Dr Craig Boote

Senior lecturer

: BooteC@caerdydd.ac.uk
: +44 29208 70586

: Sylwebydd y cyfryngau
: Ar gael fel goruchwyliwr ôl-raddedig

Research Overview

My main research interests are the biophysical properties and structural biology of the cornea and sclera. I am using x-ray scattering and microscopic imaging to investigate the factors that govern corneal transparency and refractive status, and their compromise in disease and surgery. I am also researching the structural biology and biomechanical function of the sclera and optic nerve head, and investigating their role in the development of glaucoma.

Teaching Overview

I am module leader for the BSc Optometric Physics (OP0204) and Research & Study Skills (OP1204) modules. I also teach on the MSc Research & Study Skills (OPT7108) module.

2020

Chuangsuwanich, T., Hung, P. T., Wang, X., Liang, L. H., Schmetterer, L., Boote, C. and Girard, M. J. A. 2020. Morphometric, hemodynamic, and biomechanical factors influencing blood flow and oxygen concentration in the human lamina cribrosa. Investigative Ophthalmology & Visual Science 61(4), article number: 3. (10.1167/iovs.61.4.3)
Jin, Y. et al. 2020. Effect of changing heart rate on the ocular pulse and dynamic biomechanical behavior of the optic nerve head. Investigative Ophthalmology & Visual Science 61(4), article number: 27. (10.1167/iovs.61.4.27)
Devalla, S. K., Liang, Z., Pham, T. H., Boote, C., Strouthidis, N. G., Thiery, A. H. and Girard, M. J. A. 2020. Glaucoma management in the era of artificial intelligence. British Journal of Ophthalmology 104(3), pp. 301-311. (10.1136/bjophthalmol-2019-315016)
Zhang, L. et al. 2020. In vivo measurements of prelamina and lamina cribrosa biomechanical properties in humans. Investigative Ophthalmology & Visual Science 61(3), article number: 27. (10.1167/iovs.61.3.27)
Boote, C., Sigal, I. A., Grytz, R., Hua, Y., Nguyen, T. D. and Girard, M. J. 2020. Scleral structure and biomechanics. Progress in Retinal and Eye Research 74, article number: 100773. (10.1016/j.preteyeres.2019.100773)
Tan, R. K. Y., Perera, S. A., Tun, T. A., Boote, C. and Girard, M. J. A. 2020. Performance of a temperature-controlled shape-memory pupil expander for cataract surgery.. Journal of Cataract and Refractive Surgery 46(1), pp. 116-124. (10.1016/j.jcrs.2019.08.042)
Cheong, H. et al. 2020. DeshadowGAN: a deep learning approach to remove shadows from optical coherence tomography images. Translational Vision Science & Technology 9(2), article number: 23. (10.1167/tvst.9.2.23)

2019

Chuangsuwanich, T., Tan, H. P., Liang, L. H., Schmetterer, L., Boote, C. and Girard, M. J. 2019. Morphometric, hemodynamic and biomechanical factors influencing blood flow and oxygen concentration in the human lamina cribrosa. Presented at: 2019 ARVO Annual Meeting, Vancouver, B.C., Canada, 28 April - 2 May 2019ARVO Annual Meeting Abstract Issue 2019, Vol. 60. Investigative Ophthalmology and Visial Science pp. 1785.
Pijanka, J. K. et al. 2019. Quantification of collagen fiber structure using second harmonic generation imaging and two‐dimensional discrete Fourier transform analysis: application to the human optic nerve head. Journal of Biophotonics 12(5), article number: e201800376. (10.1002/jbio.201800376)
Tan, R. K., Wang, X., Chan, A. S., Nongpiur, M. E., Boote, C., Perera, S. A. and Girard, M. J. 2019. Permeability of the porcine iris stroma. Experimental Eye Research 181, pp. 190-196. (10.1016/j.exer.2019.02.005)
Zhou, D. et al. 2019. Analysis of X-ray scattering microstructure data for implementation in numerical simulations of ocular biomechanical behaviour. PLoS ONE 14(4), pp. -., article number: e0214770. (10.1371/journal.pone.0214770)
Markov, P., Boote, C., Zhu, H. and Blain, E. 2019. Effects of mechanical load on cytoskeletal protein arrangement in scleral fibroblasts. Presented at: The Association for Research in Vision and Ophthalmology Annual Meeting, Vancouver, BC, Canada, 28 April -- 2 May 2019.
Markov, P., Boote, C., Zhu, H. and Blain, E. 2019. Building a cell-specific cytoskeletal finite element model of scleral fibroblasts. Presented at: 25th Congress of the European Society of Biomechanics (ESB 2019), Vienna, Austria, 7-10 July 2019. pp. -.

