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Dr Victoria Shepherd
Uwch Gymrawd Ymchwil - Nyrs
- ShepherdVL1@caerdydd.ac.uk
- Neuadd Meirionnydd, Ystafell 413, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4YS
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwyg
Rwy'n Uwch Gymrawd Ymchwil yn y Ganolfan Treialon Ymchwil lle mae gen i ddiddordeb arbennig mewn ymchwil sy'n cynnwys poblogaethau sydd heb eu gwasanaethu'n ddigonol gyda ffocws penodol ar boblogaethau a lleoliadau lle gall caniatâd gwybodus fod yn heriol fel pobl hŷn sy'n byw mewn cartrefi gofal, gofal critigol a lleoliadau brys, a threialon sy'n cynnwys defnyddio modelau dirprwy a 'chaniatâd gohiriedig'.
Rwy'n arwain rhaglen o ymchwil fethodolegol sy'n archwilio'r materion moesegol, cyfreithiol ac ymarferol sy'n ymwneud ag ymchwil sy'n cynnwys oedolion nad oes ganddynt ganiatâd capasiti. Mae hyn yn cynnwys Cymrodoriaeth Uwch NIHR gyfredol a Chymrodoriaeth Ymchwil Ddoethurol NIHR blaenorol. Mae'r rhaglen ymchwil hon yn cynnwys datblygu ymyriadau cymhleth i fynd i'r afael â'r rhwystrau moesegol a methodolegol i gynnal treialon gydag oedolion nad oes ganddynt alluedd. Fel rhan o'r rhaglen ymchwil hon, datblygwyd gwefan sy'n darparu gwybodaeth ac adnoddau ar gapasiti a chaniatâd i ymchwil: https://www.capacityconsentresearch.com/
Rwy'n cymryd rhan mewn ac yn arwain nifer o astudiaethau ymchwil cartrefi gofal, gan gynnwys arwain astudiaeth i sefydlu'r blaenoriaethau ymchwil mewn cartrefi gofal gan ddefnyddio dulliau sy'n seiliedig ar gonsensws, ac rwy'n aelod o nifer o gydweithrediadau ymchwil cartrefi gofal cenedlaethol a rhyngwladol. Rwy'n Gadeirydd Grŵp Cynghori ENRICH Cymru. Cyn hyn cefais yrfa glinigol helaeth fel Nyrs Gofrestredig, treuliodd y mwyafrif mewn lleoliadau gofal critigol yng Nghymru a Lloegr. Rwyf hefyd yn aelod arbenigol ar Bwyllgor Moeseg Ymchwil y GIG. O fewn CTR rwy'n cyd-arwain y Grŵp Cynhwysiant mewn Treialon / Astudiaethau a'r Grŵp RN&AHP.
Cyhoeddiad
2024
- Shepherd, V. et al. 2024. Improving the inclusion of an under-served group in trials: development and implementation of the INCLUDE Impaired Capacity to Consent Framework. Trials 25(1), article number: 83. (10.1186/s13063-024-07944-x)
2023
- Gillespie, D. et al. 2023. Gut microbiology of UK care home residents: cross-sectional analysis from a randomised controlled trial. Clinical Microbiology and Infection 29(11), pp. 1437-1442. (10.1016/j.cmi.2023.08.001)
- Shepherd, V., Hood, K. and Wood, F. 2023. Planning ahead for research participation: survey of public and professional stakeholders' view about the acceptability and feasibility of advance research planning. BMC Medical Ethics 24, article number: 70. (10.1186/s12910-023-00948-3)
- Seeger, R. et al. 2023. Advance consent in acute stroke trials: survey of Canadian Research Ethics Board chairs. Canadian Journal of Neurological Sciences (10.1017/cjn.2023.247)
- Nocivelli, B., Shepherd, V., Hood, K., Wallace, C. and Wood, F. 2023. Identifying barriers and facilitators to the inclusion of older adults living in UK care homes in research: a scoping review. BMC Geriatrics 23(1), article number: 446. (10.1186/s12877-023-04126-3)
- Goodwin, V. A. et al. 2023. Including older people in health and social care research: best practice recommendations based on the INCLUDE framework. Age and Ageing 52(6), article number: afad082. (10.1093/ageing/afad082)
- Burgher, T., Shepherd, V. and Nollett, C. 2023. Effective approaches to public involvement in care home research: a systematic review and narrative synthesis. Research Involvement and Engagement 9(38) (10.1186/s40900-023-00453-2)
- Russell, A. M. et al. 2023. Complex and alternate consent pathways in clinical trials: methodological and ethical challenges encountered by underserved groups and a call to action. Trials 24(1), article number: 151. (10.1186/s13063-023-07159-6)
- Udoh, U. et al. 2023. Advance consent in acute stroke trials: survey of canadian stroke physicians. Canadian Journal of Neurological Sciences (10.1017/cjn.2023.12)
- Nocivelli, B., Shepherd, V., Hood, K., Wallace, C. and Wood, F. 2023. Identifying barriers and facilitators to the inclusion of older adults living in UK care homes in research: a scoping review. BMC Geriatrics
2022
- Shepherd, V., Wood, F., Gillies, K., Martin, A., O’Connell, A. and Hood, K. 2022. Feasibility, effectiveness and costs of a decision support intervention for consultees and legal representatives of adults lacking capacity to consent (CONSULT): protocol for a randomised study within a trial. Trials 23(1), article number: 957. (10.1186/s13063-022-06887-5)
- Shepherd, V., Hood, K., Gillies, K. and Wood, F. 2022. Development of a measure to assess the quality of proxy decisions about research participation on behalf of adults lacking capacity to consent: the Combined Scale for Proxy Informed Consent Decisions (CONCORD scale). Trials 23, article number: 843. (10.1186/s13063-022-06787-8)
- Shepherd, V., Wood, F., Gillies, K., O'Connell, A., Martin, A. and Hood, K. 2022. Recruitment interventions for trials involving adults lacking capacity to consent: methodological and ethical considerations for designing Studies Within a Trial (SWATs). Trials 23, article number: 756. (10.1186/s13063-022-06705-y)
- Shepherd, V. et al. 2022. Development of a core outcome set for the evaluation of interventions to prevent COVID-19 in care homes (COS-COVID-PCARE Study). BMC Geriatrics 22, article number: 710. (10.1186/s12877-022-03395-8)
- Dawson, S. et al. 2022. Trial Forge Guidance 3: randomised trials and how to recruit and retain individuals from ethnic minority groups- practical guidance to support better practice. Trials 23, article number: 672.
