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 David Gillespie

David Gillespie

Deputy Director of Infection, Inflammation & Immunity Trials and Senior Research Fellow

Email:
gillespied1@cardiff.ac.uk
Telephone:
+44 (0)29 2068 7610
Location:
410, 4th Floor, Neuadd Meirionnydd, Heath Park
Available for postgraduate supervision

I am the Deputy Director of Infection, Inflammation & Immunity Trials and Senior Research Fellow at the Centre for Trials Research.

I have recently been awarded a five-year post-doctoral research fellowship by Health and Care Research Wales to investigate the use of Pre-Exposure Prophylaxis (PrEP) in individuals at-risk of HIV-acquisition living in Wales.

My background is in Medical Statistics, and I have been working on the design, conduct, analysis, and reporting of randomised trials and other well designed studies since 2007. I completed my PhD at the end of 2016, with my thesis titled “Medication Adherence in Clinical Research and Associated Methodological Challenges”. As Deputy Director, I provide leadership to the Infection, Inflammation & Immunity division within the Centre for Trials Research.

Clinically, my research interests focus on prudent medication use in the field of infectious diseases, and my work can be broadly split into two key areas:

  • Medication adherence – specifically, ways in which adherence to medication is conceptualised, measured, and modelled
  • The development and evaluation of antimicrobial stewardship interventions

I am also actively involved in a large programme of research in the field of intellectual disabilities and other neurodevelopmental disorders.

My areas of methodological interest include:

  • Trials and general research methodology (improving the ways in which we do randomised trials and other well designed studies)
  • Causal modelling (modelling approaches that aim to answer causal questions, rather than purely associational)
  • Missing data (prevention of, and fitting models when there are missing data).

Education and qualifications:

  • 2013 - 2016: PhD "Medication Adherence in Clinical Research and Associated Methodological Challenges" (School of Medicine) Cardiff University, Cardiff, UK
  • 2005 - 2009: BSc in Mathematics, Operational Research and Statistics (School of Mathematics) Cardiff University, Cardiff, UK (with placement year)

Career overview:

  • May 2018 onwards: Deputy Director of Infection, Inflammation & Immunity Trials and Senior Research Fellow, Centre for Trials Research, Cardiff University
  • December 2016 - May 2018: Research Fellow in Statistics, Centre for Trials Research, Cardiff University
  • October 2015 - March 2016: Methodological Consultant, Research Design and Conduct Service, Cardiff University (part-time secondment)
  • August 2015 - November 2016: Research Associate in Statistics, Centre for Trials Research, Cardiff University
  • March 2012 - November 2016: Research Associate in Statistics, South East Wales Trials Unit, Cardiff University
  • June 2009 - March 2012: Junior Statistician, South East Wales Trials Unit, Cardiff University
  • July 2007 - September 2008: Trainee Statistician, South East Wales Trials Unit, Cardiff University

Honours and awards

  • Nominated for a Cardiff University Celebrating Excellence Award in the category of "Rising Star" (2016)
  • Received an Outstanding Contribution Award from Cardiff University (2016)
  • Received a prize at graduation for achieving the highest grade across the School of Mathematics for my BSc dissertation (2009)

Professional memberships

I am a member of the Society for Academic Primary Care (SAPC).

Speaking engagements

Invited speaker:

  • December 2016: Infections Group Meeting within the Centre for Academic Primary Care, School of Social and Community Medicine, University of Bristol
  • July 2016: School of Healthcare Sciences away day, School of Healthcare Sciences, Cardiff University
  • June 2016: Royal Statistical Society Primary Healthcare Special Interest Group, RSS Headquarters, London
  • March 2015: National Parenting Coordinators' Network, Llandridnod Wells
  • May 2014: Royal Statistical Society Primary Healthcare Special Interest Group, University of Leeds

Conference presentations:

Given presentations at regional, national, and international conferences, including:

  • Regional:
    • South West Society for Academic Primary Care (2008, 2014)
  • National:
    • Young Statisticians' Meeting (2010, 2011, 2013)
    • UK CRC Registered CTU Statisticians' Meeting (2012)
    • Society for Academic Primary Care (2015)
  • International:
    • International Clinical Trials Methodology Conference (2011, 2015)
    • General Practitioners' Research in Infections Network (2009, 2012, 2013, 2014, 2015, 2016, 2017)
    • Society for Clinical Trials (2015)
    • European Society for Patient Adherence, Compliance and Persistence (2015)
    • European Association for Mental Health in Intellectual Disabilities (2017)

