Professor Kim Graham

BSc, PhD

Pro Vice-Chancellor Research, Innovation and Enterprise

School of Psychology

: grahamks@cardiff.ac.uk
: +44 (0)29 2087 0652
: Main Building, Park Place, Cardiff, CF10 3AT

: Media commentator
: Available for postgraduate supervision

I am a Professor of Cognitive Neuroscience and Pro Vice-Chancellor, Research, Innovation and Enterprise, Cardiff University. I am also a member of the UKRI MRC Council, the Wales Science and Innovation Advisory Council and the HEFCW Research Committee.

My research focuses on understanding how distinct brain circuits underpin different memory systems, and how damage to these networks influences risk and resilience to dementia across the lifespan. I use state-of-the-art scanning facilities at the Cardiff University Brain Research Imaging Centre (CUBRIC) to ask how inter-individual variation in the structure and function of different brain networks is linked to human memory, such as our ability to remember events from the past. With Professor Andrew Lawrence and Dr Mark Postans, and funded by the MRC, we are collaborating with the Bristol-based Avon Longitudinal Study of Parents and Children to investigate how genes associated with later life cognitive health influence brain structure and function, as well as cognitive performance in young adults, as well as their parents.

I am also interested in the evolution of memory systems, and am co-author on an award-winning book, The Evolution of Memory Systems.

Undergraduate education

My undergraduate degree (BSc Biological Sciences, Psychology, First Class Honours) was from Edinburgh University (1990), during which I was awarded the Class Medal for Psychology (1998) and the Drever Prize in Psychology (1990).

Postgraduate education

I undertook postgraduate education at the MRC Cognition and Brain Sciences Unit and St John's College, Cambridge University (PhD completed 1995). During this time, I worked with Professors John Hodges and Karalyn Patterson investigating language and memory in semantic dementia (Graham et al., 1994; Graham et al., 1995; Graham and Hodges, 1997).

Career Highlights

After my PhD, I stayed at the MRC Cognition and Brain Sciences Unit where I was a Programme Leader, with responsibilty for two major programmes of research on memory disorders, including dementia.

I moved to Cardiff University in 2007, where I took up a position as Professor of Cognitive Neuroscience. Since then, I have been Theme Lead for Mind, Brain and Neuroscience at the University (between 2012-2015), as well as Dean of Research in the College of Biomedical and Life Sciences (between 2015-2018). I am currently Cardiff University's Pro Vice-Chancellor for Research, Innovation and Enterprise, a role I started in Septemer 2018.

Externally, I have held leadership positions for grant funders and organisations, including the role of Deputy Chair for the MRC Non-Clinical Career Development and Training Panel and panel member for REF 2014 UoA4.

I am currently a member of the Wales Science and Innovation Advvisory Council, HEFCW Research Wales Committee and MRC Council.

Honours and awards

1988: Class Medal in Psychology (Edinburgh University)
1990: Drever Prize in Psychology (Edinburgh University)
2005: Paul Bertelson Award (European Society for Cognitive Psychology)
2014: Elected to AcademiaNet, a portal showcasing outstanding European female researchers
2017: BMA Highly Commended Award, Neurology Category, 'The Evolution of Memory Systems'
2017: Royal Society Wolfson Merit Award Holder
2020: British Psychological Society, Academic Monograph Award 2020 for ‘The Evolution of Memory Systems’

Professional memberships

British Neuroscience Association
Society for Neuroscience
Memory Disorders Research Society.

Academic positions

Sept 2018 – present: Pro Vice-Chancellor, Research, Innovation and Enterprise, Cardiff University

Aug 2015-Sept 2018: Dean of Research, College of Biomedical and Life Sciences, Cardiff University

Mar 2013-Mar 2016: Theme Lead, Cardiff University Research Theme ‘Mind, Brain & Neuroscience.

Mar 2007-present: Professor of Cognitive Neuroscience, School of Psychology, Cardiff University.

Jun 2002-Feb 2007: Programme Leader, MRC Cognition and Brain Sciences Unit, Cambridge, UK.

Jan 2001-Jun 2002: Scientist (Career Track), MRC Cognition and Brain Sciences Unit, Cambridge, UK

Feb-Aug 2001: Visiting Scholar, Department of Psychology, UC Berkeley, USA.

Oct 1997-Dec 2000: Postdoctoral Scientist, MRC Cognition and Brain Sciences Unit, Cambridge, UK.

April 1995-Sep1997: Wellcome Research Associate, University of Cambridge, Cambridge, UK

Speaking engagements

Memory is a topic that the public is extremely interested in, and I am happy to engage with the media, including undertaking radio, TV and newspaper interviews, and discussing the implications of our, and others, research findings.

Talks and interviews

2000: BBC World Radio: Interviewed for Discovery Series, “Memory Disorders”
2001: BBC Radio 4: Interviewed for scientific series on, “Human Memory”
2001: Noticias (South American version of ‘Time’): Article on “Human Memory”
2002: BBC Radio 4, Interviewee, “In Our Times – Science of Memory”
2005: BBC World Radio: Interviewed for programmes on “Exploring Memory”
2006: Research reported in Reuters, Daily Express, Daily Mirror, Cambridge Evening News
2006: BBC Radio 4: Interviewee, “Sharpen Your Memory”, Memory Experience programmes
2006: BBC Look East: Intervieew, 100th Centenary of first published case of Alzheimer's disease
2014: Invited guest, International Longevity Centre, House of Lords
2014: Games presenter, Cardiff Brain Games, Cardiff Museum.
2014: Invited panel discussant, Cardiff SciScreen, ‘Iris’.
2016: Member of Seren Network, helping Welsh sixth-formers gain access to leading Universities
2016: Invited panel discussant, Cardiff SciScreen, ‘Away from Her’.
2017: Article for Health Check Wales on ‘Different forms of dementia’.
2017: Pint of Science talk, Beautiful Mind, Cardiff
2019: Publication of Evolutionary Road to Human Memory (Oxford University Press)

