![Sally Hayes](https://profiles-cardiff.imgix.net/attachments/2835?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Sally Hayes
Uwch Gymrawd Ymchwil
Yr Ysgol Optometreg a Gwyddorau'r Golwg
- HayesS5@caerdydd.ac.uk
- +44 29208 70459
- Optometreg a Gwyddorau'r Golwg , Ystafell Ystafell 3.22, Heol Maendy, Cathays, Caerdydd, CF24 4HQ
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwyg
After graduating from Aberystwyth University in 2000 with a First Class Honours in Animal (Equine) Science, I took up a 5-year MRC funded Research Assistant post within the Structural Biophysics Group at Cardiff University to investigate the relationship between corneal structure and function. In 2005 I was awarded a PhD for my research into the structural organisation of collagen in the corneas of primates and other animals and the stromal changes associated with the disease keratoconus. Since then, I have continued to follow this line of research as a post-doctorate scientist.
Research Interests
My current research is aimed at further understanding the relationship between structure and function in normal and diseased corneas. I am particularly interested in keratoconus, a disease characterised by progressive thinning and steepening of the cornea and severe irregular astigmatism. Keratoconus is one of the leading causes of corneal transplant surgery in the UK.
Using a combination of videokeratography to assess corneal shape, and synchrotron x-ray diffraction to gain quantitative structural information about the organisation and distribution of collagen in normal and keratoconus corneas, we attempted to form a link between corneal structure and specific keratoconus shape changes and proposed a mechanism (involving lamellar slippage) that may explain how the keratoconus cornea thins and steepens. In recent years a therapeutic treatment has been developed to halt these changes. The treatment involves the use of UVA/riboflavin cross linking to stabilise the collagen and its surrounding matrix and my primary interest at present is to identify precisely how this occurs.
I am also very interested in human corneal development, in particular the structural changes that lead to the cornea becoming strong, transparent and precisely curved. Recently granted access to the MRC/Wellcome Trust-funded Human Developmental Biology Resource (HDBR) has provided us with a unique opportunity to examine structural changes occurring at key stages of foetal development.
Selected Publications
Hayes, S., Boote, C., Tuft, S., Quantock, A. and Meek, K. 2007. A study of corneal thickness, shape and collagen organisation in keratoconus using videokeratography and x-ray scattering techniques. Experimental Eye Research. 84. 423-434.
Hayes S , Boote C, Lewis J, Sheppard J, Abahussin M, Quantock AJ, Purslow C, Votruba M, Meek KM. 2007. Comparative study of fibrillar collagen arrangement in the corneas of primates and other mammals. Anatomical Record (Hoboken). 290(12):1542-50.
Hayes S , O'Brart DP, Lamdin LS, Doutch J, Samaras K, Marshall J, Meek KM. 2008. Effect of complete epithelial debridement before riboflavin-ultraviolet-A corneal collagen crosslinking therapy. Journal of Cataract and Refractive Surgery. 34(4):657-61
Hayes S, Boote C, Kamma-Lorger CS, Rajan MS, Harris J, Dooley E, Hawksworth N, Hiller J, Terill NJ, Hafezi F, Brahma AK, Quantock AJ and Meek KM. Riboflavin/UVA collagen cross-linking-induced changes in normal and keratoconus corneal stroma. PloS One. 2011; 6(8): e22405
Cyhoeddiad
2024
- Morgan, S. R., O'Brart, D. P. S., Huang, J., Meek, K. M. and Hayes, S. 2024. An in vitro investigation into the impact of corneal rinsing on riboflavin/UVA corneal cross-linking. Eye and Vision 11(8) (10.1186/s40662-024-00375-4)
- Meek, K. M., Knupp, C., Lewis, P. N., Morgan, S. R. and Hayes, S. 2024. Structural control of corneal transparency, refractive power and dynamics. Eye (10.1038/s41433-024-02969-7)
2023
- Hayes, S., Jaycock, P., Rees, N., Figuerio, F., O'Brart, D. and Meek, K. 2023. National survey of corneal cross-linking (CXL) practice patterns in the United Kingdom during 2019. Eye 37, pp. 2511-2517. (10.1038/s41433-022-02365-z)
2022
- Gao, R. et al. 2022. The impact of different rose bengal formulations on corneal thickness and the efficacy of rose bengal/green light corneal cross-linking in the rabbit eye. Journal of Refractive Surgery 38(7), pp. 450-458. (10.3928/1081597X-20220601-03)
- Bell, J., Morgan, S., Koudouna, E., Hayes, S. and Meek, K. 2022. The hierarchical response of human corneal collagen to controlled inflation. Presented at: 2022 ARVO Annual Meeting, Denver, CO, USA, 1-4 May 2022, Vol. 63. Vol. 7. IOVS pp. 2392.
