![Donald Fraser](https://profiles-cardiff.imgix.net/attachments/2431?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Yr Athro Donald Fraser
Clinical Reader
- FraserDJ@caerdydd.ac.uk
- +44 29207 48449
- Prif Adeilad yr Ysbyty, Ystafell 6FT-164, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwyg
My research addresses the mechanisms underlying injury and scarring in the kidney and peritoneum, in the contexts of chronic kidney disease and peritoneal dialysis. These are examples of fibro-proliferative disorders, conditions that cause significant disease and suffering, and for which treatment options are very limited. Development and testing of novel therapies is restricted by incomplete knowledge of the biology of their progression, and lack of adequate biomarkers to serve as surrogate endpoints in clinical trials.
I am Director of Wales Kidney Research Unit, a Biomedical Research Unit funded by Health and Care Research Wales to deliver an All-Wales strategy for the study of diagnosis, prevention, treatment and social context of kidney disease. See: http://kidneyresearchunit.wales/en/
I am clinically active as a consultant nephrologist within Cardiff and Vale University Health Board, for whom I am Deputy R and D Director, and Medical Lead for the UHB's Clinical Research Facility.
Cyhoeddiad
2024
- Czubala, M. A. et al. 2024. Tissue-specific transcriptional programming of macrophages controls the microRNA transcriptome targeting multiple functional pathways. Journal of Biological Chemistry, article number: 107244. (10.1016/j.jbc.2024.107244)
- Varache, M. et al. 2024. Dextrin conjugation to colistin inhibits its toxicity, cellular uptake and acute kidney injury in vivo. RSC Pharmaceutics (10.1039/D3PM00014A)
2023
- Tam, F. W. et al. 2023. Randomized trial on the effect of an oral spleen tyrosine kinase inhibitor in the treatment of IgA nephropathy. Kidney International Reports 8(12), pp. 2546-2556. (10.1016/j.ekir.2023.09.024)
- Smith, D. A., Redman, J. E., Fraser, D. J. and Bowen, T. 2023. Identification and detection of microRNA kidney disease biomarkers in liquid biopsies. Current Opinion in Nephrology and Hypertension 32(6), pp. 515-521. (10.1097/MNH.0000000000000927)
- Cetin, E. et al. 2023. Calprotectin blockade inhibits long-term vascular pathology following peritoneal dialysis-associated bacterial infection. Frontiers in Cellular and Infection Microbiology 13, article number: 1285193. (10.3389/fcimb.2023.1285193)
- Roddick, A. J. et al. 2023. UK Kidney association clinical practice guideline: sodium-glucose co-transporter-2 (SGLT-2) inhibition in adults with kidney disease 2023 UPDATE. BMC Nephrology 24(1), article number: 310. (10.1186/s12882-023-03339-3)
2022
- Williams, J., Gilchrist, M., Strain, W. D., Fraser, D. and Shore, A. 2022. An exploratory study of the relationship between systemic microcirculatory function and small solute transport in incident peritoneal dialysis patients. Peritoneal Dialysis International 42(5), pp. 513-521. (10.1177/08968608211047332)
- Williams, J., Gilchrist, M., Strain, W. D., Fraser, D. and Shore, A. 2022. 24-h Glycaemic profiles in peritoneal dialysis patients and non-dialysis controls with advanced kidney disease. Peritoneal Dialysis International 42(5), pp. 497-504. (10.1177/08968608211047787)
- Zeni, L. et al. 2022. Exploration of a panel of urine biomarkers of kidney disease in two paediatric cohorts with Type 1 diabetes mellitus of differing duration. Diabetology and Metabolic Syndrome 14(1), article number: 71. (10.1186/s13098-022-00839-4)
2021
- Lu, Y. et al. 2021. Single-nucleus RNA sequencing identifies new classes of proximal tubular epithelial cells in kidney fibrosis. Journal of the American Society of Nephrology 32(10), pp. 2501-2516. (10.1681/ASN.2020081143)
- Newbury, L. J. et al. 2021. miR-141 mediates recovery from acute kidney injury. Scientific Reports 11(1), article number: 16499. (10.1038/s41598-021-94984-x)
- Smith, D. A. et al. 2021. Detection of urinary microRNA biomarkers using diazo sulfonamide-modified screen printed carbon electrodes. RSC Advances 11(31), pp. 18832-18839. (10.1039/D0RA09874D)
- Khalid, U. et al. 2021. Determination of a microRNA signature of protective kidney ischemic preconditioning originating from proximal tubules. Scientific Reports 11(1), article number: 9862. (10.1038/s41598-021-89195-3)
2020
- Marchant, V. et al. 2020. IL-17A as a potential therapeutic target for patients on peritoneal dialysis. Biomolecules 10(10), article number: 1361. (10.3390/biom10101361)
- Catar, R. A. et al. 2020. Control of neutrophil influx during peritonitis by transcriptional cross-regulation of chemokine CXCL1 by IL‐17 and IFN‐γ. Journal of Pathology 251(2), pp. 175-186. (10.1002/path.5438)
2019
- Brook, A. C. et al. 2019. Neutrophil-derived miR-223 as local biomarker of bacterial peritonitis. Scientific Reports 9, article number: 10136. (10.1038/s41598-019-46585-y)
- Pottanat, N. D. et al. 2019. Analysis of the Ribonuclease a superfamily of antimicrobial peptides in patients undergoing chronic peritoneal dialysis. Scientific Reports 9, pp. -., article number: 7753. (10.1038/s41598-019-44219-x)
- Khalid, U. et al. 2019. A urinary microRNA panel that is an early predictive biomarker of delayed graft function following kidney transplant. Scientific Reports 9, article number: 3584. (10.1038/s41598-019-38642-3)
2018
- Thomas, M., Fraser, D. and Bowen, T. 2018. Biogenesis, stabilization, and transport of microRNAs in kidney health and disease. Non-Coding RNA 4(4), pp. 30., article number: 30. (10.3390/ncrna4040030)