2018

Markov, P. et al. 2018. Bulk changes in posterior scleral collagen microstructure in human high myopia. Molecular Vision 24, pp. 818-833.
Morgan, S. et al. 2018. Microwave treatment of the cornea leads to localised disruption of the extracellular matrix. Scientific Reports 8, article number: 13742. (10.1038/s41598-018-32110-0)

2017

Abass, A., Bell, J. S., Spang, M. T., Hayes, S., Meek, K. M. A. and Boote, C. 2017. SAXS4COLL: an integrated software tool for analysing fibrous collagen-based tissues. Journal of Applied Crystallography 50, pp. 1235-1240. (10.1107/S1600576717007877)
Hayes, S. et al. 2017. The structural response of the cornea to changes in stromal hydration. Interface 14(131) (10.1098/rsif.2017.0062)

2016

Boote, C. et al. 2016. Changes in posterior scleral collagen microstructure in canine eyes with an ADAMTS10 mutation. Molecular Vision 22, pp. 503-517.

2015

Coudrillier, B., Pijanka, J., Jefferys, J., Sorensen, T., Quigley, H. A., Boote, C. and Nguyen, T. D. 2015. Effects of age and diabetes on scleral stiffness. Journal of Biomechanical Engineering 137(7), pp. 1-10., article number: BIO-14-1565. (10.1115/1.4029986)
Coudrillier, B., Pijanka, J. K., Jefferys, J. L., Goel, A., Quigley, H. A., Boote, C. and Nguyen, T. D. 2015. Glaucoma-related changes in the mechanical properties and collagen micro-architecture of the human sclera. PLoS ONE 10(7), article number: e0131396. (10.1371/journal.pone.0131396)
Coudrillier, B., Pijanka, J. K., Jefferys, J., Sorensen, T., Quigley, H. A., Boote, C. and Nguyen, T. D. 2015. Collagen structure and mechanical properties of the human sclera: Analysis for the effects of age. Journal of Biomechanical Engineering 137(4), article number: BIO-14-1028. (10.1115/1.4029430)
Quantock, A. J., Winkler, M., Parfitt, G. J., Young, R. D., Brown, D. J., Boote, C. and Jester, J. V. 2015. From nano to macro: Studying the hierarchical structure of the corneal extracellular matrix. Experimental Eye Research 133, pp. 81-99. (10.1016/j.exer.2014.07.018)
Whitford, C., Studer, H., Boote, C., Meek, K. M. and Elsheikh, A. 2015. Biomechanical model of the human cornea: considering shear stiffness and regional variation of collagen anisotropy and density. Journal of the Mechanical Behavior of Biomedical Materials 42, pp. 76-87. (10.1016/j.jmbbm.2014.11.006)
Pijanka, J. K., Spang, M. T., Sorensen, T., Liu, J., Nguyen, T. D., Quigley, H. A. and Boote, C. 2015. Depth-dependent changes in collagen organization in the hman peripapillary sclera. PLoS ONE 10(2), article number: e0118648. (10.1371/journal.pone.0118648)