- Shepherd, V. 2022. (Re)conceptualising 'good' proxy decision-making for research: the implications for proxy consent decision quality. BMC Medical Ethics 23, article number: 75. (10.1186/s12910-022-00809-5)
- Shepherd, V., Hood, K. and Wood, F. 2022. Unpacking the 'black box of horrendousness': a qualitative exploration of the barriers and facilitators to conducting trials involving adults lacking capacity to consent. Trials 23, article number: 471. (10.1186/s13063-022-06422-6)
- Fitzpatrick, A., Wood, F. and Shepherd, V. 2022. Trials using deferred consent in the emergency setting: a systematic review and narrative synthesis of stakeholders' attitudes. Trials 23, article number: 411. (10.1186/s13063-022-06304-x)
2021
- Shepherd, V., Wood, F., Robling, M., Randell, E. and Hood, K. 2021. Development of a core outcome set for the evaluation of interventions to enhance trial participation decisions on behalf of adults who lack capacity to consent: a mixed methods study (COnSiDER Study). Trials 22, article number: 935. (10.1186/s13063-021-05883-5)
- Andreae, M. H., Shah, L. D., Shepherd, V., Sheehan, M., Sacks, H. S. and Rhodes, R. 2021. Decisions on innovation or research for devastating disease. American Journal of Bioethics 21(12), pp. 28-31. (10.1080/15265161.2021.1991042)
- Raven-Gregg, T. and Shepherd, V. 2021. Exploring the inclusion of under-served groups in trials methodology research: an example from ethnic minority populations' views on deferred consent. Trials 22, article number: 589. (10.1186/s13063-021-05568-z)
- Raven-Gregg, T., Wood, F. and Shepherd, V. 2021. Effectiveness of participant recruitment strategies for critical care trials: a systematic review and narrative synthesis. Clinical Trials 18(4), pp. 436-448. (10.1177/1740774520988678)
- Shepherd, V. 2021. Consent support tool: Including people with communication disorders in health research studies [Book Review]. Dementia 20(5), pp. 1855-1856. (10.1177/1471301220985401)
- Butler, C. C. et al. 2021. Probiotics to reduce antibiotic administration in care home residents aged 65 years and older: the PRINCESS RCT. Efficacy and Mechanism Evaluation 8(7) (10.3310/eme08070)
- Shepherd, V. 2021. How nurses can support the inclusion in research of older people who lack capacity to consent. Nursing Older People 33(2), pp. 26-31. (10.7748/nop.2020.e1267)
- Wachhloz, P. A. et al. 2021. Mapping research conducted on long-term care facilities for older people in Brazil: a scoping review. International Journal of Environmental Research and Public Health 18(4), article number: 1522. (10.3390/ijerph18041522)
- Jones, A., Morgan-Jones, P., Busse, M., Shepherd, V. and Wood, F. 2021. Conducting focus groups in neurodegenerative disease populations: ethical and methodological considerations. BMJ Open 11(1), article number: e041869. (10.1136/bmjopen-2020-041869)
- Shepherd, V., Wood, F., Griffith, R., Sheehan, M. and Hood, K. 2021. Development of a decision support intervention for family members of adults who lack capacity to consent to trials. BMC Medical Informatics and Decision Making 21, article number: 30. (10.1186/s12911-021-01390-4)
- Shepherd, V., Griffith, R., Hood, K., Sheehan, M. and Wood, F. 2021. 'There's more to life than money and health': family caregivers' views on the role of Power of Attorney in proxy decisions about research participation for people living with dementia. Dementia 20(1), pp. 308-325. (10.1177/1471301219884426)
2020
- Shepherd, V., Sheehan, M., Hood, K., Griffith, R. and Wood, F. 2020. Constructing authentic decisions: proxy decision making for research involving adults who lack capacity to consent. Journal of Medical Ethics 47(12), article number: e42. (10.1136/medethics-2019-106042)
- Jacinto, A. F. et al. 2020. Using international collaborations to shape research and innovation into care homes in Brazil: a white paper. Journal of Nursing Home Research Sciences 6, pp. 109-113. (10.14283/jnhrs.2020.28)
- Shepherd, V. 2020. Advances and challenges in conducting ethical trials involving populations lacking capacity to consent: a decade in review. Contemporary Clinical Trials 95, article number: 106054. (10.1016/j.cct.2020.106054)
- Kirby, N., Shepherd, V., Howick, J., Betteridge, S. and Hood, K. 2020. Nocebo effects and participant information leaflets: evaluating information provided on adverse effects in UK clinical trials. Trials 21(1), article number: 658. (10.1186/s13063-020-04591-w)
- Butler, C. C. et al. 2020. Effect of probiotic use on antibiotic administration among care home residents: a randomized clinical trial. Journal of the American Medical Association 324(1), pp. 47 - 56. (10.1001/jama.2020.8556)
- Shepherd, V. 2020. Decision-making during pandemics and other serious illness. Geriatrics, Gerontology and Aging 14(2), pp. 79-80. (10.5327/Z2447-21232020142EDT1)
- Shepherd, V. 2020. An under-represented and underserved population in trials: methodological, structural, and systemic barriers to the inclusion of adults lacking capacity to consent. Trials 21(1), article number: 445. (10.1186/s13063-020-04406-y)
- Shepherd, V. and Davies, J. 2020. Conducting a randomized controlled trial in care homes: the challenges of recruiting residents who lack capacity to consent. In: SAGE Research Methods Cases: Medicine and Health. SAGE, (10.4135/9781529726626)
2019
- Shepherd, V., Hood, K., Sheehan, M., Griffith, R. and Wood, F. 2019. 'It's a tough decision': A qualitative study of proxy decision-making for research involving adults who lack capacity to consent in England and Wales. Age and Ageing 48(6), pp. 903-909. (10.1093/ageing/afz115)
- Wachholz, P. et al. 2019. Research on long-term care homes for older people in Brazil: protocol for a scoping review. East Midlands Research into Ageing Network 32, pp. 1-16.
