Dr Konrad Beck
Position:Lecturer in Protein Biophysics
Research Theme
Tissue Engineering & Reparative Dentistry
Research Group
Extracellular Matrix (ECM) in Repair & Remodelling
Research Interests
- Structure and folding of multidomain proteins of the extracellular matrix
- Amyloid fibril formation
- Osmolyte effects on protein structure
- Circular Dichroism Spectroscopy
Selected Publications
- Heparin binds to the laminin α4 chain LG4 domain at a different site than found for other laminins.
- Destabilization of Osteogenesis Imperfecta collagen-like model peptides correlates with the identity of the residue replacing glycine.
- Supercoiled protein motifs: The collagen triple-helix and the α-helical coiled coil.
- A single amino acid can switch the oligomerization state of the α-helical coiled-coil domain of cartilage matrix protein.
Selected Projects
- Folding and Stability of α-Helical Coiled-Coil and Collagenous Proteins
- In Vitro Modulation of Alzheimer's Amyloid Fibril Formation by Small Organic Cofactors