Yr Athro Aled Rees
(e/fe)

MBBCh FRCP PhD

Athro Sefydliad Arloesi Endocrinoleg, Niwrowyddoniaeth ac Iechyd Meddwl

: ReesDA@caerdydd.ac.uk
: +44 29207 45002

: Siarad Cymraeg

Mae gen i ddiddordeb ymchwil clinigol a throsiadol mewn sawl agwedd ar endocrinoleg, gyda ffocws penodol ar endocrinoleg atgenhedlu, clefyd y thyroid ac anhwylderau steroid.

Mae fy astudiaethau presennol yn defnyddio cofnodion iechyd electronig, dadansoddi genetig ac MRI uwch i ddeall effaith yr amgylchedd hormonaidd mewn bywyd cynnar ar ganlyniadau iechyd tymor hir. Mae fy ngrŵp wedi nodweddu canlyniadau metabolig, iechyd meddwl a cardiofasgwlaidd hirdymor cleifion â Syndrom Ofari Polysystig (PCOS), ac mae'n archwilio effaith PCOS ar ddefnyddio adnoddau iechyd a baich economaidd. Rydym wedi cynnal astudiaethau ffisiolegol i ddangos newid microstructure, metaboledd a swyddogaeth serebrofasgwlaidd yn y boblogaeth hon, ac rydym yn archwilio'r potensial ar gyfer therapi ymarfer corff a blocâd androgen i addasu'r risgiau hyn.

Mae ein hastudiaeth ddilynol hirdymor o blant a anwyd i famau yn y treial Sgrinio Thyroid Antenatal Rheoledig (CATS) yn cynnwys MRI uwch a gynhaliwyd yng Nghanolfan Ymchwil Delweddu'r Ymennydd Prifysgol Caerdydd (CUBRIC) i archwilio effaith statws thyroid mamol diwygiedig ar niwroddatblygiad. Rydym wedi defnyddio Banc Data SAIL i ddangos mwy o risg o ddigwyddiadau cardiofasgwlaidd mewn cleifion sydd â Gwrthwynebiad i Hormon Thyroid-Beta, gyda'r bwriad o archwilio therapïau newydd a allai liniaru'r risg hon.

Mae ein gwaith mewn anhwylderau steroid wedi dangos gwerth cortisol poer fel dewis arall i fesur serwm ar gyfer diagnosis annigonolrwydd adrenal. Rydym yn cymryd rhan mewn treialon clinigol mewn Hyperplasia Adrenal Cynhenid sydd wedi dod â chyffuriau newydd i'r farchnad, ac rydym yn cydweithio ar astudiaethau aml-ganolfan (CAHASE2) i nodweddu canlyniadau clefydau yn yr anhwylder hwn.

Date
Type

2024

Doyle, L. M. et al. 2024. Service evaluation suggests variation in clinical care provision in adults with congenital adrenal hyperplasia in the UK and Ireland. Clinical Endocrinology (10.1111/cen.15043)
El-Farhan, N., Tennant, S., Rees, S. E., Evans, C. and Rees, D. A. 2024. Salivary cortisol response to ACTH stimulation is a reliable alternative to serum cortisol in evaluating hypoadrenalism. The Journal of Clinical Endocrinology & Metabolism 109(2), pp. e579-e588., article number: dgad576. (10.1210/clinem/dgad576)
Green, K., MacIver, C. L., Ebden, S., Rees, D. A. and Peall, K. J. 2024. Pearls and Oy-sters: AARS2 leukodystrophy – tremor and tribulations. Neurology

