
Dr John Ingram
Clinical Senior Lecturer
- Email:
- ingramjr@cardiff.ac.uk (academic use only, please telephone for patient-related queries).
- Telephone:
- +44 (0)29 2074 2190
- Location:
- Glamorgan House
Improving the care of people with hidradenitis suppurativa is my principal research and clinical focus within dermatology. Hidradenitis suppurativa (HS) is a neglected, painful chronic inflammatory skin disease, characterised by recurrent skin boils in flexural sites, producing a large impact on quality of life and affecting about 1% of the adult European population.
I run one of the few dedicated HS clinics in the UK and champion a multi-disciplinary team approach to HS care. My aim is to conduct HS clinical trials to improve patient outcomes, with the support of the UK Dermatology Clinical Trials Network and other collaborative groups. As part of laying the foundations for HS trials, I led the Cochrane review of Interventions for HS and chaired a HS Priority Setting Partnership with support from the James Lind Alliance.
My research to investigate HS epidemiology, impact and outcome measures is supported by a five year Health Fellowship from Health and Care Research Wales. I am also leading the British Association of Dermatologists guideline development group for HS.
In terms of international roles, I am Deputy Editor of the British Journal of Dermatology, a leading dermatology journal.
Education & Qualifications
FRCP(Derm) | Medicine | Royal College of Physicians | 2017 |
FAcadMedEd | Medical Education | Academy of Medical Educators | 2014 |
MSc | Medical Education | Cardiff University | 2012 |
Certificate of Completion of Training | Dermatology | General Medical Council | 2011 |
DM (Oxon) | Medicine | Oxford University | 2008 |
MA | Physiological Science | Oxford University | 2004 |
MRCP (UK) | Medicine | Royal College of Physicians | 2002 |
BM BCh | Medicine | Oxford University | 1999 |
BA | Physiological Science | Oxford University | 1996 |
Career Overview
My present appointment is Senior Clinical Lecturer, Cardiff University & Honorary Consultant Dermatologist, Cardiff & Vale University Health Board (2013 - present).
Previously I trained in dermatology on the South Wales Training Rotation and worked for 12 months in dermatology and general medicine in Australia. I performed my DM doctoral studies in Cardiff after completing my SHO medical rotation in South Wales and undertook all of my undergraduate medical training at Oxford University.
Professional memberships
Grant Advisory Committees
- Member of Health and Care Research Wales Research for Patient and Public Benefit Funding Board
- Member of British Skin Foundation Large Grant Advisory Committee
- External peer reviewer for Psoriasis Association annual research grant awards
Examination Boards
- Royal College of Physicians (RCP) Dermatology Specialty Certificate Examination Board member
UK Advisory Roles
- British Association of Dermatologists (BAD) representative for NICE STA of adalimumab for hidradenitis suppurativa
- NICE Evidence Resources Reference Panel member - dual RCP & BAD representative
- Medical Adviser for Hidradenitis Suppurativa Trust, the main HS charity in the UK
-
UK Department of Work & Pensions Adviser regarding HS disability
UK Dermatology Clinical Trials Network (UK DCTN)
- Steering Committee member
All Wales Roles
- Health and Care Research Wales Dermatology Lead
Speaking engagements
2018
- UK Dermatology Clinical Trials Network Evidence Based Update meeting. “HS Guidelines from the BAD.” Nottingham, UK.
- Symposium on Hidradenitis Suppurativa Advances. “UK guidelines for HS Management.” Toronto.
2017
- SID Annual Meeting Residents Retreat. Invited speaker: “Publishing a manuscript.” Portland, Oregon.
- British Association of Dermatologists Annual Meeting. Invited speaker and session chair. “Biologic Interventions for Hidradenitis Suppurativa.” Liverpool, UK 2017.
