Yr Athro David Williams

Professor David Williams

Theme Lead for Oral and Biomedical Sciences, Professor of Oral Microbiology, School of Dentistry

School of Dentistry

Mae'r cynnwys hwn ar gael yn Saesneg yn unig.

Professor of Oral Microbiology and academic lead of the Microbial Disease Research Group at the School of Dentistry.

Career Profile

2013-PresentProfessor of Oral Microbiology  (Cardiff University)
2007- 2013  Reader in Oral Microbiology (Cardiff University)
2003-2007Lecturer in Oral Microbiology(UWCM)
1999-2003Lecturer in Oral Microbiology  (UWCM)
1997-1999 Postdoctoral Research Fellow (UWCM)
1994 Diploma in Biomedical Methods (with Distinction)(UWCM)
1993-1996MRC PhD Studentship (UWCM)
1987-1993 Research Officer (Leatherhead Food
Research Association)
1983-1987  BSc (Hons.) Applied Biology (First Class) (UWCC)

Teaching Profile

I teach a variety of subjects associated with Oral Microbiology for the dental undergraduate course and for additional postgraduate courses. My teaching responsibilities comprise lectures, seminars, practical classes and student assessment. I am a full member of the The Higher Education Academy and a member of the Association of Basic Science Teachers in Dentistry (ABSTD).

External Assessment

Past and current - External Examiner for PhD, MPhil, MSc, The Integrated Human Diseases (IHD) Course Sheffield University (2014-present)

Memberships / External Activities

International Association of Dental Research (IADR)
British Society of Oral and Dental Research (BSODR), and Honorary Secretary (2011-present)
British Society of Medical Mycology (BSMM)
Association of Basic Science Teachers in Dentistry (ABSTD)
Association of Clinical Oral Microbiologists (ACOM)
The Higher Education Academy
Cardiff Institute of Tissue Engineering and Repair (CITER)
Oral Microbiology and Immunology Group (OMIG), and committee member (2011-present)
Oral Medicine and Pathology Group (OMPG)
Editorial board member of the Journal, Oral Microbiology and Immunology

Invited Lectures

  • Sheffield University Dental Seminar Series (Sheffield, UK, 2014)
  • ETRS (Reims, France, 2013)
  • Fungal Biofilms (Glasgow, UK, 2013)
  • Annual Postgraduate Research Day (Swansea, UK, 2012)
  • Eastman Dental Institute Seminar Series (London, UK, 2012)
  • Journal of Wound Care (Manchester, UK, 2011)
  • SARTRE Science Showcase: (Newport, UK, 2011)
  • ImechE (London, UK, 2011)
  • MediWales (Cardiff, UK, 2011)
  • Second International Practical Course in Biofilm Science, (University of Minho, Braga, Portugal, 2009)
  • 19th Annual Microbiology Symposium (Oglebay Resort and Conference Center, Wheeling, West Virginia, USA, 2008).
  • Yeasts and Moulds: An Update.   West Virgina University, Morgantown, USA, 2008.
  • European Tissue Repair Society, San Gorg Hotel Conference Centre, Malta, 2008.
  • OMIG/ABSTD, Durham, UK 2007.
  • Emerging Microbiological Threats in Dentistry. Royal College of Physicians and Surgeons of Glasgow, Glasgow, UK, 2007.
  • Immunopathogenesis of Oral Candidosis. Kanazawa Medical School, Kanazawa, Japan, 2006.
  • The Biology of Microbial and Epithelial Interactions, OMIG/Biofilm Club, Port Sunlight, UK, 2006.
  • Colgate Plenary Symposium, BSDR Annual Meeting Dundee, UK, 2005.
  • The Formation of Oral Biofilms and their Significance in Disease, SUDI conference, Cardiff, 2005.
  • Identification and Typing of Candida species.   IADR/PEF Goteborg, Sweden, 2003.

