![Lee Parry BSc (Hons), PhD, FHEA](https://profiles-cardiff.imgix.net/attachments/1154?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Lee Parry
(Translated he/him)
BSc (Hons), PhD, FHEA
Lecturer
Ysgol y Biowyddorau
- ParryL3@caerdydd.ac.uk
- +44 29206 88017
- Adeilad Hadyn Ellis, Ystafell 1.23, Heol Maendy, Caerdydd, CF24 4HQ
- Sylwebydd y cyfryngau
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwyg
Darlithydd/Darlithydd
Atal a Chanfod Canser yn Gynnar
Swyddog Meinwe Dynol, Ysgol y Biowyddorau 2020-presennol
Arweinydd Canolfan Ymchwil Canser Cymru ar gyfer Canfod Cynnar 2020-23
Arweinydd Canolfan Ymchwil Canser Cymru ar gyfer Atal Personol 2020-23
Trosolwg ymchwil
Mae canser y colon yn arwain at oddeutu 600,000 o farwolaethau yn fyd-eang bob blwyddyn ac mae'n un o brif achosion marwolaeth yn y byd gorllewinol. Dyma'r pedwerydd canser mwyaf cyffredin yn y DU, gyda thua 40,000 o achosion newydd yn cael eu diagnosio bob blwyddyn (Cancer Research UK). Credir bod modd atal o leiaf hanner yr achosion hyn, gan fod dewisiadau ar gyfer diet a ffordd o fyw yn chwarae rhan sylweddol wrth newid risg person o ddatblygu canser.
Efallai nad yw'n syndod bod cysylltiad cryf rhwng canser y coluddyn â dewisiadau dietegol, er enghraifft mae deiet ffeibr uchel yn gysylltiedig â risg is o ganser. Fodd bynnag, nid yw'r rhesymau dros y cysylltiadau hyn yn hysbys o hyd. Er mwyn cael gwell dealltwriaeth mae angen i ni astudio'r bôn-gelloedd perfeddol sy'n gyfrifol am gynnal coluddyn iach, gan mai niwed i'r celloedd hyn sy'n gallu achosi canser.
Fodd bynnag, o gymharu â chanser, ychydig iawn o waith a wneir ar y coluddyn arferol, yn rhannol oherwydd anhawster cael samplau gan bobl iach a diffyg timau ymchwil sy'n gallu deall effaith gyflawn deiet ar y coluddyn. Mae'r grŵp yn gweithio i nodi sut mae'r bacteria, y system imiwnedd, epigenom a'r bôn-gelloedd yn y coluddyn arferol a chanseraidd yn ymateb i wahanol fathau o fwyd. Ffocws yr ymchwil yw gwella ein dealltwriaeth o ddeiet ac iechyd i ddarparu cyngor cyhoeddus cywir a datblygu ffyrdd o atal neu ganfod canser y coluddyn.