Committees and reviewing

Current External Grant Committees

UKRI Future Leaders Fellowship (Panel Chair and Roving Panellist)

Past External Grant Committees

MRC Neurosciences and Mental Health Board
MRC Centenary Award Panel
MRC Addiction Capacity Building Programme Panel
MRC Addiction and Substance Abuse Research Strategy Oversight Group
The Royal Society Dorothy Hodgkin Fellowship Panel
Dementias Platform UK Steering Group
MRC Non-Clinical Training and Career Development Panel (Deputy Chair)
MRC Stratified Medicine Panel
Medical Sciences Foundation, Emerging Leaders Prize Panel (Core Panellist)
Alzheimer’s Research UK, Early Career Researcher Panel
Alzheimer’s Research UK, Network Assessment Panel

2023

Read, M. et al. 2023. A role for the Fornix in temporal sequence memory. European Journal of Neuroscience 57(7), pp. 1141-1160. (10.1111/ejn.15940)

2016

Hodgetts, C. J., Shine, J. P., Lawrence, A. D., Downing, P. E. and Graham, K. S. 2016. Evidencing a place for the hippocampus within the core scene processing network. Human Brain Mapping 37(11), pp. 3779-3794. (10.1002/hbm.23275)
Murray, E. A., Wise, S. P. and Graham, K. S. 2016. The evolution of memory systems: ancestors, anatomy, and adaptations. Oxford Psychology Series. Oxford University Press.
Behrmann, M., Lee, A. C. H., Geskin, J. Z., Graham, K. S. and Barense, M. D. 2016. Temporal lobe contribution to perceptual function: A tale of three patient groups. Neuropsychologia 90, pp. 33-45. (10.1016/j.neuropsychologia.2016.05.002)
Harry, B. B., Umla-Runge, K., Lawrence, A. D., Graham, K. S. and Downing, P. E. 2016. Evidence for integrated visual face and body representations in the anterior temporal lobes. Journal of Cognitive Neuroscience 28(8), pp. 1178-1193. (10.1162/jocn_a_00966)

2015

Shine, J. P., Hodgetts, C. J., Postans, M., Lawrence, A. D. and Graham, K. S. 2015. APOE-ε4 selectively modulates posteromedial cortex activity during scene perception and short-term memory in young healthy adults. Scientific Reports 5, article number: 16322. (10.1038/srep16322)
Hodgetts, C. J., Postans, M., Shine, J. P., Jones, D. K., Lawrence, A. D. and Graham, K. S. 2015. Dissociable roles of the inferior longitudinal fasciculus and fornix in face and place perception. eLife 4, article number: e07902. (10.7554/eLife.07902)
Rogers, T. T., Graham, K. S. and Patterson, K. 2015. Semantic impairment disrupts perception, memory, and naming of secondary but not primary colours. Neuropsychologia 70, pp. 296-308. (10.1016/j.neuropsychologia.2015.01.010)

2014

Postans, M., Hodgetts, C. J., Mundy, M. E., Jones, D. K., Lawrence, A. D. and Graham, K. S. 2014. Individual variation in fornix microstructure and macrostructure is related to visual discrimination accuracy for scenes but not faces. Journal of Neuroscience 34(36), pp. 12121-12126. (10.1523/JNEUROSCI.0026-14.2014)
Mundy, M. E., Downing, P. E., Honey, R. C., Singh, K. D., Graham, K. S. and Dwyer, D. M. 2014. Brain correlates of experience-dependent changes in stimulus discrimination based on the amount and schedule of exposure. PLoS ONE 9(6), article number: e101011. (10.1371/journal.pone.0101011)

2013

Mundy, M. E., Downing, P. E., Dwyer, D. M., Honey, R. C. and Graham, K. S. 2013. A critical role for the hippocampus and perirhinal cortex in perceptual learning of scenes and faces: complementary findings from amnesia and fMRI. Journal of Neuroscience 33(25), pp. 10490-10502. (10.1523/JNEUROSCI.2958-12.2013)

2012

Mundy, M. E., Downing, P. E. and Graham, K. S. 2012. Extrastriate cortex and medial temporal lobe regions respond differentially to visual feature overlap within preferred stimulus category. Neuropsychologia 50(13), pp. 3053-3061. (10.1016/j.neuropsychologia.2012.07.006)
Watson, H. C., Wilding, E. L. and Graham, K. S. 2012. A role for perirhinal cortex in memory for novel object-context associations. The Journal of Neuroscience 32(13), pp. 4473-4481. (10.1523/JNEUROSCI.5751-11.2012)
Irish, M., Graham, A., Graham, K. S., Hodges, J. R. and Hornberger, M. 2012. Differential Impairment of Source Memory in Progressive Versus Non-progressive Behavioral Variant Frontotemporal Dementia. Archives of Clinical Neuropsychology 27(3), pp. 338-347. (10.1093/arclin/acs033)