- Shepherd, V. 2019. Deciding about research for others: normative, empirical, and legal accounts of proxy decision-making for research and the development of a decision support intervention. PhD Thesis, Cardiff University.
- Owen-Jones, E. et al. 2019. Protocol for a double-blind placebo-controlled trial to evaluate the efficacy of probiotics in reducing antibiotics for infection in care home residents: the Probiotics to Reduce Infections iN CarE home reSidentS (PRINCESS) trial. BMJ Open 9(6), article number: e027513. (10.1136/bmjopen-2018-027513)
- Shepherd, V., Wood, F., Griffith, R., Sheehan, M. and Hood, K. 2019. Research involving adults lacking capacity to consent: a content analysis of participant information sheets for consultees and legal representatives in England and Wales. Trials 20, article number: 233. (10.1186/s13063-019-3340-5)
- Edvardsson, D. et al. 2019. Advancing long-term care science through using common data elements: candidate measures for care outcomes of personhood, well-being, and quality of life. Gerontology and Geriatric Medicine 5, pp. 1-15. (10.1177/2333721419842672)
- Shepherd, V., Wood, F., Griffith, R., Sheehan, M. and Hood, K. 2019. Protection by exclusion? The (lack of) inclusion of adults who lack capacity to consent to research in clinical trials in the UK. Trials 20, article number: 474. (10.1186/s13063-019-3603-1)
2018
- Shepherd, V., Hood, K., Sheehan, M., Griffith, R., Jordan, A. and Wood, F. 2018. Ethical understandings of proxy decision making for research involving adults lacking capacity: a systematic review (framework synthesis) of empirical research. American Journal of Bioethics 9(4), pp. 267-286. (10.1080/23294515.2018.1513097)
- Francis, N. A. et al. 2018. Oral steroids for hearing loss associated with otitis media with effusion in children aged 2 8 years: the OSTRICH RCT. Health Technology Assessment 22(61) (10.3310/hta22610)
- Jordan, A., Wood, F., Edwards, A., Shepherd, V. and Joseph-Williams, N. 2018. What adolescents living with long-term conditions say about being involved in decision-making about their healthcare: A systematic review and narrative synthesis of preferences and experiences. Patient Education and Counseling 101(10), pp. 1725-1735. (10.1016/j.pec.2018.06.006)
- Shepherd, V., Griffith, R., Sheehan, M., Wood, F. and Hood, K. 2018. Healthcare professionals' understanding of the legislation governing research involving adults lacking mental capacity in England and Wales: a national survey. Journal of Medical Ethics 44(9), pp. 632-637. (10.1136/medethics-2017-104722)
- Francis, N. A. et al. 2018. Oral steroids for resolution of otitis media with effusion in children (OSTRICH): a double-blinded, placebo-controlled randomised trial. Lancet 392(10147), pp. 557-568. (10.1016/S0140-6736(18)31490-9)
2017
- Shepherd, V., Thomas-Jones, E., Ridd, M. J., Hood, K., Addison, K. and Francis, N. 2017. Impact of a deferred recruitment model in a randomised controlled trial in primary care (CREAM study). Trials 18(1), article number: 533. (10.1186/s13063-017-2284-x)
- Francis, N. A. et al. 2017. Oral and topical antibiotics for clinically infected eczema in children: a pragmatic randomized controlled trial in ambulatory care. Annals of Family Medicine 15(2), pp. 124-130. (10.1370/afm.2038)
- Shepherd, V., Wood, F. and Hood, K. 2017. Establishing a set of research priorities in care homes for older people in the UK: a modified Delphi consensus study with care home staff. Age and Ageing 46(2), pp. 284-290. (10.1093/ageing/afw204)
2016
- Gkiousias, V., Butler, C. C., Shepherd, V., Kilgour, J. M., Waldron, C., Thomas-Jones, E. and Francis, N. 2016. Parental perceptions and understanding of information provision, management options and factors influencing the decision-making process in the treatment of children with glue ear. International Journal of Pediatric Otorhinolaryngology 89, pp. 6-12. (10.1016/j.ijporl.2016.07.021)
- Shepherd, V. 2016. Research involving adults lacking capacity to consent: the impact of research regulation on 'evidence biased' medicine. BMC Medical Ethics 17(1), article number: 55. (10.1186/s12910-016-0138-9)
- Francis, N. A. et al. 2016. A randomised placebo-controlled trial of oral and topical antibiotics for children with clinically infected eczema in the community: the ChildRen with Eczema, Antibiotic Management (CREAM) study. Health Technology Assessment 20(19), pp. 1-84. (10.3310/hta20190)
- Waldron, C. et al. 2016. Oral Steroids for the Resolution of Otitis Media with Effusion (OME) in Children (OSTRICH): study protocol for a randomised controlled trial. Trials 17, article number: 115. (10.1186/s13063-016-1236-1)
2015
- Shepherd, V., Nuttall, J., Hood, K. and Butler, C. C. 2015. Setting up a clinical trial in care homes: challenges encountered and recommendations for future research practice. BMC Research Notes 8, article number: 306. (10.1186/s13104-015-1276-8)
2014
- Hood, K. et al. 2014. Probiotics for Antibiotic-Associated Diarrhoea (PAAD): a prospective observational study of antibiotic-associated diarrhoea (including Clostridium difficile-associated diarrhoea) in care homes. Health Technology Assessment 18(63) (10.3310/hta18630)
Articles
- Shepherd, V. et al. 2024. Improving the inclusion of an under-served group in trials: development and implementation of the INCLUDE Impaired Capacity to Consent Framework. Trials 25(1), article number: 83. (10.1186/s13063-024-07944-x)
- Gillespie, D. et al. 2023. Gut microbiology of UK care home residents: cross-sectional analysis from a randomised controlled trial. Clinical Microbiology and Infection 29(11), pp. 1437-1442. (10.1016/j.cmi.2023.08.001)