- Bell, J. S. et al. 2022. Tropocollagen springs allow collagen fibrils to stretch elastically. Acta Biomaterialia 142, pp. 185-193. (10.1016/j.actbio.2022.01.041)
2021
- Zhou, D. et al. 2021. Fibril density reduction in keratoconic corneas. Journal of the Royal Society Interface 18(175), article number: 20200900. (10.1098/rsif.2020.0900)
- Hayes, S., Morgan, S. R. and Meek, K. M. 2021. Keratoconus: cross-linking the window of the eye. Therapeutic Advances in Rare Disease 2, pp. 1-14. (10.1177/26330040211003573)
2020
- Hayes, S. et al. 2020. The effect of bacteriochlorophyll derivative WST-D and near infrared light on the molecular and fibrillar architecture of the corneal stroma. Scientific Reports 10, article number: 9836. (10.1038/s41598-020-66869-y)
- Meek, K. M., Quantock, A. J., Hayes, S. and Bell, J. 2020. X-ray diffraction imaging of corneal ultrastructure. In: Ahearne, M. ed. Corneal Regeneration: Methods and Protocols., Vol. 2145. Methods in Molecular Biology New York, NY, USA: Humana, pp. 231-247., (10.1007/978-1-0716-0599-8_16)
- Feneck, E. M., Souza, R. B., Lewis, P. N., Hayes, S., Pereira, L. V. and Meek, K. M. 2020. Developmental abnormalities in the cornea of a mouse model for Marfan syndrome. Experimental Eye Research 194, article number: 108001. (10.1016/j.exer.2020.108001)
2018
- Morgan, S. et al. 2018. Microwave treatment of the cornea leads to localised disruption of the extracellular matrix. Scientific Reports 8, article number: 13742. (10.1038/s41598-018-32110-0)
- Hayes, S., Meek, K. and Mukherjee, A. 2018. Use of donors predisposed by corneal collagen cross-linking in penetrating keratoplasty for treating patients with keratoconus. American Journal of Ophthalmology 188, pp. 181-181. (10.1016/j.ajo.2017.12.026)
- Pinsky, P. M., Ma, Y., Hwang, Y., Hayes, S. and Meek, K. M. 2018. A simple mathematical model for collagen fibril organization in normal and keratoconic corneas. Journal for Modeling in Ophthalmology 1
- O'Brart, N., O'Brart, D., Aldahlawi, N., Hayes, S. and Meek, K. 2018. An investigation of the effects of riboflavin concentration on the efficacy of corneal cross-linking using an enzymatic resistance model in porcine corneas. Investigative Ophthalmology and Visual Science 59, pp. 1058-1065. (10.1167/iovs.17-22994)
- Bell, J. S. et al. 2018. The hierarchical response of human corneal collagen to load. Acta Biomaterialia 65, pp. 216-225. (10.1016/j.actbio.2017.11.015)
- Islam, M. M. et al. 2018. Biomaterials-enabled cornea regeneration in patients at high risk for rejection of donor tissue transplantation. npj Regenerative Medicine 3, article number: 2. (10.1038/s41536-017-0038-8)
- O’Brart, D. P. S., O’Brart, N. A. L., Aldahlawi, N., Hayes, S. and Meek, K. 2018. The role of riboflavin concentration and oxygen in the efficacy and depth of corneal crosslinking. Investigative Ophthalmology and Visual Science 59, pp. 4449-4450. (10.1167/iovs.18-24437)
- Bell, J. et al. 2018. A subfibrillar deformation mechanism in corneal collagen that affords flexibility. Presented at: ARVO Annual Meeting 2018, Honolulu, April 29 - May 3, 2018, Vol. 59. Vol. 9. Association for Research in Vision and Ophthalmology
2017
- Abass, A., Bell, J. S., Spang, M. T., Hayes, S., Meek, K. M. A. and Boote, C. 2017. SAXS4COLL: an integrated software tool for analysing fibrous collagen-based tissues. Journal of Applied Crystallography 50, pp. 1235-1240. (10.1107/S1600576717007877)
- Hayes, S. et al. 2017. The structural response of the cornea to changes in stromal hydration. Interface 14(131) (10.1098/rsif.2017.0062)
- White, T. et al. 2017. The structural role of elastic fibres in the cornea investigated using a mouse model for Marfan syndrome. Investigative Ophthalmology and Vision Science 58(4), pp. 2106-2116. (10.1167/iovs.16-21358)
2016
- Aldahlawi, N. H., Hayes, S., O'Brart, D. P., O'Brart, N. and Meek, K. M. A. 2016. An investigation into corneal enzymatic resistance following epithelium-off and epithelium-on corneal cross-linking protocols. Experimental Eye Research 153, pp. 141-151. (10.1016/j.exer.2016.10.014)
- Aldahlawi, N. H., Hayes, S., O'Brart, D. P. S., Akhbanbetova, A., Littlechild, S. L. and Meek, K. M. A. 2016. Enzymatic resistance of corneas crosslinked using riboflavin in conjunction with low energy, high energy, and pulsed UVA irradiation modes. Investigative Ophthalmology & Visual Science 57(4), pp. 1547-1552. (10.1167/iovs.15-18769)
2015
- Hayes, S. et al. 2015. The structural and optical properties of type III human collagen biosynthetic corneal substitutes. Acta Biomaterialia 25, pp. 121-130. (10.1016/j.actbio.2015.07.009)
- Hayes, S., Morgan, S. R., O'Brart, D. P., O'Brart, N. and Meek, K. M. A. 2015. A study of stromal riboflavin absorption inex vivoporcine corneas using new and existing delivery protocols for corneal cross-linking. Acta Ophthalmologica 94(2), pp. e109-e117. (10.1111/aos.12884)
- Mukherjee, A., Hayes, S., Aslanides, I., Lanchares, E. and Meek, K. M. 2015. Donor cross-linking for keratoplasty: a laboratory evaluation. Graefe's Archive for Clinical and Experimental Ophthalmology 252(12), pp. 2223-2228. (10.1007/s00417-015-3160-6)
- Aldahlawi, N., Hayes, S., OBrart, D. and Meek, K. M. A. 2015. Standard versus accelerated riboflavin/ultraviolet corneal cross-linking: Resistance against enzymatic digestion. Journal of Cataract and Refractive Surgery 41(9), pp. 1989-1996. (10.1016/j.jcrs.2015.10.004)
- Abass, A., Hayes, S., White, N., Sorensen, T. and Meek, K. M. 2015. Transverse depth-dependent changes in corneal collagen lamellar orientation and distribution. Journal of the Royal Society Interface 12(104), article number: 20140717. (10.1098/rsif.2014.0717)
2013
