Ewch i’r prif gynnwys
Jean-Yves Maillard

Yr Athro Jean-Yves Maillard

Professor of Pharmaceutical Microbiology

Ysgol Fferylliaeth a Gwyddorau Fferyllol

Email
MaillardJ@caerdydd.ac.uk
Telephone
+44 29208 79088
Campuses
Adeilad Redwood , Ystafell 1.49, Rhodfa'r Brenin Edward VII, Caerdydd, CF10 3NB
Comment
Sylwebydd y cyfryngau

Trosolwyg

I am a member of the School's research themes:

My research focuses on antimicrobial biocides, an area of continuing global importance due in part to the rise in hospital acquired infections (HAIs) and emerging microbial resistance.  

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Qualifications

  • PhD - Welsh School of Pharmacy, Cardiff University, Wales, UK - 1994
  • BSc (Hons) - School of Pure and Applied Microbiology, Cardiff University, Wales, UK -1991
  • DUT (Diplôme Universitaire de Technologie) - Claude Bernard University, Lyon, France - 1988

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Ymchwil


Research interests include: 

  • Sporicides, disinfectants and preservatives (biocides)
  • Efficacy of biocides and biocidal products against micro-organisms including mycobacteria, Clostridium difficile and protozoa
  • Mechanisms of action of biocides
  • Mechanisms of microbial resistance and cross-resistance to antimicrobials
  • Development of realistic efficacy test protocols for biocidal product development
  • Enhanced formulations for biocidal products

Current research projects

Collaborators

  • Prof. S. Sattar; University of Ottawa, Canada
  • Dr M.A. Webber; University of Birmingham
  • Prof. A. Sloan (Cardiff University, School of Dentistry)
  • Dr C. Lynch (Cardiff University, School of Dentistry)
  • Dr A. Fraise (NHS Trust, Birmingham)
  • Dr T. Bradley (NHS Trust, Birmingham)
  • Dr J. Walker (HPA, Porton Down)
  • Dr M. Samoes (University of Porto, Portugal)
  • Prof. N. Woodford (PHE, London)
  • Dr M. Sutton (PHE, Porton Down)
  • Dr I. Fallis (Cardiff University, School of Chemistry)
  • Dr E. Mahenthiralingam, School of Biosciences, Cardiff University
  • Dr P.J. de Pablo (university of Madrid)

Postdoctoral fellows

  • Dr Maria Rubiano Saavedra (2015): Antimicrobial surfaces
  • Dr Jawal Said (2015-2017): Development of anti-biofilm wipe products
  • Dr Wayne Ayre (2013-)

Key expertise 

  • Determining biocides  and biocidal products efficacy against micro-organisms: bacteria (including mycobacteria), viruses (including poliovirus and adenovirus type 5), bacterial endospores including Clostridium difficile, protozoa
  • Designing an developing realistic ad hoc biocide efficacy test protocols for product development
  • Biocide interactions with microbial cells
  • Development of microbial resistance to biocides and to chemotherapeutic antibiotics

Current research funding

YearFunderProjectAmount
2015NIHRBiocide impregnated surface materials for use in clinical areas – under what conditions do they work?£54,185
2015-2016KTP (Cardiff University/GAMA Healthcare)Development of anti-biofilm wipe products£115,895
2015-2018HISEffect of commonly used antimicrobial biocides in healthcare settings on the maintenance and transfer of multi drug resistance genes in Gram-negative bacteria£92,999
2011-2016 DENTLCharacterisation of pulpal responses to bacterial challenge and novel antimicrobials for management of bacterial contamination of infected pulps and root canals. 
2014-2016 Reckitt BenckiserUSA Mechanisms of virucidal action of novel formulations£110,500
2015-2016MRCLiposomal delivery of antimicrobials from dental£45,391

Addysgu

I lecture on Pharmaceutical Microbiology to all 4 years of the MPharm degree: 

  • MPharm 1:  PH1123: Structure and Function of Cells and Microbes (module leader)
  • MPharm 2:  PH2107: Formulation Science 1
  • MPharm 3: PH3101: Optimisation of Drug Design 
  • MPharm 4: PH4112: Pharmacy Advanced Research Specialisation 
  • MPharm 4: PH4208: Pharmacy Research Project 