2023

Papanikolaou, N. et al. 2023. Clinical characteristics of functioning gonadotroph adenoma in women presenting with ovarian hyperstimulation: audit of UK pituitary centres. Clinical Endocrinology 99(4), pp. 386-395. (10.1111/cen.14949)
Schröder, M. et al. 2023. Hormonal control during infancy and testicular adrenal rest tumor development in males with congenital adrenal hyperplasia: A retrospective multicenter cohort study. European journal of endocrinology 189(4), pp. 460-468. (10.1093/ejendo/lvad143)
Dong, J. and Rees, D. A. 2023. Polycystic Ovary Syndrome: Pathophysiology and therapeutic opportunities. BMJ Medicine 2, article number: e000548. (10.1136/bmjmed-2023-000548)
Okosieme, O. et al. 2023. Cardiovascular morbidity and mortality in patients in Wales, UK with resistance to thyroid hormone β (RTHβ): a linked-record cohort study. The Lancet Diabetes & Endocrinology 11(9), pp. 657-666. (10.1016/S2213-8587(23)00155-9)
Daughters, K., Unwin, K. and Rees, D. A. 2023. The psychological impact of adult-onset craniopharyngioma: A qualitative study of the experience of patients and clinicians. European Journal of Oncology Nursing 65, article number: 102346. (10.1016/j.ejon.2023.102346)
Elhassan, Y. S. et al. 2023. COVID-19-related Adrenal haemorrhage multicentre UK experience and systematic review of the literature. Clinical Endocrinology 98(6), pp. 766-778. (10.1111/cen.14881)
Taylor, P., Lansdown, A., Witczak, J., Khan, R., Rees, A., Dayan, C. and Okosieme, O. 2023. Age-related variation in thyroid function – a narrative review highlighting important implications for research and clinical practice. Thyroid Research 16, article number: 7. (10.1186/s13044-023-00149-5)
Tschaidse, L. et al. 2023. Modified-release hydrocortisone is associated with lower plasma renin activity in patients with salt-wasting congenital adrenal hyperplasia. European Journal of Endocrinology 188(1), article number: lvac006. (10.1093/ejendo/lvac006)

2022

Daughters, K., Rees, A. and Unwin, K. 2022. ODP365 The psychological impact of adult-onset craniopharyngioma: the experience of patients and clinicians. Journal of the Endocrine Society 6(S1), article number: A516. (10.1210/jendso/bvac150.1073)
Perros, P. et al. 2022. Post-radioiodine Graves' management: the PRAGMA study. Clinical Endocrinology 97(5), pp. 664-675. (10.1111/cen.14719)
Allen, L., Shrikrishnapalasuriyar, N. and Rees, D. A. 2022. Long-term health outcomes in young women with Polycystic Ovary Syndrome: a narrative review. Clinical Endocrinology 97(2), pp. 187-198. (10.1111/cen.14609)
Daughters, K., Rees, A., Hunnikin, L., Wells, A., Hall, J. and van Goozen, S. 2022. Oxytocin administration versus emotion training in healthy males: Considerations for future research. Philosophical Transactions of the Royal Society B: Biological Sciences 377(1858), article number: 20210056. (10.1098/rstb.2021.0056)
McCarthy, O. et al. 2022. Passing on the exercise baton: What can endocrine patients learn from elite athletes?. Clinical Endocrinology 96(6), pp. 781-792. (10.1111/cen.14683)
Whelan, C., Burnley-Hall, N., Morris, K., Rees, D. A. and James, P. E. 2022. The procoagulant effects of extracellular vesicles derived from hypoxic endothelial cells can be selectively inhibited by inorganic nitrite. Nitric Oxide: Biology and Chemistry 122-12, pp. 6-18. (10.1016/j.niox.2022.02.002)
Cauldwell, M. et al. 2022. Pregnancies in women with Turner Syndrome: A retrospective multicentre UK study. BJOG: An International Journal of Obstetrics and Gynaecology 129, pp. 796-803. (10.1111/1471-0528.17025)