2018
- Thorlacius, L.et al. 2018. A core domain set for hidradenitis suppurativa trial outcomes: an international Delphi process. British Journal of Dermatology 179(3), pp. 642-650. (10.1111/bjd.16672)
- Garcia-Doval, I.et al. 2018. Optimizing case reports and case series: guidance on how to improve quality. British Journal of Dermatology 178(6), pp. 1257-1262. (10.1111/bjd.16467)
- Wernham, A., Ingram, J. R. and Matin, R. 2018. Clinician surveys: time to make better use of this valuable resource for dermatologists. British Journal of Dermatology 178(6), pp. 1466-1467. (10.1111/bjd.16444)
- Ingram, J. R. 2018. Atopic eczema and cardiovascular disease. BMJ 361, article number: k2064. (10.1136/bmj.k2064)
- Ingram, J. R.et al. 2018. Population-based Clinical Practice Research Datalink study using algorithm modelling to identify the true burden of hidradenitis suppurativa. British Journal of Dermatology 178(4), pp. 917-924. (10.1111/bjd.16101)
- George, S. and Ingram, J. 2018. BJD support for dermatology journal clubs: nurturing Sir William Osler's legacy. British Journal of Dermatology 178(2), pp. 313-314. (10.1111/bjd.16164)
- Ingram, J.et al. 2018. Levels of wound calprotectin and other inflammatory biomarkers aid in deciding which patients with a diabetic foot ulcer need antibiotic therapy (INDUCE study). Diabetic Medicine 35(2), pp. 255-261. (10.1111/dme.13431)
2017
- Sbidian, E.et al. 2017. Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis. Cochrane Database of Systematic Reviews(12), article number: CD011535. (10.1002/14651858.CD011535.pub2)
- Zouboulis, C. C.et al. 2017. Development and validation of IHS4, a novel dynamic scoring system to assess hidradenitis suppurativa/acne inversa severity. British Journal of Dermatology 177(5), pp. 1401-1409. (10.1111/bjd.15748)
- Garcia-Doval, I.et al. 2017. Systematic reviews: let's keep them trustworthy. British Journal of Dermatology 177(4), pp. 888-889. (10.1111/bjd.15826)
- Callander, J.et al. 2017. How to write a Critically Appraised Topic: evidence to underpin routine clinical practice. British Journal of Dermatology 177(4), pp. 1007-1013. (10.1111/bjd.15873)
- Atwan, A.et al. 2017. Dermatology life quality index (DLQI) as a psoriasis referral triage tool. British Journal of Dermatology 177(4), pp. e136-e137. (10.1111/bjd.15446)
- Tang, H. K. C.et al. 2017. Delayed and localized pemphigus vulgaris after breast cancer radiotherapy. The Breast Journal 23(6), pp. 747-749. (10.1111/tbj.12910)
- Ingram, J. R. 2017. Interventions for hidradenitis suppurativa. JAMA Dermatology 153(5), pp. 458-459. (10.1001/jamadermatol.2017.0432)
- Williams, H. C.et al. 2017. Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic, non-inferiority, randomised controlled trial. The Lancet 389(10079), pp. 1630-1638. (10.1016/S0140-6736(17)30560-3)
- Ingram, J. R. and Burton, T. 2017. NICE approval of adalimumab for moderate-to-severe hidradenitis suppurativa: the end of the beginning for hidradenitis suppurativa therapeutics?. British Journal of Dermatology 176(2), pp. 281-282. (10.1111/bjd.15255)
- Thorlacius, L.et al. 2017. Protocol for the development of a core domain set for hidradenitis suppurativa trial outcomes. BMJ Open 7(2), article number: e014733. (10.1136/bmjopen-2016-014733)
- Tappenden, P.et al. 2017. Adalimumab for treating moderate-to-severe hidradenitis suppurativa: an evidence review group perspective of a NICE single technology appraisal. PharmacoEconomics 35(8), pp. 805-815. (10.1007/s40273-017-0488-2)
- Ingram, J. R. and Anstey, A. 2017. The evolution of clinical guidelines for dermatologists: GRADE, AGREE and occasionally consensus by experts. British Journal of Dermatology 176(1), pp. 3-4. (10.1111/bjd.15178)
- Mukkanna, K. S., Stone, N. M. and Ingram, J. R. 2017. Para-phenylenediamine allergy: current perspectives on diagnosis and management. Journal of Asthma and Allergy 10, pp. 9-15. (10.2147/JAA.S90265)
2016