2014

Pijanka, J. K. et al. 2014. Changes in scleral collagen organization in murine chronic experimental glaucoma. Investigative Ophthalmology & Visual Science 55(10), pp. 6554-6564. (10.1167/iovs.14-15047)
Geraghty, B., Whitford, C., Boote, C., Akhtar, R. and Elsheikh, A. 2014. Age-related variation in the biomechanical and structural properties of the corneo-scleral tunic. In: Derby, B. and Akhtar, R. eds. Mechanical Properties of Aging Soft Tissues. Engineering Materials and Processes Springer, pp. 207-235., (10.1007/978-3-319-03970-1_9)
Whitford, C., Studer, H., Boote, C., Meek, K. M. A. and Elsheikh, A. 2014. Modelo biomecanico de la cornea humana considerano la variacion regional de la anisotropia, la densidad y la cohesion interlaminar de las fibrillas de collageno. In: del Buey Sayas, M. A. and Martez, C. P. eds. Biomecanica y Arquitectura Corneal. Barcelona: Elsevier, pp. 343-357.

2013

Coudrillier, B., Boote, C., Quigley, H. A. and Nguyen, T. D. 2013. Scleral anisotropy and its effects on the mechanical response of the optic nerve head. Biomechanics and Modeling in Mechanobiology 12(5), pp. 941-963. (10.1007/s10237-012-0455-y)
Boote, C. et al. 2013. Quantification of Collagen Ultrastructure after Penetrating Keratoplasty - Implications for Corneal Biomechanics. PLoS ONE 8(7), article number: e68166. (10.1371/journal.pone.0068166)
Morgan, S. R. et al. 2013. An X-Ray scattering study into the structural basis of corneal refractive function in an Avian Model. Biophysical Journal 104(12), pp. 2586-2594. (10.1016/j.bpj.2013.04.053)
Hayes, S. et al. 2013. The effect of Riboflavin/UVA collagen cross-linking therapy on the structure and hydrodynamic behaviour of the ungulate and rabbit corneal stroma. PLoS ONE 8(1), article number: e52860. (10.1371/journal.pone.0052860)
Pijanka, J. K., Abass, A., Sorensen, T., Elsheikh, A. and Boote, C. 2013. A wide-angle X-ray fibre diffraction method for quantifying collagen orientation across large tissue areas: application to the human eyeball coat. Journal of Applied Crystallography 46(5), pp. 1481-1489. (10.1107/S0021889813022358)

2012

Pijanka, J. K. et al. 2012. Quantitative mapping of collagen fiber orientation in non-glaucoma and glaucoma posterior human scleras. Investigative Ophthalmology & Visual Science 53(9), pp. 5258-5270. (10.1167/iovs.12-9705)
Boote, C. et al. 2012. Quantitative assessment of ultrastructure and light scatter in mouse corneal debridement wounds. Investigative Ophthalmology and Visual Science 53(6), pp. 2786-2795. (10.1167/iovs.11-9305)
Hayes, S. et al. 2012. Depth Profile Study of Abnormal Collagen Orientation in Keratoconus Corneas. Archives of Ophthalmology 130(2), pp. 251-252. (10.1001/archopthalmol.2011.1467)
Coudrillier, B., Boote, C. and Nguyen, T. D. 2012. Effects of the scleral collagen structure on the biomechanical response of the optic nerve head. Presented at: ASME 2012 Summer Bioengineering Conference, Fajardo, Puerto Rico, 20-23 June 2012Proceedings of the ASME Summer Bioengineering Conference--2012 : presented at ASME 2012 Summer Bioengineering Conference, June 20-23, 2012, Fajardo, Puerto Rico. New York, N.Y.: ASME pp. 513-514., (10.1115/SBC2012-80540)