2011

Barense, M. D., Henson, R. N. A. and Graham, K. S. 2011. Perception and conception: temporal lobe activity during complex discriminations of familiar and novel faces and objects. Journal of Cognitive Neuroscience 23(10), pp. 3052-3067. (10.1162/jocn_a_00010)
Clague, F., Graham, K. S., Thompson, S. A. and Hodges, J. R. 2011. Is knowledge of famous people compromised in mild cognitive impairment?. Cognitive and Behavioral Neurology 24(3), pp. 134-144. (10.1097/WNN.0b013e318234315a)
Greve, A., Evans, C. J., Graham, K. S. and Wilding, E. L. 2011. Functional specialisation in the hippocampus and perirhinal cortex during the encoding of verbal associations. Neuropsychologia 49(9), pp. 2746-2754. (10.1016/j.neuropsychologia.2011.06.002)
Duarte, A., Henson, R. N. and Graham, K. S. 2011. Stimulus content and the neural correlates of source memory. Brain Research 1373, pp. 110-123. (10.1016/j.brainres.2010.11.086)

2010

Milton, F., Muhlert, N., Pindus, D., Butler, C., Kapur, N., Graham, K. S. and Zeman, A. 2010. Remote memory deficits in transient epileptic amnesia [Abstract]. Journal of Neurology, Neurosurgery & Psychiatry 81(10), article number: E7. (10.1136/jnnp.2010.217554.15)
Milton, F., Muhlert, N., Pindus, D. M., Butler, C. R., Kapur, N., Graham, K. S. and Zeman, A. Z. J. 2010. Remote memory deficits in transient epileptic amnesia. Brain 133(5), pp. 1368-1379. (10.1093/brain/awq055)
Barense, M. D., Henson, R. N., Lee, A. C. and Graham, K. S. 2010. Medial temporal lobe activity during complex discrimination of faces, objects, and scenes: Effects of viewpoint. Hippocampus 20(3), pp. 389-401. (10.1002/hipo.20641)
Duarte, A., Graham, K. S. and Henson, R. N. 2010. Age-related changes in neural activity associated with familiarity, recollection and false recognition. Neurobiology of Aging 31(10), pp. 1814-1830. (10.1016/j.neurobiolaging.2008.09.014)
Barense, M. D., Rogers, T. T., Bussey, T. J., Saksida, L. M. and Graham, K. S. 2010. Influence of conceptual knowledge on visual object discrimination: insights from semantic dementia and MTL amnesia. Cerebral Cortex 20(11), pp. 2568-2582. (10.1093/cercor/bhq004)
Twigg, G. L. et al. 2010. Obstructive Sleep Apnea Syndrome Is Associated with Deficits in Verbal but Not Visual Memory. American Journal of Respiratory and Critical Care Medicine 182(1), pp. 98-103. (10.1164/rccm.200901-0065OC)
Graham, K. S., Barense, M. D. and Lee, A. C. H. 2010. Going beyond LTM in the MTL: A synthesis of neuropsychological and neuroimaging findings on the role of the medial temporal lobe in memory and perception. Neuropsychologia 48(4), pp. 831-853. (10.1016/j.neuropsychologia.2010.01.001)
Duarte, A., Henson, R. N., Knight, R. T., Emery, T. and Graham, K. S. 2010. Orbito-frontal cortex is necessary for temporal context memory. Journal of Cognitive Neuroscience 22(8), pp. 1819-1831. (10.1162/jocn.2009.21316)

2009

Butler, C. R. et al. 2009. Transient epileptic amnesia: regional brain atrophy and its relationship to memory deficits. Brain 132(2), pp. 357-368. (10.1093/brain/awn336)
Mundy, M. E., Honey, R. C., Downing, P. E., Wise, R. G., Graham, K. S. and Dwyer, D. M. 2009. Material-independent and material-specific activation in functional MRI after perceptual learning. NeuroReport 20(16), pp. 1397-1401. (10.1097/WNR.0b013e32832f81f4)
Hornberger, M., Bell, B., Graham, K. S. and Rogers, T. T. 2009. Are judgments of semantic relatedness systematically impaired in Alzheimer's disease?. Neuropsychologia 47(14), pp. 3084-3094. (10.1016/j.neuropsychologia.2009.07.006)
Davies, R. R., Scahill, V. L., Graham, A., Williams, G. B., Graham, K. S. and Hodges, J. R. 2009. Development of an MRI rating scale for multiple brain regions: comparison with volumetrics and with voxel-based morphometry. Neuroradiology 51(8), pp. 491-503. (10.1007/s00234-009-0521-z)
Dewar, B., Patterson, K., Wilson, B. A. and Graham, K. S. 2009. Re-acquisition of person knowledge in semantic memory disorders. Neuropsychological Rehabilitation 19(3), pp. 383-421. (10.1080/09602010802278152)

2008

Duarte, A., Henson, R. N. and Graham, K. S. 2008. The effects of aging on the neural correlates of subjective and objective recollection. Cerebral Cortex 18(9), pp. 2169-2180. (10.1093/cercor/bhm243)
Lee, A. C. H., Scahill, V. L. and Graham, K. S. 2008. Activating the medial temporal lobe during oddity judgment for faces and scenes. Cerebral Cortex 18(3), pp. 683-696. (10.1093/cercor/bhm104)
Graham, K. S., Lee, A. C. and Barense, M. D. 2008. Chapter 5.1 Memory and perceptual impairments in amnesia and dementia. In: Dere, E. et al. eds. Handbook of Episodic Memory. Handbook of Behavioral Neuroscience Vol. 18. Amsterdam: Elsevier, pp. 485-501, 631., (10.1016/S1569-7339(08)00226-9)
Ahmed, S., Arnold, R., Thompson, S. A., Graham, K. S. and Hodges, J. R. 2008. Naming of objects, faces and buildings in mild cognitive impairment. Cortex 44(6), pp. 746-752. (10.1016/j.cortex.2007.02.002)
Graham, K. S., Lee, A. C. H. and Barense, M. D. 2008. Invited Address at the Occasion of the Bertelson Award 2005 Impairments in visual discrimination in amnesia: Implications for theories of the role of medial temporal lobe regions in human memory. European Journal of Cognitive Psychology 20(4), pp. 655-696. (10.1080/09541440701554110)