- Beltrami, C. et al. 2018. Association of elevated urinary miR-126, miR-155, and miR-29b with diabetic kidney disease. American Journal of Pathology 188(9), pp. 1982-1992. (10.1016/j.ajpath.2018.06.006)
- Raby, A., González-Mateo, G. T., Williams, A., Topley, N., Fraser, D., López-Cabrera, M. and Labeta, M. O. 2018. Targeting toll-like receptors with soluble toll-like receptor 2 prevents peritoneal dialysis solution-induced fibrosis. Kidney International 94(2), pp. 346-362. (10.1016/j.kint.2018.03.014)
2017
- Wonnacott, A., Bowen, T. and Fraser, D. 2017. MicroRNAs as biomarkers in chronic kidney disease. Current Opinion in Nephrology and Hypertension 26(6), pp. 460-466. (10.1097/MNH.0000000000000356)
- Aufricht, C. et al. 2017. Biomarker research to improve clinical outcomes of peritoneal dialysis: consensus of the European Training and Research in Peritoneal Dialysis (EuTRiPD) network. Kidney International 92(4), pp. 824-835. (10.1016/j.kint.2017.02.037)
- Lopez-Anton, M. et al. 2017. miR-21 promotes fibrogenesis in peritoneal dialysis. American Journal of Pathology 187(7), pp. 1537-1550. (10.1016/j.ajpath.2017.03.007)
- Zhang, J. et al. 2017. Machine-learning algorithms define pathogen-specific local immune fingerprints in peritoneal dialysis patients with bacterial infections. Kidney International 92(1), pp. 179-191. (10.1016/j.kint.2017.01.017)
- Lopez Anton, M. et al. 2017. Telomere length profiles in primary human peritoneal mesothelial cells are consistent with senescence. Mechanisms of Ageing and Development 164, pp. 37-40. (10.1016/j.mad.2017.03.010)
- Liao, C. et al. 2017. Peritoneal macrophage heterogeneity is associated with different peritoneal dialysis outcomes. Kidney International 91(5), pp. 1088-1103. (10.1016/j.kint.2016.10.030)
- Raby, A. et al. 2017. Toll-like receptors 2 and 4 are potential therapeutic targets in peritoneal dialysis-associated fibrosis. Journal of the American Society of Nephrology 28(2), pp. 461-478. (10.1681/ASN.2015080923)
2016
- Liao, C. et al. 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46(9), pp. 2222-2232. (10.1002/eji.201646528)
- Liuzzi, A. R. et al. 2016. Unconventional human T cells accumulate at the site of infection in response to microbial ligands and induce local tissue remodeling. Journal of Immunology 197(6), pp. 2195-2207. (10.4049/jimmunol.1600990)
- Simpson, K., Wonnacott, A., Fraser, D. J. and Bowen, T. 2016. MicroRNAs in diabetic nephropathy: from biomarkers to therapy. Current Diabetes Reports 16(3), article number: 35. (10.1007/s11892-016-0724-8)
- Khalid, U., Ablorsu, E., Szabo, L., Jenkins, R. H., Bowen, T., Chavez, R. and Fraser, D. J. 2016. MicroRNA-21 (miR-21) expression in hypothermic machine perfusate may be predictive of early outcomes in kidney transplantation. Clinical Transplantation 30(2), pp. 99-104. (10.1111/ctr.12679)
- Chavez, R., Fraser, D. J., Bowen, T., Jenkins, R. H., Nesargikar, P., Pino-Chavez, G. and Khalid, U. 2016. Kidney ischaemia reperfusion injury in the rat: the EGTI scoring system as a valid and reliable tool for histological assessment. Journal of Histology and Histopathology 3, article number: 1. (10.7243/2055-091X-3-1)
- Beelen, R. H. J., Fraser, D. J., Rutherford, P. and Witowski, J. 2016. Addressing peritoneal dialysis: in vitro PD models, in vivo rodent PD model, clinical biobanks, and underutilization of PD. BioMed Research International 2016, article number: 4964316. (10.1155/2016/4964316)
2015
- Khalid, U., Jenkins, R. H., Pino-Chavez, G., Bowen, T., Fraser, D. J. and Chavez, R. 2015. A localized ischemic preconditioning regimen increases tumor necrosis factor a expression in a rat model of kidney ischemia-reperfusion injury. Experimental and Clinical Transplantation 13(6), pp. 535-542. (10.6002/ect.2015.0039)
- Khalid, U., Pino-Chavez, G., Nesargikar, P., Jenkins, R., Bowen, T., Fraser, D. J. and Chavez, R. 2015. A new comprehensive scoring system is an accurate and robust tool for histological assessment of rat kidney IRI [Abstract]. Transplant International 28(S4), pp. 260-260. (10.1111/tri.12701)
- Nesargikar, P., Spiller, B., Jenkins, R., Khalid, U., Fraser, D. and Chavez, R. 2015. Modulation of leukocytes and endothelium by anti-thymocyte globulin confers protection against renal ischemia reperfusion injury in rats. Transplant International 28(54), pp. 61., article number: O158. (10.1111/tri.12700)
- Khalid, U., Ablorsu, E., Szabo, L., Jenkins, R., Bowen, T., Fraser, D. J. and Chavez, R. 2015. Expression of mir-10a,-21,-29a,-221 and-429 in hypothermic machine perfusate predicts early outcomes in kidney transplantation [Abstract]. Transplant International 28(S4), pp. 177-177. (10.1111/tri.12701)
- Khalid, U., Jenkins, R. H., Simpson, K., Ablorsu, E., Bowen, T., Fraser, D. J. and Chavez, R. 2015. Urinary microrna expression predicts delayed graft function in kidney transplantation [Abstract]. Transplant International 28(S4), pp. 367-367. (10.1111/tri.12702)
- Nesargikar, P., Pino-Chavez, G., Spiller, O. B., Fraser, D. J., Jenkins, R. H. and Chavez, R. 2015. Single dose sCR1 attenuates renal ischemia reperfusion injury in rats despite early reconstitution of the complement system [Abstract]. Transplant International 28(S4), pp. 62-62. (10.1111/tri.12700)
- Beltrami, C. et al. 2015. Stabilization of urinary microRNAs by association with exosomes and argonaute 2 protein. Non-Coding RNA 1(2), pp. 151-166. (10.3390/ncrna1020151)
- Liao, C., Fraser, D., Topley, N. and Taylor, P. 2015. Deciphering the peritoneal mononuclear phagocyte system in mice: Steady state and inflammation [Poster abstract]. Nephrology Dialysis Transplantation 30(iii), pp. iii265-. (10.1093/ndt/gfv180.25)