- Shepherd, V., Hood, K. and Wood, F. 2023. Planning ahead for research participation: survey of public and professional stakeholders' view about the acceptability and feasibility of advance research planning. BMC Medical Ethics 24, article number: 70. (10.1186/s12910-023-00948-3)
- Seeger, R. et al. 2023. Advance consent in acute stroke trials: survey of Canadian Research Ethics Board chairs. Canadian Journal of Neurological Sciences (10.1017/cjn.2023.247)
- Nocivelli, B., Shepherd, V., Hood, K., Wallace, C. and Wood, F. 2023. Identifying barriers and facilitators to the inclusion of older adults living in UK care homes in research: a scoping review. BMC Geriatrics 23(1), article number: 446. (10.1186/s12877-023-04126-3)
- Goodwin, V. A. et al. 2023. Including older people in health and social care research: best practice recommendations based on the INCLUDE framework. Age and Ageing 52(6), article number: afad082. (10.1093/ageing/afad082)
- Burgher, T., Shepherd, V. and Nollett, C. 2023. Effective approaches to public involvement in care home research: a systematic review and narrative synthesis. Research Involvement and Engagement 9(38) (10.1186/s40900-023-00453-2)
- Russell, A. M. et al. 2023. Complex and alternate consent pathways in clinical trials: methodological and ethical challenges encountered by underserved groups and a call to action. Trials 24(1), article number: 151. (10.1186/s13063-023-07159-6)
- Udoh, U. et al. 2023. Advance consent in acute stroke trials: survey of canadian stroke physicians. Canadian Journal of Neurological Sciences (10.1017/cjn.2023.12)
- Nocivelli, B., Shepherd, V., Hood, K., Wallace, C. and Wood, F. 2023. Identifying barriers and facilitators to the inclusion of older adults living in UK care homes in research: a scoping review. BMC Geriatrics
- Shepherd, V., Wood, F., Gillies, K., Martin, A., O’Connell, A. and Hood, K. 2022. Feasibility, effectiveness and costs of a decision support intervention for consultees and legal representatives of adults lacking capacity to consent (CONSULT): protocol for a randomised study within a trial. Trials 23(1), article number: 957. (10.1186/s13063-022-06887-5)
- Shepherd, V., Hood, K., Gillies, K. and Wood, F. 2022. Development of a measure to assess the quality of proxy decisions about research participation on behalf of adults lacking capacity to consent: the Combined Scale for Proxy Informed Consent Decisions (CONCORD scale). Trials 23, article number: 843. (10.1186/s13063-022-06787-8)
- Shepherd, V., Wood, F., Gillies, K., O'Connell, A., Martin, A. and Hood, K. 2022. Recruitment interventions for trials involving adults lacking capacity to consent: methodological and ethical considerations for designing Studies Within a Trial (SWATs). Trials 23, article number: 756. (10.1186/s13063-022-06705-y)
- Shepherd, V. et al. 2022. Development of a core outcome set for the evaluation of interventions to prevent COVID-19 in care homes (COS-COVID-PCARE Study). BMC Geriatrics 22, article number: 710. (10.1186/s12877-022-03395-8)
- Dawson, S. et al. 2022. Trial Forge Guidance 3: randomised trials and how to recruit and retain individuals from ethnic minority groups- practical guidance to support better practice. Trials 23, article number: 672.
- Shepherd, V. 2022. (Re)conceptualising 'good' proxy decision-making for research: the implications for proxy consent decision quality. BMC Medical Ethics 23, article number: 75. (10.1186/s12910-022-00809-5)
- Shepherd, V., Hood, K. and Wood, F. 2022. Unpacking the 'black box of horrendousness': a qualitative exploration of the barriers and facilitators to conducting trials involving adults lacking capacity to consent. Trials 23, article number: 471. (10.1186/s13063-022-06422-6)
- Fitzpatrick, A., Wood, F. and Shepherd, V. 2022. Trials using deferred consent in the emergency setting: a systematic review and narrative synthesis of stakeholders' attitudes. Trials 23, article number: 411. (10.1186/s13063-022-06304-x)
- Shepherd, V., Wood, F., Robling, M., Randell, E. and Hood, K. 2021. Development of a core outcome set for the evaluation of interventions to enhance trial participation decisions on behalf of adults who lack capacity to consent: a mixed methods study (COnSiDER Study). Trials 22, article number: 935. (10.1186/s13063-021-05883-5)
- Andreae, M. H., Shah, L. D., Shepherd, V., Sheehan, M., Sacks, H. S. and Rhodes, R. 2021. Decisions on innovation or research for devastating disease. American Journal of Bioethics 21(12), pp. 28-31. (10.1080/15265161.2021.1991042)
- Raven-Gregg, T. and Shepherd, V. 2021. Exploring the inclusion of under-served groups in trials methodology research: an example from ethnic minority populations' views on deferred consent. Trials 22, article number: 589. (10.1186/s13063-021-05568-z)
- Raven-Gregg, T., Wood, F. and Shepherd, V. 2021. Effectiveness of participant recruitment strategies for critical care trials: a systematic review and narrative synthesis. Clinical Trials 18(4), pp. 436-448. (10.1177/1740774520988678)
- Shepherd, V. 2021. Consent support tool: Including people with communication disorders in health research studies [Book Review]. Dementia 20(5), pp. 1855-1856. (10.1177/1471301220985401)
- Butler, C. C. et al. 2021. Probiotics to reduce antibiotic administration in care home residents aged 65 years and older: the PRINCESS RCT. Efficacy and Mechanism Evaluation 8(7) (10.3310/eme08070)