2011

Koudouna, E. et al. 2011. Preliminary electron microscopical studies of connective tissue in the human lamina cribrosa [Abstract]. International Journal of Experimental Pathology 92(6), pp. A26. (10.1111/j.1365-2613.2011.00780.x)
Boote, C. et al. 2011. Quantification of collagen organization in the peripheral human cornea at micron-scale resolution. Biophysical Journal 101(1), pp. 33-42. (10.1016/j.bpj.2011.05.029)
Boote, C. et al. 2011. The influence of lamellar orientation on corneal material behavior: biomechanical and dtructural changes in an avian corneal disorder. Investigative Ophthalmology & Visual Science 52(3), pp. 1243-1251. (10.1167/iovs.10-5962)
Hayes, S. et al. 2011. Riboflavin/UVA Collagen Cross-Linking-Induced Changes in Normal and Keratoconus Corneal Stroma. PLoS ONE 6(8), article number: e22405. (10.1371/journal.pone.0022405)
Hayes, S. et al. 2011. The effect of vitamin C deficiency and chronic ultraviolet-B exposure on corneal ultrastructure: a preliminary investigation. Molecular Vision 17, pp. 3107-3115.
Kamma-Lorger, C. S., Wehbe, K., Boote, C., Meek, K. M. A. and Cinque, G. 2011. FTIR has the potential to detect stem cells in the bovine corneal stroma. Journal of Physical Chemistry and Biophysics 1(1), article number: 10000103.
Coudrillier, B., Boote, C. and Nguyen, T. D. 2011. Modeling the effect of the experimentally-derived collagen structure on the mechanical anisotropy of the human sclera. Presented at: ASME Summer Bioengineering Conference 2011, Farmington, PA, USA, 22-25 June 2011Proceedings of the ASME Summer Bioengineering Conference--2011 : presented at 2010 ASME Summer Bioengineering Conference, June 22-25, 2011, Farmington, Pennsylvania, USA. New York, N.Y.: ASME pp. 419-420., (10.1115/SBC2011-53272)

2010

Palka, B. P. et al. 2010. Structural Collagen Alterations in Macular Corneal Dystrophy Occur Mainly in the Posterior Stroma. Current Eye Research 35(7), pp. 580-586. (10.3109/02713681003760150)
Sheppard, J., Hayes, S., Boote, C., Votruba, M. and Meek, K. M. A. 2010. Changes in corneal collagen architecture during mouse postnatal development. Investigative Ophthalmology & Visual Science 51(6), pp. 2936-2942. (10.1167/iovs.09-4612)
Kamma-Lorger, C. S. et al. 2010. Collagen and mature elastic fibre organisation as a function of depth in the human cornea and limbus. Journal of Structural Biology 169(3), pp. 424-430. (10.1016/j.jsb.2009.11.004)

2009

Boote, C. et al. 2009. Ultrastructural changes in the retinopathy, globe enlarged (rge) chick cornea. Journal of Structural Biology 166(2), pp. 195-204. (10.1016/j.jsb.2009.01.009)
Kamma-Lorger, C. S., Boote, C., Hayes, S., Albon, J., Boulton, M. E. and Meek, K. M. A. 2009. Collagen ultrastructural changes during stromal wound healing in organ cultured bovine corneas. Experimental Eye Research 88(5), pp. 953-959. (10.1016/j.exer.2008.12.005)
Young, R. D. et al. 2009. Stromal Edema in Klf4 Conditional Null Mouse Cornea Is Associated with Altered Collagen Fibril Organization and Reduced Proteoglycans. Investigative Ophthalmology & Visual Science 50(9), pp. 4155-4161. (10.1167/iovs.09-3561)
Meek, K. M. A. and Boote, C. 2009. The use of X-ray scattering techniques to quantify the orientation and distribution of collagen in the corneal stroma. Progress in Retinal and Eye Research 28(5), pp. 369-392. (10.1016/j.preteyeres.2009.06.005)
Kamma-Lorger, C. S., Hayes, S., Boote, C., Burghammer, M., Boulton, M. E. and Meek, K. M. A. 2009. Effects on collagen orientation in the cornea after trephine injury. Molecular Vision 15, pp. 378-385.
Hayes, S., Young, R. D., Boote, C., Hawksworth, N., Huang, Y. and Meek, K. M. A. 2009. A structural investigation of corneal graft failure in suspected recurrent keratoconus. Eye 24(4), pp. 728-734. (10.1038/eye.2009.159)

2008

Boote, C. et al. 2008. Collagen organization in the chicken cornea and structural alterations in the retinopathy, globe enlarged (rge) phenotype - An X-ray diffraction study. Journal of Structural Biology 161(1), pp. 1-8. (10.1016/j.jsb.2007.08.015)