2007

Butler, C. R., Graham, K. S., Hodges, J. R., Kapur, N., Wardlaw, J. M. and Zeman, A. Z. J. 2007. The syndrome of transient epileptic amnesia. Annals of Neurology 61(6), pp. 587-598. (10.1002/ana.21111)
Rogers, T. T., Patterson, K. and Graham, K. S. 2007. Colour knowledge in semantic dementia: It is not all black and white. Neuropsychologia 45(14), pp. 3285-3298. (10.1016/j.neuropsychologia.2007.06.020)
Barense, M. D., Gaffan, D. and Graham, K. S. 2007. The human medial temporal lobe processes online representations of complex objects. Neuropsychologia 45(13), pp. 2963-2974. (10.1016/j.neuropsychologia.2007.05.023)
Lee, A., Levi, N., Davies, R., Hodges, J. and Graham, K. S. 2007. Differing profiles of face and scene discrimination deficits in semantic dementia and Alzheimer's disease. Neuropsychologia 45(9), pp. 2135-2146. (10.1016/j.neuropsychologia.2007.01.010)
Taylor, K. J., Henson, R. N. A. and Graham, K. S. 2007. Recognition memory for faces and scenes in amnesia: Dissociable roles of medial temporal lobe structures. Neuropsychologia 45(11), pp. 2428-2438. (10.1016/j.neuropsychologia.2007.04.004)
Simons, J. S. and Graham, K. S. 2007. Amnesia. In: Fink, G. ed. Encyclopaedia of Stress (2nd ed.). San Diego: Academic Press, pp. 158-160.

2006

Lee, A. C. H., Bandelow, S., Schwarzbauer, C., Henson, R. N. A. and Graham, K. S. 2006. Perirhinal cortex activity during visual object discrimination: an event-related fMRI study. Neuroimage 33(1), pp. 362-373. (10.1016/j.neuroimage.2006.06.021)
Lee, A. C. H., Buckley, M. J., Gaffan, D., Emery, T., Hodges, J. R. and Graham, K. S. 2006. Differentiating the roles of the hippocampus and perirhinal cortex in processes beyond long-term declarative memory: a double dissociation in dementia. Journal of Neuroscience 26(19), pp. 5198-5203. (10.1523/JNEUROSCI.3157-05.2006)
Cumming, T. B., Patterson, K., Verfaellie, M. and Graham, K. S. 2006. One bird with two stones: Abnormal word length effects in pure alexia and semantic dementia. Cognitive Neuropsychology 23(8), pp. 1130-1161. (10.1080/02643290600674143)
Cumming, T. B., Graham, K. S. and Patterson, K. 2006. Repetition priming and hyperpriming in semantic dementia. Brain and Language 98(2), pp. 221-234. (10.1016/j.bandl.2006.05.002)
Graham, K. S., Scahill, V. L., Hornberger, M., Barense, M. D., Lee, A. C. H., Bussey, T. J. and Saksida, L. M. 2006. Abnormal categorization and perceptual learning in patients with hippocampal damage. Journal of Neuroscience 26(29), pp. 7547-7554. (10.1523/JNEUROSCI.1535-06.2006)
Ikeda, M., Patterson, K., Graham, K. S., Ralph, M. A. L. and Hodges, J. R. 2006. A horse of a different colour: Do patients with semantic dementia recognise different versions of the same object as the same?. Neuropsychologia 44(4), pp. 566-575. (10.1016/j.neuropsychologia.2005.07.006)

2005

Barense, M. D. et al. 2005. Functional specialization in the human medial temporal lobe. Journal of Neuroscience 25(44), pp. 10239-10246. (10.1523/JNEUROSCI.2704-05.2005)
Scahill, V. L., Hodges, J. R. and Graham, K. S. 2005. Can episodic memory tasks differentiate semantic dementia from Alzheimer's Disease?. Neurocase 11(6), pp. 441-451. (10.1080/13554790500287734)
Manes, F., Graham, K. S., Zeman, A., de Luján Calcagno, M. and Hodges, J. R. 2005. Autobiographical amnesia and accelerated forgetting in transient epileptic amnesia. Journal of Neurology, Neurosurgery & Psychiatry 76(10), pp. 1387-1391. (10.1136/jnnp.2004.036582)
Lee, A. C. H. et al. 2005. Specialization in the medial temporal lobe for processing of objects and scenes. Hippocampus 15(6), pp. 782-797. (10.1002/hipo.20101)
Murray, E., Graham, K. S. and Gaffan, D. 2005. Perirhinal cortex and its neighbours in the medial temporal lobe: contributions to memory and perception. Quarterly Journal of Experimental Psychology. B: Comparative and Physiological Psychology 58(3-4), pp. 378-396. (10.1080/02724990544000077)
Lee, A. C. H., Barense, M. and Graham, K. S. 2005. The contribution of the human medial temporal lobe to perception: bridging the gap between animal and human studies. Quarterly Journal of Experimental Psychology. B: Comparative and Physiological Psychology 58(3-4), pp. 300-325. (10.1080/02724990444000168)
Graham, K. S. and Gaffan, D. 2005. The role of the medial temporal lobe in memory and perception: evidence from rats, nonhuman primates and humans. Quarterly Journal of Experimental Psychology. B: Comparative and Physiological Psychology 58(3-4), pp. 193-201. (10.1080/02724990544000059)
Clague, F., Dudas, R. B., Thompson, S. A., Graham, K. S. and Hodges, J. R. 2005. Multidimensional measures of person knowledge and spatial associative learning: can these be applied to the differentiation of Alzheimer's disease from frontotemporal and vascular dementia?. Neuropsychologia 43(9), pp. 1338-1350. (10.1016/j.neuropsychologia.2004.11.023)
Dudas, R. B., Clague, F., Thompson, S. A., Graham, K. S. and Hodges, J. R. 2005. Episodic and semantic memory in mild cognitive impairment. Neuropsychologia 43(9), pp. 1266-1276. (10.1016/j.neuropsychologia.2004.12.005)
Simons, J. S. et al. 2005. Failing to Get the Gist: Reduced False Recognition of Semantic Associates in Semantic Dementia. Neuropsychology 19(3), pp. 353-361. (10.1037/0894-4105.19.3.353)
Graham, A. et al. 2005. Pathologically proven frontotemporal dementia presenting with severe amnesia. Brain 128(3), pp. 597-605. (10.1093/brain/awh348)
Lee, A. C. H. et al. 2005. Perceptual deficits in amnesia: challenging the medial temporal lobe 'mnemonic' view. Neuropsychologia 43(1), pp. 1-11. (10.1016/j.neuropsychologia.2004.07.017)