- Davidson, A. E., Hayes, S., Hardcastle, A. J. and Tuft, S. J. 2013. The pathogenesis of keratoconus. Eye 28(2), pp. 189-195. (10.1038/eye.2013.278)
- Boote, C. et al. 2013. Quantification of Collagen Ultrastructure after Penetrating Keratoplasty - Implications for Corneal Biomechanics. PLoS ONE 8(7), article number: e68166. (10.1371/journal.pone.0068166)
- Abahussin, M., Hayes, S., Edelhauser, H., Dawson, D. G. and Meek, K. M. A. 2013. A microscopy study of the structural features of post-LASIK human corneas. PLoS ONE 8(5), article number: e63268. (10.1371/journal.pone.0063268)
- Meek, K. M. A. and Hayes, S. 2013. Corneal crosslinking - A review. Ophthalmic and Physiological Optics 33(2), pp. 78-93. (10.1111/opo.12032)
- Hayes, S. et al. 2013. The effect of Riboflavin/UVA collagen cross-linking therapy on the structure and hydrodynamic behaviour of the ungulate and rabbit corneal stroma. PLoS ONE 8(1), article number: e52860. (10.1371/journal.pone.0052860)
2012
- Boote, C. et al. 2012. Quantitative assessment of ultrastructure and light scatter in mouse corneal debridement wounds. Investigative Ophthalmology and Visual Science 53(6), pp. 2786-2795. (10.1167/iovs.11-9305)
- Hayes, S. et al. 2012. Depth Profile Study of Abnormal Collagen Orientation in Keratoconus Corneas. Archives of Ophthalmology 130(2), pp. 251-252. (10.1001/archopthalmol.2011.1467)
2011
- Boote, C. et al. 2011. Quantification of collagen organization in the peripheral human cornea at micron-scale resolution. Biophysical Journal 101(1), pp. 33-42. (10.1016/j.bpj.2011.05.029)
- Hayes, S. et al. 2011. Riboflavin/UVA Collagen Cross-Linking-Induced Changes in Normal and Keratoconus Corneal Stroma. PLoS ONE 6(8), article number: e22405. (10.1371/journal.pone.0022405)
- Hayes, S. et al. 2011. The effect of vitamin C deficiency and chronic ultraviolet-B exposure on corneal ultrastructure: a preliminary investigation. Molecular Vision 17, pp. 3107-3115.
2010
- Sheppard, J., Hayes, S., Boote, C., Votruba, M. and Meek, K. M. A. 2010. Changes in corneal collagen architecture during mouse postnatal development. Investigative Ophthalmology & Visual Science 51(6), pp. 2936-2942. (10.1167/iovs.09-4612)
- Kamma-Lorger, C. S. et al. 2010. Collagen and mature elastic fibre organisation as a function of depth in the human cornea and limbus. Journal of Structural Biology 169(3), pp. 424-430. (10.1016/j.jsb.2009.11.004)
2009
- Abahussin, M. O., Hayes, S., Knox Cartwright, N. E., Kamma-Lorger, C. S., Khan, Y., Marshall, J. and Meek, K. M. A. 2009. 3D collagen orientation study of the human cornea using X-ray diffraction and femtosecond laser technology. Investigative Ophthalmology & Visual Science 50(11), pp. 5159-5164. (10.1167/iovs.09-3669)
- Boote, C. et al. 2009. Ultrastructural changes in the retinopathy, globe enlarged (rge) chick cornea. Journal of Structural Biology 166(2), pp. 195-204. (10.1016/j.jsb.2009.01.009)
- Kamma-Lorger, C. S., Boote, C., Hayes, S., Albon, J., Boulton, M. E. and Meek, K. M. A. 2009. Collagen ultrastructural changes during stromal wound healing in organ cultured bovine corneas. Experimental Eye Research 88(5), pp. 953-959. (10.1016/j.exer.2008.12.005)
- Samaras, K., O'Brart, D. P., Doutch, J., Hayes, S., Marshall, J. and Meek, K. M. A. 2009. Effect of Epithelial Retention and Removal on Riboflavin Absorption in Porcine Corneas. Journal of Refractive Surgery 25(9), pp. 771-775. (10.3928/1081597X-20090813-03)
- Kamma-Lorger, C. S., Hayes, S., Boote, C., Burghammer, M., Boulton, M. E. and Meek, K. M. A. 2009. Effects on collagen orientation in the cornea after trephine injury. Molecular Vision 15, pp. 378-385.
- Hayes, S., Young, R. D., Boote, C., Hawksworth, N., Huang, Y. and Meek, K. M. A. 2009. A structural investigation of corneal graft failure in suspected recurrent keratoconus. Eye 24(4), pp. 728-734. (10.1038/eye.2009.159)
2008
- Boote, C. et al. 2008. Collagen organization in the chicken cornea and structural alterations in the retinopathy, globe enlarged (rge) phenotype - An X-ray diffraction study. Journal of Structural Biology 161(1), pp. 1-8. (10.1016/j.jsb.2007.08.015)
2007
- Hayes, S. et al. 2007. Comparative Study of Fibrillar Collagen Arrangement in the Corneas of Primates and Other Mammals. The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology 290(12), pp. 1542-1550. (10.1002/ar.20613)
- Hayes, S., Boote, C., Tuft, S. J., Quantock, A. J. and Meek, K. M. A. 2007. A study of corneal thickness, shape and collagen organisation in keratoconus using videokeratography and X-ray scattering techniques. Experimental Eye Research 84(3), pp. 423-434. (10.1016/j.exer.2006.10.014)
- Quantock, A. J. et al. 2007. Small-angle fibre diffraction studies of corneal matrix structure: a depth profiled investigation of the human eye-bank cornea. Journal of Applied Crystallography 40(S1), pp. S335-S340. (10.1107/S0021889807005523)
2006
- Boote, C., Hayes, S., Abahussin, M. and Meek, K. M. A. 2006. Mapping collagen organization in the human cornea: left and right eyes are structurally distinct. Investigative Ophthalmology and Visual Science 47(3), pp. 901-908. (10.1167/iovs.05-0893)
2005
- Meek, K. M. A., Tuft, S. J., Huang, Y., Gill, P. S., Hayes, S., Newton, R. H. and Bron, A. J. 2005. Changes in collagen orientation and distribution in keratoconus corneas. Investigative Ophthalmology and Visual Science 46(6), pp. 1948-1956. (10.1167/iovs.04-1253)
- Boote, C., Hayes, S., Huang, Y., Quantock, A. J. and Meek, K. M. A. 2005. Lamellar orientation in human cornea in relation to mechanical properties. Journal of Structural Biology 149(1), pp. 1-6. (10.1016/j.jsb.2004.08.009)
- Hayes, S. 2005. Structural organisation of collagen in the corneas of primates and other mammals and the stromal changes associated with the disease keratoconus. PhD Thesis, Cardiff University.