2021

Zhang, L. et al. 2021. The role of mitochondria-linked fatty-acid uptake-driven adipogenesis in Graves’ Orbitopathy. Endocrinology 162(12), article number: bqab188. (10.1210/endocr/bqab188)
Draman, M. S. et al. 2021. Expression of endogenous putative TSH binding protein in orbit. Current Issues in Molecular Biology 43(3), pp. 1794-1804. (10.3390/cimb43030126)
Berni, T. R., Morgan, C. L. and Rees, D. A. 2021. Women with Polycystic Ovary Syndrome have an increased risk of major cardiovascular events: a population study. Journal of Clinical Endocrinology and Metabolism 106(9), pp. e3369-e3380. (10.1210/clinem/dgab392)
Connolly, K. D., Rees, D. A. and James, P. E. 2021. Role of adipocyte-derived extracellular vesicles in vascular inflammation. Free Radical Biology and Medicine 172, pp. 58-64. (10.1016/j.freeradbiomed.2021.04.031)
Richards, C. T., Meah, V. L., James, P. E., Rees, D. A. and Lord, R. N. 2021. HIIT’ing or MISS’ing the optimal management of polycystic ovary syndrome: a systematic review and meta-analysis of high- versus moderate-intensity exercise prescription. Frontiers in Physiology 12, article number: 715881. (10.3389/fphys.2021.715881)
Merke, D. P. et al. 2021. Modified-release hydrocortisone in congenital adrenal hyperplasia. Journal of Clinical Endocrinology and Metabolism 106(5), pp. e2063-e2077. (10.1210/clinem/dgab051)
Thomas, M. et al. 2021. Insulin‐like growth factor‐1, growth hormone and disease outcomes in acromegaly: a population study. Clinical Endocrinology 95(1), pp. 143-152. (10.1111/cen.14468)
Chambers, T. et al. 2021. Effects of thyroid status on regional brain volumes: a diagnostic and genetic imaging study in UK Biobank. Journal of Clinical Endocrinology and Metabolism 106(3), pp. 688-696. (10.1210/clinem/dgaa903)
Lewis, R. D., Narayanaswamy, A. K., Farewell, D. and Rees, D. A. 2021. Complement activation in polycystic ovary syndrome occurs in the post-prandial and fasted state, and is influenced by obesity and insulin sensitivity. Clinical Endocrinology 94(1), pp. 74-84. (10.1111/cen.14322)

2020

Zhang, L. et al. 2020. Distinctive features of orbital adipose tissue (OAT) in Graves' orbitopathy. International Journal of Molecular Sciences 21(23), article number: 9145. (10.3390/ijms21239145)
Pak, H. Y., Lansdown, A., Taylor, P., Rees, A. D., Davies, J. and Hayhurst, C. 2020. Acromegaly and the information gap: patient perceptions of the journey from primary to tertiary care. Endocrine Connections 9(10), pp. 971-977. (10.1530/EC-20-0335)
Galloway, L., Ali, M., Lansdown, A., Taylor, P., Rees, A., Davies, J. S. and Hayhurst, C. 2020. The impact of endoscopic transsphenoidal pituitary adenoma surgery on endocrine function: a single-centre study. Acta Neurochirurgica 163(2), pp. 391-398. (10.1007/s00701-020-04609-x)
Muller, I. et al. 2020. CATS II long-term anthropometric and metabolic effects of maternal sub-optimal thyroid function in offspring and mothers. Journal of Clinical Endocrinology and Metabolism 105(7), article number: dgaa129. (10.1210/clinem/dgaa129)
Ellins, E., Shipley, M., Rees, D., Kemp, A., Deanfield, J., Brunner, E. and Halcox, J. 2020. Associations of depression-anxiety and dyslipidaemia with subclinical carotid arterial disease: Findings from the Whitehall II Study. European Journal of Preventive Cardiology 27(8), pp. 800-807. (10.1177/2047487319876230)
Napier, C. et al. 2020. Residual adrenal function in autoimmune addison's disease - effect of dual therapy with rituximab and depot tetracosactide. Journal of Clinical Endocrinology and Metabolism 105(4), article number: Volume 105, Issue 4, April 2020,. (10.1210/clinem/dgz287)
Hayhurst, C., Taylor, P., Lansdown, A., Palaniappan, N., Rees, D. and Davis, J. 2020. Current perspectives on recurrent pituitary adenoma: the role and timing of surgery vs adjuvant treatment. Clinical Endocrinology 92(2), pp. 89-97. (10.1111/cen.14127)

