![Catharine Porter](https://profiles-cardiff.imgix.net/attachments/3629?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Catharine Porter
Research Associate - Statistics
- PorterC3@cardiff.ac.uk
- Neuadd Meirionnydd, Room 514, University Hospital of Wales, Heath Park, Cardiff, CF14 4YS
- Available for postgraduate supervision
Overview
I am a Research Associate in Statistics in the Centre for Trials Research at Cardiff University where I have worked since September 2014. I initially joined Wales Cancer Trials Unit which later merged with other trials units within Cardiff University to become the Centre for Trials Research. As such, my main areas of interest are solid tumour and haematology trials. I have built up a wealth of experience over the years in developing and running cancer clinical trials, from initial funding applications and clinical trial design, through pre-trial developement including Case Report Forms, metadata and database development, the recruitment phase include central monitoring of data and reporting to Independent Data monitoring Committees, data cleaning prior to final analysis, submission of abstracts to conferences and final publication in internationally-renowned journals. I am senior statistician on trials and supervise junior statisticians in these projects.
I have previously worked for many years as a Data Manager in Clinical Haematology and have extensive experience of Haematology Clinical trials from both the hospital side as well as the Trials Unt side.
I am hold BSc (Hons) in Biological Sciences with Biochemistry, PhD in Biochemistry (University of Birmingham) and Master in Public Health (Cardiff University). I have held Post-doctoral Research Fellowships in Molecular Biology and Genetics.
Publication
2022
- Fennell, D. A. et al. 2022. Olaparib maintenance versus placebo monotherapy in patients with advanced non-small cell lung cancer (PIN): A multicentre, randomised, controlled, phase 2 trial. EClinicalMedicine 52, article number: 101595. (10.1016/j.eclinm.2022.101595)
- Fennell, D. A. et al. 2022. Active symptom control with or without oral vinorelbine in patients with relapsed malignant pleural mesothelioma (VIM): A randomised, phase 2 trial. eClinicalMedicine 48, article number: 101432. (10.1016/j.eclinm.2022.101432)
2021
- Byrne, A., Adamson, D., Porter, C. and Hurt, C. 2021. Stent insertion for incurable oesophageal carcinoma: what is the optimal treatment? - authors' reply. The Lancet Gastroenterology & Hepatology 6(7), article number: 525. (10.1016/S2468-1253(21)00174-6)
- Adamson, D. et al. 2021. Palliative radiotherapy combined with stent insertion to reduce recurrent dysphagia in oesophageal cancer patients: the ROCS RCT. Health Technology Assessment 25(31) (10.3310/hta25310)
- Adamson, D. et al. 2021. Palliative radiotherapy after oesophageal cancer stenting (ROCS): a multicentre, open-label, phase 3 randomised controlled trial. Lancet Gastroenterology and Hepatology 6(4), pp. 292-303. (10.1016/S2468-1253(21)00004-2)
2020
- Byrne, A. T. et al. 2020. Radiotherapy after esophageal cancer stenting (ROCS): A pragmatic randomized controlled trial evaluating the role of palliative radiotherapy in maintaining swallow.. Journal of Clinical Oncology 38(15_sup), article number: 4569. (10.1200/JCO.2020.38.15_suppl.4569)
2019
- Hurt, C. et al. 2019. Feasibility and economic assessment of chromocolonoscopy for detection of proximal serrated neoplasia within a population-based colorectal cancer screening programme (CONSCOP): an open-label, randomised controlled non-inferiority trial. Lancet Gastroenterology and Hepatology 4(5), pp. 364-375. (10.1016/S2468-1253(19)30035-4)
2018
- Prout, H. C. et al. 2018. Patient understanding and acceptability of an early lung cancer diagnosis trial: a qualitative study. Trials 19, article number: 419. (10.1186/s13063-018-2803-4)
2017
- Neal, R. D. et al. 2017. Immediate chest X-ray for patients at risk of lung cancer presenting in primary care: randomised controlled feasibility trial. British Journal of Cancer 116(3), pp. 293-302. (10.1038/bjc.2016.414)