2007

Hayes, S. et al. 2007. Comparative Study of Fibrillar Collagen Arrangement in the Corneas of Primates and Other Mammals. The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology 290(12), pp. 1542-1550. (10.1002/ar.20613)
Hayes, S., Boote, C., Tuft, S. J., Quantock, A. J. and Meek, K. M. A. 2007. A study of corneal thickness, shape and collagen organisation in keratoconus using videokeratography and X-ray scattering techniques. Experimental Eye Research 84(3), pp. 423-434. (10.1016/j.exer.2006.10.014)
Quantock, A. J. et al. 2007. Small-angle fibre diffraction studies of corneal matrix structure: a depth profiled investigation of the human eye-bank cornea. Journal of Applied Crystallography 40(S1), pp. S335-S340. (10.1107/S0021889807005523)

2006

Boote, C., Hayes, S., Abahussin, M. and Meek, K. M. A. 2006. Mapping collagen organization in the human cornea: left and right eyes are structurally distinct. Investigative Ophthalmology and Visual Science 47(3), pp. 901-908. (10.1167/iovs.05-0893)
Pinsky, P. M., van der Heide, D., Chernyak, D., Meek, K. M. and Boote, C. 2006. Modeling the human cornea - a stromal tissue constitutive model based on measured collagen architecture [Abstract]. Journal of Biomechanics 39(S1), pp. S386. (10.1016/S0021-9290(06)84558-6)

2005

Boote, C., Hayes, S., Huang, Y., Quantock, A. J. and Meek, K. M. A. 2005. Lamellar orientation in human cornea in relation to mechanical properties. Journal of Structural Biology 149(1), pp. 1-6. (10.1016/j.jsb.2004.08.009)

2004

Boote, C., Hayes, S. and Meek, K. M. A. 2004. Spatial mapping of collagen fibril organisation in primate cornea - an X-ray diffraction investigation. Journal of Structural Biology 146(3), pp. 359-367. (10.1016/j.jsb.2003.12.009)
Meek, K. M. A. and Boote, C. 2004. The organization of collagen in the corneal stroma. Experimental Eye Research 78(3), pp. 503-512. (10.1016/j.exer.2003.07.003)
Sturrock, E. J., Boote, C., Attenburrow, G. E. and Meek, K. M. A. 2004. The effects of the biaxial stretching of leather on fibre orientation and tensile modulus. Journal of Materials Science 39(7), pp. 2481-2486. (10.1023/B:JMSC.0000020013.90114.92)

2003

Boote, C., Dennis, S., Newton, R. H., Puri, H. and Meek, K. M. A. 2003. Collagen fibrils appear more closely packed in the prepupillary cornea: Optical and biomechanical implications. Investigative Ophthalmology and Visual Science 44(7), pp. 2941-2948. (10.1167/iovs.03-0131)
Hayes, S. et al. 2003. Ultrastructural Changes in Keratoconic-like Mice Corneas [Abstract]. Fibre Diffraction Review 11, pp. 135.
Quantock, A. J. et al. 2003. Annulus of collagen fibrils in mouse cornea and structural matrix alterations in a murine-specific keratopathy. Investigative Ophthalmology & Visual Science 44(5), pp. 1906-1911. (10.1167/iovs.02-0884)
Quantock, A. J., Boote, C., Siegler, V. and Meek, K. M. A. 2003. Collagen organization in the secondary chick cornea during development. Investigative Ophthalmology and Visual Science 44(1), pp. 130-136.
Boote, C., Hayes, S. and Meek, K. M. A. 2003. Collagen organisation in adult and foetal marmoset cornea. Investigative Ophthalmology and Visual Science 44(E-Abst)
Boote, C., Siegler, V., Meek, K. and Quantock, A. 2003. Collagen orientation during development of the embryonic avian cornea. Fibre Diffraction Review 11(1), pp. 130.
Boote, C., Siegler, V., Meek, K. and Quantock, A. 2003. A wide-angle x-ray diffraction study of the developing embryonic chicken cornea. Fibre Diffraction Review 11(1), pp. 123-129.
Quantock, A. J., Boote, C., Siegler, V. and Meek, K. M. A. 2003. Collagen Organization in the Secondary Chick Cornea during Development. Investigative Ophthalmology & Visual Science 44(1), pp. 130-136. (10.1167/iovs.02-0544)
Boote, C., Hayes, S., Newton, R. H., Puri, H. and Meek, K. M. A. 2003. Collagen fibrils appear more closely packed in the prepupilliary cornea: optical and biomechanical implications. Investigative Ophthalmology & Visual Science 44(7), pp. 2941-2948. (10.1167/iovs.03-0131)