- Shepherd, V. 2021. How nurses can support the inclusion in research of older people who lack capacity to consent. Nursing Older People 33(2), pp. 26-31. (10.7748/nop.2020.e1267)
- Wachhloz, P. A. et al. 2021. Mapping research conducted on long-term care facilities for older people in Brazil: a scoping review. International Journal of Environmental Research and Public Health 18(4), article number: 1522. (10.3390/ijerph18041522)
- Jones, A., Morgan-Jones, P., Busse, M., Shepherd, V. and Wood, F. 2021. Conducting focus groups in neurodegenerative disease populations: ethical and methodological considerations. BMJ Open 11(1), article number: e041869. (10.1136/bmjopen-2020-041869)
- Shepherd, V., Wood, F., Griffith, R., Sheehan, M. and Hood, K. 2021. Development of a decision support intervention for family members of adults who lack capacity to consent to trials. BMC Medical Informatics and Decision Making 21, article number: 30. (10.1186/s12911-021-01390-4)
- Shepherd, V., Griffith, R., Hood, K., Sheehan, M. and Wood, F. 2021. 'There's more to life than money and health': family caregivers' views on the role of Power of Attorney in proxy decisions about research participation for people living with dementia. Dementia 20(1), pp. 308-325. (10.1177/1471301219884426)
- Shepherd, V., Sheehan, M., Hood, K., Griffith, R. and Wood, F. 2020. Constructing authentic decisions: proxy decision making for research involving adults who lack capacity to consent. Journal of Medical Ethics 47(12), article number: e42. (10.1136/medethics-2019-106042)
- Jacinto, A. F. et al. 2020. Using international collaborations to shape research and innovation into care homes in Brazil: a white paper. Journal of Nursing Home Research Sciences 6, pp. 109-113. (10.14283/jnhrs.2020.28)
- Shepherd, V. 2020. Advances and challenges in conducting ethical trials involving populations lacking capacity to consent: a decade in review. Contemporary Clinical Trials 95, article number: 106054. (10.1016/j.cct.2020.106054)
- Kirby, N., Shepherd, V., Howick, J., Betteridge, S. and Hood, K. 2020. Nocebo effects and participant information leaflets: evaluating information provided on adverse effects in UK clinical trials. Trials 21(1), article number: 658. (10.1186/s13063-020-04591-w)
- Butler, C. C. et al. 2020. Effect of probiotic use on antibiotic administration among care home residents: a randomized clinical trial. Journal of the American Medical Association 324(1), pp. 47 - 56. (10.1001/jama.2020.8556)
- Shepherd, V. 2020. Decision-making during pandemics and other serious illness. Geriatrics, Gerontology and Aging 14(2), pp. 79-80. (10.5327/Z2447-21232020142EDT1)
- Shepherd, V. 2020. An under-represented and underserved population in trials: methodological, structural, and systemic barriers to the inclusion of adults lacking capacity to consent. Trials 21(1), article number: 445. (10.1186/s13063-020-04406-y)
- Shepherd, V., Hood, K., Sheehan, M., Griffith, R. and Wood, F. 2019. 'It's a tough decision': A qualitative study of proxy decision-making for research involving adults who lack capacity to consent in England and Wales. Age and Ageing 48(6), pp. 903-909. (10.1093/ageing/afz115)
- Wachholz, P. et al. 2019. Research on long-term care homes for older people in Brazil: protocol for a scoping review. East Midlands Research into Ageing Network 32, pp. 1-16.
- Owen-Jones, E. et al. 2019. Protocol for a double-blind placebo-controlled trial to evaluate the efficacy of probiotics in reducing antibiotics for infection in care home residents: the Probiotics to Reduce Infections iN CarE home reSidentS (PRINCESS) trial. BMJ Open 9(6), article number: e027513. (10.1136/bmjopen-2018-027513)
- Shepherd, V., Wood, F., Griffith, R., Sheehan, M. and Hood, K. 2019. Research involving adults lacking capacity to consent: a content analysis of participant information sheets for consultees and legal representatives in England and Wales. Trials 20, article number: 233. (10.1186/s13063-019-3340-5)
- Edvardsson, D. et al. 2019. Advancing long-term care science through using common data elements: candidate measures for care outcomes of personhood, well-being, and quality of life. Gerontology and Geriatric Medicine 5, pp. 1-15. (10.1177/2333721419842672)
- Shepherd, V., Wood, F., Griffith, R., Sheehan, M. and Hood, K. 2019. Protection by exclusion? The (lack of) inclusion of adults who lack capacity to consent to research in clinical trials in the UK. Trials 20, article number: 474. (10.1186/s13063-019-3603-1)
- Shepherd, V., Hood, K., Sheehan, M., Griffith, R., Jordan, A. and Wood, F. 2018. Ethical understandings of proxy decision making for research involving adults lacking capacity: a systematic review (framework synthesis) of empirical research. American Journal of Bioethics 9(4), pp. 267-286. (10.1080/23294515.2018.1513097)
- Francis, N. A. et al. 2018. Oral steroids for hearing loss associated with otitis media with effusion in children aged 2 8 years: the OSTRICH RCT. Health Technology Assessment 22(61) (10.3310/hta22610)
- Jordan, A., Wood, F., Edwards, A., Shepherd, V. and Joseph-Williams, N. 2018. What adolescents living with long-term conditions say about being involved in decision-making about their healthcare: A systematic review and narrative synthesis of preferences and experiences. Patient Education and Counseling 101(10), pp. 1725-1735. (10.1016/j.pec.2018.06.006)
- Shepherd, V., Griffith, R., Sheehan, M., Wood, F. and Hood, K. 2018. Healthcare professionals' understanding of the legislation governing research involving adults lacking mental capacity in England and Wales: a national survey. Journal of Medical Ethics 44(9), pp. 632-637. (10.1136/medethics-2017-104722)