AR GYFER CYFLEOEDD POSTION AC EFRYDIAETH EDRYCHWCH AR Y TAB GORUCHWYLIO
Cyhoeddiad
2024
- Williams, J. S. et al. 2024. Enhanced bacterial cancer therapy delivering therapeutic RNA interference of c-Myc. Cell & Bioscience 14(38) (10.1186/s13578-024-01206-8)
2023
- Michael, D. R., Kerry-Smith, J., Webberley, T. S., Murphy, K., Plummer, S. F., Parry, L. and Marchesi, J. R. 2023. Does flow culture impact upon gut-probiotic interactions: a comparison with static culture. Journal of Functional Foods 104, article number: 105519. (10.1016/j.jff.2023.105519)
2022
- Williams, N. G. and Parry, L. 2022. Balancing the scales: Do healthy lifestyle choices offset the colorectal cancer risk of unhealthy choices?. eFood 3(6), article number: e45. (10.1002/efd2.45)
- Parry, L. 2022. Stemming the flow toward disease: A research profile of Lee Parry. eFood 3(6), article number: e46. (10.1002/efd2.46)
- May, S. et al. 2022. Modification of diet to reduce the stemness and tumourigenicity of murine and human intestinal cells. Molecular Nutrition & Food Research 66(19), article number: 2200234. (10.1002/mnfr.202200234)
2021
- Stott, K. J., Phillips, B., Parry, L. and May, S. 2021. Recent advancements in the exploitation of the gut microbiome in the diagnosis and treatment of colorectal cancer. Bioscience Reports 41(7), article number: BSR20204113. (10.1042/BSR20204113)
- Jukes, Z. et al. 2021. Lipid profiling of mouse intestinal organoids for studying APC mutations. Bioscience Reports 41(3), article number: BSR20202915. (10.1042/BSR20202915)
- Kermanizadeh, A., Jacobsen, N. R., Murphy, F., Parry, L., Zhang, H. and Møller, P. 2021. A review of the current state of nanomedicines for targeting and treatment of cancers - achievements and future challenges. Advanced Therapeutics 4(2), article number: 2000186. (10.1002/adtp.202000186)
2020
- May, S., Parry, C. and Parry, L. 2020. Berry chemoprevention: do berries decrease the window of opportunity for tumourigenesis. Food Frontiers 1(3) (10.1002/fft2.32)
- May, S., McDermott, G., Marchesi, J. and Parry, L. 2020. Impact of black raspberries on the normal and malignant Apc deficient murine gut microbiome. Journal of Berry Research 10(1), pp. 61-76. (10.3233/JBR-180372)
2019
- Kannen, V., Parry, L. and Martin, F. L. 2019. Phages enter the fight against colorectal cancer. Trends in Cancer 5(10), pp. 577-579. (10.1016/j.trecan.2019.08.002)
- Parry, L. and Phesse, T. J. 2019. FXR regulates intestinal stem cells response to bile acids in a high fat diet. Biotarget 3(12) (10.21037/biotarget.2019.07.01)
- Young, M. A., May, S., Damo, A., Yoon, Y. S., Hur, M., Swat, W. and Parry, L. 2019. Epigenetic regulation of Dlg1, via Kaiso, alters mitotic spindle polarity and promotes intestinal tumourigenesis. Molecular Cancer Research 17(3), pp. 686-696. (10.1158/1541-7786.MCR-18-0280)
2018
- Greenow, K. R., Zverev, M., May, S., Kendrick, H., Williams, G. T., Phesse, T. and Parry, L. 2018. Lect2 deficiency is characterised by altered cytokine levels and promotion of intestinal tumourigenesis. Oncotarget 9(92), pp. 36430-36443. (10.18632/oncotarget.26335)
- May, S. et al. 2018. Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation. Journal of Pathology 245(3), pp. 270-282. (10.1002/path.5074)
2017
- Colbeck, E. J. et al. 2017. Treg depletion licenses T cell-driven HEV neogenesis and promotes tumor destruction. Cancer Immunology Research 5(11), pp. 1005-1015. (10.1158/2326-6066.CIR-17-0131)
- Planells-Palop, V. et al. 2017. Human germ/stem cell-specific gene TEX19 influences cancer cell proliferation and cancer prognosis. Molecular Cancer 16, article number: 84. (10.1186/s12943-017-0653-4)
- May, S., Evans, S. and Parry, L. 2017. Organoids, organs-on-chips and other systems, and microbiota. Emerging Topics in Life Sciences 1(4), pp. 385-400. (10.1042/ETLS20170047)
2016
- Hollins, A. J. and Parry, L. 2016. Long-term culture of intestinal cell progenitors: an overview of their development, application, and associated technologies. Current Pathobiology Reports 4(4), pp. 209-219. (10.1007/s40139-016-0119-1)