2019

Lansdown, A., Warbert, E., Sverrisdottir, Y., Wise, R. and Rees, D. 2019. Regional cerebral activation accompanies sympathoexcitation in women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism 104(9), pp. 3614-3623. (10.1210/jc.2019-00065)
Wilson, N. et al. 2019. Role of hyaluronan in human adipogenesis: Evidence from in-vitro and in-vivo studies. International Journal of Molecular Sciences 20(11), article number: 2675. (10.3390/ijms20112675)
Wadey, R. M., Connolly, K. D., Mathew, D., Walters, G., Rees, D. A. and James, P. E. 2019. Inflammatory adipocyte-derived extracellular vesicles promote leukocyte attachment to vascular endothelial cells. Atherosclerosis 283, pp. 19-27. (10.1016/j.atherosclerosis.2019.01.013)
Bhargava, R., Daughters, K. L. and Rees, D. A. 2019. Oxytocin therapy in hypopituitarism: challenges and opportunities. Clinical Endocrinology 90(2), pp. 257-264. (10.1111/cen.13909)

2011

Lansdown, A. J. and Rees, D. A. 2011. Endocrine oncology in pregnancy. Best Practice & Research Clinical Endocrinology & Metabolism 25(6), pp. 911-926. (10.1016/j.beem.2011.06.011)
Rice, S. J. and Rees, D. A. 2011. DHEA and vascular function. In: Watson, R. R. ed. DHEA in Human Health and Aging. Boca Raton, Fl: CRC Press, pp. 375-388.
Stephens, M. W., Ludgate, M. E. and Rees, D. A. 2011. Brown fat and obesity: the next big thing?. Clinical Endocrinology 74(6), pp. 661-670. (10.1111/j.1365-2265.2011.04018.x)

2010

Wiebke, A. et al. 2010. Health status of adults with congenital adrenal hyperplasia: A cohort study of 203 patients. Journal of Clinical Endocrinology & Metabolism 95(11), pp. 5110-5121. (10.1210/jc.2010-0917)
Biswas, M., Hampton, D., Turkes, A., Newcombe, R. G. and Rees, D. A. 2010. Reduced total testosterone concentrations in young healthy South Asian men are partly explained by increased insulin resistance but not by altered adiposity. Clinical Endocrinology 73(4), pp. 457-462. (10.1111/j.1365-2265.2010.03824.x)
Agarwal, N., Rice, S. P. L., Bolusani, H., Luzio, S. D., Dunseath, G. J., Ludgate, M. E. and Rees, D. A. 2010. Metformin reduces arterial stiffness and improves endothelial function in young women with polycystic ovary syndrome: A randomized, placebo-controlled, crossover trial. Obstetrical & Gynecological Survey 65(6), pp. 381-382. (10.1097/OGX.0b013e3181e5a167)
Rice, S. P. L., Zhang, L., Grennan-Jones, F. A., Agarwal, N., Lewis, M. D., Rees, D. A. and Ludgate, M. E. 2010. Dehydroepiandrosterone (DHEA) treatment in vitro inhibits adipogenesis in human omental but not subcutaneous adipose tissue. Molecular and Cellular Endocrinology 320(1-2), pp. 51-57. (10.1016/j.mce.2010.02.017)
De Lloyd, A. C., Bursell, J. D. H., Gregory, J. W., Rees, D. A. and Ludgate, M. E. 2010. TSH receptor activation and body composition. Journal of Endocrinology 204(1), pp. 13-20. (10.1677/JOE-09-0262)
Rees, D. A. and Dayan, C. M. 2010. Commentary: Testosterone and the metabolic syndrome: cause or consequence?. International Journal of Epidemiology 40(1), pp. 207-209. (10.1093/ije/dyq254)
Agarwal, N., Rice, S. P. L., Bolusani, H., Luzio, S. D., Dunseath, G., Ludgate, M. and Rees, D. A. 2010. Metformin Reduces Arterial Stiffness and Improves Endothelial Function in Young Women with Polycystic Ovary Syndrome: A Randomized, Placebo-Controlled, Crossover Trial. Journal of Clinical Endocrinology & Metabolism 95(2), pp. 722-730. (10.1210/jc.2009-1985)