- Francis, N. A. et al. 2018. Oral steroids for resolution of otitis media with effusion in children (OSTRICH): a double-blinded, placebo-controlled randomised trial. Lancet 392(10147), pp. 557-568. (10.1016/S0140-6736(18)31490-9)
- Shepherd, V., Thomas-Jones, E., Ridd, M. J., Hood, K., Addison, K. and Francis, N. 2017. Impact of a deferred recruitment model in a randomised controlled trial in primary care (CREAM study). Trials 18(1), article number: 533. (10.1186/s13063-017-2284-x)
- Francis, N. A. et al. 2017. Oral and topical antibiotics for clinically infected eczema in children: a pragmatic randomized controlled trial in ambulatory care. Annals of Family Medicine 15(2), pp. 124-130. (10.1370/afm.2038)
- Shepherd, V., Wood, F. and Hood, K. 2017. Establishing a set of research priorities in care homes for older people in the UK: a modified Delphi consensus study with care home staff. Age and Ageing 46(2), pp. 284-290. (10.1093/ageing/afw204)
- Gkiousias, V., Butler, C. C., Shepherd, V., Kilgour, J. M., Waldron, C., Thomas-Jones, E. and Francis, N. 2016. Parental perceptions and understanding of information provision, management options and factors influencing the decision-making process in the treatment of children with glue ear. International Journal of Pediatric Otorhinolaryngology 89, pp. 6-12. (10.1016/j.ijporl.2016.07.021)
- Shepherd, V. 2016. Research involving adults lacking capacity to consent: the impact of research regulation on 'evidence biased' medicine. BMC Medical Ethics 17(1), article number: 55. (10.1186/s12910-016-0138-9)
- Francis, N. A. et al. 2016. A randomised placebo-controlled trial of oral and topical antibiotics for children with clinically infected eczema in the community: the ChildRen with Eczema, Antibiotic Management (CREAM) study. Health Technology Assessment 20(19), pp. 1-84. (10.3310/hta20190)
- Waldron, C. et al. 2016. Oral Steroids for the Resolution of Otitis Media with Effusion (OME) in Children (OSTRICH): study protocol for a randomised controlled trial. Trials 17, article number: 115. (10.1186/s13063-016-1236-1)
- Shepherd, V., Nuttall, J., Hood, K. and Butler, C. C. 2015. Setting up a clinical trial in care homes: challenges encountered and recommendations for future research practice. BMC Research Notes 8, article number: 306. (10.1186/s13104-015-1276-8)
- Hood, K. et al. 2014. Probiotics for Antibiotic-Associated Diarrhoea (PAAD): a prospective observational study of antibiotic-associated diarrhoea (including Clostridium difficile-associated diarrhoea) in care homes. Health Technology Assessment 18(63) (10.3310/hta18630)
Book sections
- Shepherd, V. and Davies, J. 2020. Conducting a randomized controlled trial in care homes: the challenges of recruiting residents who lack capacity to consent. In: SAGE Research Methods Cases: Medicine and Health. SAGE, (10.4135/9781529726626)
Thesis
- Shepherd, V. 2019. Deciding about research for others: normative, empirical, and legal accounts of proxy decision-making for research and the development of a decision support intervention. PhD Thesis, Cardiff University.
Ymchwil
Oedolion sydd â galluedd diffygiol i gydsynio
Fy mhrif ddiddordeb ymchwil yw mynd i'r afael â'r heriau moesegol a methodolegol o ran cynnwys oedolion nad oes ganddynt allu mewn ymchwil. Ar hyn o bryd mae gen i Gymrodoriaeth Uwch NIHR 'Penderfynu am ymchwil i eraill: treial astudiaeth ddichonoldeb ac effeithiolrwydd o ymyriad cymorth penderfyniadau newydd i ymgyngoreion a chynrychiolwyr cyfreithiol oedolion nad oes ganddynt y gallu i gydsynio (CONSULT)' (2021-2026). Bydd yr ymyrraeth (offeryn cymorth penderfynu i wella gwneud penderfyniadau drwy ddirprwy ar gyfer ymchwil yn cael ei werthuso gan ddefnyddio dyluniad 'Astudio o fewn Treial' (SWAT) i wreiddio'r gwerthusiad mewn hyd at 5 treial cynnal.
Fel rhan o brosiect CONSULT, arweiniais astudiaeth ansoddol yn archwilio barn ymchwilwyr a gweithwyr gofal iechyd proffesiynol am y rhwystrau a'r hwyluswyr i gynnal treialon yn ymwneud ag oedolion nad oes ganddynt alluedd i gydsynio (Astudiaeth CONSULT-ENABLE ). Rwyf hefyd yn arwain yr Astudiaeth CONSULT-ADVANCE i archwilio barn rhanddeiliaid ynghylch ymarferoldeb a derbynioldeb cynllunio ymchwil ymlaen llaw, sy'n broses i bobl fynegi eu dymuniadau am gyfranogiad ymchwil cyn colli galluedd i gydsynio. Ar hyn o bryd mae gen i Gymrodoriaeth Churchill i archwilio safbwyntiau rhyngwladol ar gynllunio ymlaen llaw ar gyfer ymchwil gydag ymweliadau â Chanada ac Awstralia yn 2024.
Rwy'n arwain y gwaith o ddatblygu canlyniad craidd a osodwyd i werthuso ymyriadau sy'n gwella penderfyniadau dirprwyol ynghylch cyfranogiad ar ran oedolion nad oes ganddynt gapasiti (Astudiaeth COnSiDER) sydd wedi'i gofrestru ar gronfa ddata COMET (#1409). Ochr yn ochr â hyn, rwy'n datblygu mesur canlyniadau newydd i asesu ansawdd y penderfyniadau a wneir am ymchwil ar ran rhywun nad oes ganddynt alluedd i gydsynio - y Raddfa Gyfunol ar gyfer Penderfyniadau Cydsyniad Gwybodus trwy Ddirprwy (graddfa CONCORD).
Rwyf hefyd yn arwain y gwaith o ddatblygu'r Fframwaith NIHR CYNNWYS Galluedd Diffygiol i Gydsynio sy'n offeryn i helpu ymchwilwyr i ddylunio treialon sy'n cynnwys oedolion â galluedd diffygiol i gydsynio. Mae pecyn cymorth gweithredu yn cael ei ddatblygu fel rhan o brosiect a gefnogir gan gyllid 'Arloesi i Bawb' gan Brifysgol Caerdydd (2022-2023). Rwyf bellach yn arwain prosiect i ddatblygu hyfforddiant CONSULT sy'n seiliedig ar randdeiliaid ar gyfer ymchwilwyr ar ddylunio a chynnal treialon sy'n cynnwys oedolion â galluedd diffygiol i gydsynio.