- Schmidt, N. et al. 2016. Epigenetic silencing of serine protease HTRA1 drives polyploidy. BMC Cancer 16, article number: 399. (10.1186/s12885-016-2425-8)
- Zhao, C. et al. 2016. Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation. Nature Communications 7, article number: 10883. (10.1038/ncomms10883)
2015
- Parry, L., Young, M., El Marjou, F. and Clarke, A. R. 2015. Protocols for analyzing the role of Paneth cells in regenerating the murine intestine using conditional cre-lox mouse models. Journal of Visualized Experiments(105), article number: e53429. (10.3791/53429)
- Huels, D. J. et al. 2015. E-cadherin can limit the transforming properties of activating β‐catenin mutations. EMBO Journal 34(18), pp. 2321-2333. (10.15252/embj.201591739)
2014
- Koh, D. -. et al. 2014. KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes. Proceedings of the National Academy of Sciences of the United States of America 111(42), pp. 15078-15083. (10.1073/pnas.1318780111)
2013
- Parry, L., Young, M., El Marjou, F. and Clarke, A. R. 2013. Evidence for a crucial role of Paneth Cells in mediating the intestinal response to injury. Stem Cells 31(4), pp. 776-785. (10.1002/stem.1326)
- Jarde, T. et al. 2013. In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-OΔN89β-catenin system. Oncogene 32(7), pp. 883-893. (10.1038/onc.2012.103)
- Meniel, V. et al. 2013. Cited1 deficiency suppresses intestinal tumorigenesis. PLoS Genetics 9(8), article number: e1003638. (10.1371/journal.pgen.1003638)
2012
- Smartt, H. J. M. et al. 2012. β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells. Gut 61(9), pp. 1306-1314. (10.1136/gutjnl-2011-300817)
2011
- Parry, L. and Clarke, A. R. 2011. The roles of the methyl-CpG binding proteins in cancer. Genes & Cancer 2(6), pp. 618-630. (10.1177/1947601911418499)
2010
- Cole, A. et al. 2010. p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium. EMBO Molecular Medicine 2(11), pp. 472-486. (10.1002/emmm.201000101)
2008
- Phesse, T., Parry, L., Reed, K. R., Ewan, K. B. R., Dale, T. C., Sansom, O. J. and Clarke, A. R. 2008. Deficiency of Mbd2 attenuates Wnt induced tumourigenesis via deregulation of a novel Wnt inhibitor, Lect.2. Molecular and Cellular Biology 28(19), pp. 6094-6103. (10.1128/MCB.00539-08)
2005
- Wilson, C. H. et al. 2005. A mouse model of tuberous sclerosis 1 showing background specific early post-natal mortality and metastatic renal cell carcinoma. Human Molecular Genetics 14(13), pp. 1839-1850. (10.1093/hmg/ddi190)
2004
- Kirby, D. M. et al. 2004. NDUFS6 mutations are a novel cause of lethal neonatal mitochondrial complex I deficiency. The Journal of Clinical Investigation 114(6), pp. 837-845. (10.1172/JCI200420683)
2003
- Dixon, P. F. et al. 2003. Four years of monitoring for viral haemorrhagic septicaemia virus in marine waters around the United Kingdom. Disease of Aquatic Organisms 54(3), pp. 175-186. (10.3354/dao054175)
2001
- Hodges, A. K. et al. 2001. Pathological mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin. Human Molecular Genetics 10(25), pp. 2899-9205. (10.1093/hmg/10.25.2899)
- Parry, L. et al. 2001. Analysis of the TSC1 and TSC2 genes in sporadic renal cell carcinomas. British Journal of Cancer 85, pp. 1226-1230. (10.1054/bjoc.2001.2072)
2000
- Parry, L., Maynard, J. H., Patel, A., Hodges, A., von Deimling, A., Sampson, J. R. and Cheadle, J. P. 2000. Molecular analysis of the TSC1 and TSC2 tumour suppressor genes in sporadic glial and glioneuronal tumours. Human Genetics 107(4), pp. 350-356. (10.1007/s004390000390)
1997
- Dixon, P., Feist, S., Kehoe, E., Parry, L., Stone, D. and Way, K. 1997. Isolation of viral haemorrhagic septicaemia virus from Atlantic herring Clupea harengus from the Atlantic herring Clupea harengus from the English channel. Diseases of Aquatic Organisms 30(2), pp. 81-89.
- Parry, L. and Dixon, P. F. 1997. Stability of nine viral haemorrhagic septicaemia virus (VHSV) isolates in seawater. Bulletin of the European Association of Fish Pathologists 17(1), pp. 31-36.