2009

Krone, N. et al. 2009. Current management, morbidity and genotypephenotype correlation in adults with congenital adrenal hyperplasia – analysis of the United Kingdom congenital adrenal hyperplasia adult study executive (CaHASE) cohort [Abstract]. Hormone Research 72(S3), pp. 41-41. (10.1159/000239668)
Rice, S. P. L., Agarwal, N., Bolusani, H., Newcombe, R. G., Scanlon, M. F., Ludgate, M. E. and Rees, D. A. 2009. Effects of dehydroepiandrosterone replacement on vascular function in primary and secondary adrenal insufficiency: A randomized crossover trial. Journal of Clinical Endocrinology & Metabolism 94(6), pp. 1966-1972. (10.1210/jc.2008-2636)
Rees, D. A., Giles, P. J., Lewis, M. D. and Ham, J. 2009. Adenosine regulates thrombomodulin and endothelial protein C receptor expression in folliculostellate cells of the pituitary gland. Purinergic Signalling 6(1), pp. 19-29. (10.1007/s11302-009-9172-0)
Watson, S., Blundell, H. L., Evans, W., Griffiths, H., Newcombe, R. G. and Rees, D. A. 2009. Can abdominal bioelectrical impedance refine the determination of visceral fat from waist circumference?. Physiological Measurement 30(7), pp. N53-N58. (10.1088/0967-3334/30/7/N01)
Colao, A. et al. 2009. Octreotide LARvs.surgery in newly diagnosed patients with acromegaly: a randomized, open-label, multicentre study. Clinical Endocrinology 70(5), pp. 757-768. (10.1111/j.1365-2265.2008.03441.x)

2008

Ham, J. and Rees, D. A. 2008. The adenosine a2b receptor: its role in inflammation. Endocrine‚ Metabolic & Immune Disorders - Drug Targets 8(4), pp. 244-254.
Millar, D. S. et al. 2008. Growth hormone (GH1) gene variation and the growth hormone receptor (GHR) exon 3 deletion polymorphism in a West-African population. Molecular and Cellular Endocrinology 296(1-2), pp. 18-25. (10.1016/j.mce.2008.09.023)
Scanlon, M. F. and Rees, D. A. eds. 2008. Specialist training in endocrinology. Edinburgh: Mosby/Elsevier,.

2007

Cozma, I., Zhang, L., Uddin, J., Lane, C., Rees, D. A. and Ludgate, M. E. 2007. Modulation of expression of somatostatin receptor subtypes in Graves' opthalmopathy orbits : relevance to novel analogues. American Journal of Physiology. Endocrinology and Metabolism (10.1152/ajpendo.00177.2007)

2006

Lewis, B. M. et al. 2006. Adenosine stimulates connexin 43 expression and gap junctional communication in pituitary folliculostellate cells. The FASEB Journal 20(14), pp. 2585-2587. (10.1096/fj.06-6121fje)

2003

Rees, D. A., Lewis, B. M., Lewis, M. D., Francis, K., Scanlon, M. F. and Ham, J. 2003. Adenosine-induced IL-6 expression in pituitary folliculostellate cells is mediated via A2b adenosine receptors coupled to PKC and p38 MAPK. British Journal of Pharmacology 140(4), pp. 764-72. (10.1038/sj.bjp.0705488)
De, P. et al. 2003. Transsphenoidal surgery for acromegaly in Wales: results based on stringent criteria of remission. Journal of Clinical Endocrinology & Metabolism 88(8), pp. 3567-72. (10.1210/jc.2002-021822)

