Dr Josephine Haddon
PhD Cardiff
Research Associate
- HaddonJE2@cardiff.ac.uk
- +44 29206 88379
-
Hadyn Ellis Building, Room 3.28 - Desk 40, Maindy Road, Cardiff, CF24 4HQ
Tower Building, 70 Park Place, Cardiff, CF10 3AT
Overview
Research summary
I am interested in the role that contextual or environmental cues play in the control of both goal-directed and reflexive behaviours. The contextual control of behaviour has been implicated in a wide variety of situations from drug addiction to the formation of episodic memories. My focus is on the neural and psychological mechanisms underlying the contextual modulation of behaviour, with particular emphasis on the involvement of the prefrontal cortex and hippocampal formation. In addition, I am also interested in how dysfunction to contextual processes may contribute to neuropsychological disorders such as schizophrenia.
Research projects
Nov 2006 - Present: BSRC - Project title: "Actions and habits: the relation between cognitive control and behavioural autonomy"
Aug 2004 - Nov 2006: NARSAD - Project title: "Cue and response conflict: hippocampal and prefrontal contributions in schizophrenia"
Publication
2023
- George, D. N., Killcross, S. and Haddon, J. E. 2023. Competing contextual processes rely on the infralimbic and prelimbic medial prefrontal cortices in the rat. Oxford Open Neuroscience 2, article number: kvad003. (10.1093/oons/kvad003)
2021
- George, D. N. and Haddon, J. E. 2021. Preexposure along a continuum: differentiation and association.. Journal of Experimental Psychology: Animal Learning and Cognition 47(1), pp. 48-62. (10.1037/xan0000266)
2019
- Sykes, L. et al. 2019. Genetic variation in the psychiatric risk gene CACNA1C modulates reversal learning across species. Schizophrenia Bulletin 45(5), pp. 1024-1032. (10.1093/schbul/sby146)
- Silva, A. I. et al. 2019. Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility. Nature Communications 10, article number: 3455. (10.1038/s41467-019-11119-7)
2014
- Haddon, J. E., George, D. N., Grayson, L., McGowan, C., Honey, R. C. and Killcross, S. 2014. Extreme elemental processing in a high schizotypy population: relation to cognitive deficits. The Quarterly Journal of Experimental Psychology 67(5), pp. 918-935. (10.1080/17470218.2013.838281)
- Nelson, A. J. D., Hindley, E. L., Haddon, J. E., Vann, S. D. and Aggleton, J. P. 2014. A novel role for the rat retrosplenial cortex in cognitive control. Learning and Memory 21(2), pp. 90-97. (10.1101/lm.032136.113)
2013
- Cohen, S. R., Haddon, J. E., George, D. N. and Honey, R. C. 2013. Pavlovian-to-instrumental transfer: paradoxical effects of the Pavlovian relationship explained. Journal of Experimental Psychology: Animal Behavior Processes 39(1), pp. 14-23. (10.1037/a0030594)
2011
- Haddon, J. E., George, D. N., Grayson, L., McGowan, C., Honey, R. C. and Killcross, A. S. 2011. Impaired conditional task performance in a high schizotypy population: Relation to cognitive deficits. The Quarterly Journal of Experimental Psychology 64(1), pp. 1-9. (10.1080/17470218.2010.529579)
- Haddon, J. E. and Killcross, A. S. 2011. Inactivation of the infralimbic prefrontal cortex in rats reduces the influence of inappropriate habitual responding in a response-conflict task. Neuroscience 199, pp. 205-212. (10.1016/j.neuroscience.2011.09.065)
2008
- Haddon, J. E., George, D. N. and Killcross, A. S. 2008. Contextual control of biconditional task performance: Evidence for cue and response competition in rats. The Quarterly Journal of Experimental Psychology 61(9), pp. 1307-1320. (10.1080/17470210701515819)
2007
- Marquis, J., Killcross, A. S. and Haddon, J. E. 2007. Inactivation of the prelimbic, but not infralimbic, prefrontal cortex impairs the contextual control of response conflict in rats. European Journal of Neuroscience 25(2), pp. 559-566. (10.1111/j.1460-9568.2006.05295.x)
- Haddon, J. E. and Killcross, A. S. 2007. Contextual Control of Choice Performance: Behavioral, Neurobiological, and Neurochemical Influences. Annals of the New York Academy of Sciences 1104(1), pp. 250-269. (10.1196/annals.1390.000)
2006
- Haddon, J. E. and Killcross, A. S. 2006. Prefrontal cortex lesions disrupt the contextual control of response conflict. Journal of Neuroscience 26(11), pp. 2933-2940. (10.1523/JNEUROSCI.3243-05.2006)
- Haddon, J. E. and Killcross, A. S. 2006. Both motivational and training factors affect response conflict choice performance in rats. Neural Networks 19(8), pp. 1192-1202. (10.1016/j.neunet.2006.04.004)
- Haddon, J. E. 2006. Response conflict, prefrontal cortex and dopamine: a rat model of Stroop-like performance. British Neuroscience Association Bulletin(54), pp. 18-20.
