Yr Athro Annmarie Nelson
Athro Gofal Ategol a Lliniarol; Cyfarwyddwr Gwyddonol Canolfan Ymchwil Gofal Lliniarol Marie Curie
I joined Cardiff University via the Wales Cancer Trials Unit where I worked from 2007-2010. Initially my role was a secondment from the Marie Curie Hospice in Penarth, where I had been working for the previous 17 years. In 2010, my clinical colleagues and I were awarded funding to develop a new research centre, the Marie Curie Palliative Care Research Centre. The centre is now hosted by the Division of Population Medicine, and previously by the Institute of Cancer and Genetics.
My predominant and crosscutting research interest is patient and carer experience of services, interventions, and research. I have worked extensively in palliative care, clinical trials, and with cancer research teams at all stages, from pre-clinical, early diagnosis, supportive and palliative care to the late effects of treatment, following cure, and in different settings, and using multiple methodologies.I have broad research experience and methodological expertise across palliative care and the cancer clinical research spectrum. My research portfolio includes phase 2/3 clinical trials in oncology and supportive care, as well as large-scale surveys, clinical assessment tool development, implementation research, and multi-centre, multi-country qualitative research. I have particular interests in patient experience, interventions, overtreatment, and decision-making, trials methodologies, and the implementation and impact measurement of research outputs into clinical practice.
- o Scientific Director Marie Curie Research Centre (MCPCRC), Division of Population Medicine, School of Medicine, Cardiff University
- MCPCRC Theme Lead: Patient and carer experience
- Honorary Professor Swansea Clinical Trials Unit. School of Medicine, Swansea University.
- Palliative and Supportive Care Work Package Lead, Wales Cancer Research Centre (WCRC)
- Public and Patient Involvement (PPI) Academic Lead, Wales Cancer Research Centre
- Qualitative Lead and Patient and Public Involvement Lead, Wales Cancer Trials Unit (WCTU).
I am Scientific Director of the Marie Curie Palliative Care Research Centre, which has a strong historical and ongoing link with the Wales Cancer Trials Unit. The MCPCRC supports the development of well-designed research in all palliative and supportive settings across the UK, and is not restricted to cancer diagnoses. I manage all centre operations, HR, finance, contracts, methodological support and processes, and the research portfolio on a day-to-day basis.I manage research grants and have secured grant monies as Principal Investigator and Co-Investigator in excess of nine million pounds. The Cardiff Centre is one of three funded research facilities supported by Marie Curie Cancer Care across the UK, and the only one working in partnership with a clinical trials unit.
The centre has three specified research themes each led by an experienced academic or clinical researcher: Patient and carer experience, Rehabilitation, and VTE and thrombosis with additional projects in all areas of palliative and supportive care, cancer and non- cancer. My personal research portfolio is mainly held under my role as MCPCRC Theme Lead: Patient and carer experience, although this work stream cross cuts the other themes and also the clinical trials at the WCTU. It is focussed on including patient experience at all levels of research including phase 3 clinical trials.
At an international level, I have collaborated with Scandinavian colleagues to give advice on patient experience of cancer associated thrombosis, I am co-CI (with Dr John Staffurth, Cancer and Genetics, Cardiff University) working with the international panel of Movember True North (prostate cancer) to develop and coordinate an implementation study, EAGLE, to sit within the global outcome measures framework required by the funders across three continents. I am co-applicant on a multi-country (Spain, France, UAE, New Zealand) qualitative study deriving from an original UK study, PELICAN. Further international collaboration includes invited membership of the OMERACT international working group for chronic pain, external examiner for Queensland Institute of Technology, Australia, and presentations at many international conferences.
- PhD: Palliative Care as Progressive Journey: The Interplay of Self, Hope and Death in Nurse-Patient Encounters across Three Care Settings. Department of English, Communication and Philosophy. Health Communication Research Centre. Cardiff University. 2002-2006.