Yn flaenorol, cynhaliais Gymrodoriaeth Ymchwil Ddoethurol NIHR i archwilio'r heriau moesegol, cyfreithiol ac ymarferol ynghylch cynnwys y poblogaethau hyn sydd heb gynrychiolaeth ddigonol, gan ddefnyddio dulliau cymysg a dulliau rhyngddisgyblaethol (2016-2019). Arweiniais astudiaeth ddilynol i gynnal profion gwybyddol ar yr ymyrraeth cymorth penderfyniadau (Astudiaeth PENDERFYNIAD 2) a ariannwyd gan Ymddiriedolaeth Wellcome trwy Gyllid Sefydliadol ISSF (2020).
Rwy'n goruchwylio nifer o fyfyrwyr meddygol BSc Rhyng-gyfrifedig a phrosiectau PhD yn y maes hwn, ac yn ddiweddar curadodd ymchwil ac adnoddau ar 'Ymchwil a gallu i gydsynio' ar gyfer gwefan Gofal Cymdeithasol Cymru https://socialcare.wales/curated-research/research-and-capacity-to-consent (fersiwn Gymraeg: https://gofalcymdeithasol.cymru/curadur-yr-ymchwil/ymchwil-ar-gallu-i-gydsynio ).
Cartrefi Gofal
Mae gen i ddiddordeb arbennig mewn ymchwil cartrefi gofal. Arweiniais Astudiaeth Blaenoriaethu Ymchwil ledled y DU mewn Cartrefi Gofal, a oedd â'r nod o nodi cyfres o flaenoriaethau ymchwil ar gyfer ymchwil cartrefi gofal gyda grŵp allweddol o randdeiliaid, a chanlyniad craidd cyfredol a osodwyd ar gyfer atal COVID-19 mewn cartrefi gofal (COS COVID PCARE). Rwyf hefyd yn ymwneud â chydweithio ag ymchwilwyr/sefydliadau cenedlaethol a rhyngwladol eraill i ddatblygu cynigion ymchwil sy'n cynnwys pobl hŷn mewn gofal hirdymor, y mae rhai ohonynt yn mynd i'r afael â meysydd a nodwyd fel blaenoriaethau ymchwil.
Rwy'n gyd-ymgeisydd ar brosiect sy'n datblygu hyfforddiant cymorth hunanreoli i ofalwyr oedolion hŷn ag osteoarthritis a chyflyrau ychwanegol (SUSTAIN), a phrosiect i archwilio gweithrediad y Ddeddf Galluedd Meddyliol mewn cartrefi gofal (ENACT).
Treialon Clinigol
Mae gweithgareddau ymchwil blaenorol yn cynnwys cyfrannu at ddylunio, cyflwyno ac adrodd ar hapdreialon rheoledig aml-ganolfan, gan gynnwys: Plant ag ecsema, Rheoli gwrthfiotigau - Astudiaeth CREAM (NIHR HTA), STeroids Llafar ar gyfer Datrys cyfryngau otitis gydag effusion (OME) Mewn Plant - Astudiaeth OSTRICH (NIHR HTA) a Probiotics i Leihau Heintiau iN CarE reSidentS cartref - Astudiaeth DYWYSOGES (NIHR EME).
Rwy'n arwain 'Prosiect Astudio o fewn A' (SWAP) sy'n astudiaeth fethodolegol sydd wedi'i hymgorffori â threial i werthuso effeithiolrwydd clinigol a chost ymyriad cymorth hunan-reoli osteoarthritis unigol a ddyluniwyd ar y cyd ar gyfer hyrwyddo ansawdd bywyd sy'n gysylltiedig ag iechyd a lleihau costau gofal iechyd (TIPTOE) (2023-2026). Bydd SWAP wedi'i fewnosod yn archwilio ac yn mynd i'r afael â recriwtio a chadw grwpiau sydd heb eu gwasanaethu yn y treial ac yn nodi rhwystrau i'w cynnwys. Rwyf hefyd yn arwain ail SWAP sy'n archwilio cynnwys grwpiau sydd heb eu gwasanaethu (gan gynnwys pobl hŷn bregus) mewn treial o radiotherapi adjuvant mewn cleifion â charcinoma celloedd cwanog cutaneous sylfaenol risg uchel ar ôl llawdriniaeth (SCC-AFTER) (2023-2030), ochr yn ochr â QRI QUINTET.
Treialon Ymchwil Methodoleg
Mae gen i ddiddordeb mewn ymchwil i wella ymddygiad treialon, gyda ffocws penodol ar wella cynhwysedd poblogaethau sydd heb eu gwasanaethu mewn ymchwil. Rwy'n cyd-arwain thema cynwysoldeb Gweithgor Ymddygiad Treial Partneriaeth Ymchwil Methodoleg Treialon MRC-NIHR.
Moeseg Ymchwil
Rwy'n ymwneud â nifer o brosiectau sy'n archwilio agweddau moesegol ar ymchwil, gan gynnwys modelau o gydsyniad a ddefnyddir mewn gwahanol gyd-destunau ymchwil megis sefyllfaoedd brys, a phenderfyniadau cleifion a chlinigwyr.
