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All Publications 2001-13 (R-W)

REGINI J

Regini JW, Grossmann JG, Timmins P, Harding JJ, Quantock AJ, Hodson SA and Elliott GF).
X-ray and neutron scattering studies of alpha-crystallin, and evidence that the target protein sits in the fenestrations of the alpha-crystallin shell.
Investigative Ophthalmology & Visual Science. 2007  

Regini JW, Grossmann JG, Burgio MR.
Structural changes in alpha-crystallin and whole eye lens during heating, observed by low-angle X-ray diffraction
Journal of Molecular Biology 336 (5): 1185-1194 2004 

Regini JW, Elliott GF, Hodson SA.
The ordering of corneal collagen fibrils with increasing ionic strength,
Journal of Molecular Biology 336 (1): 179-186 2004 

Regini JW and Grossman JG
Structual changes of a-crystallin during heating observed with small and wide angle X-ray scattering,
Fibre Diffraction 2003 11,95-101 

Regini J, Hodson S, Elliott G.
Why the chloride ion is important in biology: Transient anion binding to structural proteins in cornea, muscle, and other biological polyelectrolyte gels,
Journal of General Physiology 122 (1): 30 2003 

Regini JW
New insights into structural changes in lens proteins,
Journals of Biomechanics in Medicine and Biology 2003. 3, 71-78 

Regini JW, Timmins PA, Elliott GF.
Neutron and X-ray scattering by ox corneal stroma differentially loaded with bound anions,
Biochimica et Biophysica Acta-General Subjects 1620 (1-3): 54-58 2003 T

Kostyuk O, Nalovina O, Mubard TM, , Meek KM, Quantock AJ, Elliott GF, Hodson SA.
Transparency of the bovine corneal stroma at physiological hydration and its dependence on concentration of the ambient anion,
Journal of Physiology-London 543 (2): 633-642 2002 

Regini JW, Elliott GF.
The effect of temperature on the Donnan potentials in biological polyelectrolyte gels: cornea and striated muscle,
International Journal of Biological Macromolecules 28 (3): 245-254 2001 

 

ROZANOWSKA M

Retinal pigment epithelium lipofuscin proteomics.
Ng KP, Gugiu B, Renganathan K, Davies MW, Gu X, Crabb JS, Kim SR,Rózanowska MB, Bonilha VL, Rayborn ME, Salomon RG, Sparrow JR, Boulton ME, Hollyfield JG, Crabb JW.
Mol Cell Proteomics. 2008 Jul;7(7):1397-405

Perspectives on the structure and function of melanin.
Simon JD, Rózanowska M. Pigment Cell Melanoma Res. 2008 Jun;21(3):346-7.

Human RPE melanosomes protect from photosensitized and iron-mediated oxidation but become pro-oxidant in the presence of iron upon photodegradation. Rózanowski B, Burke JM, Boulton ME, Sarna T, Rózanowska M.
Invest Ophthalmol Vis Sci. 2008 Jul;49(7):2838-47.

The pro-oxidant effects of interactions of ascorbate with photoexcited melanin fade away with aging of the retina.
Rózanowski B, Burke J, Sarna T, Rózanowska M.
Photochem Photobiol. 2008 May-Jun;84(3):658-70.

The phototoxicity of aged human retinal melanosomes.
Rózanowski B, Cuenco J, Davies S, Shamsi FA, Zadło A, Dayhaw-Barker P, Rózanowska M, Sarna T, Boulton ME.
Photochem Photobiol. 2008 May-Jun;84(3):650-7.

A. Żądło, M. Różanowska, J.M. Burke, T. Sarna:
Photobleaching of retinal pigment epithelium melanosomes reduces their ability to inhibit iron-induced peroxidation of lipids.
Pigment Cell Research.20 (1):52-60, 2007. 

B. Płytycz, J. Homa, B. Kozioł, M. Różanowska, A. J. Morgan:
Riboflavin content in autofluorescent earthworm coelomocytes is species-specific.
Folia Histochem Cytobiol. 44(4):275-80, 2006. 

Różanowska, M., Sarna, T.
Light-induced damage to the retina: Role of rhodopsin chromophore revisited.
Photochem Photobiol. 81(6):1305-30, 2005. 