- Liao, C., Fraser, D. J., Topley, N. and Taylor, P. R. 2015. Determining the identity and functional specialization of peritoneal mononuclear phagocytes in peritoneal dialysis patients. Nephrology Dialysis Transplantation 30(S3), pp. iii264., article number: FP569. (10.1093/ndt/gfv180.21)
- Jenkins, R., Liao, C., Wallace, L., Bowen, T., Topley, N., Taylor, P. and Fraser, D. 2015. Microrna regulation of macrophage phenotype in peritoneal fibrosis. Nephrology Dialysis Transplantation 30(iii262) (10.1093/ndt/gfv180.15)
2014
- Khalid, U., Bowen, T., Fraser, D. and Jenkins, R. 2014. Acute kidney injury: a paradigm for miRNA regulation of the cell cycle. Biochemical Society Transactions 42(4), pp. 1219-1223. (10.1042/BST20140093)
- Rosas, M. et al. 2014. The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal. Science 344(6184), pp. 645-648. (10.1126/science.1251414)
- Jenkins, R. H. et al. 2014. miR-192 induces G2/M growth arrest in aristolochic acid nephropathy. American Journal of Pathology 184(4), pp. 996-1009. (10.1016/j.ajpath.2013.12.028)
- Jones, S. A., Fraser, D. J., Fielding, C. A. and Jones, G. W. 2014. Interleukin-6 in renal disease and therapy. Nephrology Dialysis Transplantation 30(4), pp. 564-574. (10.1093/ndt/gfu233)
2013
- Davies, L. C. et al. 2013. Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation. Nature Communications 4, article number: 1886. (10.1038/ncomms2877)
- Bowen, T., Jenkins, R. H. and Fraser, D. J. 2013. MicroRNAs, transforming growth factor Beta-1, and tissue fibrosis. The Journal of Pathology 229(2), pp. 274-285. (10.1002/path.4119)
2012
- Bodenham, T., Topley, N. and Fraser, D. J. 2012. Peritoneal fibrosis is mouse strain dependent. Nephrology Dialysis Transplantation 28(8), pp. 1966-1969. (10.1093/ndt/gfs446)
- Jenkins, R. H., Martin, J., Phillips, A. O., Bowen, T. and Fraser, D. J. 2012. Transforming growth factor β1 represses proximal tubular cell microRNA-192 expression through decreased hepatocyte nuclear factor DNA binding. Biochemical Journal 443(2), pp. 407-416. (10.1042/BJ20111861)
- Jenkins, R. H., Martin, J., Phillips, A. O., Bowen, T. and Fraser, D. J. 2012. Pleiotropy of microRNA-192 in the kidney. Biochemical Society Transactions 40(4), pp. 762-767. (10.1042/BST20120085)
- Beltrami, C., Clayton, A., Phillips, A. O., Fraser, D. J. and Bowen, T. 2012. Analysis of urinary microRNAs in chronic kidney disease. Biochemical Society Transactions 40(4), pp. 875-879. (10.1042/BST20120090)
- Beltrami, C., Clayton, A., Phillips, A. O., Fraser, D. J. and Bowen, T. 2012. Analysis of urinary microRNAs in chronic kidney disease. Biochemical Society Transactions 40(4), pp. 875-879. (10.1042/BST20120090)
2011
- Martin, J., Jenkins, R. H., Bennagi, R., Krupa, A., Phillips, A. O., Bowen, T. and Fraser, D. J. 2011. Post-transcriptional regulation of transforming growth factor beta-1 by microrna-744. PLoS ONE 6(10), article number: e25044. (10.1371/journal.pone.0025044)
- Davies, L. C., Rosas, M., Smith, P. J., Fraser, D. J., Jones, S. A. and Taylor, P. R. 2011. A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation. European Journal of Immunology 41(8), pp. 2155-2164. (10.1002/eji.201141817)
- Jenkins, R. H. and Fraser, D. J. 2011. BMP-6 emerges as a potential major regulator of fibrosis in the kidney [Commentary]. American Journal of Pathology 178(3), pp. 964-965. (10.1016/j.ajpath.2010.12.010)
2010
- Jenkins, R. H., Bennagi, R., Martin, J., Phillips, A. O., Redman, J. E. and Fraser, D. J. 2010. A conserved stem loop motif in the 5'Untranslated Region regulates transforming growth factor-β1 translation. PLoS One 5(8), article number: e12283. (10.1371/journal.pone.0012283)
- Krupa, A., Jenkins, R. H., Luo, D. D., Lewis, A. G., Phillips, A. O. and Fraser, D. J. 2010. Loss of microRNA-192 promotes fibrogenesis in diabetic nephropathy. Journal of the American Society of Nephrology 21(3), pp. 438-447. (10.1681/ASN.2009050530)
- Phillips, A. O. and Fraser, D. J. 2010. BMP-7 stops TGF-β in peritoneal fibrosis. Nephrology Dialysis Transplantation 25(4), pp. 1036-1038. (10.1093/ndt/gfq032)
- Luo, D. D., Phillips, A. O. and Fraser, D. J. 2010. Bone morphogenetic protein-7 inhibits proximal tubular epithelial cell smad3 signaling via increased SnoN expression. American Journal of Pathology 176(3), pp. 1139-1147. (10.2353/ajpath.2010.090459)
2009
- Luo, D. D., Fielding, C. A., Phillips, A. O. and Fraser, D. J. 2009. Interleukin-1 beta regulates proximal tubular cell transforming growth factor beta-1 signalling. Nephrology Dialysis Transplantation 24(9), pp. 2655-2665. (10.1093/ndt/gfp208)
- Fraser, D. J. and Topley, N. 2009. Altering peritoneal membrane function: removing the GAG?. Nephrology Dialysis Transplantation 24(11), pp. 3271-3273. (10.1093/ndt/gfp440)
2008
- Fraser, D. J., Phillips, A. O., Zhang, X. L., van Roeyen, C. R., Muehlenberg, P., En-Nia, A. and Mertens, P. R. 2008. Y-box protein-1 controls transforming growth factor-β1 translation in proximal tubular cells. Kidney International 73(6), pp. 724-732. (10.1038/sj.ki.5002719)
2007
- Zhang, M., Lee, C., Luo, D. D., Krupa, A., Fraser, D. J. and Phillips, A. O. 2007. Polarity of response to transforming growth factor-beta1 in proximal tubular epithelial cells is regulated by beta-catenin. Journal of Biological Chemistry 282(39), pp. 28639-28647. (10.1074/jbc.m700594200)
- Fraser, D. J. 2007. SMAD7: at the interface of TGF-beta and proinflammatory signalling[review]. Peritoneal Dialysis International 27(5), pp. 523-525.
