Professor Monica Busse
Director of Mind, Brain and Neuroscience Trials
I am a chartered physiotherapist, trials methodologist and Director for Mind, Brain, Neuroscience Trials in the Centre for Trials Research (CTR) at Cardiff University. I have a specific interest in the development and evaluation of complex clinical interventions across the life span. An important research focus of mine is the in-depth understanding of intervention components and related trial design aspects that are required to inform appropriate assessment of outcomes in complex health conditions. My ORCID-ID is 0000-0002-5331-5909.
I was awarded my Bachelor of Science in Physiotherapy in 1993 from the University of Stellenbosch, South Africa. After graduation, I worked clinically as well as in clinical supervision in university settings in South Africa, USA and UK for more than 10 years as well as undertaking further studies in Ergonomics and Biomechanics. I was awarded my BSc (Med) Hons. Ergonomics (first class) from the University of Cape Town) in December 1996 and my MSc (Med) Biomedical Sciences (distinction) from the University of Cape Town), South Africa in December 2001.
In 2002, I registered for a full time PhD at the University of Wales College of Medicine in Cardiff and was awarded my PhD in 2005. I have worked as a Lecturer, Senior lecturer, Reader and then Professor at Cardiff University since 2005.
I was awarded a Post Graduate Certificate in Teaching and Learning (Kingston University) in July 2001, a Diploma in Research Methods (University of Wales College of Medicine) in May 2003, a Post Graduate Certificate in Teaching Statistics in Higher Education (Royal Statistical Society) in February 2005 and a Post graduate diploma in Clinical Trials (London School of Hygiene and Tropical Medicine) in July 2017.
Registered Physiotherapist Health Professions Council PH 53577 January 1998
Member of Chartered Society of Physiotherapy January 1998
Fellow of Higher Education Institute July 2001
I am in possession of a Post Graduate Certificate in Teaching and Learning in Higher Education, a Certificate in Teaching Statistics in Higher Education (Royal Statistical Society) and a Post Graduate Diploma in Clinical Trials (LSHTM). My research has a clear focus on physical activity and development and evaluation of complex interventions in clinical settings. I collaborate closely with colleagues working in engineering and biosciences to achieve a translational focus to my work. I also have a particular interest in innovative methods for teaching research and statistics and the use of reliability analyses and mixed methods in healthcare research that has developed as a direct result of application in my research area.
As Director for Mind, Brain, Neuroscience Trials in the Centre for Trials Research (CTR), I am actively involved as either principle investigator or co-applicant in a range of trials and studies of complex clinical interventions across the lifespan. These extend across our CTR thematic areas of the Older Person, Children and Young People and Behavior Change. Such interventions are complex, and involve many components. The Medical Research Council (MRC) Framework for design and evaluation of complex interventions provides a structure for this research with a view to robust and efficient evaluation of clinical interventions.
My personal research has mainly focused on developing evidence and guidelines for targeted physical interventions in Huntington's disease (HD), Parkinson's disease (PD) and Multiple Sclerosis. Working closely with people with HD and their families as part of the research process is a very important part of my work. I established the Wales HD Involving People Group in 2010 (now BRAIN Involve) with a view to ensuring that our work is always relevant and applicable to the needs of the HD community. We have successfully conducted and published data from the first randomised and controlled multi-centre studies investigating different physiotherapy and exercise interventions for HD (MOVE TO EXERCISE, TRAIN-HD, COMMET-HD, ENGAGE-HD and ExeRT-HD. The growing recognition of the importance of physical activity and mobility in HD is further evidenced by the FP-7 funded programme of work being conducted in REPAIR-HD (http://www.repair-hd.eu/) where I am a principle investigator along with a consortia of researchers based in Germany, France and Italy. I am also a principle investigator in the Wales BRAIN Unit where I lead the patient monitoring work-package.
NIHR HTA. A Pragmatic Randomised Controlled Trial of Sensory Integration Therapy versus usual care for sensory processing difficulties in Autism Spectrum Disorder in children: impact on behavioural difficulties, adaptive skills and socialisation (SenITA) £1,193 million.
Multiple Sclerosis Society. Life-style, Exercise and Activity Package for People living with Progressive Multiple Sclerosis (LEAP-MS). £298509.00.
Jacques and Gloria Gossweiler Foundation Research Grants in the field of Neurology "Physical Activity and Exercise Outcomes in Huntington's Disease (PACE-HD)." £411 00.00.
Health and Care Research Wales. £1,733,333. South East Wales Trials Unit/ Centre for Trials Research Infrastructure funding.
MRC Confidence in Concept "Using wearable technology to predict perioperative high-risk patient outcomes." £39,490.
MRC Confidence in Concept "Developing clinical applications for a novel multi-task functional assessment." £49,902.00.
Wellcome Trust ISSF Cross disciplinary awards “Pilot study of motor coordination disorder in 22q11.2 deletion syndrome.“ £8,935.
Wellcome Trust ISSF Cross disciplinary awards “Automated assessment of timing and movement signatures in Huntington’s Disease.” £47,945
Wellcome Trust ISSF ISSF populations pilot awards “Feasibility of using consumer-targeted activity monitors in collecting physical activity data within the HealthWise Wales cohort: a pragmatic pilot study.” £28,414
Jacques and Gloria Gossweiler Foundation Research Grants in the field of Neurology “Exploring cognitive training as a non-pharmaceutical intervention for people with Huntingtons disease.” £94,071
Division of Health and Care Research Wales (DHCRW); Brain Repair And Intracranial Neurotherapeutics- Wales BRAIN Unit. £1.2m; lead applicant Professor W. Grey.
FP7-HEALTH-2013-INNOVATION-1 "REPAIR-HD Human pluripotent stem cell differentiation, safety and preparation for therapeutic transplantation in Huntington's disease". £1,705,800
Jacques and Gloria Gossweiler Foundation "ExeRT-HD Exercise Rehabilitation Trial in Huntington's Disease". £172,805
National Institute of Social Care and Health Research/ National Institute of Health Research "Move to Exercise: Home based exercise for people with Huntington's Disease". £687,362
Linden. Morris, Subramanian, Busse Wellcome Trust ISSF Seedcorn "Real Time fMRI neurofeedback as a treatment for Parkinson's Disease". £45,000
Neil Glendinning Research Grant Huntington's Disease Association: Task Training in Huntington's Disease £99,230
European Huntington's Disease Network. Feasibility and benefit of inspiratory muscle training in people with Huntington's disease. £38,384.
National Institute for Social Care and Health Research Health Research Funding Scheme: Can community supported exercise benefit subjective wellbeing, physical activity levels and abilities in people with Huntington's disease? A randomised feasibility study and process evaluation (COMMET-HD). £122,720.
Medical Research Council. National Prevention Research Initiative. Health Eating and Lifestyle in Pregnancy Study (HELP). £1,041,422.
European Huntington's Disease Network. Reliability and minimal detectable change of measures of participation, functional activities and impairments in individuals with Huntington's disease. £36,000.
Physiotherapy Research Foundation Scheme B. Respiratory Function in people with Huntington's disease: a cross sectional study. £6,500.
Research Capacity Building Consortium Wales PhD studentship. Respiratory Function in people with Huntington's disease: a cross sectional study. £51,558.
Chief Medical Officer for Wales Research Budget. Development and evaluation of a DVD resource for people with a neurodegenerative disease who may be at risk of falls. £9,938.
Paul Jeffries Waters Bequest Fund to support research in Huntington' disease. £2,820.
Physiotherapy Research Society. Mobility and Falls in Huntington's Disease. £500