Professor Simon Jones

Professor Simon Jones

Dean of Research; Research Theme Lead - Infection, Inflammation & Immunity

School of Medicine

Email:
jonessa@cardiff.ac.uk
Telephone:
+44 (0)29 2068 7325
Location:
Tenovus Institute
Media commentator

I am the Dean of Research for The School of Medicine, and the Research Theme Lead for Infection, Immunology and Inflammation for the College of Biomedical and Life Sciences. As Professor of Inflammation Biology I have an international reputation in the field of cytokine biology. My research considers the mode-of-action of anti-cytokine therapies, the identification of cytokine signatures that reflect patient outcome, and the development of novel cytokine-directed therapies. With a focus on cytokines that signal through the Jak-STAT pathway my research examines how cytokine networks deliver protective immunity and the transition to pathology and chronic disease progression. I am particularly recognised for studies of IL-6, and sit on various pharmaceutical company advisory boards relating to the clinical development of IL-6 targeted therapies. 

Education:

  • Oct 1990- Dec 1993 Ph.D. (Biochemistry) Supervisors: Professor O.T.G. Jones (Department of Biochemistry, University of Bristol, Bristol, UK) and Dr N. Topley (Institute of Renal Medicine, University of Wales, College of Medicine, Cardiff, UK)
  • Oct 1986- Jun 1990 B.Sc. Applied Biological Sciences (2.i Hons.) Bristol Poytechnic, Bristol, UK

Career Overview:

  • 2017: Dean of Research, The School of Medicine, Cardiff University
  • 2015: Theme Lead for Infection, Immunology & Inflammation, The College of Biomedical & Life Sciences, Cardiff University
  • 2012 - 2017: Associate Director of Research, Division of Infection & Immunity, The School of Medicine, Cardiff University
  • 2008 ‑ Professor of Inflammation Biology, School of Medicine, Cardiff University
  • 2005 - 2008 Reader, School of Medicine, Cardiff University
  • 2004 ‑ Dec 2004 Reader, Cardiff School of Biosciences, Cardiff University
  • 2003 - 2004 Senior Lecturer, Cardiff School of Biosciences, Cardiff University
  • 1999 - 2003 Lecturer, Cardiff School of Biosciences, Cardiff University
  • 1996 -1998 American Heart Association Fellow, Department of Cell Biology, University of Alabama at Birmingham, Alabama, USA (Director: Professor G.M. Fuller).
  • 1994 - 1996 Swiss Foundation Research Fellow, Theodor Kocher Institute, University of Bern, Switzerland (Director: Professor M. Baggiolini).

Honours and awards

Conference invitations:

  • British Society for Rheumatology (Apr ’17) – Invited speaker, Melbourne, Australia
  • International Congress of Immunology (Aug ’16) – Invited speaker, Melbourne, Australia
  • Keystone Conference- Cytokine Jak-STAT signalling in immunity & disease (Jan ’16) – Invited speaker, Colorado, USA
  • 12th European peritoneal dialysis meeting (Oct ’15) – Invited speaker, Krakow, Poland
  • 14th Scleroderma Research Workshop (Aug ’15) – Invited speaker, Cambridge, UK
  • International Cytokine & Interferon Society (Oct ‘14)- Invited plenary speaker, Melbourne, Australia
  • British Society for Rheumatology (April ‘14)- Invited plenary speaker, Liverpool, UK
  • American College of Rheumatology (Oct ‘13)- Keynote plenary speaker, San Diego, USA
  • Keystone Conference- Biology of Cytokines & Th17 Cells in Health & Disease (Feb ’12), Colorado, USA
  • European League against rheumatism: Roche sponsored satellite meeting (Jun ’12)- Berlin, Germany.
  • American College of Rheumatology: Roche sponsored satellite meeting (Nov ’11)- Chicago, USA
  • University of Pennsylvania, USA, Department of Veterinary Pathology – Invited Speaker (Oct ’11)
  • University of Alabama at Birmingham, USA, Department of Pathology – Invited Speaker (Oct ’11)
  • German Society for Biochemistry & Molecular Biology (Oct ’07) - Plenary speaker, Hamburg, Germany
  • Australian Society for Medical Research (Sept ’06)- Invited plenary speaker, Melbourne, Australia

Organisation of International Scientific Conferences:

  • International Cytokine & Interferon Society Conference (Oct ‘14)- International Organising Committee, Melbourne, Australia
  • Biochemical Society- Member of Them Panel-V (2008-12)- Evaluation and planning of scientific conference proposals in Signal transduction.

Scientific Awards:  

  • The 2004 Bolzmann Award -  The award is presented by the International Cytokine Society (ICS) and the International Society for Interferon and Cytokine Research (ISICR) to a pair of scientists who are considered to have made an important contribution to cytokine biology. Awarded jointly with Professor Stefan Rose-John (Christian Albrecht Universität zu Kiel, Germany)
  • Fellow of The Royal Society of Biology (June 2015)
  • Health & Care Research Wales- Faculty Research Lead

Professional memberships

Grant panel membership

  • Royal Irish Academy Early Entry Grant Panel- 2008
  • Arthritis Research UK Disease Research Committee 2016 - to present (Deputy Chair)
  • Arthritis Research UK Research Sub-Committee- 2011- 2016 (Deputy Chair; 2015- 2016)
  • Arthritis Research UK Programme Grant Outline Committee- 2015 - 2016
  • Arthritis Research UK USER Committee (Lay persons panel)- 2015 - 2016
  • Health & Care Research Wales- Health Grants Committee Member- Oct 2012 (onwards)
  • Health & Care Research Wales- Research for patient and public benefit Wales Panel (Deputy Chair)- Jan 2013 (onwards)
  • Health & Care Research Wales- Health Fellowships Committee Member- June 2014 (onwards)
  • Sêr Cymru II – College of Experts for the Independent Evaluation Panel- 2015 -2018
  • Medical Research Charities Group (MRCG)/Health Research Board, Ireland – Joint Select funding Committee (2016)
  • Welsh Higher Education Brussels (WHEB) Board