2004
- Boote, C., Hayes, S. and Meek, K. M. A. 2004. Spatial mapping of collagen fibril organisation in primate cornea - an X-ray diffraction investigation. Journal of Structural Biology 146(3), pp. 359-367. (10.1016/j.jsb.2003.12.009)
2003
- Hayes, S. et al. 2003. Ultrastructural Changes in Keratoconic-like Mice Corneas [Abstract]. Fibre Diffraction Review 11, pp. 135.
- Quantock, A. J. et al. 2003. Annulus of collagen fibrils in mouse cornea and structural matrix alterations in a murine-specific keratopathy. Investigative Ophthalmology & Visual Science 44(5), pp. 1906-1911. (10.1167/iovs.02-0884)
- Boote, C., Hayes, S. and Meek, K. M. A. 2003. Collagen organisation in adult and foetal marmoset cornea. Investigative Ophthalmology and Visual Science 44(E-Abst)
- Hayes, S., Khan, S. and Meek, K. M. A. 2003. Changes in the refractive index of the cornea when the stroma swells [Abstract]. Investigative Ophthalmology & Visual Science 44, article number: 886.
- Meek, K., Hayes, S. and Khan, S. 2003. Changes in the refractive index of the stroma and its extrafibrillar matrix when the cornea swells. Biophysical Journal 85(4), pp. 2205-2212.
- Boote, C., Hayes, S., Newton, R. H., Puri, H. and Meek, K. M. A. 2003. Collagen fibrils appear more closely packed in the prepupilliary cornea: optical and biomechanical implications. Investigative Ophthalmology & Visual Science 44(7), pp. 2941-2948. (10.1167/iovs.03-0131)
- Meek, K. M. A., Leonard, D., Connon, C. J., Hayes, S. and Khan, S. 2003. Transparency, swelling and scarring in the corneal stroma. Eye 17(8), pp. 927-936. (10.1038/sj.eye.6700574)
Adrannau llyfrau
- Meek, K. M., Quantock, A. J., Hayes, S. and Bell, J. 2020. X-ray diffraction imaging of corneal ultrastructure. In: Ahearne, M. ed. Corneal Regeneration: Methods and Protocols., Vol. 2145. Methods in Molecular Biology New York, NY, USA: Humana, pp. 231-247., (10.1007/978-1-0716-0599-8_16)
Cynadleddau
- Bell, J., Morgan, S., Koudouna, E., Hayes, S. and Meek, K. 2022. The hierarchical response of human corneal collagen to controlled inflation. Presented at: 2022 ARVO Annual Meeting, Denver, CO, USA, 1-4 May 2022, Vol. 63. Vol. 7. IOVS pp. 2392.
- Bell, J. et al. 2018. A subfibrillar deformation mechanism in corneal collagen that affords flexibility. Presented at: ARVO Annual Meeting 2018, Honolulu, April 29 - May 3, 2018, Vol. 59. Vol. 9. Association for Research in Vision and Ophthalmology
Erthyglau
- Morgan, S. R., O'Brart, D. P. S., Huang, J., Meek, K. M. and Hayes, S. 2024. An in vitro investigation into the impact of corneal rinsing on riboflavin/UVA corneal cross-linking. Eye and Vision 11(8) (10.1186/s40662-024-00375-4)
- Meek, K. M., Knupp, C., Lewis, P. N., Morgan, S. R. and Hayes, S. 2024. Structural control of corneal transparency, refractive power and dynamics. Eye (10.1038/s41433-024-02969-7)
- Hayes, S., Jaycock, P., Rees, N., Figuerio, F., O'Brart, D. and Meek, K. 2023. National survey of corneal cross-linking (CXL) practice patterns in the United Kingdom during 2019. Eye 37, pp. 2511-2517. (10.1038/s41433-022-02365-z)
- Gao, R. et al. 2022. The impact of different rose bengal formulations on corneal thickness and the efficacy of rose bengal/green light corneal cross-linking in the rabbit eye. Journal of Refractive Surgery 38(7), pp. 450-458. (10.3928/1081597X-20220601-03)
- Bell, J. S. et al. 2022. Tropocollagen springs allow collagen fibrils to stretch elastically. Acta Biomaterialia 142, pp. 185-193. (10.1016/j.actbio.2022.01.041)
- Zhou, D. et al. 2021. Fibril density reduction in keratoconic corneas. Journal of the Royal Society Interface 18(175), article number: 20200900. (10.1098/rsif.2020.0900)
- Hayes, S., Morgan, S. R. and Meek, K. M. 2021. Keratoconus: cross-linking the window of the eye. Therapeutic Advances in Rare Disease 2, pp. 1-14. (10.1177/26330040211003573)
- Hayes, S. et al. 2020. The effect of bacteriochlorophyll derivative WST-D and near infrared light on the molecular and fibrillar architecture of the corneal stroma. Scientific Reports 10, article number: 9836. (10.1038/s41598-020-66869-y)
- Feneck, E. M., Souza, R. B., Lewis, P. N., Hayes, S., Pereira, L. V. and Meek, K. M. 2020. Developmental abnormalities in the cornea of a mouse model for Marfan syndrome. Experimental Eye Research 194, article number: 108001. (10.1016/j.exer.2020.108001)
- Morgan, S. et al. 2018. Microwave treatment of the cornea leads to localised disruption of the extracellular matrix. Scientific Reports 8, article number: 13742. (10.1038/s41598-018-32110-0)
- Hayes, S., Meek, K. and Mukherjee, A. 2018. Use of donors predisposed by corneal collagen cross-linking in penetrating keratoplasty for treating patients with keratoconus. American Journal of Ophthalmology 188, pp. 181-181. (10.1016/j.ajo.2017.12.026)