2004

Davies, R. R., Graham, K. S., Xuereb, J. H., Williams, G. B. and Hodges, J. R. 2004. The human perirhinal cortex and semantic memory. European Journal of Neuroscience 20(9), pp. 2441-2446. (10.1111/j.1460-9568.2004.03710.x)
Bernard, F. A., Bullmore, E. T., Graham, K. S., Thompson, S. A., Hodges, J. R. and Fletcher, P. C. 2004. The hippocampal region is involved in successful recognition of both remote and recent famous faces. NeuroImage 22(4), pp. 1704-1714. (10.1016/j.neuroimage.2004.03.036)
Thompson, S. A., Graham, K. S., Williams, G., Patterson, K., Kapur, N. and Hodges, J. R. 2004. Dissociating person-specific from general semantic knowledge: roles of the left and right temporal lobes. Neuropsychologia 42(3), pp. 359-370. (10.1016/j.neuropsychologia.2003.08.004)

2003

Price, C. J., Gorno-Tempini, M. L., Graham, K. S., Biggio, N., Mechelli, A., Patterson, K. and Noppeney, U. 2003. Normal and pathological reading: converging data from lesion and imaging studies. NeuroImage 20(S1), pp. S30-S41. (10.1016/j.neuroimage.2003.09.012)
Graham, K. S., Kropelnicki, A., Goldman, W. P. and Hodges, J. R. 2003. Two further investigations of autobiographical memory in semantic dementia. Cortex 39(4-5), pp. 729-750. (10.1016/S0010-9452(08)70861-X)
Lee, A. C. H., Rahman, S., Hodges, J. R., Sahakian, B. J. and Graham, K. S. 2003. Associative and recognition memory for novel objects in dementia: implications for diagnosis. European Journal of Neuroscience 18(6), pp. 1660-1670. (10.1046/j.1460-9568.2003.02883.x)
Evans, J. J., Graham, K. S., Pratt, K. H. and Hodges, J. R. 2003. The impact of disrupted cortico-cortico connectivity: A long term follow-up of a case of local retrograde amnesia. Cortex 39(4-5), pp. 767-790. (10.1016/S0010-9452(08)70863-3)
Epstein, R., Graham, K. S. and Downing, P. E. 2003. Viewpoint-specific scene representations in human parahippocampal cortex. Neuron 37(5), pp. 865-876. (10.1016/S0896-6273(03)00117-X)
Bozeat, S. et al. 2003. A duck with four legs: Investigating the structure of conceptual knowledge using picture drawing in semantic dementia. Cognitive Neuropsychology 20(1), pp. 27-47. (10.1080/02643290244000176)
Hovius, M., Kellenbach, M. L., Graham, K. S., Hodges, J. R. and Patterson, K. 2003. What does the object decision task measure? Reflections on the basis of evidence from semantic dementia. Neuropsychology 17(1), pp. 100-107. (10.1037/0894-4105.17.1.100)
Graham, K. S., Johnsrude, I. S. and Simons, J. S. 2003. Temporal lobe. In: Aminoff, M. J. and Daroff, R. B. eds. Encyclopedia of the Neurological Sciences., Vol. 4. San Diego, CA: Academic Press, pp. 486-495., (10.1016/B0-12-226870-9/00779-6)
Graham, K. S., Lee, A. C. H., Brett, M. and Patterson, K. 2003. The neural basis of autobiographical and semantic memory: New evidence from three PET studies. Cognitive, Affective, & Behavioral Neuroscience 3(3), pp. 234-254. (10.3758/CABN.3.3.234)