2006
- Zhang, M., Fraser, D. J. and Phillips, A. O. 2006. ERK, p38, and Smad signaling pathways differentially regulate transforming growth factor-beta1 autoinduction in proximal tubular epithelial cells. American Journal of Pathology 169(4), pp. 1282-1293. (10.2353/ajpath.2006.050921)
- Monslow, J. et al. 2006. Sp1 and Sp3 mediate constitutive transcription of the human hyaluronan synthase 2 gene. The Journal of Biological Chemistry 281(26), pp. 18043-18050. (10.1074/jbc.M510467200)
- Matsumoto, N. et al. 2006. Butyrate modulates TGF-beta1 generation and function: potential renal benefit for Acacia(sen) SUPERGUM (gum arabic)?. Kidney International 69(2), pp. 257-65. (10.1038/sj.ki.5000028)
2004
- Ito, T., Williams, J. D., Fraser, D. J. and Phillips, A. O. 2004. Hyaluronan regulates transforming growth factor-beta1 receptor compartmentalization. The Journal of Biological Chemistry 279(24), pp. 25326-25332. (10.1074/jbc.M403135200)
- Ito, T., Williams, J. D., Fraser, D. and Phillips, A. O. 2004. Hyaluronan attenuates transforming growth factor-beta1-mediated signaling in renal proximal tubular epithelial cells. American Journal of Pathology 164(6), pp. 1979-1988. (10.1016/s0002-9440(10)63758-3)
2003
- Fraser, D. J., Brunskill, N., Ito, T. and Phillips, A. O. 2003. Long-term exposure of proximal tubular epithelial cells to glucose induces transforming growth factor-beta 1 synthesis via an autocrine PDGF loop. American Journal of Pathology 163(6), pp. 2565-2574.
- Tian, Y., Fraser, D. J., Attisano, L. and Phillips, A. O. 2003. TGF-beta1-mediated alterations of renal proximal tubular epithelial cell phenotype. American Journal of Physiology - Renal Physiology 285(1), pp. F130-142. (10.1152/ajprenal.00408.2002)
2002
- Fraser, D. J., Phillips, A. O. and Wakefield, L. 2002. Independent regulation of transforming growth factor-beta1 transcription and translation by glucose and platelet-derived growth factor. American Journal of Pathology 161(3), pp. 1039-1049.
2000
- Fraser, D. J. and Jibani, M. 2000. An unexpected and serious complication of treatment with the atypical antipsychotic drug clozapine. Clinical Nephrology 54(1), pp. 78-80.
Articles
- Czubala, M. A. et al. 2024. Tissue-specific transcriptional programming of macrophages controls the microRNA transcriptome targeting multiple functional pathways. Journal of Biological Chemistry, article number: 107244. (10.1016/j.jbc.2024.107244)
- Varache, M. et al. 2024. Dextrin conjugation to colistin inhibits its toxicity, cellular uptake and acute kidney injury in vivo. RSC Pharmaceutics (10.1039/D3PM00014A)
- Tam, F. W. et al. 2023. Randomized trial on the effect of an oral spleen tyrosine kinase inhibitor in the treatment of IgA nephropathy. Kidney International Reports 8(12), pp. 2546-2556. (10.1016/j.ekir.2023.09.024)
- Smith, D. A., Redman, J. E., Fraser, D. J. and Bowen, T. 2023. Identification and detection of microRNA kidney disease biomarkers in liquid biopsies. Current Opinion in Nephrology and Hypertension 32(6), pp. 515-521. (10.1097/MNH.0000000000000927)
- Cetin, E. et al. 2023. Calprotectin blockade inhibits long-term vascular pathology following peritoneal dialysis-associated bacterial infection. Frontiers in Cellular and Infection Microbiology 13, article number: 1285193. (10.3389/fcimb.2023.1285193)
- Roddick, A. J. et al. 2023. UK Kidney association clinical practice guideline: sodium-glucose co-transporter-2 (SGLT-2) inhibition in adults with kidney disease 2023 UPDATE. BMC Nephrology 24(1), article number: 310. (10.1186/s12882-023-03339-3)
- Williams, J., Gilchrist, M., Strain, W. D., Fraser, D. and Shore, A. 2022. An exploratory study of the relationship between systemic microcirculatory function and small solute transport in incident peritoneal dialysis patients. Peritoneal Dialysis International 42(5), pp. 513-521. (10.1177/08968608211047332)
- Williams, J., Gilchrist, M., Strain, W. D., Fraser, D. and Shore, A. 2022. 24-h Glycaemic profiles in peritoneal dialysis patients and non-dialysis controls with advanced kidney disease. Peritoneal Dialysis International 42(5), pp. 497-504. (10.1177/08968608211047787)
- Zeni, L. et al. 2022. Exploration of a panel of urine biomarkers of kidney disease in two paediatric cohorts with Type 1 diabetes mellitus of differing duration. Diabetology and Metabolic Syndrome 14(1), article number: 71. (10.1186/s13098-022-00839-4)
- Lu, Y. et al. 2021. Single-nucleus RNA sequencing identifies new classes of proximal tubular epithelial cells in kidney fibrosis. Journal of the American Society of Nephrology 32(10), pp. 2501-2516. (10.1681/ASN.2020081143)
- Newbury, L. J. et al. 2021. miR-141 mediates recovery from acute kidney injury. Scientific Reports 11(1), article number: 16499. (10.1038/s41598-021-94984-x)