2002

Boote, C., Sturrock, E., Attenburrow, G. E. and Meek, K. M. A. 2002. Psuedo-affine behaviour of collagen fibres during the uniaxial deformation of leather. Journal of Materials Science 37(17), pp. 3651-3656. (10.1023/A:1016505107534)
Boote, C., Siegler, V., Meek, K. M. A. and Quantock, A. J. 2002. Collagen orientation during development of the embryonic avian cornea [Abstract]. Investigative Ophthalmology and Visual Science 43, article number: E-Abstract 3214.

2001

Sturrock, E. J., Attenburrow, G. E., Boote, C. and Meek, K. M. A. 2001. The effect on bending stiffness of drying leather under strain. Jornal of Leather Tech and Chem 86, pp. 6-10.

1998

Shotton, M. W. et al. 1998. New Developments in Instrumentation for X-ray and Neutron Fibre Diffraction Experiments. Journal of Applied Crystallography 31(5), pp. 758-766. (10.1107/S0021889898005287)
Forsyth, V. T., Shotton, M. W., Ye, H., Boote, C., Langan, P., Pope, L. H. and Denny, R. C. 1998. Instrument D19 at the Institut Laue-Langevin: A high resolution diffractometer for single crystal and fibre diffraction studies. Fibre Diffraction Review 7, pp. 17-24.

Research Topics and Related Projects:

Fig. 1: SHG multiphoton microscopy images showing collagen fibril bundles as a function of tissue depth in the posterior sclera of a human eye

The role of scleral and optic nerve head micro-architecture in glaucoma.

Elevated IOP is a major glaucoma risk factor. However the exact role that IOP plays in the RGC cell loss that characterises glaucoma is unknown. The biomechanical model of glaucoma proposes that IOP-induced deformation in and around the lamina cribrosa of the optic nerve head results in axonal dysfunction and apoptosis. The physical effects of IOP on nerve head axons are primarily mediated by the collagen-rich tissues of the lamina cribrosa and surrounding sclera. Our research aims are to: (i) characterise scleral and laminar tissue micro-architecture as a function of age and glaucoma, and (ii) use this information to determine the biomechanical factors that underpin glaucoma susceptibility and pathogenesis. We have developed novel synchrotron x-ray scattering and laser scanning multiphoton imaging (Fig. 1) tools, to quantify scleral and laminar collagen fibre arrangement, and are using the information to build finite-element models to describe the mechanical behaviour of these tissues under normal/elevated IOP, and thereby their projected influence on nerve head axons.

Corneal dysfunction and the development of therapeutic strategies.

The cornea is a uniquely transparent, precisely curved tissue whose functionality depends heavily on the hierarchical structure and complex micro-anatomy of its extracellular matrix. Despite their importance for vision, the fundamental basis of corneal transparency and shape, and their compromise due to injury and disease, is not fully understood. Our ultimate objective is to relate loss of transparency and changes in corneal shape/astigmatism to tissue micro- and ultra-structure. We are using x-ray scattering methods (Fig. 2) and a range of complementary microscopic imaging modalities to determine in three-dimensions the relationships between the constituent collagen, proteoglycans and cells within normal and pathological mature/developing corneas, post-surgical corneas and emerging biosynthetic corneal replacements. Our aims are to: (i) model corneal transparency at the cellular and fibrillar level, and use this to explain the loss of transparency in a range of pathological conditions, including corneal wounds; (ii) characterize the full three-dimensional structure of the cornea, explain the structural basis of astigmatism, and demonstrate how ectatic and astigmatic pathologies and their surgical treatments can be modelled and their effect on the cornea$acirc; s macroscopic behaviour predicted by finite element analysis; (iii) develop methodologies for stabilizing corneal curvature and restoring transparency, including cell-based and photochemical cross-linking methods.

