Jordanna Dally

Research student, Ysgol Deintyddiaeth

Qualifications

BSc (Hons) Biomedical Science, Plymouth University (2012)

MRes Biomedical Research, Cardiff University (2014)

Thesis

Pharmaceutical evaluation of novel tiglianes as modulators of dermal fibroblast-myofibroblast differentiation, scar formation and fibrosis; and elucidation of their underlying mechanisms of action.

My PhD is evaluating the potential of novel epoxy-tigliane pharmaceuticals, EBC-46 and EBC-211, as anti-scarring agents.  These compounds occur naturally in seeds of the Fontain’s Blushwood Tree, indigenous to Queensland’s tropical rainforest.  In clinical trials, QBiotics (www.qbiotics.com/) have shown that EBC-46 stimulates dermal wound healing responses, including wound closure and minimal scarring.  Transforming growth factor-β1 (TGF-β1)-driven fibroblast-myofibroblast differentiation is pivotal to wound closure and scarring.  Thus, fibroblasts and myofibroblasts represent viable targets for the anti-scarring properties of epoxy-tiglianes.  My research is elucidating the mechanisms underlying the modulatory effects of epoxy-tiglianes on fibroblasts/myofibroblast responses, to develop these compounds as anti-scarring treatments.

Dr Ryan Moseley

Senior Lecturer in Tissue Repair & Programme Director CITER MSc in Tissue Engineering