Erthyglau
- Williams, J. S. et al. 2024. Enhanced bacterial cancer therapy delivering therapeutic RNA interference of c-Myc. Cell & Bioscience 14(38) (10.1186/s13578-024-01206-8)
- Michael, D. R., Kerry-Smith, J., Webberley, T. S., Murphy, K., Plummer, S. F., Parry, L. and Marchesi, J. R. 2023. Does flow culture impact upon gut-probiotic interactions: a comparison with static culture. Journal of Functional Foods 104, article number: 105519. (10.1016/j.jff.2023.105519)
- Williams, N. G. and Parry, L. 2022. Balancing the scales: Do healthy lifestyle choices offset the colorectal cancer risk of unhealthy choices?. eFood 3(6), article number: e45. (10.1002/efd2.45)
- Parry, L. 2022. Stemming the flow toward disease: A research profile of Lee Parry. eFood 3(6), article number: e46. (10.1002/efd2.46)
- May, S. et al. 2022. Modification of diet to reduce the stemness and tumourigenicity of murine and human intestinal cells. Molecular Nutrition & Food Research 66(19), article number: 2200234. (10.1002/mnfr.202200234)
- Stott, K. J., Phillips, B., Parry, L. and May, S. 2021. Recent advancements in the exploitation of the gut microbiome in the diagnosis and treatment of colorectal cancer. Bioscience Reports 41(7), article number: BSR20204113. (10.1042/BSR20204113)
- Jukes, Z. et al. 2021. Lipid profiling of mouse intestinal organoids for studying APC mutations. Bioscience Reports 41(3), article number: BSR20202915. (10.1042/BSR20202915)
- Kermanizadeh, A., Jacobsen, N. R., Murphy, F., Parry, L., Zhang, H. and Møller, P. 2021. A review of the current state of nanomedicines for targeting and treatment of cancers - achievements and future challenges. Advanced Therapeutics 4(2), article number: 2000186. (10.1002/adtp.202000186)
- May, S., Parry, C. and Parry, L. 2020. Berry chemoprevention: do berries decrease the window of opportunity for tumourigenesis. Food Frontiers 1(3) (10.1002/fft2.32)
- May, S., McDermott, G., Marchesi, J. and Parry, L. 2020. Impact of black raspberries on the normal and malignant Apc deficient murine gut microbiome. Journal of Berry Research 10(1), pp. 61-76. (10.3233/JBR-180372)
- Kannen, V., Parry, L. and Martin, F. L. 2019. Phages enter the fight against colorectal cancer. Trends in Cancer 5(10), pp. 577-579. (10.1016/j.trecan.2019.08.002)
- Parry, L. and Phesse, T. J. 2019. FXR regulates intestinal stem cells response to bile acids in a high fat diet. Biotarget 3(12) (10.21037/biotarget.2019.07.01)
- Young, M. A., May, S., Damo, A., Yoon, Y. S., Hur, M., Swat, W. and Parry, L. 2019. Epigenetic regulation of Dlg1, via Kaiso, alters mitotic spindle polarity and promotes intestinal tumourigenesis. Molecular Cancer Research 17(3), pp. 686-696. (10.1158/1541-7786.MCR-18-0280)
- Greenow, K. R., Zverev, M., May, S., Kendrick, H., Williams, G. T., Phesse, T. and Parry, L. 2018. Lect2 deficiency is characterised by altered cytokine levels and promotion of intestinal tumourigenesis. Oncotarget 9(92), pp. 36430-36443. (10.18632/oncotarget.26335)
- May, S. et al. 2018. Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation. Journal of Pathology 245(3), pp. 270-282. (10.1002/path.5074)
- Colbeck, E. J. et al. 2017. Treg depletion licenses T cell-driven HEV neogenesis and promotes tumor destruction. Cancer Immunology Research 5(11), pp. 1005-1015. (10.1158/2326-6066.CIR-17-0131)
- Planells-Palop, V. et al. 2017. Human germ/stem cell-specific gene TEX19 influences cancer cell proliferation and cancer prognosis. Molecular Cancer 16, article number: 84. (10.1186/s12943-017-0653-4)
- May, S., Evans, S. and Parry, L. 2017. Organoids, organs-on-chips and other systems, and microbiota. Emerging Topics in Life Sciences 1(4), pp. 385-400. (10.1042/ETLS20170047)
- Hollins, A. J. and Parry, L. 2016. Long-term culture of intestinal cell progenitors: an overview of their development, application, and associated technologies. Current Pathobiology Reports 4(4), pp. 209-219. (10.1007/s40139-016-0119-1)
