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Prof David Kipling 


Position:Professor, Pathology

Telephone:+44(0)29 2068 7037
Extension:87037
Location:Department of Pathology, Cardiff University, Heath Park, Cardiff
 

Research Group

Cancer Studies

Education & Qualifications

1986   BA (Hons), Natural Sciences, Cambridge University.  1st Class.  Frank Smart Prize for Zoology (top University mark in subject)

1989   DPhil.  Oxford University, Zoology Department

Research Interests

The role of replicative senescence in human ageing and cancer, with a particular interest in the human progeroid syndrome Werner syndrome.  This is a cancer-prone premature ageing syndrome associated with accelerated replicative senescence.

Selected Recent Publications

  1. Davis, T., Baird, D. M., Haughton, M. F., Jones, C. J. and Kipling, D. (2005a). Prevention of accelerated cell aging in Werner syndrome using a p38 mitogen-activated protein kinase inhibitor.  J Gerontol A Biol Sci Med Sci60, 1386
  2. Kipling, D., Davis, T., Ostler, E. L. and Faragher, R. G. (2004). What can progeroid syndromes tell us about human aging? Science305, 1426-31.
  3. Wyllie, F. S., Jones, C. J., Skinner, J. W., Haughton, M. F., Wallis, C., Wynford-Thomas, D., Faragher, R. G. and Kipling, D. (2000). Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts. Nat Genet24, 16-7.
  4. Baird, D. M., Rowson, J., Wynford-Thomas, D. and Kipling, D. (2003). Extensive allelic variation and ultrashort telomeres in senescent human cells. Nat Genet33, 203-7.

Selected Projects

Project Name: Dissecting the cause of premature replicative senescence of Werner syndrome cells using selective chemical inhibitors
Funder: BBSRC
Duration: 3 years
Value: £420,603

Project Name: Establishment and validation of a stable, cell-based diabetic wound bioassay.
Funder: MRC (NC3Rs)
PI: Phil Stephens
Co-Apps: David Kipling, Dave Thomas
Duration: 2009-2011
Amount: £243,612

 Project Name: The role of cell senescence in a murine model of delayed ageing.
Funder: Research into Ageing
PI: Richard Faragher
Co-Apps: David Kipling, Linda Partridge, Dominic Withers
Amount: £220,000
Duration: 3 years

 Project Name: The role of B cell repertoire diversity restriction in ageing and frailty.
PI: Deborah Dunn-Walters (KCL)
Co-App: David Kipling
Funder: Research into Ageing
Duration: 3 years
Amount: £225,000

Project Name: Anglo-Japanese Werner Syndrome Consortium
Funder: BBSRC
Duration: 3 years
Value: £50,000

Project Name: Physiological responses to genome instability
Funder: MRC
Duration: 3 years
Value: £75,000