Ewch i’r prif gynnwys
Yr Athro Rudolf Allemann

Yr Athro Rudolf Allemann

Dirprwy Is-ganghellor a Phennaeth y Coleg Gwyddorau Ffisegol a Pheirianneg

Yr Ysgol Cemeg

Links

Research Group: Biological and Organic Chemistry

Personal Web Site: http://www.cardiff.ac.uk/chemy/staffinfo/allemann/

See Also: Cardiff Catalysis Institute

Research Interests

The Allemann laboratory studies the relationship between the structure and function of enzymes and develops and applies chemical tools to probe biological processes in vitro and in live cells. Our work relies on an interdisciplinary approach at the interface of chemistry, physical organic chemistry, biophysics, synthetic biology, biochemistry, molecular and cellular biology and medicinal chemistry and involves a wide range of techniques. Based on an understanding of enzymatic catalysis and mechanism we develop tools that mimic Nature$acirc;  s reagents. For more information, click on the 'Research' tab above.

Teaching

CH2317 Chemical Biology III

CH3404 Organic Chemistry 1

CHT207 Biosynthetic approach to natural products

Dipl. Chem. ETH (B.Sc.), EidgenÃssische Technische Hochschule (ETH), ZÃ rich (1985), PhD Harvard University / ETH ZÃ rich (1986-89).

Royal Society and Swiss National Science Foundation Postdoctoral Research Fellow, MRC-National Institute for Medical Research, Mill Hill (1989-1990), Staff Scientist MRC-National Institute for Medical Research, Mill Hill (1990-1992), Research group leader, Department of Chemistry, ETH-Zurich and Lecturer (Lehrbeauftragter) in Biological Chemistry (1992-1998), Habilitation, Department of Chemistry, ETH ZÃ rich (1999), Senior Lecturer in Chemistry, University of Birmingham (1999-2001), Professor of Chemical Biology, University of Birmingham (2001-2004), Since 2005: Distinguished Research Professor and Head of Chemical Biology, Cardiff School of Chemistry.

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  • Johnson, K., Allemann, R. K. and Benner, S. A. 1990. Designed enzymes. In: Bleasdale, C. and Golding, R. eds. Molecular mechanisms in bioorganic processes.. London: Royal Society of Chemistry, pp. 166-187.

1989

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1987

  • CH2317 Chemical Biology III

To see a full list of all our Chemistry modules please visit our Course Finder section.

The Allemann laboratory studies the relationship between the structure and function of enzymes and develops and applies chemical tools to probe biological processes in vitro and in live cells. Our work relies on an interdisciplinary approach at the interface of chemistry, physical organic chemistry, biophysics, synthetic biology, biochemistry, molecular and cellular biology and medicinal chemistry and involves a wide range of techniques. Based on an understanding of enzymatic catalysis and mechanism we develop tools that mimic Nature$acirc;  s reagents. The main research themes are

Physical and Chemical Basis of Enzyme Catalysis.

Fig 1

The high chemical selectivity and specificity as well as the enormous rate accelerations relative to the uncatalysed reactions are studied in a multi-disciplinary approach.

Synthetic Biology.

Fig 2

Synthetic Biology capitalises on the advances in genomics and proteomics and the new insights into the molecular mechanisms of action brought about by fundamental chemical and physical studies. Our projects aim to redesign existing, natural biological systems for useful purposes and to design de novo new biological components, devices and systems. They include the design and application of miniature enzymes, the photonic control of biomacromolecular structure to regulate cellular events and approaches for an expansion of the pool of secondary metabolites.

Medicinal Chemistry.

Small molecule chemistry together with mechanistic studies of enzymes for the development of selective inhibitors for a variety of autoimmune diseases such as osteoarthritis.

Fig 3

Organic Chemistry.

Diversity Oriented Synthesis; synthesis of novel $acirc;  terpenoids$acirc;  , carbohydrate derivatives and biophotonic nanoswitches.