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Miss Elena Meuser

Research student, Cancer & Genetics, School of Medicine

I am an affiliated member of the Inherited Tumour Syndromes Research Group (ITSRG) and the aim of my research is to facilitate better or novel approaches to cancer diagnosis, treatment and prevention.

Research interests

During my PhD, I have worked on a project dealing with the mechanisms underlying duodenal tumourigenesis in the two inherited polyposis syndromes familial adenomatous polypsis (FAP) and MUTYH-associated polyposis (MAP). To find driver genes and pathways that might lead to intestinal cancers as well as characterise molecular adenoma evolution in different gastrointestinal regions, I have made use of high throughput omics technology and bioinformatics. In a side project, I have also tried to establish 3D in vitro models from patient tissue samples.

Thesis

Molecular mechanisms of duodenal tumourigenesis in familial adenomatous polyposis and MUTYH-associated polyposis

The management of colorectal disease in the inherited disorders familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP) has greatly improved during recent years. Genetic testing, surveillance programmes and prophylactic surgery have reduced the incidence of colorectal cancer and significantly improved patient survival. The relatively neglected extra-colonic manifestations of the diseases, particularly those affecting the duodenum, have become leading causes of morbidity and cancer-death for these patients, yet the processes underlying duodenal polyposis and tumourigenesis remain insufficiently understood. 


My thesis addresses gaps in the current knowledge about the molecular mechanisms underlying duodenal tumourigenesis in both disorders hoping to find opportunities for targeted prevention and treatment interventions in FAP and MAP duodenal disease.

Dr Laura Thomas

Research Associate

Dr Matthew Mort

Senior Software Developer and Analyst

Professor Julian Sampson

Director, Division of Cancer and Genetics

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