2002

Simons, J. S., Verfaellie, M., Galton, C. J., Miller, B. L., Hodges, J. R. and Graham, K. S. 2002. Recollection-based memory in frontotemporal dementia: Implications for theories of long-term memory. Brain: A Journal of Neurology 125(11), pp. 2523-2536. (10.1093/brain/awf247)
Lee, A. C. H., Graham, K. S., Simons, J. S., Hodges, J. R., Owen, A. M. and Patterson, K. 2002. Regional brain activations differ for semantic features but not categories. Neuroreport 13(12), pp. 1497-1501.
Simons, J. S., Graham, K. S. and Hodges, J. R. 2002. Perceptual and semantic contributions to episodic memory: evidence from semantic dementia and Alzheimer's disease. Journal of Memory and Language 47(2), pp. 197-213. (10.1016/S0749-596X(02)00003-7)
Lee, A. C. H., Robbins, T. W., Graham, K. S. and Owen, A. M. 2002. "Pray or prey?" Dissociation of semantic memory retrieval from episodic memory processes using positron emission tomography and a novel homophone task. NeuroImage 16(3A), pp. 724-735. (10.1006/nimg.2002.1101)
Thompson, S. A., Graham, K. S., Patterson, K., Sahakian, B. J. and Hodges, J. R. 2002. Is knowledge of famous people disproportionately impaired in patients with early and questionable Alzheimer's disease?. Neuropsychology 16(3), pp. 344-358. (10.1037/0894-4105.16.3.344)
Graham, K. S., Patterson, K., Powis, J., Drake, J. and Hodges, J. R. 2002. Multiple inputs to episodic memory: Words tell another story. Neuropsychology 16(3), pp. 380-389. (10.1037/0894-4105.16.3.380)
Nestor, P. J., Graham, K. S., Bozeat, S., Simons, J. S. and Hodges, J. R. 2002. Memory consolidation and the hippocampus: further evidence from studies of autobiographical memory in semantic dementia and frontal variant frontotemporal dementia. Neuropsychologia 40(6), pp. 633-654. (10.1016/S0028-3932(01)00155-5)
Kapur, N. and Graham, K. S. 2002. Recovery of memory function in neurological disease. In: Baddeley, A. D., Kopelman, M. D. and Wilson, B. A. eds. Handbook of Memory Disorders (2nd ed.). Chichester: Wiley-Blackwell, pp. 233-248.
Thomas, R. M., Forde, E. M., Humphreys, G. W. and Graham, K. S. 2002. A Longitudinal Study of Category-specific Agnosia. Neurocase 8(6), pp. 466-479. (10.1076/neur.8.5.466.16179)

2001

Hodges, J. R. and Graham, K. S. 2001. Episodic memory: insights from semantic dementia. Philosophical Transactions of the Royal Society of London, Series B - Biological Sciences 356(1413), pp. 1423-1434. (10.1098/rstb.2001.0943)
Graham, K. S., Patterson, K., Pratt, K. H. and Hodges, J. R. 2001. Can repeated exposure to "forgotten" vocabulary help alleviate word-finding difficulties in semantic dementia? An illustrative case study. Neuropsychological Rehabilitation 11(3-4), pp. 429-454. (10.1080/09602010042000060)
Simons, J. S., Graham, K. S., Owen, A. M., Patterson, K. and Hodges, J. R. 2001. Perceptual and semantic components of memory for objects and faces: A PET study. Journal of Cognitive Neuroscience 13(4), pp. 430-443. (10.1162/08989290152001862)
Murre, J. M. J., Graham, K. S. and Hodges, J. R. 2001. Semantic dementia: relevance to connectionist models of long-term memory. Brain 124(4), pp. 647-675. (10.1093/brain/124.4.647)
Manes, F., Hodges, J. R., Graham, K. S. and Zeman, A. 2001. Focal autobiographical amnesia in association with transient epileptic amnesia. Brain 124(3), pp. 499-509. (10.1093/brain/124.3.499)
Simons, J. S., Graham, K. S., Galton, C. J., Patterson, K. and Hodges, J. R. 2001. Semantic knowledge and episodic memory for faces in semantic dementia. Neuropsychology 15(1), pp. 101-114. (10.1037/0894-4105.15.1.101)
Galton, C. J. et al. 2001. Differing patterns of temporal atrophy in Alzheimer’s disease and semantic dementia. Neurology 57(2), pp. 216-225. (10.1212/WNL.57.2.216)

2000

Simons, J. S. and Graham, K. S. 2000. New learning in semantic dementia: Implications for cognitive and neuroanatomical models of long-term memory. Revue de Neuropsychologie 10(1), pp. 199-215.
Graham, K. S., Simons, J. S., Pratt, K. H., Patterson, K. and Hodges, J. R. 2000. Insights from semantic dementia on the relationship between episodic and semantic memory. Neuropsychologia 38(3), pp. 313-324. (10.1016/S0028-3932(99)00073-1)
Simons, J. S. and Graham, K. S. 2000. Amnesia. In: Fink, G. ed. Encyclopaedia of Stress., Vol. 1 A-D. San Diego, CA: Academic Press, pp. 176-177., (10.1016/B978-012373947-6.00030-1)

1999

Lambon-Ralph, M. A., Graham, K. S., Patterson, K. and Hodges, J. R. 1999. Is a picture worth a thousand words? Evidence from concept definitions by patients with semantic dementia. Brain and Language 70(3), pp. 309-335. (10.1006/brln.1999.2143)
Graham, K. S., Lambon-Ralph, M. A. and Hodges, J. R. 1999. A questionable semantics: The interaction between semantic knowledge and autobiographical experience in semantic dementia. Cognitive Neuropsychology 16(7), pp. 689-698. (10.1080/026432999380708)
Simons, J. S., Graham, K. S. and Hodges, J. R. 1999. What does semantic dementia reveal about the functional role of the perirhinal cortex?. Trends in Cognitive Sciences 3(7), pp. 248-249. (10.1016/S1364-6613(99)01334-0)
Graham, K. S., Patterson, K., Pratt, K. H. and Hodges, J. R. 1999. Relearning and subsequent forgetting of semantic category exemplars in a case of semantic dementia. Neuropsychology 13(3), pp. 359-380. (10.1037/0894-4105.13.3.359)
Graham, K. S. and Hodges, J. R. 1999. Episodic memory in semantic dementia: Implications for the roles played by the perirhinal and hippocampal memory systems in new learning [Letter]. Behavioral and Brain Sciences 22(3), pp. 452-453. (10.1017/S0140525X99292035)
Graham, K. S., Patterson, K. and Hodges, J. R. 1999. Episodic memory: new insights from the study of semantic dementia. Current Opinion in Neurobiology 9(2), pp. 245-250. (10.1016/S0959-4388(99)80035-X)
Graham, K. S. 1999. Semantic dementia: a challenge to the multiple-trace theory?. Trends in Cognitive Sciences 3(3), pp. 85-87. (10.1016/S1364-6613(99)01284-X)
Graham, K. S., Murre, J. M. J. and Hodges, J. R. 1999. Episodic memory in semantic dementia: A computational approach based on the TraceLink model. In: Reggia, J. A., Ruppin, E. and Glanzman, D. eds. Disorders of Brain, Behaviour and Cognition: The neurocomputational perspective. Progress in Brain Research Vol. 121. Amsterdam: Elsevier, pp. 47-65., (10.1016/S0079-6123(08)63066-6)