- Thomas, K. S.et al. 2016. Clinical outcomes and response of patients applying topical therapy for pyoderma gangrenosum: a prospective cohort study. Journal of the American Academy of Dermatology 75(5), pp. 940-949. (10.1016/j.jaad.2016.06.016)
- Callander, J.et al. 2016. Treatment of clinically amyopathic dermatomyositis in adults: a systematic review. British Journal of Dermatology (10.1111/bjd.14726)
- Ingram, J. R.et al. 2016. Interventions for hidradenitis suppurativa: a Cochrane systematic review incorporating GRADE assessment of evidence quality. British Journal of Dermatology 174(5), pp. 970-978. (10.1111/bjd.14418)
- Atwan, A.et al. 2016. Oral fumaric acid esters for psoriasis: abridged Cochrane systematic review including GRADE assessments. British Journal of Dermatology 175(5), pp. 873-881. (10.1111/bjd.14676)
- Ingram, J. R., Hadjieconomou, S. and Piguet, V. 2016. Development of core outcome sets in hidradenitis suppurativa:a systematic review of outcome measure instruments to inform the process. British Journal of Dermatology 175(2), pp. 263-272. (10.1111/bjd.14475)
- Ingram, J. R. 2016. The genetics of Hidradenitis Suppurativa. Dermatologic Clinics 34(1), pp. 23-28. (10.1016/j.det.2015.07.002)
- Daxhelet, M.et al. 2016. Establishment of a European Registry for hidradenitis suppurativa/acne inversa by using an open source software. Journal of the European Academy of Dermatology and Venereology 30(8), pp. 1424-1426. (10.1111/jdv.13267)
- Ingram, J. R. 2016. Hidradenitis suppurativa: an update. Clinical Medicine 16(1), pp. 70-73. (10.7861/clinmedicine.16-1-70)
2015
- Ingram, J. R.et al. 2015. Interventions for hidradenitis suppurativa. Cochrane Database of Systematic Reviews(10), article number: CD010081. (10.1002/14651858.CD010081.pub2)
- Ingram, J. R. and Paul, C. 2015. Academic mentorship in dermatology. British Journal of Dermatology 173(5), pp. 1113-1114. (10.1111/bjd.14197)
- Ingram, J. R. and McPhee, M. 2015. Management of hidradenitis suppurativa: a UK survey of current practice. British Journal of Dermatology 173(4), pp. 1070-1072. (10.1111/bjd.13866)
- George, S. and Ingram, J. R. 2015. Introducing cover image as a new category of publication in the BJD. British Journal of Dermatology 173(2), pp. 315-315. (10.1111/bjd.13964)
- Chalmers, J. R.et al. 2015. A randomized controlled trial to compare the safety and effectiveness of doxycycline (200 mg daily) with oral prednisolone (0·5 mg kg-1 daily) for initial treatment of bullous pemphigoid: a protocol for the Bullous Pemphigoid Steroids and Tetracyclines (BLISTER) trial. British Journal of Dermatology 173(1), pp. 227-234. (10.1111/bjd.13729)
- Ormerod, A. D.et al. 2015. Comparison of the two most commonly used treatments for pyoderma gangrenosum: results of the STOP GAP randomised controlled trial. BMJ 350(jun12), article number: h2958. (10.1136/bmj.h2958)
- Nankervis, H.et al. 2015. Validation of the global resource of eczema trials (GREAT database). BMC Dermatology 15(4), pp. 1-7. (10.1186/s12895-015-0024-z)
- Atwan, A.et al. 2015. Oral fumaric acid esters for psoriasis. Cochrane Database of Systematic Reviews(8), article number: CD010497. (10.1002/14651858.CD010497.pub2)
2014
- Ingram, J. R.et al. 2014. The Hidradenitis Suppurativa Priority Setting Partnership. British Journal of Dermatology 171(6), pp. 1422-1427. (10.1111/bjd.13163)
- Ingram, J. 2014. Hidradenitis suppurativa outcome measures and treatment goals. British Journal of Dermatology 171(6), pp. 1293-1294. (10.1111/bjd.13396)
- Ingram, J. 2014. The quest for excellence (part 2): reviewing a clinical trial for the British Journal of Dermatology. British Journal of Dermatology 171(6), pp. 1277-1278. (10.1111/bjd.13445)
- Warburton, K. L.et al. 2014. Management of morphoea: results of a national survey of U.K. clinicians. British Journal of Dermatology 171(5), pp. 1243-1245. (10.1111/bjd.13062)
- Warburton, K. L.et al. 2014. Management of morphoea: results of a national survey of UK clinicians. British Journal of Dermatology 171(5), pp. 1243-1245.