2002

Rees, D. A., Gayle, C., Gaillard, R. C. and Fear, S. 2002. Gender-specific responses of lean body composition and non-gender-specific cardiac function improvement after GH replacement in GH-deficient adults. Journal of Clinical Endocrinology & Metabolism 87(6), pp. 2725-33. (10.1210/jc.87.6.2725)
Rees, D. A., Lewis, M. D., Lewis, B. M., Smith, P. J., Scanlon, M. F. and Ham, J. 2002. Adenosine-regulated cell proliferation in pituitary folliculostellate and endocrine cells: differential roles for the A(1) and A(2B) adenosine receptors. Endocrinology 143(6), pp. 2427-2436. (10.1210/en.143.6.2427)

1992

Clarke, A. J., Bradley, D. M., Gillespie, K., Rees, D. A., Holland, A. and Thomas, N. S. T. 1992. Fragile X mental retardation and the iduronate sulphatase locus: testing laird's model of fra(X) inheritance. American Journal of Medical Genetics 43(1-2), pp. 299-306. (10.1002/ajmg.1320430146)

Current projects

My current studies use advanced MRI to understand the impact of the hormonal environment in early life on cognition and neurodevelopment. My group has shown altered white matter microstructure and cognitive ability in young women with Polycystic Ovary Syndrome (PCOS), building on previous epidemiological and basic science studies which have established the long-term metabolic and cardiovascular outcomes in this patient population. Our long-term follow-up study of children born to mothers in the Controlled Antenatal Thyroid Screening (CATS) trial will enable us to assess the effects of thyroid hormone exposure in pregnancy on neurodevelopment, using the state-of-the-art MRI facilities in the new Cardiff University Brain Research Imaging Centre (CUBRIC).

Recent studies have also sought to explore the potential utility of extracellular vesicles, including those derived from adipocytes, as biomarkers and mediators of cardiometabolic risk in patients with obesity and PCOS.

Funding

2015-2017 “Cell-derived microparticles as mediators of obesity-induce vascular disease”; Type: Clinical Research Fellowship (to Witczak); Principal Investigator: Rees DA; Co-Investigators: James PJ, Witczak J; Agency: Royal College of Physicians; Budget: £120,417

2015-2018 “Extracellular vesicle transport in the circulation – a missing link between adipocytes and accelerated vascular dysfunction”;Type: Project Grant; Principal Investigator: James PJ; Co-Investigators: Rees DA, Ludgate M, Lewis T, Clayton A, O’Donnell V. Agency: British Heart Foundation; Budget: £226,891

2014-2017“Measurement of pathologically relevant microvesicle populations in obesity-driven cardiovascular disease”;Type: PhD studentship; Principal Investigator:James PJ; Co-Investigator: Rees DA; Agency: Cardiff University College of Biomedical & Life Sciences; Budget: £75,000

2014-2017“Can we prevent generation of pro-thrombotic and pro-coagulant extracellular vesicle populations in blood via a simple dietary intervention?” Type: PhD studentship; Principal Investigator: Rees DA; Co-Investigator: James PJ; Agency: National Institute for Social Care and Health Research; Budget: £66,926

2014-2015“Diabetes Research Network Statistician” Type: Grant. Principal Investigator: Rees DA; Co-Investigator: Dayan C; Agency: National Institute for Social Care and Health Research; Budget: £53,344

2012-2015 “The interface between adipose tissue-derived microvesicles and vascular endothelium in polycystic ovary syndrome”;Type: PhD studentship; Principal Investigator: Rees DA; Co-Investigator: James PJ; Agency: Cardiff University Ewen Maclean Bequest Scholarship; Budget: £66,402

2012-2013 “Anthropometric and metabolic correlates of sympathetic nervous system activity in young women with PCOS: a functional MRI study”; Type: Early Career Award; Principal Investigator: Rees DA; Co-Investigator: Lansdown A; Agency: Society for Endocrinology; Budget: £10,000

