Demonstrating in 1st and 2nd year clinical practicals (Dispensing and Primary Care)
Educational and Professional Qualifications
2009 BSc (Hons) Optometry Cardiff University
Research Topics and Related Projects
Light entering the eye reduces the concentration of visual pigment in the retinal photoreceptor layer. At bleaching cessation, these visual pigments begin to regenerate. Using a highly sensitive Luca Andor CCD, we are able to capture retinal images in very low light levels. Recording these retinal images following retinal exposure to a bleaching source provides us with the ability to monitor the regeneration of visual pigments. Densitometry is the measurement of visual pigment optical density, and the change over time corresponds to visual pigment regeneration. Using 10 wavelengths across the visible spectrum it is possible to separate responses from rods, M- and L-cones.
Currently in its second generation, our densitometer has provided us with absorption spectra for 1 protanope and 3 control participants. Using these data, it is possible to create a spatial map of both rod and cone distribution and regeneration recovery rates across the retina. Visual pigment regeneration has been shown to be reduced in patients with AMD, and as such, densitometry will aid with the diagnosis and monitoring of early AMD.
Dr Tom Margrain, School of Optometry and Vision Sciences, Cardiff University
Dr Alison Binns, School of Health Sciences, City University
Dr Carole Tucker, School of Physics and Astronomy, Cardiff University
UK Astronomy Technology Centre (UKATC), Edinburgh, Evaluation and development of a retinal imaging densitometer