Rozanowska M, Cantrell A, Edge R.
Pulse radiolysis study of the interaction of retinoids with peroxyl radicals,
Free Radical Biology and Medicine 39 (10): 1399-1405 2005 

Vakrat-Haglili Y, Weiner L, Brumfeld V, Brandis A, Salomon Y, McIlroy B, Wilson BC, Pawlak A, Rozanowska M, Sarna T, Scherz A.
The microenvironment effect on the generation of reactive oxygen species by Pd-bacteriopheophorbide,
Journal of the American Chemical Society 127 (17): 6487-6497 2005 

Boulton M, Rozanowska M, Rozanowski B.
The photoreactivity of ocular lipofuscin,
Photochemical & Photobiological Sciences 3 (8): 759-764 2004 

Rozanowska M, Pawlak A, Rozanowski B.
Age-related changes in the photoreactivity of retinal lipofuscin granules: Role of chloroform-insoluble components,
Investigative Ophthalmology & Visual Science 45 (4): 1052-1060 2004 

Boulton M, Rozanowska M, Wess T.
Ageing of the retinal pigment epithelium: implications for transplantation,
Graefes Archive for Clinical and Experimental Ophthalmology 242 (1): 76-84 2004

Wrona, M., Różanowska, M., Sarna, T.:
Zeaxanthin in combination with ascorbic acid or α-tocopherol protects ARPE-19 cells against photosensitized peroxidation of lipids.
Free Radic. Biol. Med. 36: 1094-1101; 2004. 

Wrona M, Korytowski W, Rozanowska M, Sarna T, Truscott TG.
Cooperation of antioxidants in protection against photosensitized oxidation.
Free Radic Biol Med. 2003 15;35(10):1319-29. PMID: 14607531 

Pawlak A, Wrona M, Rozanowska M.
Comparison of the aerobic photoreactivity of A2E with its precursor retinal,
Photochemistry and Photobiology 77 (3): 253-258 2003 

Sarna T, Burke JM, Korytowski W, Rozanowska M, Skumatz CMB, Zareba A, Zareba M.
Loss of melanin from human RPE with aging: possible role of melanin photooxidation,
Experimental Eye Research 76 (1): 89-98 2003 Times Cited: 18

Pawlak A, Rozanowska M, Zareba M, Lamb LE, Simon JD, Sarna T.
Action spectra for the photoconsumption of oxygen by human ocular lipofuscin and lipofuscin extracts,
Archives of Biochemistry and Biophysics 403 (1): 59-62 2002 

Rozanowska M, Korytowski W, Rozanowski B.
Photoreactivity of aged human RPE melanosomes: A comparison with lipofuscin,
Investigative Ophthalmology & Visual Science 43 (7): 2088-2096 2002 

Haralampus-Grynaviski N, Ransom C, Ye T, Rozanowska M, Wrona M, Sarna T, Simon JD.
Photogeneration and quenching of reactive oxygen species by urocanic acid,
Journal of the American Chemical Society 124 (13): 3461-3468 2002 

Boulton M, Rozanowska M, Rozanowski B.
Retinal photodamage
Journal of Photochemistry and Photobiology B-Biology 64 (2-3): 144-161 2001 

Haralampus-Grynaviski NM, Lamb LE, Simon JD, Rozanowska M.
Probing the spatial dependence of the emission spectrum of single human retinal lipofuscin granules using near-field scanning optical microscopy,
Photochemistry and Photobiology 74 (2): 364-368 2001 

Krogmeier JR, Clancy CMR, Pawlak A, Rozanowska M.
Mapping the distribution of emissive molecules in human ocular lipofuscin granules with near-field scanning optical microscopy,
Journal of Microscopy-Oxford 202: 386-390 Part 2 2001 

 

SHEEN N

Novel optometrist led all Wales primary eye care services: Evaluation of prospective case-series.
Sheen NJ, Fone D, Phillips CJ, Sparrow JM,
Pointer JS, Wild JM. Br J Ophthalmol. 2008 Nov 21. [Epub ahead of print] PMID: 19028737 [PubMed - as supplied by publisher]

Morgan JE, Sheen NJL, North RV, Goyal R, Morgan S, Ansari E, Wild JM.
Discrimination of glaucomatous optic neuropathy by digital stereoscopic analysis,
Ophthalmology 112 (5): 855-862 2005 

Morgan JE, Sheen NJ, North RV, Choong Y, Ansari E.
Digital imaging of the optic nerve head: monoscopic and stereoscopic analysis.
British Journal of Ophthalmology. 2005 ;89(7):879-84. 