- Pinsky, P. M., Ma, Y., Hwang, Y., Hayes, S. and Meek, K. M. 2018. A simple mathematical model for collagen fibril organization in normal and keratoconic corneas. Journal for Modeling in Ophthalmology 1
- O'Brart, N., O'Brart, D., Aldahlawi, N., Hayes, S. and Meek, K. 2018. An investigation of the effects of riboflavin concentration on the efficacy of corneal cross-linking using an enzymatic resistance model in porcine corneas. Investigative Ophthalmology and Visual Science 59, pp. 1058-1065. (10.1167/iovs.17-22994)
- Bell, J. S. et al. 2018. The hierarchical response of human corneal collagen to load. Acta Biomaterialia 65, pp. 216-225. (10.1016/j.actbio.2017.11.015)
- Islam, M. M. et al. 2018. Biomaterials-enabled cornea regeneration in patients at high risk for rejection of donor tissue transplantation. npj Regenerative Medicine 3, article number: 2. (10.1038/s41536-017-0038-8)
- O’Brart, D. P. S., O’Brart, N. A. L., Aldahlawi, N., Hayes, S. and Meek, K. 2018. The role of riboflavin concentration and oxygen in the efficacy and depth of corneal crosslinking. Investigative Ophthalmology and Visual Science 59, pp. 4449-4450. (10.1167/iovs.18-24437)
- Abass, A., Bell, J. S., Spang, M. T., Hayes, S., Meek, K. M. A. and Boote, C. 2017. SAXS4COLL: an integrated software tool for analysing fibrous collagen-based tissues. Journal of Applied Crystallography 50, pp. 1235-1240. (10.1107/S1600576717007877)
- Hayes, S. et al. 2017. The structural response of the cornea to changes in stromal hydration. Interface 14(131) (10.1098/rsif.2017.0062)
- White, T. et al. 2017. The structural role of elastic fibres in the cornea investigated using a mouse model for Marfan syndrome. Investigative Ophthalmology and Vision Science 58(4), pp. 2106-2116. (10.1167/iovs.16-21358)
- Aldahlawi, N. H., Hayes, S., O'Brart, D. P., O'Brart, N. and Meek, K. M. A. 2016. An investigation into corneal enzymatic resistance following epithelium-off and epithelium-on corneal cross-linking protocols. Experimental Eye Research 153, pp. 141-151. (10.1016/j.exer.2016.10.014)
- Aldahlawi, N. H., Hayes, S., O'Brart, D. P. S., Akhbanbetova, A., Littlechild, S. L. and Meek, K. M. A. 2016. Enzymatic resistance of corneas crosslinked using riboflavin in conjunction with low energy, high energy, and pulsed UVA irradiation modes. Investigative Ophthalmology & Visual Science 57(4), pp. 1547-1552. (10.1167/iovs.15-18769)
- Hayes, S. et al. 2015. The structural and optical properties of type III human collagen biosynthetic corneal substitutes. Acta Biomaterialia 25, pp. 121-130. (10.1016/j.actbio.2015.07.009)
- Hayes, S., Morgan, S. R., O'Brart, D. P., O'Brart, N. and Meek, K. M. A. 2015. A study of stromal riboflavin absorption inex vivoporcine corneas using new and existing delivery protocols for corneal cross-linking. Acta Ophthalmologica 94(2), pp. e109-e117. (10.1111/aos.12884)
- Mukherjee, A., Hayes, S., Aslanides, I., Lanchares, E. and Meek, K. M. 2015. Donor cross-linking for keratoplasty: a laboratory evaluation. Graefe's Archive for Clinical and Experimental Ophthalmology 252(12), pp. 2223-2228. (10.1007/s00417-015-3160-6)
- Aldahlawi, N., Hayes, S., OBrart, D. and Meek, K. M. A. 2015. Standard versus accelerated riboflavin/ultraviolet corneal cross-linking: Resistance against enzymatic digestion. Journal of Cataract and Refractive Surgery 41(9), pp. 1989-1996. (10.1016/j.jcrs.2015.10.004)
- Abass, A., Hayes, S., White, N., Sorensen, T. and Meek, K. M. 2015. Transverse depth-dependent changes in corneal collagen lamellar orientation and distribution. Journal of the Royal Society Interface 12(104), article number: 20140717. (10.1098/rsif.2014.0717)
- Davidson, A. E., Hayes, S., Hardcastle, A. J. and Tuft, S. J. 2013. The pathogenesis of keratoconus. Eye 28(2), pp. 189-195. (10.1038/eye.2013.278)
- Boote, C. et al. 2013. Quantification of Collagen Ultrastructure after Penetrating Keratoplasty - Implications for Corneal Biomechanics. PLoS ONE 8(7), article number: e68166. (10.1371/journal.pone.0068166)
- Abahussin, M., Hayes, S., Edelhauser, H., Dawson, D. G. and Meek, K. M. A. 2013. A microscopy study of the structural features of post-LASIK human corneas. PLoS ONE 8(5), article number: e63268. (10.1371/journal.pone.0063268)
- Meek, K. M. A. and Hayes, S. 2013. Corneal crosslinking - A review. Ophthalmic and Physiological Optics 33(2), pp. 78-93. (10.1111/opo.12032)
- Hayes, S. et al. 2013. The effect of Riboflavin/UVA collagen cross-linking therapy on the structure and hydrodynamic behaviour of the ungulate and rabbit corneal stroma. PLoS ONE 8(1), article number: e52860. (10.1371/journal.pone.0052860)
- Boote, C. et al. 2012. Quantitative assessment of ultrastructure and light scatter in mouse corneal debridement wounds. Investigative Ophthalmology and Visual Science 53(6), pp. 2786-2795. (10.1167/iovs.11-9305)
