Ahmed Al Qarakhli

Research student, Ysgol Deintyddiaeth

Altered bone cell biology associated with type 2 diabetes Mellitus – consequences for periodontal disease

Type 2 Diabetes Mellitus develops in response to exposure of the body’s cells to supra-physiological levels of glucose, rendering them resistant to insulin, although biological mechanisms are unknown. Our own previous research has indicated a delay in bone healing, which has particular consequences for placement of implants and susceptibility to periodontal disease.  Significantly, our research has a large increase in the extracellular matrix protein called osteopontin within diabetic healing bone tissues which could have a detrimental effect on mineral tissue formation.  This project aims to gain a greater understanding of the effect of supra-physiological glucose levels on mesenchymal stem cells - their ability to synthesise osteopontin and hence their ability to synthesis of bone tissue.  Further, the influence of LPS derived from P. gingivalis will also be examined, assessing the consequences of periodontal infection on the diabetic healing environment.

BDS University of Bagdad (1996)

Master of Science Periodontics University of Bagdad (2002)