Bywgraffiad
Anrhydeddau a dyfarniadau
NHS 75 Faces of Nursing Research (2024)
Enillydd y rownd derfynol yng Ngwobrau Nyrs y Flwyddyn yng Nghymru - Gwobr Cefnogi Gwella Drwy Ymchwil (ail orau, 2019)
PhD Penderfynu ar ymchwil i eraill: cyfrifon normadol, empirig a chyfreithiol o wneud penderfyniadau drwy ddirprwy ar gyfer ymchwil a datblygu ymyrraeth cymorth penderfyniadau (Tachwedd 2019)
BSc Gofal Acíwt a Beirniadol, MA Cyfraith Gofal Iechyd a Moeseg. Traethawd hir: Poblogaethau bregus mewn ymchwil feddygol: a yw rheoleiddio ymchwil yn 'eu diogelu i farwolaeth'? (Medi 2014)
Aelodaethau proffesiynol
NMC (Cyngor Nyrsio a Bydwreigiaeth)
Sefydliad Moeseg Meddygol
Rhwydwaith Cyn-fyfyrwyr Nyrs y Flwyddyn RCN Cymru
Pwyllgorau ac adolygu
Aelod o Bwyllgor Moeseg Ymchwil y GIG (2019-presennol)
Cadeirydd Grŵp Cynghori ENRICH Cymru (2021-presennol)
Golygydd Ymgynghorol mewn treialon clinigol ac astudiaethau cartrefi gofal ar gyfer Geriatreg, Gerontoleg a Heneiddio (Mawrth 2020-presennol)
adolygydd cyfnodolion (e.e. treialon, oedran a heneiddio, addysg nyrsio mewn ymarfer)
Adolygydd grant (e.e. NIHR, Ymchwil Iechyd a Gofal Cymru, Ymddiriedolaeth Feddygol Dunhill)
Meysydd goruchwyliaeth
Mae gen i ddiddordeb mewn goruchwylio myfyrwyr PhD ym meysydd:
- treialon ymchwil methodoleg sy'n canolbwyntio ar gynnwys grwpiau sydd heb eu gwasanaethu'n ddigonol
- materion moesegol a chyfreithiol mewn ymchwil sy'n cynnwys poblogaethau lle gallai fod heriau o ran galluedd i gydsynio
- Ymchwil cartrefi gofal a chartrefi gofal
- nyrsio gyda ffocws penodol ar ofal critigol a gofal pobl hŷn
Goruchwylio PhD cyfredol:
Teitl: Ymgysylltu â phreswylwyr cartrefi gofal mewn ymchwil: nodi rhwystrau a hwyluswyr a datblygu ymyrraeth i gefnogi preswylwyr i wneud penderfyniadau a chynllunio ymlaen llaw ar gyfer ymchwil (ENGAGE)
Myfyriwr PhD: Llydaw Nocivelli
Tîm goruchwylio: Yr Athro Fiona Wood, Dr Victoria Shepherd, Yr Athro Kerry Hood, Yr Athro Carolyn Wallace
Nod y prosiect PhD dulliau cymysg hwn yw archwilio sut y gall preswylwyr cartrefi gofal a'u gofalwyr ymwneud yn well ag ymchwil, a'r rhwystrau a'r hwyluswyr i'w cynnwys. Gan ddefnyddio dulliau datblygu ymyrraeth sefydledig, bydd ymyrraeth yn cael ei datblygu i gefnogi sgyrsiau am ymchwil gyda phreswylwyr cartrefi gofal a hwyluso cynllunio ymlaen llaw ar gyfer cyfranogiad ymchwil. Bydd y canfyddiadau'n cefnogi cyfleoedd i drigolion cartrefi gofal gymryd rhan mewn ymchwil, sicrhau bod eu lleisiau'n cael eu clywed, a derbyn gofal o ansawdd sy'n seiliedig ar dystiolaeth yn y dyfodol. Fe'i hariennir trwy efrydiaeth PhD Ymchwil Iechyd a Gofal Cymdeithasol Cymru (2021-2024).
Manylion pellach: https://healthandcareresearchwales.org/researchers/our-funded-projects/engaging-care-home-residents-research-identification-barriers-and
Teitl: Ei gwneud hi'n haws i dimau treial ddylunio treialon cynhwysol
Myfyriwr PhD: Azar Alexander-Sefre
Tîm goruchwylio: Yr Athro Shaun Treweek, Dr Heidi Gardner, Dr Victoria Shepherd, Dr Frances Sherratt
Mae angen i gyfranogwyr treial gynrychioli'r rhai mewn cymdeithas y bwriedir iddynt elwa o ganlyniadau'r treial. Bydd y grwpiau sydd angen cynrychiolaeth fwyaf yn amrywio o dreial i dreial. Gall grŵp heb ei wasanaethu ar gyfer un math o dreial fod yn wahanol iawn i grŵp arall. Gall rhesymau dros pam nad yw grwpiau sydd heb eu gwasanaethu yn cael eu cynnwys mewn rhywfaint o ymchwil fod yn gymhleth, ond mae'n haws penderfynu a yw atebion i ddatrys rhwystrau cynhwysiant yn haws i'w penderfynu os cânt eu hystyried o ddechrau treial. Mae croestoriadedd yn mynd gam ymhellach i gydnabod y gallai fod sawl ffactor (er enghraifft ethnigrwydd a rhyw) sy'n cyfuno ac yn arwain at anfantais neu wahaniaethu. Datblygwyd ychydig o offer yn ddiweddar o'r enw Fframweithiau INCLUDE (gweler https://www.trialforge.org/trial-forge-centre/diversity/) i helpu timau treialu i feddwl sut y gallai eu penderfyniadau dylunio ei gwneud hi'n hawdd neu'n anodd i rai grwpiau gymryd rhan. Nod y prosiect PhD dulliau cymysg hwn yw darparu proses symlach i dimau treial lywio eu ffordd trwy'r Fframweithiau'n effeithlon. I wneud hyn, yn gyntaf bydd angen i ni benderfynu ble mae croestoriadoldeb rhwng gwahanol grwpiau sydd heb wasanaeth digonol yn bodoli a beth mae hyn yn ei olygu i ymchwilwyr y bydd angen iddynt ystyried y grwpiau hyn wrth ddylunio eu treialon. Yn ogystal, bydd y prosiect yn ystyried pa fathau o awgrymiadau a all alluogi ymchwilwyr i ymchwilio'n effeithiol i'r rhwystrau a'r heriau y gallai'r poblogaethau croestoriadol hyn eu cael gyda chyfranogiad. Yn olaf, bydd y prosiect yn ymchwilio pa fathau o atebion y gellid eu rhoi i ymchwilwyr i sicrhau bod y cwestiynau Fframwaith hanfodol hyn nid yn unig yn cael eu gofyn ond eu gweithredu, i sicrhau bod eu treialon yn wirioneddol gynhwysol mewn ymarfer. Fe'i hariennir trwy MRC TMRP DTP Ysgoloriaeth ym Mhrifysgol Aberdeen (2022-2025).
Manylion pellach: https://www.abdn.ac.uk/hsru/what-we-do/research/projects/making-it-easier-for-trial-teams-to-design-inclusive-trials-341
Goruchwyliwr a enwyd ar Raglen Hyfforddiant Academaidd Clinigol GW4 ar gyfer Gweithwyr Iechyd Proffesiynol (GW4-CAT HP)