- Ingram, J. 2014. The quest for excellence (part 1): becoming a reviewer for the British Journal of Dermatology. British Journal of Dermatology 171(5), pp. 921-922. (10.1111/bjd.13404)
- Ingram, J. R.et al. 2014. A Cochrane Systematic Review of interventions for Hidradenitis Suppurativa. Journal of Investigative Dermatology 134, pp. S40-S40.
- Chin, M. F.et al. 2014. Patient-reported outcome measure of pain experienced during administration of local anaesthesia in cutaneous surgery: a tool for appraisal [Abstract]. British Journal of Dermatology 171, pp. 80-80.
- Ingram, J. R., Hughes, T. M. and Stone, N. M. 2014. Potential danger of hair dyes marketed as free from para-phenylenediamine. International Journal of Dermatology 53(4), pp. e257-e258. (10.1111/ijd.12296)
2013
- Ingram, J. R. 2013. Interpreting outcome measures and defining treatment success. British Journal of Dermatology 169(6), pp. 1177-1178. (10.1111/bjd.12709)
- Ponnambath, N.et al. 2013. Practical experience of biological treatment of very severe psoriasis: a retrospective case-cohort study of patients with a baseline Psoriasis Area and Severity Index score greater than 20 [Abstract]. British Journal of Dermatology 169(s1), pp. 41-41. (10.1111/bjd.12306)
- Matin, R. N.et al. 2013. The UK Dermatology Clinical Trials Network Trainee Group: developing evidence-based practice and research engagement among dermatology trainees. British Journal of Dermatology 169, pp. 35-35.
- Ingram, J. R.et al. 2013. Segmental cherry angiomas associated with extragenital lichen sclerosus: a report of two cases. Clinical and Experimental Dermatology 38(4), pp. 386-389. (10.1111/j.1365-2230.2012.04479.x)
- Ingram, J. R. and Piguet, V. 2013. Phenotypic heterogeneity in Hidradenitis Suppurativa (Acne Inversa): classification is an essential step toward personalized therapy. Journal of Investigative Dermatology 133(6), pp. 1453-1456. (10.1038/jid.2012.476)
- Burr, M. L.et al. 2013. The natural history of eczema from birth to adult life: a cohort study. British Journal of Dermatology 168(6), pp. 1339-1342. (10.1111/bjd.12216)
- Ingram, J. R., Anderson, E. J. and Pugsley, L. 2013. Difficulty giving feedback on underperformance undermines the educational value of multi-source feedback. Medical Teacher 35(10), pp. 838-846. (10.3109/0142159X.2013.804910)
- Ingram, J. R.et al. 2013. Absence of pathogenic gamma-secretase mutations in a South Wales cohort of familial and sporadic hidradenitis suppurativa (acne inversa). British Journal of Dermatology 168(4), pp. 874-876. (10.1111/bjd.12048)
- Ingram, J. R.et al. 2013. Absence of pathogenic γ-secretase mutations in a South Wales cohort of familial and sporadic hidradenitis suppurativa (acne inversa). British Journal Of Dermatology 168(4), pp. 874-876. (10.1111/bjd.12048)
2012
- Ingram, J. R., Anstey, A. V. and Piguet, V. 2012. Combination treatment with a tumour necrosis factor antagonist and an oral retinoid: efficacy in severe acral psoriasis? [Letter]. British Journal Of Dermatology 167(4), pp. 949-951. (10.1111/j.1365-2133.2012.10983.x)
- Ingram, J. R.et al. 2012. A bum deal from wooden toilet seats: reemergence of allergic contact dermatitis. Dermatitis 23(5), pp. 244-245.