1998

Hodges, J. R. and Graham, K. S. 1998. A reversal of the temporal gradient for famous person knowledge in semantic dementia: implications for the neural organisation of long term memory. Neuropsychologia 36(8), pp. 803-825. (10.1016/S0028-3932(97)00126-7)
Graham, K. S., Pratt, K. H. and Hodges, J. R. 1998. A reverse temporal gradient for public events in a single case of semantic dementia. Neurocase 4(6), pp. 461-470. (10.1080/13554799808410639)
Ralph, M. A. L., Graham, K. S., Ellis, A. W. and Hodges, J. R. 1998. Naming in semantic dementia - what matters?. Neuropsychologia 36(8), pp. 775-784. (10.1016/S0028-3932(97)00169-3)
Graham, K. S., Patterson, K. and Hodges, J. R. 1998. Semantic dementia and pure anomia: Two varieties of progressive fluent aphasia. In: Visch-Brink, E. G. and Bastiaane, R. eds. Linguistic Levels in Aphasiology. Neurogenic Communication Disorders Series San Diego, CA: Singular Publishing Group, pp. 49-67.

1997

Graham, K. S. and Hodges, J. R. 1997. Differentiating the roles of the hippocampal complex and the neocortex in long-term memory storage: Evidence from the study of semantic dementia and Alzheimer's disease. Neuropsychology 11(1), pp. 77-89. (10.1037/0894-4105.11.1.77)
Graham, K. S., Lambon-Ralph, M. A. and Hodges, J. R. 1997. Determining the impact of autobiographical experience on "meaning": New insights from investigating sports-related vocabulary and knowledge in two cases with semantic dementia. Cognitive Neuropsychology 14(6), pp. 801-837. (10.1080/026432997381367)
Graham, K. S., Becker, J. T. and Hodges, J. R. 1997. On the relationship between knowledge and memory for pictures: Evidence from the study of patients with semantic dementia and Alzheimer's disease. Journal of the International Neuropsychological Society 30(6), pp. 534-544.
Graham, K. S., Becker, J. T., Patterson, K. and Hodges, J. R. 1997. Lost for words: A case of primary progressive aphasia?. In: Parkin, A. J. ed. Case studies in the neuropsychology of memory. Hove: Pychology Press, pp. 83-110.

1995

Graham, K., Patterson, K. and Hodges, J. R. 1995. Progressive pure anomia: Insufficient activation of phonology by meaning. Neurocase 1(1), pp. 25-38. (10.1080/13554799508402344)

I have taught Year 1 students on PS2020 (Language and Memory), Year 3 students on PS3208 (Memory Processes and Memory Disorders) and MSc Neuroimaging students on PST505 (Memory: Functions and Failures).

These lectures introduce students to disorders of memory, in particular amnesia, semantic dementia, semantic aphasia and encephalitis. They also cover advanced brain imaging techniques, such as functional neuroimaging (fMRI), diffusion MRI, transcranial magnetic stimulation (TMS) and magnetoencephalography (MEG).

By bringing together findings from different cognitive neuroscience methods, students acquire an in-depth and rich understanding of cognitive neuroscience as a discipline, and how these studies have informed our understanding of the neuroanatomical and functional architecture of human memory.

This teaching is additionally informed by work on the evolution of memory, specifically how human memory has been refined and developed over many millions of years, informed by the memory systems developed in our ancestors. Our book The Evolutionary Road to Human Memory, outlines this work in an easily accessible form, designed for students and the public who know less about neuroscience and brain anatomy.

Summary

I am interested in understanding how the brain has developed, over evolution, to support different forms of human memory, and how damage to those brain networks leads to memory disorders, such as dementia. With Dr Elisabeth Murray and Dr Steven Wise, I co-authored an award-winning book, The Evolution of Memory Systems, which outlines a novel account of how different representational (memory) systems emerged over evolution, and how these networks form the framework for our modern (human) memory.

Currently, my lab, which is run jointly with Professor Andrew Lawrence, is working on the following research projects:

Inter-individual differences in memory

Using state-of-the-art imaging techniques, we are interested in how variations in the structure and function of different brain systems can explain inter-individual variations in memory performance. We previously showed that microstructure of white matter tracts - the major motorways of the brain - is linked to memory performance, and are now interested in the relationship between white matter, brain function and behaviour. We are also studying how early in the lifespan these key inter-individual variations may emerge via studies in children.

