Prof Rachel Waddington
Selected Projects
- Osseointegration around titanium implants and diabetic bone healing.
- Influence of surface modification of titanium on progenitor bone cell behaviour during osseointegration.
- Adult stem / progenitor cells from bone marrow and dental pulp and role of the extracellular matrix in stem cell biology and mineralised tissue repair.
- Influence of bacterial pathogens (LPS) on altered bone cell activity, protein synthesis and remodelling of the extracellular matrix during inflammatory periodontal disease.
- Matrix metabolites and cytokine profiles as biomarkers in gingival crevicular fluid and their development as chair-side diagnostic assays of active periodontal disease.
- An ex vivo mandible culture model to study inflammatory bone disease and bone regeneration.
- The role of the extracellular matrix in growth factor presentation during mineralised tissue repair.
- Ex vivo modelling of antimicrobial measures in pulpal disease.
- Dentinal matrix components in gingival crevicular fluid as biomarkers of root resorption.
- Host-microbial interactions and cellular responses associated with Streptococcus milleri infections.
- Use of recombinant and native proteins in the evaluation of the functional roles of small leucine rich proteoglycans and dentine phosphoproteins in bone and dentine.
- Influence of fluoride on protein on altered bone cell activity, protein synthesis and remodelling of the extracellular matrix.
Recent Grants
MRC- Harnessing Dental Pulp Stem Cells to Enhance Tissue Regeneration AJ Sloan (PI), RJ Waddington 2010 – 2012 £274K
GSK - Effect of GSK agent on bone cell/tissue behaviour ex-vivo. AJ Sloan, RJ Waddington, JS Rees, 10/2009; £25,000
NC3Rs - An ex vivo mouse mandible culture model to study inflammatory bone disease. AJ Sloan (PI), RJ Waddington and XQ Wei, 2006 – 2008; £195,000
General Implant Forum Training. Behaviour of bone cells on modified titanium surfaces, RJ Waddington (PI) StJ Crean, AJ Sloan, 2006 – 2009; £60,000
NC3Rs – Human Pulpal Progenitor Cells: The development of a dental pulp stem cell assay system. AJ Sloan (PI), RJ Waddington, DP Aeschlimann 2007 – 2008; £2,000
Grant in aid for scientific research in Japanese Ministry of Education, Culture, Sports, Science and Technology - Functional control to dental titanium implants using biomimetic matrix, J Okazaki, RJ Waddington 2006-2008; £16,000
Cardiff University, Richard Whipp Studentship - Ex vivo modelling of anti-microbial control measures in pulpal disease. AJ Sloan (Co-PI) J-Y Maillard (Co-PI), S Denyer, RJ Waddington, M Wilson and D Schmaljohann, 2006 – 2009; £35,000
Welsh Office for Research & Development – Commitment and potential of dental pulp stem cells: their role in directing dental tissue regeneration. AJ Sloan (PI), RJ Waddington, J Rees 2007-2010; £70,000