Postgraduate students 

Current research students

  • Kerry Guest (2011- ) Bacterial resistance to biocides: an assessment of resistance mechanisms and method development.
  • Michelle OJeil (2010-) Biocide impregnated surface materials for use in clinical areas – under what conditions do they work?
  • Laura Knapp (2010-) Bacterial resistance to biocides: an assessment of resistance and mechanisms
  • Madhan Mohan Natarajan (2010-) Characterisation of pulpal responses to bacterial challenge and novel antimicrobials for management of bacterial contamination of infected pulps and root canals

Past research students 

  • Ezra Linley (2008-2012) Understanding the interactions of oxidizing agents with macromolecules and microbial cell components
  • Jenna Bowen (2008-2012) Detection of Lipopolysaccharide pyrogens by molecularly-imprinted polymers
  • Callum Cooper (2007-2010) Controlled delivery of bacterial viruses for the eradication of bacterial infection
  • Keely Cheeseman (2006-2009) Surveillance of susceptibility profile to antiseptics in ITU isolates of Staphylococcus aureus including MRSA
  • Federica Pinto (2006-2009) Mechanisms of viricidal action of polyhexamethylene biguanide 
  • Jessica Roberts (2006-2009) Ex-vivo modelling of antimicrobial control measures in pulpal disease. Joint with School of Dentistry (Richard Whipp studentship)
  • Deborah Martin (2005-2008) Understanding survival in, and the development of microbial resistance to, high-level disinfectants
  • Alexandra Henein (2003-2007) The potential of bacteriophage therapy in Acinetobacter spp. infections (University of Brighton), writing up
  • Bee Ann Yeep (2003-2007) Novel dendrimer-functionalised surfaces for fast DNA detection and extraction (University of Brighton)
  • Jennifer Shackelford (2003-2006) Investigation into the activity of ortho-phthalaldehyde against biofilm bacteria using an in vitro model system (University of Brighton)
  • Hannah Pearce (2002-2005) The preservation of complex oral liquids (University of Brighton)
  • Teresa Gallagher (2002-2005) Light activated antibiotic delivery to control microbial colonisation of medical devices (University of Brighton)
  • Alison Cottell (2001-2004) Understanding bacterial resistance to biocides: study of the effects of sub-minimal inhibitory concentrations on bacterial growth (University of Brighton)
  • Caroline Codling (2000-2003) Mechanisms of the antimicrobial action of Poliquad and Aldox.
  • Emma Rees (2000-2003) Mechanisms of mycobacterial resistance to biocides.
  • Margarita Gomez-Escalada (1999-2002) Diphenyl-ethers mode of action and possible relation with antibiotic resistance.
  • Sebastien Fraud (1999-2002) Mechanisms of the mycobactericidal action of ortho-phthalaldehyde
  • Syndie Messager (1998-2001) Development of an "ex-vivo" test to study microbial survival on human skin and antimicrobial formulations with an antiseptic property.
  • John Lear (1998-2001): Possible linked biocide-antibiotic resistance in bacteria
  • Louise Thomas (1998-2001) Development of resistance to chlorhexidine diacetate in Pseudomonas aeruginosa and the effect of a 'residual' concentration.
  • Caroline Huntley (1997-2000) Novel RNA binding agents.
  • Susannah Walsh (1996-1999): Studies on the antibacterial activity and mechanisms of action of ortho-phthalaldehyde: a possible alternative to glutaraldehyde for high level disinfection

Bywgraffiad

After completing a PhD on "the mechanisms of action biocides against viruses" at the Welsh School of Pharmacy, and a brief spell as an officer in the French Health Corp (St Anne' hospital, Toulon, France), I was fortunate to be appointed as a Lecturer at the Welsh School of Pharmacy at Cardiff. 

In 2001, I accepted a position of Senior Lecturer at the School of Pharmacy and Biomolecular Sciences at Brighton, before returning to Cardiff in 2004. My return to Cardiff enabled me to redevelop Pharmaceutical Microbiology Research within the Welsh School of Pharmacy. I was made Professor of Pharmaceutical Microbiology in July 2013.

Anrhydeddau a dyfarniadau

AwardYearDetails
AD Russel Memorial Lecture Award2012

This lecture award is given at the annual January Conference by a microbiologist who has made substantial contribution to the field of Applied Microbiology. This Memorial Lecture was instituted in 2005 to commemorate the life and works of the late A. Denver Russell (1936-2004), Professor of Pharmaceutical Microbiology and a long-time member of the Society.