- Smith, D. A. et al. 2021. Detection of urinary microRNA biomarkers using diazo sulfonamide-modified screen printed carbon electrodes. RSC Advances 11(31), pp. 18832-18839. (10.1039/D0RA09874D)
- Khalid, U. et al. 2021. Determination of a microRNA signature of protective kidney ischemic preconditioning originating from proximal tubules. Scientific Reports 11(1), article number: 9862. (10.1038/s41598-021-89195-3)
- Marchant, V. et al. 2020. IL-17A as a potential therapeutic target for patients on peritoneal dialysis. Biomolecules 10(10), article number: 1361. (10.3390/biom10101361)
- Catar, R. A. et al. 2020. Control of neutrophil influx during peritonitis by transcriptional cross-regulation of chemokine CXCL1 by IL‐17 and IFN‐γ. Journal of Pathology 251(2), pp. 175-186. (10.1002/path.5438)
- Brook, A. C. et al. 2019. Neutrophil-derived miR-223 as local biomarker of bacterial peritonitis. Scientific Reports 9, article number: 10136. (10.1038/s41598-019-46585-y)
- Pottanat, N. D. et al. 2019. Analysis of the Ribonuclease a superfamily of antimicrobial peptides in patients undergoing chronic peritoneal dialysis. Scientific Reports 9, pp. -., article number: 7753. (10.1038/s41598-019-44219-x)
- Khalid, U. et al. 2019. A urinary microRNA panel that is an early predictive biomarker of delayed graft function following kidney transplant. Scientific Reports 9, article number: 3584. (10.1038/s41598-019-38642-3)
- Thomas, M., Fraser, D. and Bowen, T. 2018. Biogenesis, stabilization, and transport of microRNAs in kidney health and disease. Non-Coding RNA 4(4), pp. 30., article number: 30. (10.3390/ncrna4040030)
- Beltrami, C. et al. 2018. Association of elevated urinary miR-126, miR-155, and miR-29b with diabetic kidney disease. American Journal of Pathology 188(9), pp. 1982-1992. (10.1016/j.ajpath.2018.06.006)
- Raby, A., González-Mateo, G. T., Williams, A., Topley, N., Fraser, D., López-Cabrera, M. and Labeta, M. O. 2018. Targeting toll-like receptors with soluble toll-like receptor 2 prevents peritoneal dialysis solution-induced fibrosis. Kidney International 94(2), pp. 346-362. (10.1016/j.kint.2018.03.014)
- Wonnacott, A., Bowen, T. and Fraser, D. 2017. MicroRNAs as biomarkers in chronic kidney disease. Current Opinion in Nephrology and Hypertension 26(6), pp. 460-466. (10.1097/MNH.0000000000000356)
- Aufricht, C. et al. 2017. Biomarker research to improve clinical outcomes of peritoneal dialysis: consensus of the European Training and Research in Peritoneal Dialysis (EuTRiPD) network. Kidney International 92(4), pp. 824-835. (10.1016/j.kint.2017.02.037)
- Lopez-Anton, M. et al. 2017. miR-21 promotes fibrogenesis in peritoneal dialysis. American Journal of Pathology 187(7), pp. 1537-1550. (10.1016/j.ajpath.2017.03.007)
- Zhang, J. et al. 2017. Machine-learning algorithms define pathogen-specific local immune fingerprints in peritoneal dialysis patients with bacterial infections. Kidney International 92(1), pp. 179-191. (10.1016/j.kint.2017.01.017)
- Lopez Anton, M. et al. 2017. Telomere length profiles in primary human peritoneal mesothelial cells are consistent with senescence. Mechanisms of Ageing and Development 164, pp. 37-40. (10.1016/j.mad.2017.03.010)
- Liao, C. et al. 2017. Peritoneal macrophage heterogeneity is associated with different peritoneal dialysis outcomes. Kidney International 91(5), pp. 1088-1103. (10.1016/j.kint.2016.10.030)
- Raby, A. et al. 2017. Toll-like receptors 2 and 4 are potential therapeutic targets in peritoneal dialysis-associated fibrosis. Journal of the American Society of Nephrology 28(2), pp. 461-478. (10.1681/ASN.2015080923)
- Liao, C. et al. 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46(9), pp. 2222-2232. (10.1002/eji.201646528)
- Liuzzi, A. R. et al. 2016. Unconventional human T cells accumulate at the site of infection in response to microbial ligands and induce local tissue remodeling. Journal of Immunology 197(6), pp. 2195-2207. (10.4049/jimmunol.1600990)
- Simpson, K., Wonnacott, A., Fraser, D. J. and Bowen, T. 2016. MicroRNAs in diabetic nephropathy: from biomarkers to therapy. Current Diabetes Reports 16(3), article number: 35. (10.1007/s11892-016-0724-8)
- Khalid, U., Ablorsu, E., Szabo, L., Jenkins, R. H., Bowen, T., Chavez, R. and Fraser, D. J. 2016. MicroRNA-21 (miR-21) expression in hypothermic machine perfusate may be predictive of early outcomes in kidney transplantation. Clinical Transplantation 30(2), pp. 99-104. (10.1111/ctr.12679)
- Chavez, R., Fraser, D. J., Bowen, T., Jenkins, R. H., Nesargikar, P., Pino-Chavez, G. and Khalid, U. 2016. Kidney ischaemia reperfusion injury in the rat: the EGTI scoring system as a valid and reliable tool for histological assessment. Journal of Histology and Histopathology 3, article number: 1. (10.7243/2055-091X-3-1)