- Hayes, S. et al. 2012. Depth Profile Study of Abnormal Collagen Orientation in Keratoconus Corneas. Archives of Ophthalmology 130(2), pp. 251-252. (10.1001/archopthalmol.2011.1467)
- Boote, C. et al. 2011. Quantification of collagen organization in the peripheral human cornea at micron-scale resolution. Biophysical Journal 101(1), pp. 33-42. (10.1016/j.bpj.2011.05.029)
- Hayes, S. et al. 2011. Riboflavin/UVA Collagen Cross-Linking-Induced Changes in Normal and Keratoconus Corneal Stroma. PLoS ONE 6(8), article number: e22405. (10.1371/journal.pone.0022405)
- Hayes, S. et al. 2011. The effect of vitamin C deficiency and chronic ultraviolet-B exposure on corneal ultrastructure: a preliminary investigation. Molecular Vision 17, pp. 3107-3115.
- Sheppard, J., Hayes, S., Boote, C., Votruba, M. and Meek, K. M. A. 2010. Changes in corneal collagen architecture during mouse postnatal development. Investigative Ophthalmology & Visual Science 51(6), pp. 2936-2942. (10.1167/iovs.09-4612)
- Kamma-Lorger, C. S. et al. 2010. Collagen and mature elastic fibre organisation as a function of depth in the human cornea and limbus. Journal of Structural Biology 169(3), pp. 424-430. (10.1016/j.jsb.2009.11.004)
- Abahussin, M. O., Hayes, S., Knox Cartwright, N. E., Kamma-Lorger, C. S., Khan, Y., Marshall, J. and Meek, K. M. A. 2009. 3D collagen orientation study of the human cornea using X-ray diffraction and femtosecond laser technology. Investigative Ophthalmology & Visual Science 50(11), pp. 5159-5164. (10.1167/iovs.09-3669)
- Boote, C. et al. 2009. Ultrastructural changes in the retinopathy, globe enlarged (rge) chick cornea. Journal of Structural Biology 166(2), pp. 195-204. (10.1016/j.jsb.2009.01.009)
- Kamma-Lorger, C. S., Boote, C., Hayes, S., Albon, J., Boulton, M. E. and Meek, K. M. A. 2009. Collagen ultrastructural changes during stromal wound healing in organ cultured bovine corneas. Experimental Eye Research 88(5), pp. 953-959. (10.1016/j.exer.2008.12.005)
- Samaras, K., O'Brart, D. P., Doutch, J., Hayes, S., Marshall, J. and Meek, K. M. A. 2009. Effect of Epithelial Retention and Removal on Riboflavin Absorption in Porcine Corneas. Journal of Refractive Surgery 25(9), pp. 771-775. (10.3928/1081597X-20090813-03)
- Kamma-Lorger, C. S., Hayes, S., Boote, C., Burghammer, M., Boulton, M. E. and Meek, K. M. A. 2009. Effects on collagen orientation in the cornea after trephine injury. Molecular Vision 15, pp. 378-385.
- Hayes, S., Young, R. D., Boote, C., Hawksworth, N., Huang, Y. and Meek, K. M. A. 2009. A structural investigation of corneal graft failure in suspected recurrent keratoconus. Eye 24(4), pp. 728-734. (10.1038/eye.2009.159)
- Boote, C. et al. 2008. Collagen organization in the chicken cornea and structural alterations in the retinopathy, globe enlarged (rge) phenotype - An X-ray diffraction study. Journal of Structural Biology 161(1), pp. 1-8. (10.1016/j.jsb.2007.08.015)
- Hayes, S. et al. 2007. Comparative Study of Fibrillar Collagen Arrangement in the Corneas of Primates and Other Mammals. The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology 290(12), pp. 1542-1550. (10.1002/ar.20613)
- Hayes, S., Boote, C., Tuft, S. J., Quantock, A. J. and Meek, K. M. A. 2007. A study of corneal thickness, shape and collagen organisation in keratoconus using videokeratography and X-ray scattering techniques. Experimental Eye Research 84(3), pp. 423-434. (10.1016/j.exer.2006.10.014)
- Quantock, A. J. et al. 2007. Small-angle fibre diffraction studies of corneal matrix structure: a depth profiled investigation of the human eye-bank cornea. Journal of Applied Crystallography 40(S1), pp. S335-S340. (10.1107/S0021889807005523)
- Boote, C., Hayes, S., Abahussin, M. and Meek, K. M. A. 2006. Mapping collagen organization in the human cornea: left and right eyes are structurally distinct. Investigative Ophthalmology and Visual Science 47(3), pp. 901-908. (10.1167/iovs.05-0893)
- Meek, K. M. A., Tuft, S. J., Huang, Y., Gill, P. S., Hayes, S., Newton, R. H. and Bron, A. J. 2005. Changes in collagen orientation and distribution in keratoconus corneas. Investigative Ophthalmology and Visual Science 46(6), pp. 1948-1956. (10.1167/iovs.04-1253)
- Boote, C., Hayes, S., Huang, Y., Quantock, A. J. and Meek, K. M. A. 2005. Lamellar orientation in human cornea in relation to mechanical properties. Journal of Structural Biology 149(1), pp. 1-6. (10.1016/j.jsb.2004.08.009)
- Boote, C., Hayes, S. and Meek, K. M. A. 2004. Spatial mapping of collagen fibril organisation in primate cornea - an X-ray diffraction investigation. Journal of Structural Biology 146(3), pp. 359-367. (10.1016/j.jsb.2003.12.009)
- Hayes, S. et al. 2003. Ultrastructural Changes in Keratoconic-like Mice Corneas [Abstract]. Fibre Diffraction Review 11, pp. 135.