- Enk, A., Ingram, J. R. and Piguet, V. 2012. Future leaders: mentor investment in young investigators. Journal of Investigative Dermatology 132(8), pp. 1943-1944. (10.1038/jid.2012.55)
- Hodges, N., Anstey, A. and Ingram, J. R. 2012. Fumaric acid esters for psoriasis: patient perceptions of an unlicensed medication [Abstract]. Journal of the American Academy of Dermatology 66(4), pp. AB193-AB193. (10.1016/j.jaad.2011.11.809)
- Craig, F. F.et al. 2012. UK Dermatology Clinical Trials Network's STOP GAP trial (a multicentre trial of prednisolone versus ciclosporin for pyoderma gangrenosum): protocol for a randomised controlled trial. Trials 13(1), pp. 51. (10.1186/1745-6215-13-51)
2011
- Ingram, J. R.et al. 2011. Absence of pathogenic gamma-secretase mutations in familial and sporadic acne inversa in a European population [Abstract]. Journal of Investigative Dermatology 131(Supp 2), pp. S68-S68. (10.1038/jid.2011.214)
- Ingram, J. R. 2011. The aetiology of acne inversa: an evolving story. British Journal of Dermatology 165(2), pp. 231-232. (10.1111/j.1365-2133.2011.10459.x)
- Ali, F.et al. 2011. X-linked dominant protoporphyria due to a novel mutation in ALAS2: a case report [Abstract]. British Journal of Dermatology 164(5), pp. 1167-1167. (10.1111/j.1365-2133.2011.10357.x)
- Ingram, J. R.et al. 2011. An unusual complication of jaundice [Abstract]. British Journal of Dermatology 164(5), pp. 1168-1168. (10.1111/j.1365-2133.2011.10357.x)
2010
- Ingram, J. R., Grindlay, D. J. C. and Williams, H. C. 2010. Problems in the reporting of acne clinical trials: a spot check from the 2009 Annual Evidence Update on Acne Vulgaris. Trials 11, article number: 77. (10.1186%2F1745-6215-11-77)
- Ingram, J. R., Grindlay, D. J. C. and Williams, H. C. 2010. Management of "acne vulgaris": an evidence-based update. Clinical and Experimental Dermatology 35(4), pp. 351-354. (10.1111/j.1365-2230.2009.03683.x)
- Paulden, M.et al. 2010. Alitretinoin for the treatment of severe chronic hand eczema. Health Technology Assessment 14, pp. 39-46. (10.3310/hta14Suppl1/06)
- Rodgers, M.et al. 2010. Alitretinoin for severe chronic hand eczema: a NICE single technology appraisal. Pharmacoeconomics 28(5), pp. 351-362. (10.2165/11532160-000000000-00000.)
2009
- Batchelor, J. M., Ingram, J. R. and Williams, H. 2009. Adalimumab vs Methotrexate for the treatment of chronic plaque psoriasis. Archives of Dermatology 145(6), pp. 704-706. (10.1001/archdermatol.2009.104)
- Ingram, J. R. 2009. Nicotine: does it have a role in the treatment of skin disease?. Postgraduate Medical Journal 85(1002), pp. 196-201. (10.1136/pgmj.2008.073577.)
- Ingram, J. R., Batchelor, J. M. and Williams, H. C. 2009. Alitretinoin as a potential advance in the management of severe chronic hand eczema. Archives of Dermatology 145(3), pp. 314-315. (10.1001/archdermatol.2008.608.)