2005
- Haddon, J. E. and Killcross, A. S. 2005. Medial Prefrontal Cortex Lesions Abolish Contextual Control of Competing Responses. Journal of the Experimental Analysis of Behavior 84(3), pp. 485-504. (10.1901/jeab.2005.81-04)
Articles
- George, D. N., Killcross, S. and Haddon, J. E. 2023. Competing contextual processes rely on the infralimbic and prelimbic medial prefrontal cortices in the rat. Oxford Open Neuroscience 2, article number: kvad003. (10.1093/oons/kvad003)
- George, D. N. and Haddon, J. E. 2021. Preexposure along a continuum: differentiation and association.. Journal of Experimental Psychology: Animal Learning and Cognition 47(1), pp. 48-62. (10.1037/xan0000266)
- Sykes, L. et al. 2019. Genetic variation in the psychiatric risk gene CACNA1C modulates reversal learning across species. Schizophrenia Bulletin 45(5), pp. 1024-1032. (10.1093/schbul/sby146)
- Silva, A. I. et al. 2019. Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility. Nature Communications 10, article number: 3455. (10.1038/s41467-019-11119-7)
- Haddon, J. E., George, D. N., Grayson, L., McGowan, C., Honey, R. C. and Killcross, S. 2014. Extreme elemental processing in a high schizotypy population: relation to cognitive deficits. The Quarterly Journal of Experimental Psychology 67(5), pp. 918-935. (10.1080/17470218.2013.838281)
- Nelson, A. J. D., Hindley, E. L., Haddon, J. E., Vann, S. D. and Aggleton, J. P. 2014. A novel role for the rat retrosplenial cortex in cognitive control. Learning and Memory 21(2), pp. 90-97. (10.1101/lm.032136.113)
- Cohen, S. R., Haddon, J. E., George, D. N. and Honey, R. C. 2013. Pavlovian-to-instrumental transfer: paradoxical effects of the Pavlovian relationship explained. Journal of Experimental Psychology: Animal Behavior Processes 39(1), pp. 14-23. (10.1037/a0030594)
- Haddon, J. E., George, D. N., Grayson, L., McGowan, C., Honey, R. C. and Killcross, A. S. 2011. Impaired conditional task performance in a high schizotypy population: Relation to cognitive deficits. The Quarterly Journal of Experimental Psychology 64(1), pp. 1-9. (10.1080/17470218.2010.529579)
- Haddon, J. E. and Killcross, A. S. 2011. Inactivation of the infralimbic prefrontal cortex in rats reduces the influence of inappropriate habitual responding in a response-conflict task. Neuroscience 199, pp. 205-212. (10.1016/j.neuroscience.2011.09.065)
- Haddon, J. E., George, D. N. and Killcross, A. S. 2008. Contextual control of biconditional task performance: Evidence for cue and response competition in rats. The Quarterly Journal of Experimental Psychology 61(9), pp. 1307-1320. (10.1080/17470210701515819)
- Marquis, J., Killcross, A. S. and Haddon, J. E. 2007. Inactivation of the prelimbic, but not infralimbic, prefrontal cortex impairs the contextual control of response conflict in rats. European Journal of Neuroscience 25(2), pp. 559-566. (10.1111/j.1460-9568.2006.05295.x)
- Haddon, J. E. and Killcross, A. S. 2007. Contextual Control of Choice Performance: Behavioral, Neurobiological, and Neurochemical Influences. Annals of the New York Academy of Sciences 1104(1), pp. 250-269. (10.1196/annals.1390.000)
- Haddon, J. E. and Killcross, A. S. 2006. Prefrontal cortex lesions disrupt the contextual control of response conflict. Journal of Neuroscience 26(11), pp. 2933-2940. (10.1523/JNEUROSCI.3243-05.2006)
- Haddon, J. E. and Killcross, A. S. 2006. Both motivational and training factors affect response conflict choice performance in rats. Neural Networks 19(8), pp. 1192-1202. (10.1016/j.neunet.2006.04.004)
- Haddon, J. E. 2006. Response conflict, prefrontal cortex and dopamine: a rat model of Stroop-like performance. British Neuroscience Association Bulletin(54), pp. 18-20.