2012-2013 “A pilot study to determine whether complement activation modulates lipid metabolism in health and disease” Type: Wellcome Trust ISSF Fellowship; Principal Investigator: Lewis R; Co-Investigators: Rees DA, Morgan BP; Agency: Wellcome Trust; Budget: £44,130

2011-2014 “Influence of regional adiposity on endothelial effects of LDL cholesterol in Polycystic Ovary Syndrome”; Type: PhD studentship; Principal Investigator: James PJ; Co-Investigator: Rees DA; Agency: Cardiff University John Nixon Bequest Scholarship; Budget: £68,412

Impact

I have established a large cohort of young patients with Polycystic Ovary Syndrome (PCOS), using this as a common (5-10% premenopausal women) clinical model of metabolically unhealthy obesity and early life vascular risk.

I employed a series of non-invasive cardiovascular methodologies to carefully phenotype the cohort and demonstrate the importance of insulin resistance and central obesity as independent cardiovascular risk markers. My group undertook a randomised, double blind, placebo-controlled trial to show that metformin improves vascular function in women with PCOS; this study was incorporated into the US Androgen excess-PCOS Society guidelines for cardiovascular disease prevention in 2010.

I have also exploited the power of the Clinical Practice Research Database to define the natural history of PCOS, confirming an increased risk of type 2 diabetes and several adverse pregnancy outcomes. In collaboration with Professor Philip James (Cardiff Metropolitan University) our group has shown that circulating extracellular vesicles may mediate some of these risks and highlighted the potential for apheresis as a treatment modality.

My recent studies with Dr Mike O’Sullivan (King’s College London) show that young women with PCOS have reduced cognitive function and altered white matter microstructure. I also hold a strong interest in steroid disorders; in adrenal disease, I have led two clinical trials to re-define method-specific reference limits to the synacthen test and explore the effects of DHEA on vascular function. I collaborated with Professor Richard Ross (Sheffield University) and others to establish the UK Congenital Adrenal Hyperplasia (CAH) Adult Study Executive (2005-), which has defined the health outcomes of adults with CAH.

I disseminate my work regularly via engagement with patient groups, the Society For Endocrinology and the media (S4C, Radio Cymru).

I contribute to the delivery, design and assessment of the undergraduate medical curriculum from years 1 through to 5, and play an active role in postgraduate medical teaching at local and national levels.

Undergraduate

I deliver ward-based and outpatient teaching to year 3-5 students, and supervise student selected component (SSC) projects in years 3 and 5. Following the introduction of the C21 undergraduate curriculum in Cardiff, I completed the Medical Education Orientation Programme (MEOP), became a tutor on ‘reproductive hormones’ for the Platform in Clinical Science in phase 1a (year 1) and case-based writing lead (‘Diabetes in an older person’) for phase 1b (year 2). I am an academic mentor for medical undergraduates and have been an examiner at medical finals for the last 10 years. I regularly host students on the Erasmus exchange programme.

Beyond my University commitments, I also organise monthly small group teaching on Endocrinology for year 3-5 students undertaking placements at the University Hospital of Wales; based on sustained excellence from student feedback I was awarded a Certificate of Teaching Excellence from Cardiff and Vale University Health Board in 2010. I deliver an annual lecture to dental undergraduates on steroid disorders.

On a UK level, I helped develop a set of National Standards, adopted jointly by the Society for Endocrinology, the Association of British Clinical Diabetologists (ABCD) and Diabetes UK, for undergraduate education in Endocrinology and Diabetes, benchmarked against Tomorrow’s Doctors (2012). In 2014 I was invited to edit and author Clinical Endocrinology and Diabetes at a Glance, a leading UK undergraduate text series in clinical medicine, which is due for publication in 2015.