- Schmidt, N. et al. 2016. Epigenetic silencing of serine protease HTRA1 drives polyploidy. BMC Cancer 16, article number: 399. (10.1186/s12885-016-2425-8)
- Zhao, C. et al. 2016. Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation. Nature Communications 7, article number: 10883. (10.1038/ncomms10883)
- Parry, L., Young, M., El Marjou, F. and Clarke, A. R. 2015. Protocols for analyzing the role of Paneth cells in regenerating the murine intestine using conditional cre-lox mouse models. Journal of Visualized Experiments(105), article number: e53429. (10.3791/53429)
- Huels, D. J. et al. 2015. E-cadherin can limit the transforming properties of activating β‐catenin mutations. EMBO Journal 34(18), pp. 2321-2333. (10.15252/embj.201591739)
- Koh, D. -. et al. 2014. KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes. Proceedings of the National Academy of Sciences of the United States of America 111(42), pp. 15078-15083. (10.1073/pnas.1318780111)
- Parry, L., Young, M., El Marjou, F. and Clarke, A. R. 2013. Evidence for a crucial role of Paneth Cells in mediating the intestinal response to injury. Stem Cells 31(4), pp. 776-785. (10.1002/stem.1326)
- Jarde, T. et al. 2013. In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-OΔN89β-catenin system. Oncogene 32(7), pp. 883-893. (10.1038/onc.2012.103)
- Meniel, V. et al. 2013. Cited1 deficiency suppresses intestinal tumorigenesis. PLoS Genetics 9(8), article number: e1003638. (10.1371/journal.pgen.1003638)
- Smartt, H. J. M. et al. 2012. β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells. Gut 61(9), pp. 1306-1314. (10.1136/gutjnl-2011-300817)
- Parry, L. and Clarke, A. R. 2011. The roles of the methyl-CpG binding proteins in cancer. Genes & Cancer 2(6), pp. 618-630. (10.1177/1947601911418499)
- Cole, A. et al. 2010. p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium. EMBO Molecular Medicine 2(11), pp. 472-486. (10.1002/emmm.201000101)
- Phesse, T., Parry, L., Reed, K. R., Ewan, K. B. R., Dale, T. C., Sansom, O. J. and Clarke, A. R. 2008. Deficiency of Mbd2 attenuates Wnt induced tumourigenesis via deregulation of a novel Wnt inhibitor, Lect.2. Molecular and Cellular Biology 28(19), pp. 6094-6103. (10.1128/MCB.00539-08)
- Wilson, C. H. et al. 2005. A mouse model of tuberous sclerosis 1 showing background specific early post-natal mortality and metastatic renal cell carcinoma. Human Molecular Genetics 14(13), pp. 1839-1850. (10.1093/hmg/ddi190)
- Kirby, D. M. et al. 2004. NDUFS6 mutations are a novel cause of lethal neonatal mitochondrial complex I deficiency. The Journal of Clinical Investigation 114(6), pp. 837-845. (10.1172/JCI200420683)
- Dixon, P. F. et al. 2003. Four years of monitoring for viral haemorrhagic septicaemia virus in marine waters around the United Kingdom. Disease of Aquatic Organisms 54(3), pp. 175-186. (10.3354/dao054175)
- Hodges, A. K. et al. 2001. Pathological mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin. Human Molecular Genetics 10(25), pp. 2899-9205. (10.1093/hmg/10.25.2899)
- Parry, L. et al. 2001. Analysis of the TSC1 and TSC2 genes in sporadic renal cell carcinomas. British Journal of Cancer 85, pp. 1226-1230. (10.1054/bjoc.2001.2072)
- Parry, L., Maynard, J. H., Patel, A., Hodges, A., von Deimling, A., Sampson, J. R. and Cheadle, J. P. 2000. Molecular analysis of the TSC1 and TSC2 tumour suppressor genes in sporadic glial and glioneuronal tumours. Human Genetics 107(4), pp. 350-356. (10.1007/s004390000390)
- Dixon, P., Feist, S., Kehoe, E., Parry, L., Stone, D. and Way, K. 1997. Isolation of viral haemorrhagic septicaemia virus from Atlantic herring Clupea harengus from the Atlantic herring Clupea harengus from the English channel. Diseases of Aquatic Organisms 30(2), pp. 81-89.