Additional International Presentations

IADR-PER, Helsinki, Finland, 2013
IADR Seattle, USA
IADR Iguazu Falls, Brazil, 2012
IADR, San Diego, USA, 2011
IADR, Toronto, Canada, 2008
IADR, Honolulu, USA, 2004
IADR, San Diego, USA, 2002
IADR, Washington, USA, 2000
IADR/PEF, Nice, France, 1998
IADR, Florida, USA, 1997

Awards and Prizes

Personal awards:

Senior Colgate Prize (1996, BSDR)
Edward H Hatton Award (1997, IADR)

Associated Undergraduate/Postgraduate/Postdoctoral Awards:

Franklyn Williams Elective 2004
PPP Foundation Poster Competition (3rd prize; 2002)
Dental Protection Society Premiere Award (2nd prize; 2002)
Dentsply Student Clinician Award (2002)
Graduate School in Biomedical and Life Sciences Travel Grant (2006)
Bristol Urological Institute Prize Innovation (2009)

Honours and awards

Personal awards:

Senior Colgate Prize (1996, BSDR)
Edward H Hatton Award (1997, IADR)

Associated Undergraduate/Postgraduate/Postdoctoral Awards:

Franklyn Williams Elective 2004
PPP Foundation Poster Competition (3rd prize; 2002)
Dental Protection Society Premiere Award (2nd prize; 2002)
Dentsply Student Clinician Award (2002)
Graduate School in Biomedical and Life Sciences Travel Grant (2006)
Bristol Urological Institute Prize Innovation (2009)
The Simon Foundation (2011) Poster Prize Award

Academic positions

1. Reader in Oral Microbiology 2007-2013, School of Dentistry, Cardiff University.
2. Senior lecturer in Oral Microbiology 2003-2007, Cardiff University.
3. Lecturer in Oral Microbiolgy 1999-2003, Cardiff University.

I teach a variety of subjects associated with Oral Microbiology for the dental undergraduate course and for additional postgraduate courses. My teaching responsibilities comprise lectures, seminars, practical classes and student assessment. I am a full member of the The Higher Education Academy and a member of the Association of Basic Science Teachers in Dentistry (ABSTD). In terms of external teaching contributions I examine for PhD, MPhil, and MSc students and I am external examiner for The Integrated Human Diseases (IHD) Course Sheffield University (2014-present) and BDS Part 1 within King's College London (2014-present).

My research interests primarily focus in the field of oral microbiology and microbial biofilms. Previous research has been directed towards elucidating the role of Candida in chronic hyperplastic candidosis (CHC), which led to the development of novel genotypic methods for identifying Candida species in fixed tissues. The significance of this work was recognised through receipt of both the Colgate Prize and the IADR/Unilever Hatton Award. Additional Candida research has included the study of antifungal susceptibility of Candida species, virulence gene expression and real-time PCR detection of Candida in oral samples. I have also investigated interaction of Candida with associated bacteria in oral tissue and on medical devices (e.g. silicone rubber, acrylic, and titanium). The invasive properties of Candida based on in vitro tissue models has successfully revealed strain and species variation which could have significance in disease progression. Research in this area has benefited through collaboration with colleagues at the University of Minho, Braga, Portugal, the Gdansk Institute of Technology, Gdansk, Poland, and the Piracicaba Dental School, University of Campinas, Piracicaba, Brazil. Recently, I have also been involved in studies aimed at elucidating the innate immune response to Candida through cytokine signalling and subsequent T-cell differentiation.
Additional biofilm research projects have included the study of biofilms in endotracheal tubes and their role in ventilator-associated pneumonia, a leading cause of mortality in intensive care units. This work was initiated and continues to develop through close collaboration with Professor J Thomas (University of West Virginia, USA).
Urinary tract catheter biofilms continue to be a leading cause of healthcare associated infection and with industrial collaboration together with colleagues at the Bristol Urological Institute we have developed medical devices to aid in the management of these infections.
Chronic wounds are those that do not heal within an expected time-frame and represent a significant cause of patient morbidity and increased healthcare costs. One potential factor involved in delayed wound healing is the presence of microbial biofilms within the wound which are often recalcitrant to antibiotic therapy. Our research has not only characterised these biofilms through culture and molecular analysis but also focused on mechanisms to rapidly detect pathogenic bacterial biofilms within the tissue.

Research Projects:

1. Candida and host interactions associated with colonisation and infection
2. The role of the oral flora in promoting pneumonia in artificially ventilated patients
3. Dynamics of dental plaque biofilms in intensive care patients
4. Structure, activity and gene expression of Candida albicans biofilms developed on biotic surfaces
5. Denture acrylic surface topography and effect on microbial colonisation
6. Role of polymorphisms in the dectin-1 gene in determining the risk of candidal colonisation and infection in critically ill patient in intensive care units