Sheen NJL, Morgan JE, Poulsen JL, North RV.
Digital stereoscopic analysis of the optic disc - Evaluation of a teaching program,
Ophthalmology 111 (10): 1873-1879 2004 

Sheen NJ, Aldridge C, Drasdo N, North RV, Morgan JE.
The effects of astigmatism and working distance on optic nerve head images using a Heidelberg Retina Tomograph scanning laser ophthalmoscope.
Am J Ophthalmol. 2001; 131(6):716-21. 

Jones AL, Sheen NJ, North RV, Morgan JE.
The Humphrey optical coherence tomography scanner: quantitative analysis and reproducibility study of the normal human retinal nerve fibre layer.
British Journal of Ophthalmology. 2001; 85(6):673-7. 

 

VOTRUBA M

A missense mutation in the murine Opa3 gene models human Costeff syndrome.
Davies VJ, Powell KA, White KE, Yip W, Hogan V, Hollins AJ, Davies JR, Piechota M, Brownstein DG, Moat SJ, Nichols PP, Wride MA, Boulton ME, Votruba M.
Brain. 2008 Feb;131(Pt 2):368-80.

Davies VJ, Hollins AJ, Piechota MJ, Yip W, Davies JR, White KE, Nicols PP, Boulton ME, Votruba M.
Opa1 deficiency in a mouse model of autosomal dominant optic atrophy impairs mitochondrial morphology, optic nerve structure and visual function,
Human Molecular Genetics 16 (11): 1307-1318 2007

Davies V, Votruba M.
Focus on molecules: the OPA1 protein.
Experimental Eye Research. 2006; 83(5):1003-4. . 

Votruba M.
Molecular genetic basis of primary inherited optic neuropathies
Eye 18 (11): 1126-1132 2004 

Aijaz S, Erskine L, Jeffery G, Votruba M.
Developmental expression profile of the optic atrophy gene product: OPA1 is not localized exclusively in the mammalian retinal ganglion cell layer,
Investigative Ophthalmology & Visual Science 45 (6): 1667-1673 2004 

Votruba M, Aijaz S, Moore AT.
A review of primary hereditary optic neuropathies
Journal of Inherited Metabolic Disease 26 (2): 209-227 2003

Votruba M, Thiselton D, Bhattacharya SS
Optic disc morphology of patients with OPA1 autosomal dominant optic atrophy,
British Journal of Ophthalmology 87 (1): 48-53 2003 

Granse L, Bergstrand I, Thiselton D, Ponjavic V, Heijl A, Votruba M, Andreasson S.
Electrophysiology and ocular blood flow in a family with dominant optic nerve atrophy and a mutation in the OPA1 gene.
Ophthalmic Genet. 2003; 24(4):233-45. 

Votruba M, Cornes PGS, Luthert P.
Primary monophasic synovial sarcoma of the conjunctiva,
British Journal of Ophthalmology 86 (12): 1453-1454 2002 

Thiselton DL, Alexander C, Taanman JW, Votruba M.
A comprehensive survey of mutations in the OPA1 gene in patients with autosomal dominant optic atrophy,
Investigative Ophthalmology & Visual Science 43 (6): 1715-1724 2002 

Aung T, Ocaka L, Ebenezer ND, Morris AG, Krawczak M, Thiselton DL, Alexander C, Votruba M, Brice G, Child AH, Francis PJ, Hitchings RA, Lehmann OJ, Bhattacharya SS.
A major marker for normal tension glaucoma: association with polymorphisms in the OPA1 gene,
Human Genetics 110 (1): 52-56  2002 

Thiselton DL, Alexander C, Morris A, Taanman JW, Brooks S, Rosenberg T, Eiberg H, Andreasson S, Van Regemorter N, Munier FL, Moore AT, Bhattacharya SS, Votruba M.
A frameshift mutation in exon 28 of the OPA1 gene explains the high prevalence of dominant optic atrophy in the Danish population: evidence for a founder effect,
Human Genetics 109 (5): 498-502 2001 