Fig. 2: Collagen fibril orientations in the human cornea, as determined using wide-angle x-ray scattering
(Source: http://www.projectsmagazine.eu.com/randd_projects/understanding_the_complexities_of_the_cornea)

Funding:

Boote C (PI) & Meek KM, £122,672, Project Grant: "The role of the sclera in human glaucoma", Fight For Sight, 2012-2014.

Meek KM (PI), Quantock AJ, Knupp C, Boote C, £1.75M, Programme Grant: "The ultrastructural basis of corneal dysfunction and the development and optimization of novel therapeutic strategies", MRC, 2012 - 2017.

Research Team:

Dr Jacek Pijanka, Research Associate, "The role of the sclera in human glaucoma", Fight For Sight, 2012-2014.

Research Collaborators:

Dr Harry Quigley, Wilmer Ophthalmological Institute, Johns Hopkins University.
Prof. Thao Nguyen, Department of Mechanical Engineering, Johns Hopkins University.
Prof. Ahmed Elsheikh, School of Engineering, University of Liverpool.
Prof. Rafael Grytz, Department of Ophthalmology, University of Alabama.

Educational and Professional Qualifications:

1995-1999: PhD, Structural studies of DNA using diffraction and spectroscopic methods, Keele University

1992-1995: BSc (Physics/Biochemistry Dual Hons, 1), Keele University

Academic Positions:

2010- present: Lecturer, Cardiff University

2001 - 2011: Senior research Associate, Cardiff University

1999-2001: Research Associate, Cardiff University

School and University Roles and Committees:

2012-present: Deputy chair, postgraduate research committee

2012-present:: School research seminar series organiser

2011-present: Deputy biological safety officer

Innovation and Engagement:

2012 - present: STEMNET ambassador

2010 - present: Visiting lecturer, HERCULES international training school.

Media interviews:

2012: http://insight-cdn1.phasebroadcast.net/podcastgen/?p=episode&name=2012-06-21_drboote.mp3

2011: http://www.projectsmagazine.eu.com/randd_projects/understanding_the_complexities_of_the_cornea

Invited lectures:

2013: (Key note) Diamond S4SAS Meeting, University of Sheffield, UK.

2012 : Diamond User Meeting, Diamond Light Source, UK.

Wales & West Vision Conference, University of Newport, UK.

2010: ESCRS Annual Congress, Paris, France.

2009: Nanoscience and Materials Colloquium, University of Reading, UK.

2008: Soft X-ray Imaging Workshop for Life Sciences, Diamond Light Source, UK.

2006: Moorfields Eye Hospital, UK.

Kyoto Prefectural University of Medicine, Japan.

2005 CITER annual meeting, University of Wales, Trinity College, Carmarthen, UK. CCP13 annual meeting, Cardiff University, UK. Awards: 2004: Royal Society Travel Award

Anrhydeddau a dyfarniadau

2004- Royal Society Travel Award

Aelodaethau proffesiynol

2012-Present STEMNET ambassador
2010-Present Visiting lecturer, HERCULES international training school.

Safleoedd academaidd blaenorol

2010-Present: Lecturer, Cardiff University
2001-2011 Senior research Associate, Cardiff University
1999-2001 Research Associate, Cardiff University

Pwyllgorau ac adolygu

2012-Present Deputy chair, postgraduate research committee
2012-Present School research seminar series organiser
2011-Present Deputy biological safety officer

Goruchwyliaeth gyfredol

Qian Ma

Myfyriwr ymchwil

Xiaorui (raya) Wang