AD Russel Memorail Teleclass Lecture Award2012

This lecture award is given annually by a microbiologist who has made substantial contribution to the field of Applied Microbiology. This Memorial Teleclass Lecture Award was instituted in 2011 to commemorate the life and works of the late A. Denver Russell (1936-2004), Professor of Pharmaceutical Microbiology and contributor to the Teleclass program.

Royal Pharmaceutical Society of Great Britain Academic Excellence Award 2007Joint recipient
British Pharmaceutical Conference Science Medal2004

An award given under the auspices of the Royal Pharmaceutical Society of Great Britain and the Academy of Pharmaceutical Sciences for a scientist working in a pharmaceutical or allied discipline in industry or academia, who has a proven record of independent research and whose published work shows outstanding promise. Invitations for this award are invited world-wide. 

W.H. Pierce Memorial prize2004

This prestigious prize is awarded each year at the annual Summer Conference to the young microbiologist (under 40) who has made a substantial contribution to the science of applied microbiology.

Federation of European Microbiology Societies (FEMS) Research Fellowship1998

FEMS Research Fellowships are meant to assist young European scientists in pursuing research up to 3 months in a European country different from that in which she/he lives.

Aelodaethau proffesiynol

  • Chief Editor of Letters in Applied Microbiology
  • Member of the Editorial Board of the Journal of Antimicrobial chemotherapy
  • Member of the Editorial Board of the Journal of Applied Microbiology
  • Member of the Society for Applied Microbiology
  • Member of the Healthcare Infection Society
  • Member of the CH/216/0-/01 Antimicrobial Hard Surfaces group (2012)
  • Member of the AHRAI/HIS Task force on sporicidal disinfectants (2010)
  • External examiner of Microbiology, Biotechnology, and Food Science & Microbiology degrees at the University of Surrey (2012-)
  • External examiner of the Master of Pharmacy in Pharmaceutical Sciences at Manchester University (2005-2010)
  • External scientific expert of the Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR – European Commission) (2007-2010)
  • External scientific expert of the Scientific Committee on Consumer Safety (SCCS – European Commission) (2009-2010)
  • Hearing scientific expert of the European Food Safety Authority (EFSA) (2009-2010)

Safleoedd academaidd blaenorol

2008-2013: Reader in Pharmaceutical Microbiology, Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University

2004 - 2008: Senior Lecturer in Pharmaceutical Microbiology, Welsh School of Pharmacy, Cardiff University

2004: Principal Lecturer and Reader in Pharmaceutical Microbiology, School of Pharmacy and Biomolecular Sciences at the University of Brighton

2001-2004: Senior Lecturer in Pharmaceutical Microbiology, School of Pharmacy and Biomolecular Sciences at the University of Brighton

1995-2001: Lecturer in Pharmaceutical Microbiology, Welsh School of Pharmacy, Cardiff University

Pwyllgorau ac adolygu

Editorship

Reviewer for peer-reviewed journals

I review manuscripts for journals including: Antimicrobial Agents and Chemotherapy, Journal of Hospital Infection, American Journal of Infection Control; Frontiers in Microbiology; PlosOne, Applied and Environmental Microbiology, Antimicrobial Agents and Chemotherapy, Infection Control and Hospital Epidemiology, Journal of Virology, the Journal of Virological Methods, Microbiology, Bioresource Technology; Canadian Journal of Microbiology; European Journal of Medicinal Chemistry; Biofouling; FEMS Microbiology Letters, Journal of Bacteriology, International Journal of Antimicrobial Agents, International Journal of Molecular Sciences, Journal of Pharmacy and Pharmacology, Water Research, the Journal of Drug Targeting, Journal of AOAC International, the Journal of Applied Polymer Science, Frontiers in Microbiology.

Reviewer for grant application

I am reviewing grant applications for UK, European and overseas funding bodies including: BBSRC, MRC, EPSRC, DoH, Healthcare Infection Society, PNRA (Programme de Recherche en Alimentation et Nutrition Humaine (ANR-INRA)), National Research Program on Food and Food-Industries (ALIA), Czech Foundation for Research (Czech Republic), ZonMW (The Netherlands Organisation for Health Research and Development), the Innovation and Technology Fund (Hong-Kong), JPI-AMR; Agence Nationale de la Recherche (Paris, France), NIH (National Institute of Health, USA), NBIC, Academy of Finland.

Grant panel member

2018-present: NBIC

2015-2018: JPI-AMR (co-chair in 2017 and 2018)