- Ingram, J. R., Griffiths, A. P. and Roberts, D. L. 2009. All patients with sebaceous gland neoplasms should be screened for Muir-Torre syndrome. Clinical and Experimental Dermatology 34(2), pp. 264-266. (10.1111/j.1365-2230.2008.02830.x)
- Ingram, J. R., Martin, J. A. and Finlay, A. Y. 2009. Impact of topical calcineurin inhibitors on quality of life in patients with atopic dermatitis. American Journal of Clinical Dermatology 10(4), pp. 229-237. (10.2165/00128071-200910040-00003.)
2008
- Ingram, J. R., Hughes, M. and Stone, N. M. 2008. Occupational allergic contact dermatitis to polyfunctional aziridine crosslinker in a 'tufter'. Contact Dermatitis 58(3), pp. 172-U7. (10.1111/j.1600-0536.2007.01216.x)
- Ingram, J. R.et al. 2008. Nicotine enemas for active Crohn's colitis: an open pilot study. Gastroenterology Research and Practice 2008, article number: 237185.
2005
- Ingram, J. R.et al. 2005. Preliminary observations of oral nicotine therapy for inflammatory bowel disease: An open-label phase I-II study of tolerance. Inflammatory Bowel Diseases 11(12), pp. 1092-1096.
- Ingram, J. R.et al. 2005. Plasma fibrinogen in ulcerative colitis: The effect of disease activity and nicotine therapy in a randomised controlled trial. Digestive and Liver Disease 37(11), pp. 832-837. (10.1016/j.dld.2005.05.010)
- Thomas, G. A. O., Rhodes, J. and Ingram, J. R. 2005. Mechanisms of disease: nicotine - a review of its actions in the context of gastrointestinal disease. Nature Clinical Practice Gastroenterology & Hepatology 2(11), pp. 536-544. (10.1038/ncpgasthep0316)
- Ingram, J. R.et al. 2005. A randomized trial of nicotine enemas for active ulcerative colitis. Clinical Gastroenterology and Hepatology 3(11), pp. 1107-1114. (10.1016/S1542-3565(05)00849-9)
Medical undergraduates
- Admissions interview panel chairperson
- Dermatology clinical tutor
- Academic mentor
- Finals examiner
Dermatology postgraduates
- Lecturer and examiner for Diploma & MSc in Clinical Dermatology
- Lecturer for MSc course and intercalated BSc medical undergraduate course in Medical Education
- Lead for Diploma in Practical Dermatology 2012–14. In this role I modularised the course, blueprinted assessments to level 7 learning outcomes and moved the Virtual Learning Environment to the Cardiff University Blackboard provider
All Wales dermatology training scheme
- Co-opted member of Specialty Advisory Committee with responsibility for research skills
Hidradenitis suppurativa
My main research interest is hidradenitis suppurativa (HS), a relatively common, painful chronic inflammatory skin condition which can have a large impact on quality of life and may be difficult to treat. As a result, more than 50 medical and surgical interventions have been tried and our recent Cochrane review showed that the evidence base for most interventions is relatively poor, making treatment decisions challenging.
I am building the foundations to perform rigorous clinical trials to improve the care of people with HS. Our HS Priority Setting Partnership between HS patients and clinicians (http://www.jla.nihr.ac.uk/priority-setting-partnerships/hidradenitis-suppurativa) highlighted the therapy areas that are most in need of more evidence. My five year Health Fellowship from Health and Care Research Wales (HCRW) is designed to provide better measures of the impact and epidemiology of HS, to demonstrate the degree of unmet need. In addition, I am undertaking a consensus project for HS outcome measures (HISTORIC), in collaboration with the CSG-COUSIN and IDEOM international groups, to improve the definition of treatment success or failure for future clinical trials.
INDUCE
I am Chief Investigator of INDUCE, a HCRW-funded trial investigating “Point-of-care tests to assist antibiotic prescribing decisions for diabetic foot ulcer infections”. The study has also developed an online educational tool: http://inducdfu-infection.yolasite.com/educational-tool.php. The aim is to develop a composite test of inflammatory markers to improve the diagnosis of diabetic foot ulcer infections in the community.
Research Students
- Dr Ausama Atwan. MD programme. "Optimising Psoriasis Care Pathways."