Gong YQ, Slee RB, Fukai N, Rawadi G, Roman-Roman S, Reginato AM, Wang HW, Cundy T, Glorieux FH, Lev D, Zacharin M, Oexle K, Marcelino J, Suwairi W, Heeger S, Sabatakos G, Apte S, Adkins WN, Allgrove J, Arslan-Kirchner M, Batch JA, Beighton P, Black GCM, Boles RG, Boon LM, Borrone C, Brunner HG, Carle GF, Dallapiccola B, De Paepe A, Floege B, Halfhide ML, Hall B, Hennekam RC, Hirose T, Jans A, Juppner H, Kim CA, Keppler-Noreuil K, Kohlschuetter A, LaCombe D, Lambert M, Lemyre E, Letteboer T, Peltonen L, Ramesar RS, Romanengo M, Somer H, Steichen-Gersdorf E, Steinmann B, Sullivan B, Superti-Furga A, Swoboda W, van den Boogaard MJ, Van Hul V, Vikkula M, Votruba M, Zabel B, Garcia T, Baron R, Olsen BR, Warman ML
LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development,
Cell, 107 (4): 513-523 6 2001 

Votruba M, Gregor Z.
Neovascular age-related macular degeneration: present and future treatment options,
Eye 15: 424-429 Part 3 2001 

Bremner FD, Tomlin EA, Shallo-Hoffmann J, Votruba M, Smith SE.
The pupil in dominant optic atrophy,
Investigative Ophthalmology & Visual Science 42 (3): 675-678 2001

Teplan V, Schuck O, Votruba M, Poledne R, Kazdova L, Skibova J, Maly J.
An "overtrained" ophthalmologist responds.
British Journal of Ophthalmology. 2001; 85(11):1394.

Votruba M, Gregor Z.
Neovascular age-related macular degeneration: present and future treatment options
Eye. 2001; 15(Pt 3):424-9. 

 

Wild JM

Novel optometrist led all Wales primary eye care services: Evaluation of prospective case-series.
Sheen NJ, Fone D, Phillips CJ, Sparrow JM, Pointer JS, Wild JM.
Br J Ophthalmol. 2008 Nov 21. [Epub ahead of print] PMID: 19028737 [PubMed - as supplied by publisher]

Vigabatrin and epilepsy: Lessons learned
Wild JM, Ahn HS, Baulac M, Bursztyn J, Chiron C, Gandolfo E, Safran AB, Schiefer U, Perucca E.
Epilepsia 48 (7): 1318-1327 2007 

Vonthein R, Rauscher S, Paetzold J, Nowomiejska K, Krapp E, Hermann A, Sadowski B, Chaumette C, Wild JM, Schiefer U.
The normal age-corrected and reaction time - Corrected isopter derived by semi-automated kinetic perimetry,
Ophthalmology 114 (6): 1065-1072 2007 

Hudson CJW, Kim LS, Hancock SA, Cunliffe IA, Wild JM.
Some dissociating factors in the analysis of structural and functional progressive damage in open-angle glaucoma,
British Journal of Ophthalmology 91 (5): 624-628 2007 

Lawthom C, Wild JM, Smith PEM.
Vigabatrin in utero: Visual assessment using standard and novel techniques,
Journal of Neurology Neurosurgery and Psychiatry 77 (12): 1395-1395 039 2006 

North RV, Jones AL, Hunter E, Morgan JE, Wild JM.
Evaluation of the high specificity Screening Program (C-20-1) of the Frequency Doubling Technology (FDT) perimeter in clinical practice,
Eye 20 (6): 681-687 2006 

Wild JM, Robson CR, Jones AL, Jones AL, Cunliffe IA, Smith PEM.
Detecting vigabatrin toxicity by imaging of the retinal nerve fiber layer,
Investigative Ophthalmology & Visual Science 47 (3): 917-924 2006

Wild JM, Kim LS, Pacey IE.
Evidence for a learning effect in short-wavelength automated perimetry
Ophthalmology 113 (2): 206-215 2006 

Margrain TH, Ryan B, Wild JM.
A revolution in Welsh low vision service provision
British Journal of Ophthalmology 89 (8): 933-934 2005 

Hadjikoutis S, Morgan JE, Wild JM, Smith PEM.
Ocular complications of neurological therapy,
European Journal of Neurology 12 (7): 499-507 2005 

Morgan JE, Sheen NJL, North RV, Goyal R, Morgan S, Ansari E, Wild JM.
Discrimination of glaucomatous optic neuropathy by digital stereoscopic analysis,
Ophthalmology 112 (5): 855-862 2005 

Asman P, Wild JM, Heijl A.
Appearance of the pattern deviation map as a function of change in area of localized field loss,
Investigative Ophthalmology & Visual Science 45 (9): 3099-3106 2004 

Drasdo N, Aldebasi YH, Mortlock KE, Chiti Z, Morgan JE, North RV, Wild JM.
Ocular optics, electroretinography and primary open angle glaucoma,
Ophthalmic and Physiological Optics 22 (5): 455-462 2002 