- Haddon, J. E. and Killcross, A. S. 2005. Medial Prefrontal Cortex Lesions Abolish Contextual Control of Competing Responses. Journal of the Experimental Analysis of Behavior 84(3), pp. 485-504. (10.1901/jeab.2005.81-04)
Research
- Nov 2006 - Present: BSRC - Project title: "Actions and habits: the relation between cognitive control and behavioural autonomy"
- Aug 2004 - Nov 2006: NARSAD - Project title: "Cue and response conflict: hippocampal and prefrontal contributions in schizophrenia"
Biography
Conference Presentations
Haddon, J.E., & Killcross, A.S. (2007) The effect of infralimbic inactivation on the contextual control of response conflict in rats. 11th Associative Learning Symposium. Gregynog, Wales.
Haddon, J.E., Marquis, J-P, & Killcross, A.S. (2007) Prelimbic inactivation impairs, and infralimbic inactivation enhances, the contextual control of response conflict in rats. Eastern Psychological Association, 78th Annual meeting, Philadelphia.
Haddon, J.E. & Killcross, A.S. (2006) Systemic phencyclidine administration disrupts the contextual control of response conflict in rats. 10th Associative Learning Symposium. Gregynog, Wales.
Haddon, J.E. & Killcross, A.S. (2006) The influence of motivational and training factors on the contextual control of biconditional task performance in rats. Society for the Study of Artificial Intelligence and the Simulation of Behaviour: Adaptation in Artificial and Biological Systems, Bristol, United Kingdom.
Haddon, J.E. & Killcross, A.S. (2005). Incidental contextual control of biconditional task performance: The involvement of the hippocampal formation. Experimental Psychology Society/ Canadian Society for Brain, Behaviour and Cognitive Science. Montreal, Canada.
Haddon, J.E. & Killcross, A.S. (2004). The effect of medial prefrontal cortex lesions on the control of biconditional task performance. 8th Associative Learning Symposium. Gregynog, Wales.
Posters and Abstracts
Haddon, J.E., George, D.N., & Killcross (2007) A novel approach to exploring the exploitation/exploration trade-off in rats. Eastern Psychological Association, 78th Annual meeting, Philadelphia.
Haddon, J.E. & Killcross, A.S. (2005). The influence of microinfusion of D1 dopaminergic receptor agonist SKF-38393 into the prefrontal cortex on performance of biconditional discriminations of varying levels of difficulty. 11th Biennial European Behavioural Pharmacology Society. Barcelona, Spain.
Killcross, A.S., Marquis, J-P., & Haddon, J.E. (2005) GABAA agonist injection in prelimbic cortex, but not in infralimbic cortex, impairs contextual control of response conflict in rats. Behavioral Pharmacology, 16, S27.
Haddon, J.E. & Killcross, A.S. (2004). The role of the hippocampus in configural learning: an effect of task difficulty? 8th Associative Learning Symposium. Gregynog, Wales.
Haddon, J.E. & Killcross, A.S. (2004). Behavioural control by multiple conditioning cues: A rat analogue of task interference. Experimental Psychology Society, London, U.K.
Haddon, J.E. & Killcross, A.S. (2004). Incidental contextual control of biconditional task performance disrupted by reversible inactivation of the dorsal hippocampus. Experimental Psychology Society, London, U.K.
Haddon, J.E. & Killcross, A.S. (2004). The effect of medial prefrontal cortex lesions on control of biconditional task performance. 2004 Abstract viewer. Washington DC: Society for Neuroscience, No. 551.10.
Haddon, J.E., George, D.N. & Killcross, A.S. (2003). Hippocampal lesions disrupt incidental contextual control of biconditional task performance. 2003 Abstract viewer. Washington DC: Society for Neuroscience, No. 938.12.
Honours and awards
Awards/external committees
Runner-up BNA Association Postgraduate Prize, 2005.
Attended reception at 10 Downing Street in honour of the “contribution of young scientists to the future of the UK”.