Editorial board membership

  • Journal of Biological Chemistry (Editorial Board Member – Immunology)
  • Frontiers in Immunology (Pro-inflammatory Cytokines)
  • The Open Rheumatology Journal (Bentham Science Publishers)

Research advisory board:

  • Welsh Higher Education Brussels (WHEB) Board
  • Roche- Panel Member for Actemra Translational Research Board
  • Genentech
  • Glaxo-Smith-Kline
  • Eleven Biotherapeutics
  • Janssen (Johnson & Johnson)
  • Chugai Pharmaceuticals
  • NovImmune AG
  • Ferring Pharmaceuticals
  • Regeneron/Sanofi

Society memberships

  • The Biochemical Society (Theme Panel Member; 2008-2013)
  • International Cytokine and Interferon Society
  • The Royal Society of Biology

Academic positions

  • Jun 2012-May 2015 Associate Director of Research for Infection & Immunity Institute for Infection & Immunity, The School of Medicine
  • Jan 2005‑ Jul 2008 Reader School of Medicine, Cardiff University, UK
  • Jan 2004‑ Dec 2004 Reader Cardiff School of Biosciences, Cardiff University, UK
  • Sept 2003- Jan 2004 Senior Lecturer Cardiff School of Biosciences, Cardiff University, UK
  • Jan 1999- Sept 2003 Lecturer Cardiff School of Biosciences, Cardiff University, UK
  • Jul 1996- Dec 1998 American Heart Association Research Fellow Dept. of Cell Biology, University of Alabama at Birmingham
  • Jan 1994- Jun 1996 Swiss Foundation Research Fellow Theodor Kocher Institute, University of Bern, Switzerland

Speaking engagements

  • British Society for Rheumatology (Apr ’17) – Invited speaker, Melbourne, Australia
  • International Congress of Immunology (Aug ’16) – Invited speaker, Melbourne, Australia
  • Keystone Conference- Cytokine Jak-STAT signalling in immunity & disease (Jan ’16) – Invited speaker, Colorado, USA
  • 12th European peritoneal dialysis meeting (Oct ’15) – Invited speaker, Krakow, Poland
  • 14th Scleroderma Research Workshop (Aug ’15) – Invited speaker, Cambridge, UK
  • International Cytokine & Interferon Society (Oct ‘14)- Invited plenary speaker, Melbourne, Australia
  • British Society for Rheumatology (April ‘14)- Invited plenary speaker, Liverpool, UK
  • American College of Rheumatology (Oct ‘13)- Keynote plenary speaker, San Diego, USA
  • Keystone Conference- Biology of Cytokines & Th17 Cells in Health & Disease (Feb ’12), Colorado, USA
  • European League against rheumatism: Roche sponsored satellite meeting (Jun ’12)- Berlin, Germany.
  • American College of Rheumatology: Roche sponsored satellite meeting (Nov ’11)- Chicago, USA
  • University of Pennsylvania, USA, Department of Veterinary Pathology – Invited Speaker (Oct ’11)
  • University of Alabama at Birmingham, USA, Department of Pathology – Invited Speaker (Oct ’11)
  • German Society for Biochemistry & Molecular Biology (Oct ’07) - Plenary speaker, Hamburg, Germany
  • Australian Society for Medical Research (Sept ’06)- Invited plenary speaker, Melbourne, Australia

Committees and reviewing

Current management and leadership responsibilities-

  • Dean of Research for The School of Medicine - since May 2017
  • School Board Committee - since May 2017
  • School of Medicine, Executive Committee - since May 2017
  • Chair of The REF Planning Committee, The School of Medicine - since July 2017
  • Theme Lead for Infection, Immunity & Inflammation, College of Biomedical & Life Sciences (CBLS) - since 2015
  • College Research Board Member, CBLS - since 2015
  • Wellcome Trust ISSF Board member
  • Lead for Equipment & Infrastructure in CBLS - Since 2016
  • Research Management Group Committee, School of Medicine - Since 2013
  • Division of Infection & Immunity Steering Committee - 2010-2017
  • Research Lead for Inflammation Research, Division of Infection & Immunity, The School of Medicine - 2012-2017
  • Systems Immunity URI Executive Committee- Since 2015
  • Research Lead for Inflammation Research, Systems Immunity URI - 2015-2017
  • Member of the College of Experts Peer Review Panel - Since 2012
  • Internal Review Panel member for Wellcome Trust ISSF Awards (Chair of Mobility Award Panel, Equipment Assessment Panel member)
  • Review panel member of the COFUND/Ser Cymru, and Capital Medical University (China) Fellowship Schemes
  • Executive Committee for the Cardiff Regional Experimental Arthritis Treatment Centre (Basic Science Lead) - Since 2013
  • Governance Committee for Human Tissue Bank (Kidney) - Since 2014
  • Management Committee, Arthritis Research UK Centre of Excellence - Since 2015
  • Scientific Misconduct Review – member of a panel that conducted an internal allegations review process (2016).
  • Member of the Hodge Foundation Executive Committee – linking immunology & Neuroscience

Areas of expertise