Postgraduate

As the academic lead on the Specialist Training Committee for Endocrinology and Diabetes in Wales, I have established a neuroendocrine teaching programme for specialist registrars. Supported by a grant from the Society for Endocrinology, I introduced a poster presentation session and developed undergraduate and postgraduate prizes at the annual Welsh Endocrine and Diabetes Society (WEDS) meeting. Subsequently, as chair of WEDS, I organised the first Society for Endocrinology Regional Clinical Cases meeting to be held in Wales (2013). I was selected as a Convenor for the Society for Endocrinology Clinical Update course (2012-present), where I design and deliver teaching on neuroendocrine tumours, inherited endocrine neoplasia, hyponatraemia and hypoglycaemia to over 200 Specialist Registrars and Consultants annually.

In recognition of my commitment to undergraduate and postgraduate teaching, I was elected to the Academy of Medical Educators in 2013.

Education and qualifications

2013: MAcadMEd
2010: FRCP, London
2002: PhD (Neuroendocrinology) University of Wales College of Medicine, Cardiff, UK
1996: MRCP, London
1993: MB, BCh (Hons), University of Wales College of Medicine, Cardiff, UK

Career overview

2015 - present: Reader in Neuroendocrinology and Honorary Consultant Endocrinologist, Neurosciences and Mental Health Research Institute, Cardiff University
2006 - 2015: Senior Lecturer and Honorary Consultant Endocrinologist, Cardiff University
2003 – 2006: Clinical Lecturer in Endocrinology, Cardiff University
2001 – 2003: Specialist Registrar in Endocrinology, South Wales
1998 – 2001: Society for Endocrinology Clinical Endocrinology Trust Research Fellow, University of Wales College of Medicine, Cardiff
1997 – 1998: Wellcome Trust Clinical Training Fellow, University of Wales College of Medicine, Cardiff
1996 – 1997: Registrar in General Medicine, Royal Gwent Hospital, Newport
1994 – 1996: Senior House Officer in Medicine, South Wales
1993 – 1994: House Officer in Medicine and Surgery, University Hospital of Wales and Llandough Hospital

Anrhydeddau a dyfarniadau

2015 – present: Associate Editor, Clinical Endocrinology
2005: Novartis European Young Investigator Award. Characterisation of the role of extracellular signal-regulated kinases in growth hormone action: insights from novel human growth hormone 1 (GH1) gene mutations.

Aelodaethau proffesiynol

Fellow of the Royal College of Physicians
Association of Physicians of Great Britain and Ireland
Association of Clinical Professors of Medicine
Society for Endocrinology (UK)
The Endocrine Society (USA)
European Society of Endocrinology
European Neuroendocrine Tumour Society
UK and Ireland Neuroendocrine Tumour Society
British Medical Association
Society of Physicians in Wales

Pwyllgorau ac adolygu

2011 - 2015: Member of the School of Medicine Higher Degree committee
2007 – 2010: Member of the Research Governance group

External committees

2016 – present: Member of the National Institute for Health Research Metabolic and Endocrine Specialty Group
2015 – present: Member of the Society for Endocrinology Finance committee
2015 – present: Executive group member of the Diabetes Research Unit Cymru
2014 – present: Chair, Welsh Endocrine and Diabetes Society
2012 – present: Faculty member, Society for Endocrinology Clinical Update meeting
2010 – present: Research and Development Lead, Medicine Board, Cardiff & Vale University Health Board
2014 – 2016: Editorial Board, Scientific Reports
2012 – 2016: Member of the Society for Endocrinology Clinical committee
2011 – 2016: Committee member of the UK Acromegaly study group
2009 – 2013: Editorial Board, Clinical Endocrinology
2007 – 2014: Member of the Specialist Training Committee, Endocrinology and Diabetes, Wales Deanery
2005 – 2014: Committee member of the Congenital Adrenal Hyperplasia Adult Study Executive

Themâu ymchwil

Arbenigeddau

Endocrinoleg

Cyswllt PCOS ag ADHD ac anhwylder sbectrwm awtistiaeth

09 April 2018

Yr Athro Aled Rees (e/fe) MBBCh FRCP PhD

Trosolwyg

Cyhoeddiad

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