- Post Graduate Diploma in Language and Communication Research (Distinction). Department of English, Communication and Philosophy. Cardiff University. 2001.
- BA (Hons) English Language and Literature (First Class). Open University. 1996 – 1999.
- Diploma in English Language Studies (Distinction). Open University. 1997- 1999.
Anrhydeddau a Dyfarniadau
I was awarded prizes for Innovation and Engagement by the School of Medicine in December 2012 and 2013. The 2012 award was for a series of research roadshows across all healthboards in Wales. The 2013 award was for innovative work in PPI.
Safleoedd academaidd blaenorol
2008-2010. Marie Curie Senior Research Fellow, Wales Cancer Trials Unit responsible for developing the palliative care clinical trials portfolio, embedded patient experience as secondary outcome measures in clinical trials, and PPI.
Ymrwymiadau siarad cyhoeddus
I have delivered talks at many international conferences, with invited speaker invitations for a range of topics including palliative care, PPI, clinical trials, patient experience, and qualitative methodologies.
To be added.
Pwyllgorau ac adolygu
- School of Medicine representative: Cardiff University Equality and Diversity Panel
- Honorary Professor Swansea University Clinical Trials Unit
- Wales Cancer Research Centre: Member of Senior Operational Group,
- Wales Cancer Research Centre: PPI Academic Lead
- Wales Cancer Research Centre: Work Package Lead for Palliative and Supportive Care
- Wales Cancer Trials Unit: Member of Executive Board, Trial Review Group, Qualitative Lead and Patient and Public Involvement Lead,
- TSC member for Pegasus run by the Birmingham Trials Unit, which is using embedded patient experience to fully explore pressure garment therapy for burns.
- Invited reviewer for the MRC Methodology programme, the NIHR Research for Patient Benefit programme, and for the NIHR Programme Grant for Applied Research.
- Cardiff Cancer Collaborative (CCC): Executive board member
- Trial Forge: Member of national group working on clinical trials methodology www.trialforge.org
- Past Member: NISCHR Registered Research Group: Cancer
- Past member: Chair PROMS and patient experience, NCRI group, Psycho oncology
- Past Member: NISCHR Registered Research Group: Cancer
- Currently applying for membership of NCRI CSG Palliative and Supportive Care
- Currently applying for Crosscutting Theme Lead for Cancer Division of Population Medicine
I have been involved with the MSc in Palliative Medicine since 2005. This is an international distance learning course with residential modules twice per year. Each year, I deliver around 4-5 lectures on various topics. I have supervised more than 40 students with a 100% pass rate, and a high number of merits and distinctions.
Ongoing or completed MSc projects 2015/2016
- MSc: Ms Siobhan Harkin. Mobilising patients with known long bone metastases at risk of pathological fracture. Identifying the key considerations for clinical practice.
- MSc: Dr Michelle Hills. Advance care planning for preferred place of death for children and young people with life-limiting and life-threatening conditions: A qualitative study exploring healthcare professionals attitudes and discussions with children, young people and their families
- MSc: Mrs Ceri Davies. Attitudes to Sexuality in Specialist Palliative Care Nurses. Awarded Merit.
- Awarded RSM prize and MSc merit: Dr Megumi Baba. Comparing knowledge and attitudes to palliative care of paediatric oncologists in the UK and Japan.
- MSc: Elaine McGleish. Nurse independent prescribing in palliative care. Awarded distinction
My portfolio includes research into cancer interventions, management, and decision-making, focusing on colorectal, upper GI, lung, prostate, bladder and brain, and non-cancer disease including respiratory conditions, MND, and dementia support.
I have an interest in trials and study methodologies and the ethics of research in different areas (e.g. mining data from social media, interviewing very ill patients at home, trials equipoise). Another major work stream is the modelling and implementation of Public and Patient Involvement across diverse research groups and organisations.