- Beelen, R. H. J., Fraser, D. J., Rutherford, P. and Witowski, J. 2016. Addressing peritoneal dialysis: in vitro PD models, in vivo rodent PD model, clinical biobanks, and underutilization of PD. BioMed Research International 2016, article number: 4964316. (10.1155/2016/4964316)
- Khalid, U., Jenkins, R. H., Pino-Chavez, G., Bowen, T., Fraser, D. J. and Chavez, R. 2015. A localized ischemic preconditioning regimen increases tumor necrosis factor a expression in a rat model of kidney ischemia-reperfusion injury. Experimental and Clinical Transplantation 13(6), pp. 535-542. (10.6002/ect.2015.0039)
- Khalid, U., Pino-Chavez, G., Nesargikar, P., Jenkins, R., Bowen, T., Fraser, D. J. and Chavez, R. 2015. A new comprehensive scoring system is an accurate and robust tool for histological assessment of rat kidney IRI [Abstract]. Transplant International 28(S4), pp. 260-260. (10.1111/tri.12701)
- Nesargikar, P., Spiller, B., Jenkins, R., Khalid, U., Fraser, D. and Chavez, R. 2015. Modulation of leukocytes and endothelium by anti-thymocyte globulin confers protection against renal ischemia reperfusion injury in rats. Transplant International 28(54), pp. 61., article number: O158. (10.1111/tri.12700)
- Khalid, U., Ablorsu, E., Szabo, L., Jenkins, R., Bowen, T., Fraser, D. J. and Chavez, R. 2015. Expression of mir-10a,-21,-29a,-221 and-429 in hypothermic machine perfusate predicts early outcomes in kidney transplantation [Abstract]. Transplant International 28(S4), pp. 177-177. (10.1111/tri.12701)
- Khalid, U., Jenkins, R. H., Simpson, K., Ablorsu, E., Bowen, T., Fraser, D. J. and Chavez, R. 2015. Urinary microrna expression predicts delayed graft function in kidney transplantation [Abstract]. Transplant International 28(S4), pp. 367-367. (10.1111/tri.12702)
- Nesargikar, P., Pino-Chavez, G., Spiller, O. B., Fraser, D. J., Jenkins, R. H. and Chavez, R. 2015. Single dose sCR1 attenuates renal ischemia reperfusion injury in rats despite early reconstitution of the complement system [Abstract]. Transplant International 28(S4), pp. 62-62. (10.1111/tri.12700)
- Beltrami, C. et al. 2015. Stabilization of urinary microRNAs by association with exosomes and argonaute 2 protein. Non-Coding RNA 1(2), pp. 151-166. (10.3390/ncrna1020151)
- Liao, C., Fraser, D., Topley, N. and Taylor, P. 2015. Deciphering the peritoneal mononuclear phagocyte system in mice: Steady state and inflammation [Poster abstract]. Nephrology Dialysis Transplantation 30(iii), pp. iii265-. (10.1093/ndt/gfv180.25)
- Liao, C., Fraser, D. J., Topley, N. and Taylor, P. R. 2015. Determining the identity and functional specialization of peritoneal mononuclear phagocytes in peritoneal dialysis patients. Nephrology Dialysis Transplantation 30(S3), pp. iii264., article number: FP569. (10.1093/ndt/gfv180.21)
- Jenkins, R., Liao, C., Wallace, L., Bowen, T., Topley, N., Taylor, P. and Fraser, D. 2015. Microrna regulation of macrophage phenotype in peritoneal fibrosis. Nephrology Dialysis Transplantation 30(iii262) (10.1093/ndt/gfv180.15)
- Khalid, U., Bowen, T., Fraser, D. and Jenkins, R. 2014. Acute kidney injury: a paradigm for miRNA regulation of the cell cycle. Biochemical Society Transactions 42(4), pp. 1219-1223. (10.1042/BST20140093)
- Rosas, M. et al. 2014. The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal. Science 344(6184), pp. 645-648. (10.1126/science.1251414)
- Jenkins, R. H. et al. 2014. miR-192 induces G2/M growth arrest in aristolochic acid nephropathy. American Journal of Pathology 184(4), pp. 996-1009. (10.1016/j.ajpath.2013.12.028)
- Jones, S. A., Fraser, D. J., Fielding, C. A. and Jones, G. W. 2014. Interleukin-6 in renal disease and therapy. Nephrology Dialysis Transplantation 30(4), pp. 564-574. (10.1093/ndt/gfu233)
- Davies, L. C. et al. 2013. Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation. Nature Communications 4, article number: 1886. (10.1038/ncomms2877)
- Bowen, T., Jenkins, R. H. and Fraser, D. J. 2013. MicroRNAs, transforming growth factor Beta-1, and tissue fibrosis. The Journal of Pathology 229(2), pp. 274-285. (10.1002/path.4119)
- Bodenham, T., Topley, N. and Fraser, D. J. 2012. Peritoneal fibrosis is mouse strain dependent. Nephrology Dialysis Transplantation 28(8), pp. 1966-1969. (10.1093/ndt/gfs446)
- Jenkins, R. H., Martin, J., Phillips, A. O., Bowen, T. and Fraser, D. J. 2012. Transforming growth factor β1 represses proximal tubular cell microRNA-192 expression through decreased hepatocyte nuclear factor DNA binding. Biochemical Journal 443(2), pp. 407-416. (10.1042/BJ20111861)
- Jenkins, R. H., Martin, J., Phillips, A. O., Bowen, T. and Fraser, D. J. 2012. Pleiotropy of microRNA-192 in the kidney. Biochemical Society Transactions 40(4), pp. 762-767. (10.1042/BST20120085)