- Quantock, A. J. et al. 2003. Annulus of collagen fibrils in mouse cornea and structural matrix alterations in a murine-specific keratopathy. Investigative Ophthalmology & Visual Science 44(5), pp. 1906-1911. (10.1167/iovs.02-0884)
- Boote, C., Hayes, S. and Meek, K. M. A. 2003. Collagen organisation in adult and foetal marmoset cornea. Investigative Ophthalmology and Visual Science 44(E-Abst)
- Hayes, S., Khan, S. and Meek, K. M. A. 2003. Changes in the refractive index of the cornea when the stroma swells [Abstract]. Investigative Ophthalmology & Visual Science 44, article number: 886.
- Meek, K., Hayes, S. and Khan, S. 2003. Changes in the refractive index of the stroma and its extrafibrillar matrix when the cornea swells. Biophysical Journal 85(4), pp. 2205-2212.
- Boote, C., Hayes, S., Newton, R. H., Puri, H. and Meek, K. M. A. 2003. Collagen fibrils appear more closely packed in the prepupilliary cornea: optical and biomechanical implications. Investigative Ophthalmology & Visual Science 44(7), pp. 2941-2948. (10.1167/iovs.03-0131)
- Meek, K. M. A., Leonard, D., Connon, C. J., Hayes, S. and Khan, S. 2003. Transparency, swelling and scarring in the corneal stroma. Eye 17(8), pp. 927-936. (10.1038/sj.eye.6700574)
Gosodiad
- Hayes, S. 2005. Structural organisation of collagen in the corneas of primates and other mammals and the stromal changes associated with the disease keratoconus. PhD Thesis, Cardiff University.
- Boote, C. et al. 2012. Quantitative assessment of ultrastructure and light scatter in mouse corneal debridement wounds. Investigative Ophthalmology and Visual Science 53(6), pp. 2786-2795. (10.1167/iovs.11-9305)
- Hayes, S. et al. 2012. Depth Profile Study of Abnormal Collagen Orientation in Keratoconus Corneas. Archives of Ophthalmology 130(2), pp. 251-252. (10.1001/archopthalmol.2011.1467)
- Boote, C. et al. 2011. Quantification of collagen organization in the peripheral human cornea at micron-scale resolution. Biophysical Journal 101(1), pp. 33-42. (10.1016/j.bpj.2011.05.029)
- Hayes, S. et al. 2011. Riboflavin/UVA Collagen Cross-Linking-Induced Changes in Normal and Keratoconus Corneal Stroma. PLoS ONE 6(8), article number: e22405. (10.1371/journal.pone.0022405)
- Sheppard, J., Hayes, S., Boote, C., Votruba, M. and Meek, K. M. A. 2010. Changes in corneal collagen architecture during mouse postnatal development. Investigative Ophthalmology & Visual Science 51(6), pp. 2936-2942. (10.1167/iovs.09-4612)
- Kamma-Lorger, C. S. et al. 2010. Collagen and mature elastic fibre organisation as a function of depth in the human cornea and limbus. Journal of Structural Biology 169(3), pp. 424-430. (10.1016/j.jsb.2009.11.004)
- Abahussin, M. O., Hayes, S., Knox Cartwright, N. E., Kamma-Lorger, C. S., Khan, Y., Marshall, J. and Meek, K. M. A. 2009. 3D collagen orientation study of the human cornea using X-ray diffraction and femtosecond laser technology. Investigative Ophthalmology & Visual Science 50(11), pp. 5159-5164. (10.1167/iovs.09-3669)
- Boote, C. et al. 2009. Ultrastructural changes in the retinopathy, globe enlarged (rge) chick cornea. Journal of Structural Biology 166(2), pp. 195-204. (10.1016/j.jsb.2009.01.009)
- Kamma-Lorger, C. S., Boote, C., Hayes, S., Albon, J., Boulton, M. E. and Meek, K. M. A. 2009. Collagen ultrastructural changes during stromal wound healing in organ cultured bovine corneas. Experimental Eye Research 88(5), pp. 953-959. (10.1016/j.exer.2008.12.005)
- Samaras, K., O'Brart, D. P., Doutch, J., Hayes, S., Marshall, J. and Meek, K. M. A. 2009. Effect of Epithelial Retention and Removal on Riboflavin Absorption in Porcine Corneas. Journal of Refractive Surgery 25(9), pp. 771-775. (10.3928/1081597X-20090813-03)
- Kamma-Lorger, C. S., Hayes, S., Boote, C., Burghammer, M., Boulton, M. E. and Meek, K. M. A. 2009. Effects on collagen orientation in the cornea after trephine injury. Molecular Vision 15, pp. 378-385.