Harding GFA, Spencer EL, Wild JM.
Field-specific visual-evoked potentials - Identifying field defects in vigabatrin-treated children,
Neurology 58 (8): 1261-1265  2002 

Wild JM.
Short wavelength automated perimetry.
Acta Ophthalmologica Scandinavica 79 (6): 546-559 2001 

Hutchings N, Hosking SL, Wild JM.
Long-term fluctuation in short-wavelength automated perimetry in glaucoma suspects and glaucoma patients,
Investigative Ophthalmology & Visual Science 42 (10): 2332-2337 2001

 

WOODHOUSE JM

Vernier acuity in Down syndrome.
Little JA, Woodhouse JM, Lauritzen JS, Saunders KJ.
Invest Ophthalmol Vis Sci. 2008 Sep 29. [Epub ahead of print]PMID: 18824732 [PubMed - as supplied by publisher

Little JA, Woodhouse JM, Lauritzen JS, Saunders KJ.
The impact of optical factors on resolution acuity in children with down syndrome,
Investigative Ophthalmology & Visual science 48 (9): 3995-4001 2007 

Adler PM, Cregg M, Viollier AJ, Woodhouse JM.
Influence of target type and RAF rule on the measurement of near point of convergence,
ophthalmic and physiological optics 27  2007 

Woodhouse JM, Morjaria SA, Adler PM.
Acuity measurements in adult subjects using a preferential looking test,
Ophthalmic and Physiological Optics 27 (1): 54-59  2007 

Wiggins D, Woodhouse JM, Margrain TH.
Infantile nystagmus adapts to visual demand
Investigative Ophthalmology & Visual Science 48 (5): 2089-2094 2007 

Wiggins D, Woodhouse JM, Margrain TH.
Infantile nystagmus adapts to visual demand,
Perception 36 (2): 315-315 36 2007 

Stewart RE, Woodhouse JM, Cregg M.
Association between accommodative accuracy, hypermetropia, and strabismus in children with Down's syndrome
Optometry & Vision Science 84 (2): 149-155 2007 

Stewart RE, Woodhouse JM, Trojanowska LD.
In focus: the use of bifocal spectacles with children with Down's syndrome,
Ophthalmic and Physiological Optics 25 (6): 514-522 2005

Adler P, Cregg M, Duignan A, Woodhouse JM.
Effect of training on attitudes and expertise of optometrists towards people with intellectual disabilities,
Ophthalmic and Physiological Optics 25 (2): 105-118 2005

Woodhouse JM, Adler P, Duignan.
AVision in athletes with intellectual disabilities: the need for improved eyecare,
Journal of Intellectual Disability Research 48: 736-745 Part 8 2004

Woodhouse JM, Bromham NR, Fraser WI.
Measuring sensitivity to blur in children with Down syndrome (DS): Success in psychophysical testing,
Journal of Intellectual Disability Research 48: 347-347 Part 4-5 2004

Stewart RE, Woodhouse JM, Trojanowska LD.
Bifocal wear improves near focusing for children with Down’s syndrome,
Journal of Intellectual Disability Research 48: 347-347 Part 4-5 2004

John FM, Bromham NR, Woodhouse JM.
Spatial vision deficits in infants and children with Down’s syndrome,
Investigative Ophthalmology & Visual Science 45 (5): 1566-1572 2004 

Woodhouse JM, Adler PM, Duignan A.
Ocular and visual defects amongst people with intellectual disabilities participating in Special Olympics,
Ophthalmic and Physiological Optics 23 (3): 221-232 2003 

Cregg M, Woodhouse JM, Stewart RE.
Development of refractive error and strabismus in children with Down syndrome,
Investigative Ophthalmology & Visual Science 44 (3): 1023-1030 2003 

Bromham NR, Woodhouse JM, Cregg M.
Heart defects and ocular anomalies in children with Down's syndrome,
British Journal of Ophthalmology 86 (12): 1367-1368 2002 

Bromham NR, Woodhouse JM, Cregg M, Webb E, Fraser WI.
Heart defects and ocular anomalies in children with Down's syndrome.
British Journal of Ophthalmology. 2002; 86(12):1367-8. 

Cregg M, Woodhouse JM, Pakeman VH.
Accommodation and refractive error in children with Down syndrome: Cross-sectional and longitudinal studies,
Investigative Ophthalmology & Visual Science 42 (1): 55-63 2001