- Beltrami, C., Clayton, A., Phillips, A. O., Fraser, D. J. and Bowen, T. 2012. Analysis of urinary microRNAs in chronic kidney disease. Biochemical Society Transactions 40(4), pp. 875-879. (10.1042/BST20120090)
- Beltrami, C., Clayton, A., Phillips, A. O., Fraser, D. J. and Bowen, T. 2012. Analysis of urinary microRNAs in chronic kidney disease. Biochemical Society Transactions 40(4), pp. 875-879. (10.1042/BST20120090)
- Martin, J., Jenkins, R. H., Bennagi, R., Krupa, A., Phillips, A. O., Bowen, T. and Fraser, D. J. 2011. Post-transcriptional regulation of transforming growth factor beta-1 by microrna-744. PLoS ONE 6(10), article number: e25044. (10.1371/journal.pone.0025044)
- Davies, L. C., Rosas, M., Smith, P. J., Fraser, D. J., Jones, S. A. and Taylor, P. R. 2011. A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation. European Journal of Immunology 41(8), pp. 2155-2164. (10.1002/eji.201141817)
- Jenkins, R. H. and Fraser, D. J. 2011. BMP-6 emerges as a potential major regulator of fibrosis in the kidney [Commentary]. American Journal of Pathology 178(3), pp. 964-965. (10.1016/j.ajpath.2010.12.010)
- Jenkins, R. H., Bennagi, R., Martin, J., Phillips, A. O., Redman, J. E. and Fraser, D. J. 2010. A conserved stem loop motif in the 5'Untranslated Region regulates transforming growth factor-β1 translation. PLoS One 5(8), article number: e12283. (10.1371/journal.pone.0012283)
- Krupa, A., Jenkins, R. H., Luo, D. D., Lewis, A. G., Phillips, A. O. and Fraser, D. J. 2010. Loss of microRNA-192 promotes fibrogenesis in diabetic nephropathy. Journal of the American Society of Nephrology 21(3), pp. 438-447. (10.1681/ASN.2009050530)
- Phillips, A. O. and Fraser, D. J. 2010. BMP-7 stops TGF-β in peritoneal fibrosis. Nephrology Dialysis Transplantation 25(4), pp. 1036-1038. (10.1093/ndt/gfq032)
- Luo, D. D., Phillips, A. O. and Fraser, D. J. 2010. Bone morphogenetic protein-7 inhibits proximal tubular epithelial cell smad3 signaling via increased SnoN expression. American Journal of Pathology 176(3), pp. 1139-1147. (10.2353/ajpath.2010.090459)
- Luo, D. D., Fielding, C. A., Phillips, A. O. and Fraser, D. J. 2009. Interleukin-1 beta regulates proximal tubular cell transforming growth factor beta-1 signalling. Nephrology Dialysis Transplantation 24(9), pp. 2655-2665. (10.1093/ndt/gfp208)
- Fraser, D. J. and Topley, N. 2009. Altering peritoneal membrane function: removing the GAG?. Nephrology Dialysis Transplantation 24(11), pp. 3271-3273. (10.1093/ndt/gfp440)
- Fraser, D. J., Phillips, A. O., Zhang, X. L., van Roeyen, C. R., Muehlenberg, P., En-Nia, A. and Mertens, P. R. 2008. Y-box protein-1 controls transforming growth factor-β1 translation in proximal tubular cells. Kidney International 73(6), pp. 724-732. (10.1038/sj.ki.5002719)
- Zhang, M., Lee, C., Luo, D. D., Krupa, A., Fraser, D. J. and Phillips, A. O. 2007. Polarity of response to transforming growth factor-beta1 in proximal tubular epithelial cells is regulated by beta-catenin. Journal of Biological Chemistry 282(39), pp. 28639-28647. (10.1074/jbc.m700594200)
- Fraser, D. J. 2007. SMAD7: at the interface of TGF-beta and proinflammatory signalling[review]. Peritoneal Dialysis International 27(5), pp. 523-525.
- Zhang, M., Fraser, D. J. and Phillips, A. O. 2006. ERK, p38, and Smad signaling pathways differentially regulate transforming growth factor-beta1 autoinduction in proximal tubular epithelial cells. American Journal of Pathology 169(4), pp. 1282-1293. (10.2353/ajpath.2006.050921)
- Monslow, J. et al. 2006. Sp1 and Sp3 mediate constitutive transcription of the human hyaluronan synthase 2 gene. The Journal of Biological Chemistry 281(26), pp. 18043-18050. (10.1074/jbc.M510467200)
- Matsumoto, N. et al. 2006. Butyrate modulates TGF-beta1 generation and function: potential renal benefit for Acacia(sen) SUPERGUM (gum arabic)?. Kidney International 69(2), pp. 257-65. (10.1038/sj.ki.5000028)
- Ito, T., Williams, J. D., Fraser, D. J. and Phillips, A. O. 2004. Hyaluronan regulates transforming growth factor-beta1 receptor compartmentalization. The Journal of Biological Chemistry 279(24), pp. 25326-25332. (10.1074/jbc.M403135200)
- Ito, T., Williams, J. D., Fraser, D. and Phillips, A. O. 2004. Hyaluronan attenuates transforming growth factor-beta1-mediated signaling in renal proximal tubular epithelial cells. American Journal of Pathology 164(6), pp. 1979-1988. (10.1016/s0002-9440(10)63758-3)
- Fraser, D. J., Brunskill, N., Ito, T. and Phillips, A. O. 2003. Long-term exposure of proximal tubular epithelial cells to glucose induces transforming growth factor-beta 1 synthesis via an autocrine PDGF loop. American Journal of Pathology 163(6), pp. 2565-2574.