- Hayes, S., Young, R. D., Boote, C., Hawksworth, N., Huang, Y. and Meek, K. M. A. 2009. A structural investigation of corneal graft failure in suspected recurrent keratoconus. Eye 24(4), pp. 728-734. (10.1038/eye.2009.159)
- Boote, C. et al. 2008. Collagen organization in the chicken cornea and structural alterations in the retinopathy, globe enlarged (rge) phenotype - An X-ray diffraction study. Journal of Structural Biology 161(1), pp. 1-8. (10.1016/j.jsb.2007.08.015)
- Hayes, S. et al. 2007. Comparative Study of Fibrillar Collagen Arrangement in the Corneas of Primates and Other Mammals. The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology 290(12), pp. 1542-1550. (10.1002/ar.20613)
- Hayes, S., Boote, C., Tuft, S. J., Quantock, A. J. and Meek, K. M. A. 2007. A study of corneal thickness, shape and collagen organisation in keratoconus using videokeratography and X-ray scattering techniques. Experimental Eye Research 84(3), pp. 423-434. (10.1016/j.exer.2006.10.014)
- Boote, C., Hayes, S., Abahussin, M. and Meek, K. M. A. 2006. Mapping collagen organization in the human cornea: left and right eyes are structurally distinct. Investigative Ophthalmology and Visual Science 47(3), pp. 901-908. (10.1167/iovs.05-0893)
- Meek, K. M. A., Tuft, S. J., Huang, Y., Gill, P. S., Hayes, S., Newton, R. H. and Bron, A. J. 2005. Changes in collagen orientation and distribution in keratoconus corneas. Investigative Ophthalmology and Visual Science 46(6), pp. 1948-1956. (10.1167/iovs.04-1253)
- Boote, C., Hayes, S., Huang, Y., Quantock, A. J. and Meek, K. M. A. 2005. Lamellar orientation in human cornea in relation to mechanical properties. Journal of Structural Biology 149(1), pp. 1-6. (10.1016/j.jsb.2004.08.009)
- Boote, C., Hayes, S. and Meek, K. M. A. 2004. Spatial mapping of collagen fibril organisation in primate cornea - an X-ray diffraction investigation. Journal of Structural Biology 146(3), pp. 359-367. (10.1016/j.jsb.2003.12.009)
Ymchwil
My current research is aimed at further understanding the relationship between structure and function in normal and diseased corneas. I am particularly interested in keratoconus, a disease characterised by progressive thinning and steepening of the cornea and severe irregular astigmatism. Keratoconus is one of the leading causes of corneal transplant surgery in the UK.
During my doctoral studies I used a combination of videokeratography to assess corneal shape, and synchrotron x-ray diffraction to gain quantitative structural information about the organisation and distribution of collagen in normal and keratoconus corneas, to examine the link between corneal structure and specific keratoconus shape changes. The findings of this study supported the theory that lamellar slippage is involved in the progressive thinning and steepening of keratoconus corneas. In recent years a therapeutic treatment has been developed to strenghten corneal tissue and halt the progressive steepening of keratoconus corneas. The treatment involves the combined use of UVA and riboflavin to stabilise corneal collagen and its surrounding matrix. I am currently investigating the mechanism by which the treatment strengthens the cornea and the ways in which the treatment can be modified to minimise patient treatment time and maximise patient comfort.
I am also interested in human corneal development, in particular the structural changes that lead to the cornea becoming strong, transparent and precisely curved. Recently granted access to the MRC/Wellcome Trust-funded Human Developmental Biology Resource (HDBR) has provided a unique opportunity to examine structural changes occurring at key stages of foetal development.
Recent Research Seminars
2016 Invited speaker at the CXL Experts meeting, Zurich, Switzerland
2015 Invited speaker at the 11th International Congress on Corneal Cross-linking, Boston, USA
2015 ARVO, Denver, USA
2012 8th International Congress on Corneal Cross-linking, Geneva, Switzerland
2012 XIVth Bowmans Club Annual meeting, Newcastle, UK
Addysgu
- Supervision of final year undergraduate written and practical projects.
- Supervision of work experience students from local schools.
- STEM engagement activities in local schools
Bywgraffiad
Education
2001-2005 - PhD Structural Biophysics: The structural organisation of collagen in the corneas of primates and other mammals and the stromal changes associated with the disease keratoconus, Structural Biophysics Group, School of Optometry and Vision Sciences, Cardiff University.
1997 - 2000 - First Class Honours in Animal/Equine Science Aberystwyth University
Career history
2016-present Research Fellow, Structural Biophysics Group, School of Optometry and Vision Sciences, Cardiff University
2005 - 2016 Research Associate, Structural Biophysics Group, School of Optometry and Vision Sciences, Cardiff University
2001-2005 Research Assistant, Structural Biophysics Group, School of Optometry and Vision Sciences, Cardiff University
Anrhydeddau a dyfarniadau
Finalist in the Royal Institute Science Graduate of the Year Award, 2004
Cardiff University outstanding contribution award, 2014
Aelodaethau proffesiynol
- Chair of Research Staff Committee
- Member of Safety Committee
Pwyllgorau ac adolygu
2016-present School Ethics Committee
2014-2016 School Research Committee
2012-2016 Chair of the Research Staff Forum
2009-2011 International Stakeholders Committee
2009-2011 School Charity Committee
2005-2007 Post Graduate Teaching Committee
2001-2013 School Safety Committee
Meysydd goruchwyliaeth
- Strwythur/swyddogaeth corneal, patholeg a therapïau newydd