Committees and reviewing

  • I am a consultant for the twice-weekly data clinic set-up by the College of Biomedical & Life Sciences in Cardiff University
  • I am a member of the Medicines Optimisation and Healthcare Outcomes research group led by the School of Pharmacy in Cardiff University

External committees

  • 2011 - 2014: Royal Statistical Society Primary Healthcare Special Interest Group
  • Previously independent Trial Steering Committee member for one study (BEAT-IT)
  • Independent Trial Steering Committee member for three studies (STASH, CONTRACT, FLIGHT, SUPPORT2BACK)
  • Independent Data Monitoring and Ethics Committee member for two studies (HATRIC, TEST)
  • Board member for the Health and Care Research Wales Research for Patient and Public Benefit (RfPPB) panel
  • Associate board member for NIHR HTA

Peer reviewer

I peer-review submissions to The Lancet (and associated journals), BMJ Open, Journal of Infection Prevention Research, Research in Developmental Disabilities, Trials, and Patient Preference and Adherence. I also review funding applications and final reports for the NIHR, MRC, and HCRW.

2019

2018

2017

2015

2014

2013

2012

2011

2010

2009

Teaching

  • From the 2017/2018 academic year, I am lecturing on "Randomised Controlled Trials" as part of the ME 3092 Research Methods 1 module for Medical Intercalated BSc students
  • In June 2016, I co-developed and delivered a three-day course on basic data analysis using the statistical programming language R (titled "learnR") to staff at the University of Namibia as part of the Phoenix Project (http://www.cardiff.ac.uk/phoenix-project)
  • Previously, I have taught small and medium group sizes at both undergraduate and postgraduate level on topics including quantitative research methods, statistics, and critical appraisal

Supervision

  • I am currently submitting proposals to supervise undergraduate and postgraduate students in the fields of medication adherence and infectious diseases
  • I have supervised three undergraduate dissertations (2 x Medical Intercalated BSc and BSc Mathematics, Operational Research and Statistics) and two MSc dissertations (MSc Operational Research and Applied Statistics, MSc Bioinformatics and Biostatistics)

Since 2013, I have been awarded approximately £8m in grant funding, including approx. £400k as lead applicant.

Research grants:

2018

  • HCRW HRF: "Development of an intervention to Optimise use of Pre-Exposure Prophylaxis (PrEP) to prevent HIV-acquisition in at-risk individuals living in Wales (DO-PrEP)" £393,792

2017

  • NIHR PHR: "Early positive approaches to support (E-PAtS) for families of young children with intellectual disability:
    feasibility study" £508,474
  • HCRW RfPPB: "Trial designs for delivery of novel therapies for neurodegeneration (TRIDENT)" £223,176
  • HCRW RfPPB: "Feasibility and acceptability of a new clinical pathway for the identification of non-responders to glaucoma eye drops (the TRIAGE study)" £225,255
  • The Baily Thomas charitable fund: "Behavioural activation (BeatIt) for depression in adults with severe intellectual disabilities. A feasibility randomised controlled study of BeatIt versus treatment as usual" £97,829
  • ESRC IAA: "An intervention for primary care prescribers to support the choice and use of antibiotics" £19,865

2016

  • NIHR HTA: "A pragmatic randomised controlled trial of sensory integration therapy versus usual care for sensory processing difficulties in autism spectrum disorder in children, and its impact on behavioural difficulties, adaptive skills and socialisation (SenITA)" £1,477,233

2015

  • NIHR/MRC EME: "Probiotics to reduce infections in care home residents (PRINCESS)" £1,872,938
  • NIHR SSCR: "Who's Challenging Who? A cluster randomised controlled trial to test the effectiveness of a staff training intervention to improve support staff attitudes and empathy towards adults with learning disability and challenging behaviours" £303,392

2014

  • NIHR HTA: "General Practitioner (GP) use of a C-Reactive Protein (CRP) Point of Care Test (POCT) to help target antibiotic prescribing to patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) who are most likely to benefit (PACE)" £1,375,543

2013

  • NIHR HTA: "Community-led anti-psychotic drug reduction for adults with learning disabilities: a randomised double-blind placebo controlled trial (ANDREA-LD)" £1,489,779