Research student, Ysgol Deintyddiaeth
BSc (Hons) Biomedical Science, Plymouth University (2012)
MRes Biomedical Research, Cardiff University (2014)
Pharmaceutical evaluation of novel tiglianes as modulators of dermal fibroblast-myofibroblast differentiation, scar formation and fibrosis; and elucidation of their underlying mechanisms of action.
My PhD is evaluating the potential of novel epoxy-tigliane pharmaceuticals, EBC-46 and EBC-211, as anti-scarring agents. These compounds occur naturally in seeds of the Fontain’s Blushwood Tree, indigenous to Queensland’s tropical rainforest. In clinical trials, QBiotics (www.qbiotics.com/) have shown that EBC-46 stimulates dermal wound healing responses, including wound closure and minimal scarring. Transforming growth factor-β1 (TGF-β1)-driven fibroblast-myofibroblast differentiation is pivotal to wound closure and scarring. Thus, fibroblasts and myofibroblasts represent viable targets for the anti-scarring properties of epoxy-tiglianes. My research is elucidating the mechanisms underlying the modulatory effects of epoxy-tiglianes on fibroblasts/myofibroblast responses, to develop these compounds as anti-scarring treatments.