Grant capture (circa £10million as CI, Co-CI or Co-app)
2016-2018 (Co-app) Dr Emily Harrop, Dr Anthony Byrne, Dr Despina Anagnostou, Dr Annmarie Nelson. Development of a core outcome set for bereavement interventions. Marie Curie Cancer Care £85,000
2015-2020 (Co-app) Joint lead applicants: Dr Maria Hawkins (Gray Institute for Radiation Oncology and Biology), Dr Somnath Mukherjee (University of Oxford) SCOPE2 - A randomised Phase II/III trial to study radiotherapy dose escalation in patients with oesophageal cancer treated with definitive chemo-radiation with an embedded Phase II trial for patients with a poor early response using positron emission tomography (PET) . CTAAC CRUK £1,682,836
2015-2016 (Co-app) Dr Simon Noble, Dr Annmarie Nelson. The Challenge Pathway Study: An evaluation of an innovative service model for the end of life care of people with dementia. Aneurin Bevan £30,000
2015-2018 (Co-app) Dr Anthony Byrne (co-app WCRC £4.5m) Dr Annmarie Nelson, Dr Simon Noble. Wales Cancer Research Centre: Work Package 9 Health and Social Research Wales £83,000
2015-2018 (Co-app) Dr Simon Noble, Annmarie Nelson. HIDDEN; DVT Hospice Prevalence observational study. Doppler scans of hospice inpatients to establish prevalence of asymptomatic DVT. HTA £350,000
2013-2017 (Co-app) Dr Anthony Byrne, Dr Annmarie Nelson (grant holder), Mr Gareth Griffiths, Baroness Professor Ilora Finlay, , Dr Simon Noble. Infrastructure funding for Marie Curie Palliative Care Research Centre, Wales. Marie Curie Cancer Care £1,353,928
2014-2017. (co Chief Investigator) Dr John Staffurth, Dr Annmarie Nelson et al. EAGLE: ‘Improving the wellbeing of men by evaluating and addressing the gastrointestinal late effects of radical treatment for prostate cancer’. Prostate cancer UK via Movember £468,000
2013-2016 (CI) Dr Annmarie Nelson et al. PACT development of an intervention to support lung cancer Patients and their clinicians when considering systemic Anti-Cancer Therapy. Stepping Stones, Velindre NHS Trust Charitable Funds. £206,000
2013-2016 (co Chief Investigator) Dr Annmarie Nelson and Dr Simon Noble. PhD studentship: The development and validation of a patient reported outcome measure tool for assessing skin toxicities associated with tyrosine kinase inhibitor administration. Stepping Stones, Velindre NHS Trust Charitable Funds. PhD studentship. £160, 736
2013-2014 (CI) Dr Annmarie Nelson et al After: Refinement of IWGC questionnaire Tenovus. £30,000
2013-2014 (Co-app) Dr John Green, Dr Annmarie Nelson et al. DESIGNER: Development of GI RT symptom assessment tool. Tenovus £30,000
2012-2015 (Co-app) Dr Simon Noble, Dr Annmarie Nelson et al. PELICAN: Patient Experience of Living with CANcer associated thrombosis. Leo Pharma. £250,000
2012-2014 (Co-app) Dr Simon Noble, Dr Annmarie Nelson et al. TROPHY: Thrombosis Registry of Palliative and Hospice Units. Pfizer £80,000
2012-2015 (Co-app) Dr A Byrne, Dr Annmarie Nelson et al. CaNoPy: A study of the Care Needs of Idiopathic Pulmonary Fibrosis (IPF) patients and their carers. Marie Curie Cancer Care. £117,000.