- Tian, Y., Fraser, D. J., Attisano, L. and Phillips, A. O. 2003. TGF-beta1-mediated alterations of renal proximal tubular epithelial cell phenotype. American Journal of Physiology - Renal Physiology 285(1), pp. F130-142. (10.1152/ajprenal.00408.2002)
- Fraser, D. J., Phillips, A. O. and Wakefield, L. 2002. Independent regulation of transforming growth factor-beta1 transcription and translation by glucose and platelet-derived growth factor. American Journal of Pathology 161(3), pp. 1039-1049.
- Fraser, D. J. and Jibani, M. 2000. An unexpected and serious complication of treatment with the atypical antipsychotic drug clozapine. Clinical Nephrology 54(1), pp. 78-80.
- Liao, C. et al. 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46(9), pp. 2222-2232. (10.1002/eji.201646528)
- Liuzzi, A. R. et al. 2016. Unconventional human T cells accumulate at the site of infection in response to microbial ligands and induce local tissue remodeling. Journal of Immunology 197(6), pp. 2195-2207. (10.4049/jimmunol.1600990)
- Simpson, K., Wonnacott, A., Fraser, D. J. and Bowen, T. 2016. MicroRNAs in diabetic nephropathy: from biomarkers to therapy. Current Diabetes Reports 16(3), article number: 35. (10.1007/s11892-016-0724-8)
- Khalid, U., Ablorsu, E., Szabo, L., Jenkins, R. H., Bowen, T., Chavez, R. and Fraser, D. J. 2016. MicroRNA-21 (miR-21) expression in hypothermic machine perfusate may be predictive of early outcomes in kidney transplantation. Clinical Transplantation 30(2), pp. 99-104. (10.1111/ctr.12679)
- Beltrami, C. et al. 2015. Stabilization of urinary microRNAs by association with exosomes and argonaute 2 protein. Non-Coding RNA 1(2), pp. 151-166. (10.3390/ncrna1020151)
- Rosas, M. et al. 2014. The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal. Science 344(6184), pp. 645-648. (10.1126/science.1251414)
- Jenkins, R. H. et al. 2014. miR-192 induces G2/M growth arrest in aristolochic acid nephropathy. American Journal of Pathology 184(4), pp. 996-1009. (10.1016/j.ajpath.2013.12.028)
- Davies, L. C. et al. 2013. Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation. Nature Communications 4, article number: 1886. (10.1038/ncomms2877)
- Bowen, T., Jenkins, R. H. and Fraser, D. J. 2013. MicroRNAs, transforming growth factor Beta-1, and tissue fibrosis. The Journal of Pathology 229(2), pp. 274-285. (10.1002/path.4119)
- Jenkins, R. H., Martin, J., Phillips, A. O., Bowen, T. and Fraser, D. J. 2012. Transforming growth factor β1 represses proximal tubular cell microRNA-192 expression through decreased hepatocyte nuclear factor DNA binding. Biochemical Journal 443(2), pp. 407-416. (10.1042/BJ20111861)
- Davies, L. C., Rosas, M., Smith, P. J., Fraser, D. J., Jones, S. A. and Taylor, P. R. 2011. A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation. European Journal of Immunology 41(8), pp. 2155-2164. (10.1002/eji.201141817)
- Krupa, A., Jenkins, R. H., Luo, D. D., Lewis, A. G., Phillips, A. O. and Fraser, D. J. 2010. Loss of microRNA-192 promotes fibrogenesis in diabetic nephropathy. Journal of the American Society of Nephrology 21(3), pp. 438-447. (10.1681/ASN.2009050530)
Bywgraffiad
Education and qualifications
- 2016: GCP (Good Clinical Practise in Research) Certification (Health and Care Research Wales)
- 2006: Postgraduate Medical Education and Training Board, Certificate of Completion of Training, General (Internal) Medicine and Nephrology
- 2003: PhD, University of Wales College of Medicine
- 1996: Member of The Royal College of Physicians, London
- 1993: MB ChB, University of Bristol
Career overview
- 2015-Present: Professor of Nephrology, Cardiff University School of Medicine
- 2005-2015: Cardiff University School of Medicine (2005: Lecturer, 2006: Senior Lecturer, 2011: Reader)
- 1997-2005: Specialist Registrar, All Wales Nephrology and General (Internal) Medicine Rotation
- 1995-1997: Senior House Officer, South Manchester University Hospitals Rotation
- 1994-1995: Senior House Officer, Burnley General Hospital
- 1993-1994: House Physician and Surgeon, Bristol Royal Infirmary and Southmead Hospital, Bristol
Anrhydeddau a dyfarniadau
- 2013: Health and Care Research Wales, Lead Researcher
- 2011: American Society of Nephrology Travel Scholarship
- 2010: Sir Jules Thorne Scholarship
- 2005: Welsh Office of Research Development/Medical Research Council, Clinician Scientist Fellowship
- 2000: Kidney Research UK Clinical Training Fellowship
Aelodaethau proffesiynol
- Fellow of the Royal College of Physicians, London
- American Society of Nephrology, Member
- UK Renal Association, Member
Safleoedd academaidd blaenorol
2013-18 Kidney Research UK Grants Committee, Member
2011-2017: Cardiff University Lead for Wales Clinical Academic Track Scheme
2008-2011: Postgraduate Research Degrees Committee, Member
Pwyllgorau ac adolygu
- 2015-present: Member, Systems Immunity University Research Institute
- 2011-present: Cardiff University Lead for Wales Clinical Academic Track Scheme
- 2008-2011: Member of the Postgraduate Research Degrees Committee
External committees
- 2013-present Kidney Research UK Grants Committee
Meysydd goruchwyliaeth
I am currently principal supervisor for one PhD student and cosupervisor for four PhD students, I welcome enquiries about joining the group from prospective undergraduate and postgraduate students
