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Dr Lin Ye

Dr Lin Ye

Lecturer

School of Medicine

Email:
yel@cardiff.ac.uk
Telephone:
+44 (0)29 2068 7861
Location:
UHW Main Building

My research interest is to investigate the cancer cells orientated cross-talks with the extracellular matrix (ECM) and stroma cells during the cancer development, progression and metastases. The first group of molecules of my interest is bone morphogenetic proteins and their signalling. BMPs play diverse and critical roles in a vicious cycle between cancer cells and the local environment in both primary and secondary tumours, and also contribute to the tumour-associated angiogenesis. Following my PhD study of bone morphogenetic proteins (BMP) and their signalling in prostate cancer, I continue to explore the mechanism(s) of bone metastasis from prostate cancer and breast cancer, seek and develop therapeutic approach particularly by targeting BMPs signalling.

The second group of molecules which we focus are anthrax toxin receptor 1 (ANTXR1, also known as tumour endothelial marker 8, TEM-8) and anthrax toxin receptor 2 (ANTXR2, also known as capillary morphogenesis gene 2, CMG2). These two molecules are initially identified as markers or genes for the angiogenesis. Our recent studies have shown that aberrant expression and function of these two molecules in the disease progression of breast cancer and prostate cancer. As these two transmembrane proteins play an important role mediating adhesion and migration of cancer cells upon ECM, and also orchestrating the consequent interactions between cancer cells and micro-environment to enable tumour growth and dissemination.

Selected publications:

Bone morphogenetic protein-10 (BMP-10) inhibits aggressiveness of breast cancer cells and correlates with poor prognosis in breast cancer. Ye L, Bokobza S, Li J, Moazzam M, Chen J, Mansel RE, Jiang WG, Cancer Sci, 2010, 101:2137-2144

Bone morphogenetic protein-10 suppresses the growth and aggressiveness of prostate cancer cells through a Smad independent pathway. Ye L, Kynaston H, Jiang WG, J Urol, 2009, 181:2749-2759

Bone morphogenetic protein-9 induces apoptosis in prostate cancer cells, the role of prostate apoptosis response-4. Ye L, Kynaston H, Jiang WG, Mol Cancer Res, 2008, 6:1594-1606

Endogenous bone morphogenetic protein-7 controls the motility of prostate cancer cells through regulation of bone morphogenetic protein antagonists. Ye L, Lewis-Russell JM, Kynaston H, Jiang WG, J Urol, 2007, 178:1086-1091

Hepatocyte growth factor up-regulates the expression of the bone morphogenetic protein (BMP) receptors, BMPR-IB and BMPR-II, in human prostate cancer cells. Ye L, Lewis-Russell JM, Davies G, Sanders AJ, Kynaston H, Jiang WG, Int J Oncol, 2007, 30:521-529

Capillary morphogenesis gene 2 inhibits growth of breast cancer cells and is inversely correlated with the disease progression and prognosis. Ye L, Sun PH, Malik MF, Mason MD, Jiang WG. J Cancer Res Clin Oncol. 2014, 140:957-67.

Capillary morphogenesis gene 2 regulates adhesion and invasiveness of prostate cancer cells. Ye L, Sanders AJ, Sun PH, Mason MD, Jiang WG. Oncol Lett. 2014, 7(6):2149-2153.

Education and qualifications

  • 2004-2007: PhD, Cancer Biology, Metastasis and Angiogenesis Research Group, Department of Surgery, Cardiff University School of Medicine, Cardiff, UK
  • 1993-1996: MSc, Master of Surgery, house officer at University Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China
  • 1985-1993: MB and BCh, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China

Career overview

  • 2013-present: Lecturer of Cancer Biology and Oncology, Cardiff China Medical Research Collaborative, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK
  • 2007-2013: Posdoctoral Research Associate, Metastasis and Angiogenesis Research Group, Department of Surgery, Cardiff University School of Medicine, Cardiff, UK
  • 1996-2004: Lecturer of Surgery and Registrar, Department of Surgery, University Hospital of Shandong University of TCM, Jinan, Shandong, China

Honours and awards

Merit Award from ASCO (American Society of Clinical Oncology) Prostate Symposium 2006, San Francisco, for the presentation entitled as ‘Expression of BMP7 is regulated by hepatocyte growth factor’.

Outstanding Research Award in 2002, from the State Department of Education, Shandong province, China, for the research project entitled as ‘Therapeutic Mechanisms of Regulating Vital Energy and Dispersing the Accumulation of Evils in Thyroid Benign Nodes Using Herbs’.

Annual Teaching Award in 2001, from the University Hospital, Shandong University of Traditional Chinese Medicine.

Award for Scientific Research in 1999, from the State Government, Shandong province, China, for the research project entitled as ‘Promoting Circulation Using Herbs, and the Application in Heart Attack’.

Professional memberships

Member of the British Association of Cancer Research (BACR)

Member of the European Association of Cancer Research (EACR)

Fellow of the Higher Education Academy, UK

Academic positions

  • 2013-present: Lecturer of Cancer Biology and Oncology, Cardiff China Medical Research Collaborative, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK
  • 2007-2013: Posdoctoral Research Associate, Metastasis and Angiogenesis Research Group, Department of Surgery, Cardiff University School of Medicine, Cardiff, UK
  • 1996-2004: Lecturer of Surgery and Registrar, Department of Surgery, University Hospital of Shandong University of TCM, Jinan, Shandong, China

Speaking engagements

April 2017, IGCC&CUKC 2017, Beijing, China

December 2016, Invited speech, Capital Medical University, Beijing, China

December 2016, Invited speech, Beijing Cancer Hospital and Institute of Oncology of Peking University, Beijing, China

April 2016, CUCK2016 and IGCC2016, Beijing, China

September 2015, ECCO 2015, Vienna, Austria

July 2015, CUCK Cardiff 2015.

November 2014, Pancreatic Cancer Aware Day, Pancreatic Cancer UK and Wales Assembly.

February 2010, Cancer Research Wales, open day.

February 2009, Cancer Research Wales, open day.

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