Jordanna Dally

Research student, School of Dentistry


BSc (Hons) Biomedical Science, Plymouth University (2012)

MRes Biomedical Research, Cardiff University (2014)


Pharmaceutical evaluation of novel tiglianes as modulators of dermal fibroblast-myofibroblast differentiation, scar formation and fibrosis; and elucidation of their underlying mechanisms of action.

My PhD is evaluating the potential of novel epoxy-tigliane pharmaceuticals, EBC-46 and EBC-211, as anti-scarring agents.  These compounds occur naturally in seeds of the Fontain’s Blushwood Tree, indigenous to Queensland’s tropical rainforest.  In clinical trials, QBiotics ( have shown that EBC-46 stimulates dermal wound healing responses, including wound closure and minimal scarring.  Transforming growth factor-β1 (TGF-β1)-driven fibroblast-myofibroblast differentiation is pivotal to wound closure and scarring.  Thus, fibroblasts and myofibroblasts represent viable targets for the anti-scarring properties of epoxy-tiglianes.  My research is elucidating the mechanisms underlying the modulatory effects of epoxy-tiglianes on fibroblasts/myofibroblast responses, to develop these compounds as anti-scarring treatments.

Dr Ryan Moseley

Reader in Tissue Repair