Articles
- Fennell, D. A. et al. 2022. Olaparib maintenance versus placebo monotherapy in patients with advanced non-small cell lung cancer (PIN): A multicentre, randomised, controlled, phase 2 trial. EClinicalMedicine 52, article number: 101595. (10.1016/j.eclinm.2022.101595)
- Fennell, D. A. et al. 2022. Active symptom control with or without oral vinorelbine in patients with relapsed malignant pleural mesothelioma (VIM): A randomised, phase 2 trial. eClinicalMedicine 48, article number: 101432. (10.1016/j.eclinm.2022.101432)
- Byrne, A., Adamson, D., Porter, C. and Hurt, C. 2021. Stent insertion for incurable oesophageal carcinoma: what is the optimal treatment? - authors' reply. The Lancet Gastroenterology & Hepatology 6(7), article number: 525. (10.1016/S2468-1253(21)00174-6)
- Adamson, D. et al. 2021. Palliative radiotherapy combined with stent insertion to reduce recurrent dysphagia in oesophageal cancer patients: the ROCS RCT. Health Technology Assessment 25(31) (10.3310/hta25310)
- Adamson, D. et al. 2021. Palliative radiotherapy after oesophageal cancer stenting (ROCS): a multicentre, open-label, phase 3 randomised controlled trial. Lancet Gastroenterology and Hepatology 6(4), pp. 292-303. (10.1016/S2468-1253(21)00004-2)
- Byrne, A. T. et al. 2020. Radiotherapy after esophageal cancer stenting (ROCS): A pragmatic randomized controlled trial evaluating the role of palliative radiotherapy in maintaining swallow.. Journal of Clinical Oncology 38(15_sup), article number: 4569. (10.1200/JCO.2020.38.15_suppl.4569)
- Hurt, C. et al. 2019. Feasibility and economic assessment of chromocolonoscopy for detection of proximal serrated neoplasia within a population-based colorectal cancer screening programme (CONSCOP): an open-label, randomised controlled non-inferiority trial. Lancet Gastroenterology and Hepatology 4(5), pp. 364-375. (10.1016/S2468-1253(19)30035-4)
- Prout, H. C. et al. 2018. Patient understanding and acceptability of an early lung cancer diagnosis trial: a qualitative study. Trials 19, article number: 419. (10.1186/s13063-018-2803-4)
- Neal, R. D. et al. 2017. Immediate chest X-ray for patients at risk of lung cancer presenting in primary care: randomised controlled feasibility trial. British Journal of Cancer 116(3), pp. 293-302. (10.1038/bjc.2016.414)
Research
My research interests are clinical trials in oncology, both solid tumours and haematology.
As a trial statistician I am involved in clinical trials from trial design through to final analysis and publication, producing interim analysis for data monitoring committees and central monitoring of data.
I am currently working on Phase 1-3 trials in acute lymphoblastic leukaemia, skin cancer, anal cancer, pleural mesothelioma, lung cancer, oesophageal cancer, COVID prevention in immunocompromised patients and endometrial cancer.
I am also involved as an Independent member on Data Monitoring andTrial Steering Committees.
Biography
Education and Qualifications
- 2014: Masters In Public Health, Cardiff University, UK
- 1989: PhD (Biochemistry), Birmingham University, UK
- 1985: BSc (Hons) Biological Sciences, University of East Anglia
Career overview
- January 2019 to present: Research Associate (Statistics), Centre for Trials Research, Cardiff University
- October 2017-January 2019: Acting Research Associate (Statistics), Centre for Trials Research, Cardiff University
- 2014-October 2017: Research Assistant (Statistics), Wales Cancer Trials Unit, Cardiff University
- 2001-2005: Data Coordinator, Clinical Haematology and Bone Marrow Transplant Unit, University Hospital Birmingham
- 1998-2001: Data Manager, Clinical Haematology and Bone Marrow Transplant Unit, Birmingham Heartlands Hospital
Academic positions
- 1989-1993: Post-doctoral Research Fellow, School of Biological Sciences, Birmingham University
Supervisions
Medical Statistics (particularly oncology)
Research themes
Specialisms
- Haematology
- Oncology and carcinogenesis
- clinical trials
- Cancer Trials