2012-2015 (Co-app) Dr S Noble, Dr Annmarie Nelson et al. ALICAT: A feasibility study to inform the design of a randomised controlled trial to identify the most clinically and cost effect length of Anticoagulation with Low molecular weight heparin In the treatment of Cancer Associated Thrombosis. NIHR HTA £660,000
2012-2018 HTA. (Co-app) Dr Douglas Adamson/Dr Anthony Byrne (CIs) Dr Annmarie Nelson et al. ROCS: Radiotherapy and stent in oesophageal cancer. NIHR HTA £2,200,000
2011-2013 (co Chief Investigator) Dr Simon Noble/Dr Annmarie Nelson et al. Qualfrag. Velindre Charitable Funds Stepping Stones Charity £68,000
2011-2012 (Co-app) Dr Anthony Byrne, Dr Annmarie Nelson et al. RECC: Baseline exercise and cachexia study. Tenovus £30,000
2010-2013 (Co-app) Dr Anthony Byrne, Dr Annmarie Nelson, Mr Gareth Griffiths, Baroness Professor Ilora Finlay, Prof Tim Maughan, Dr Simon Noble, Dr Andy Fowell. Marie Curie Cancer Care. Infrastructure funding for Marie Curie Palliative Care Research Centre, Wales. Marie Curie Cancer Care £750,000
2011-2014 (Co-app) Dr Richard Neal, Dr A Nelson et al. El-CID: Improved lung cancer identification by targeted chest x-ray. NIHR NAEDI £239,987
2009-2011 (Co-app) Dr Andrew Wilcock, Dr Annmarie Nelson et al. NMES: Is neuromuscular electrical stimulation an acceptable and feasibly supportive therapy for patients with non-small cell lung cancer receiving palliative chemotherapy? SuPaC £269,331
2009-2011 (Co-app) Prof John Kelly, Dr Annmarie Nelson et al. BOLERO: Open versus Laparoscopic or Robotic cystectomy. A study to determine the feasibility of randomisation to open versus minimal access cystectomy in patients with muscle invasive bladder cancer. CRUK £52,766
2008-2010. (Co-app) Prof Tim Maughan, Dr Annmarie Nelson et al. FOCUS III: A study to determine the feasibility of molecular selection of therapy in patients with metastatic colorectal cancer Medical Research Council. London £525,000
2008-2009 (Co-app) Dr Anthony Byrne, Dr Annmarie Nelson et al. BRITECOG: Validating breathlessness measures for use in patients with lung cancer: a cognitive interview study. Velindre Trust Small Grant Award Committee £8,019
2008-2010. (CI) Dr Annmarie Nelson et al. QUALZICE: A QUALitative exploration of the experiences of ZICE clinical trial participants with metastatic breast cancer receiving intravenous or oral bisphosphonates at clinic or home. Velindre Charitable Trusts Scheme. £37,180
Palliative and Supportive Care
Treatment decision support for lifr limiting conditions
Late effects of cancer treatment
Patient and Public Involvement
Patient and carer experience
Prosiectau ymchwil ôl-raddedig
Current PhD supervision
Pamela Smith. Smoking cessation in deprived communities. 2017-2020.
MPhil supervision. 2013-2016: Dr Gareth Watts. The development and validation of a patient reported outcome measure tool for assessing skin toxicities associated with tyrosine kinase inhibitor administration. Co-supervisor. Pass.
Undergraduate Medicine Intercalated degree 2017: Rhianna Church. Decisions around dying in palliative and end of life care.Supervisor. Awarded 2.1
Recent completed MSc projects 2014-2016
MSc: Dr Michelle Hills. Advance care planning for preferred place of death for children and young people with life-limiting and life-threatening conditions: A qualitative study exploring healthcare professionals’ attitudes and discussions with children, young people and their families.
Supervisor. Awarded distinction.
MSc: Mrs Ceri Davies. Attitudes to Sexuality in Specialist Palliative Care Nurses.Supervisor
MSc: Dr Megumi Baba. Comparing knowledge and attitudes to palliative care of paediatric oncologists in the UK and Japan.Supervisor. Awarded Royal Society of Medicine national prize and MSc merit
MSc: Elaine McGleish. Nurse independent prescribing in palliative care. Supervisor