- Parry, L. and Dixon, P. F. 1997. Stability of nine viral haemorrhagic septicaemia virus (VHSV) isolates in seawater. Bulletin of the European Association of Fish Pathologists 17(1), pp. 31-36.
Ymchwil
Primary research
Colorectal cancer (CRC) is the 4th most frequent type of tumour and the 2nd leading cause of malignancy-related deaths in the Western world. Worldwide CRC incidence is increasing in female patients, those younger than 50 years-old and in low/middle income nations. As ~50% of CRC cases are preventable (WCRF-UK and Cancer Research UK websites) there is a potential to significantly reduce CRC incidence and address this global clinical need. Many of the fundamental mechanisms which link nutritional intake to physiological consequences remain undetermined. An improved mechanistic understanding would form part of a wider robust evidence base which is important in determining cause-and-effect relationships. There is a need to answer fundamental questions about the mechanisms by which diet impacts upon the normal biological processes and how they link through to influences on health and disease. Primary prevention can be achieved with greater understanding of how the major CRC risk factors of diet and lifestyle impact on the intestinal stem cell from which CRC originates. Secondary prevention can be achieved with improvements in existing and new techniques for the early detection of the pre-malignant polyps prior to thier progression to carcinoma.
It is well documented that CRCs evolve through loops of deregulated inflammatory stimuli which are sustained by DNA damage signalling pathways and epigenetic re-modelling (DNA methylation). Intensive work in recent years has led to the identification of genes and mechanisms that link diet to changes in the gut microbiota, and the pigenome. These alterations drive epithelial and inflammatory/immune responses which interact with intestinal stem cell and can increase or decrease CRC risk. As a lab we aim to foster symbiotic relationships with a multidisciplinary team that includes epidemiologists, dietitians, exercise physiologists, translational scientists, basic scientists, clinical researchers, clinicians, statisticians and public health professionals, all of whom bring their individual specialties to the common purpose. As we believe that synergic analysis of all parameters could provide new biological insights and effective biomarkers that could have applications in prevention, molecular diagnosis, prognosis and treatment of intestinal disease and CRC.