Dissecting hippocampal subfield contributions to memory

With Dr Carl Hodgetts, funded by the BBSRC, we are using ultra-high field 7T MRI to investigate how different hippocampal subfields support distinct forms of human memory. This works focuses on the subiculum, which is thought to be a critical hub region for complex spatial and event memories, with our studies aiming to generate a macroscale neural-systems level understanding of how the subiculum contributes to healthy human memory and imagination.

Risk and resilience to dementia

Representational accounts of memory, such as that outlined in The Evolution of Memory Systems, provide an interesting and novel framework to understand memory disorders, in particular dementia. With Professor Andrew Lawrence and Dr Jiaxiang Zhang, we are currently testing whether young adults show functional and anatomical brain alterations that parallel later life deficits we have previously reported in individuals with Alzheimer's disease. We have also developed a new smart app which allows testing of cognitive performance on tasks sensitive to later life cognitive decline, and are currently using this to investigate the link between genetic risk, cognitive performance and age. This work is funded by the MRC.

Key Current Funding

2021-2024 - BBSRC: The subiculum: a key interface between scene representation and event memory? Lead PIs: Hodgetts & Lawrence. Co-PIs: Aggleton, Zhang, Graham £1.2M
2021-2023 - The Waterloo Foundation: How does hippocampal maturation support the development of human memory? PI: Graham. Co-PIs: Zhang, Lawrence, Hodgetts, Adlam and Langley £300K
2018-2023 - Royal Society: Inter-individual differences in representational systems underpinning human memory. Royal Society Wolfson Merit Award. £50K
2017-2021 - MRC: Characterising brain network differences during scene perception and memory in APOE-e4 carriers: multi-modal imaging in ALSPAC. Lead PIs: Graham & Lawrence. Co-PIs: Saksida, Jones, Wise, Filippini, Mackay, Kordas. £1.75M
2016-2021 - Wellcome Trust: Institutional Strategic Support Fund. PI: Graham. £3.5M (with £3.5M matched institutional funding).
2016-2021 - Wellcome Trust: Multi-scale and multi-modal assessment of coupling in the healthy and diseased brain. Lead PI: Jones, Co-PIs: Assaf, Chambers, Graham, Jezzard, Linden, Morris, Nutt, Sumner, Singh, Wise. £5.9M

I have successfully supervised over 25 PhD and clinical fellows all of whom successfully completed their PhD within four year, and passed with only minor corrections.

Students wishing to work in the group should be interested in human memory and / or aging, particularly in the context of testing hypotheses from representational accounts in which extended neural circuits support distinct aspects of human memory (e.g., Graham et al., 2010).

Skills in neuroimaging are likely to be required, as much of our research involves application of multi-modal imaging approaches to test predictions about the functionality of these neural circuits. Our translational research involves research with young and older individuals at increased genetic risk of poorer later life cognitive health, but also collaboration with researchers working on ageing and dementia in low-to-middle income countries (e.g., India). We are also starting to undertake work on memory development, which involves cognitive and brain imaging studies in children.

If you are interested in applying for a PhD, or for further information regarding potential postgraduate research projects, please contact me directly, or submit a formal application.

Current students

Rikki Lissaman (jointly with Dr Carl Hodgetts, Royal Holloway, University of London)
Aminette D'Souza (jointly with Professor Andrew Lawrence, Cardiff University)

Past projects

2014-2019: Matthew Jones (WIN ESRC Wales DTC PhD Studentship), School of Psychology, Cardiff University
2014-2017: Martina Stefani (School PhD Student), School of Psychology, Cardiff University
2013-2017: Rebecca Cavill (WIN ESRC Wales DTC PhD Studentship), School of Psychology Cardiff University (jointly with Andrew Lawrence)
2013-2016: Hannah Chandler (ESRC Wales DTC PhD Studentship), School of Psychology Cardiff University (jointly with Paul Downing, Bangor University).
2013-2016: Alison Costigan (Cardiff NMHRI PhD Student), School of Psychology Cardiff University (jointly with Julie Williams, Cardiff University)
2012-2015: Mark Postans (part BBSRC, part School funded), School of Psychology, Cardiff University.
2009-2013: Jonathan Shine (School funded), School of Psychology, Cardiff University.
2007-2010: Hilary Watson (MRC Studentship), School of Psychology, Cardiff University.
2005-2008: Karen Taylor (MRC Studentship), MRC Cognition and Brain Sciences Unit, Cambridge
2004-2007: Samrah Ahmed (Alzheimer’s Research Trust Fellow), MRC Cognition and Brain Sciences Unit, Cambridge
2002-2005: Morgan Barense (MRC Predoctoral Fellow), MRC Cognition and Brain Sciences Unit, Cambridge
2001-2005: Chris Butler (Clinical Research Fellow), University of Edinburgh, Edinburgh
2001-2005: Andrew Graham (Wellcome Clinical Research Fellow), MRC Cognition and Brain Sciences Unit, Cambridge
2001-2005: Fiona Clague (Alzheimer Research Trust Fellow), MRC Cognition and Brain Sciences Unit, Cambridge
2001-2004: Toby Cumming (Commonwealth Fellow), MRC Cognition and Brain Sciences Unit, Cambridge
2002-2003: Rhys Davies (MRC Clinical Research Fellow), Department of Neurology, Addenbrooke’s Hospital, Cambridge
2000-2003: Sian Thompson (MRC Clinical Research Fellow), Addenbrooke’s Hospital, Cambridge
1999-2003: Anna Kropelnicki (MRC Studentship), MRC Cognition and Brain Sciences Unit, Cambridge
1997-1998: Jon Simons (MRC Studentship), MRC Cognition and Brain Sciences Unit, Cambridge

Professor Kim Graham

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