayre. 2016-2017; £75,000
Philips - Effect of staining on Dental Tissue and Direct Contact of H202 on dental pulp cells. AJ Sloan (PI), RJ Waddington, WN Ayre. 2016-2017; £114,536
Dunhill Medical Research Trust - Preventing aseptic loosening of cemented joint replacements in older adults: delivery of osteogenic molecules from PMMA bone cement to encourage bone repair and implant osseointegration. AJ Sloan (PI), W Ayre, RJ Waddington, D Mason, B Evans, S Evans, SP Denyer, S Evans, RM Jones 2016-2017; £84,104
MRC P2D – Bioactive materials to manage dental tissue regeneration. W Ayre, AJ Sloan, RJ Waddington, CD Lynch, S Evans. 2016; £20,000
MRC CiC – Delivery of Antimicrobials from dental cements for Dental Tissue Repair. AJ Sloan (PI), JY Maillard, RJ Waddington, CD Lynch. 2016; £50,000
Renishaw Ltd – Antimicrobial coatings of implantable devices. AJ Sloan (PI), RJ Waddington, WN Ayre, Q Jones. 2015-2018; £50,000
Philips – Effect of novel antimicrobial agent on oral epithelial tissues. RJ Waddington, AJ Sloan, W Ayre. 2015-2015; £25,000
Petplan Charitable Trust - Development of novel in vitro models to investigate the role of pathogens in the aetiology of feline chronic gingivostomatitis and test therapeutic interventions. MP Riggio (Glasgow), D Bennett (Glasgow), DF Lapping (Glasgow), C Nile (Glasgow), AJ Sloan, SP Denyer (Brighton). 2015-2018; £89942
Philips – Effect of whitening agents on dental pulp functional behaviour AJ Sloan (PI), RJ Waddington, J Rees. 2015-2016; £105,785
Philips – Effect of ultrasound mediated CPC on 3D oral mucosa tissue cultures. RJ Waddington, AJ Sloan, W Ayre. 2014-2015; £27,000
UKRMP Partnership Award– Novel Bioactive Delivery Materials for Mineralised Tissue Repair. AJ Sloan (PI), RJ Waddington, S Evans. 2015; £50,000
NISCHR – Novel Antimicrobial Restorative Materials to Manage Dental Disease. AJ Sloan (PI), A Paul (CHEMY), RJ Waddington. 2014-2017; £66,000
Novel Antimicrobial Restorative Materials to Manage Dental Disease
Delivery of osteogenic molecules ffor bone repair and implant osseointegration
Antimicrobial coatings of implantable devices
Understanding heterogeneity of dental pulp progenitor cells through lineage tacking and biophotonic labelling
Effect of whitening agents on dental pulp functional behaviour
Dental material directed tissue regeneration
Ex vivo modelling of antimicrobial measures in pulpal disease
Ex vivo modelling of bone regeneration