Current projects:
- Molecular and Functional Characterization of the Role of Foxp3+ Regulatory T (Treg) Cells in the Development of Intestinal Cancer
- Molecular and Functional Characterisation of the Nutri-Epigenetic Effects of Chemopreventative Polyphenols in Intestinal Cancer
- Identifying the influence of the microbiome and metabolome on the normal and
malignant murine intestinal stem cell - Exploiting oncotropic bacteria for early detection of colorectal cancer
Addysgu
Darlithydd ym Mhrifysgol Caerdydd
- 2022-23
- Arweinydd yr arholiad a chyfrannwr ar BI2332: Cysyniadau Clefydau
- Goruchwyliwr ar BI3001: Prosiect Blwyddyn Derfynol
- Darlithydd imiwnoleg ar Ganser BI3352: Mecanweithiau Cellog a Moleciwlaidd a Therapeutics
- Cyfrannwr ar BI3351: Pynciau cyfoes mewn clefyd
- Goruchwyliwr ar BI4001: Prosiect Ymchwil Uwch
- Cyfrannwr ar BI4002: Dulliau Ymchwil Uwch
- Cyfrannwr ar BI4003: Ffiniau yn y Biowyddorau
- 2020-21
- Cydlynydd: Gweithdy Bioleg Canser yr 2il Flwyddyn
- Darlithydd imiwnoleg ar Ganser BI3352: Mecanweithiau Cellog a Moleciwlaidd a Therapeutics
- Goruchwyliwr ar BI4001: Prosiect Ymchwil Uwch
- Cyfrannwr ar BI4002: Dulliau Ymchwil Uwch
- Cyfrannwr ar BI4003: Ffiniau yn y Biowyddorau
- Goruchwyliwr ar BI3001: Prosiect Blwyddyn Derfynol
- Cyfrannwr ar BI2332: Cysyniadau Clefydau
Darlithydd Ocsiwn ym Mhrifysgol Gorllewin Lloegr
- 2016-presennol: Darlithydd yn y Digwyddiad Cynhadledd Rsearch MSc
Bywgraffiad
Originally from the South Wales valleys, my undergraduate training was completed in Cardiff University, followed by a PhD at the Institute of Medical Genetics at (what was then) the University of Wales College of Medicine. My Cancer Research Wales funded PhD was completed in the laboratory of Professors Julian Sampson and Jeremy Cheadle on the "Molecular and Functional Analysis of the Human Tumour Suppressor Genes TSC1 and TSC2". Upon completing my PhD in 2002 I took up a Postdoctoral Fellow position at the Murdoch Children's Research Institute (MCRI) in the Royal Children's Hospital in Melbourne, Australia. My work there was a change of focus from the cancer genetics of my PhD as I worked in the research groups of A/Prof Henrik Dahl and David Thorburn on Complex I deficiency in mitochondria. Upon completing this post I returned to Cardiff University and to cancer genetics, working on a Cancer Research UK funded project in the laboratory of Prof Alan Clarke. In July 2013 I took up a fellowship at the European Cancer Stem Cell Research Institute where my research focused on understanding and therapeutically exploiting the mechanisms that links the environment (diet & gut bacteria) to inflammation and colorectal cancer. In 2020 I became a lecture at Cardiff University's School of Biosciences, where I lead the Prevention and Early Detection of Cancer group.
Anrhydeddau a dyfarniadau
2014 Cardiff University Excellence Award For Leadership
Aelodaethau proffesiynol
- British Association of Cancer Research 2006-
- European Association of Cancer Research 2006
- Genetics Society 1998-present
Network Memberships
- ECMC UK - Therapeutic Cancer Prevention Network
- STFC Cancer Detection Network+
Safleoedd academaidd blaenorol
- 2020 - present: Lecturer, Cardiff University, UK
- 2020 - 2020: Senior Research Fellow, European Cancer Stem Cell Research Institute, Cardiff University, UK
- 2013 - 2020: Research Fellow, European Cancer Stem Cell Research Institute, Cardiff University, UK
- 2005 - 2013: Postdoctoral Research Associate, Cardiff University, UK
- 2002-2005: Postdoctoral Research Fellow, Murdoch Children's Research Institute, Melbourne, Australia
Pwyllgorau ac adolygu
2020-present: Wales Cancer Research Centre Executive Committee Member
2018- present: Review Panel Member, Cardiff University Biobank
Grant Reviewer
- American Institute of Cancer Research
- Medical Research Council
- NC3R
- KiKa Dutch Cancer Council
- Research Council of Norway
Journal Reviewer
- BMC Cancer
- Clinical and Translational Medicine
- Immunology
- Journal of Pathology
- Journal of Visualised Experiments
- Kidney International
- Oncogene
- PLOS Biology
- Scientific Reports
- Trends in Endocrinology
Meysydd goruchwyliaeth
I would be interested in supervising in the areas of:
- Mouse models of disease
- Intestinal stem cells/cancer stem cells
- Cancer prevention
- Cancer early detection
- Any interaction between the microbiome, immune system and epigenome that impacts on the intestine
- Technology to improve prevention and early detection of cancer
- Translational/clinical resaerch into
I currently supervise/co-supervise the following students:
